Published in Am J Pathol on July 01, 2005
Macrophage diversity in renal injury and repair. J Clin Invest (2008) 4.41
Tissue engineering tools for modulation of the immune response. Biotechniques (2011) 1.12
Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases. Endocr Rev (2012) 1.11
By homing to the kidney, activated macrophages potently exacerbate renal injury. Am J Pathol (2008) 1.11
Macrophages heterogeneity in atherosclerosis - implications for therapy. J Cell Mol Med (2010) 1.05
TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α. Lab Invest (2011) 1.04
Eicosanoids and renal damage in cardiometabolic syndrome. Expert Opin Drug Metab Toxicol (2008) 0.99
Pathogenic and protective role of macrophages in kidney disease. Am J Physiol Renal Physiol (2013) 0.97
Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress. Toxicol Appl Pharmacol (2012) 0.95
A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo. Immunology (2014) 0.94
Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype. PLoS One (2015) 0.89
Renal macrophage infiltration is associated with a poor outcome in IgA nephropathy. Clinics (Sao Paulo) (2012) 0.84
Dendritic cells and macrophages in kidney disease. Clin Exp Nephrol (2009) 0.84
Macrophage Phenotype in Kidney Injury and Repair. Kidney Dis (Basel) (2015) 0.82
Controlled release strategies for modulating immune responses to promote tissue regeneration. J Control Release (2015) 0.81
Delivery of microRNA-146a with polyethylenimine nanoparticles inhibits renal fibrosis in vivo. Int J Nanomedicine (2015) 0.81
Dendritic Cells and Macrophages: Sentinels in the Kidney. Clin J Am Soc Nephrol (2015) 0.80
A shift towards pro-inflammatory CD16+ monocyte subsets with preserved cytokine production potential after kidney transplantation. PLoS One (2013) 0.80
Macrophage subset sensitivity to endotoxin tolerisation by Porphyromonas gingivalis. PLoS One (2013) 0.78
Gut macrophage phenotype is dependent on the tumor microenvironment in colorectal cancer. Clin Transl Immunology (2016) 0.77
Alternative activation of macrophages. Nat Rev Immunol (2003) 27.53
Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63
NF-kappaB regulation in the immune system. Nat Rev Immunol (2002) 15.80
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science (1996) 11.29
The many faces of macrophage activation. J Leukoc Biol (2003) 8.95
Resolution of lung inflammation by CD44. Science (2002) 4.09
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J (1997) 3.34
Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol (2002) 3.00
Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest (2003) 2.66
Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury. Kidney Int (2004) 2.29
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. EMBO J (2000) 2.11
Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent. Proc Natl Acad Sci U S A (1998) 2.01
Evidence for a pathogenic role of a cell-mediated immune mechanism in experimental glomerulonephritis. J Exp Med (1978) 1.98
BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages. J Biol Chem (2004) 1.92
Initial cytokine exposure determines function of macrophages and renders them unresponsive to other cytokines. J Immunol (1998) 1.57
Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype. Blood (2003) 1.40
Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. Am J Pathol (2000) 1.40
Adoptive transfer studies demonstrate that macrophages can induce proteinuria and mesangial cell proliferation. Kidney Int (2003) 1.30
Multiple facets of macrophages in renal injury. Kidney Int (2004) 1.28
RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway. J Immunol (2001) 1.27
Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis. J Am Soc Nephrol (2003) 1.19
Functional switching of macrophage responses to tumor necrosis factor-alpha (TNF alpha) by interferons. Implications for the pleiotropic activities of TNF alpha. J Clin Invest (1994) 1.19
Specific NF-kappaB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells. Immunology (1998) 1.16
Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis. Invest Ophthalmol Vis Sci (2002) 1.16
IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J Immunol (2002) 1.02
Bone-marrow-derived macrophages genetically modified to produce IL-10 reduce injury in experimental glomerulonephritis. Mol Ther (2002) 1.01
IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis. Eur J Immunol (1999) 1.01
Expression of nitric oxide synthase isoforms in bone and bone cell cultures. J Bone Miner Res (1997) 0.96
Macrophages transfected with adenovirus to express IL-4 reduce inflammation in experimental glomerulonephritis. J Immunol (2001) 0.96
Macrophages from inflamed but not normal glomeruli are unresponsive to anti-inflammatory cytokines. Am J Pathol (2000) 0.95
Interferon-gamma augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism. J Am Soc Nephrol (2003) 0.89
Effect of interleukin-10 treatment on crescentic glomerulonephritis in rats. Kidney Int (1997) 0.89
Macrophage-mediated renal injury is dependent on signaling via the JNK pathway. J Am Soc Nephrol (2004) 0.89
The relationship of inflammation and initiation of autoimmune disease: role of TNF super family members. Curr Top Microbiol Immunol (2002) 0.88
Glomerular expression of interleukin-1 receptor antagonist and interleukin-1 beta genes in antibody-mediated glomerulonephritis. Am J Pathol (1994) 0.85
Heterogeneity of macrophage activation in anti-Thy-1.1 nephritis. Am J Pathol (2003) 0.84
Glomerular expression and cell origin of transforming growth factor-beta 1 in anti-glomerular basement membrane disease. Am J Med Sci (1994) 0.80
Transforming growth factor-beta isoforms and glomerular injury in nephrotoxic nephritis. Kidney Int (2000) 0.80
Gene transfer into inflamed glomeruli using macrophages transfected with adenovirus. Gene Ther (2000) 0.80
Intestinal inflammation targets cancer-inducing activity of the microbiota. Science (2012) 7.54
Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med (2012) 6.93
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med (2011) 6.34
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med (2010) 4.37
Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med (2008) 3.87
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology (2003) 3.51
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science (2010) 2.99
The microbiome and cancer. Nat Rev Cancer (2013) 2.86
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One (2009) 2.79
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One (2010) 2.60
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity (2012) 2.07
Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction. J Am Coll Cardiol (2008) 1.97
Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci (2002) 1.95
Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice. Kidney Int (2012) 1.92
In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol (2004) 1.84
The renal mononuclear phagocytic system. J Am Soc Nephrol (2011) 1.84
Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis. J Immunol (2007) 1.82
Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function. J Leukoc Biol (2011) 1.82
The immune system and kidney disease: basic concepts and clinical implications. Nat Rev Immunol (2013) 1.76
The fine specificity and cytokine profile of T-helper cells responsive to the alpha3 chain of type IV collagen in Goodpasture's disease. J Am Soc Nephrol (2003) 1.70
Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2. Kidney Int (2012) 1.69
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
HLA has strongest association with IgA nephropathy in genome-wide analysis. J Am Soc Nephrol (2010) 1.64
STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells. Blood (2004) 1.58
Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo. J Am Soc Nephrol (2002) 1.57
Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis. Inflamm Bowel Dis (2007) 1.55
IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines. J Biol Chem (2002) 1.48
Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem (2005) 1.41
Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. Gastroenterology (2011) 1.39
NF-kappaB and the intestine: friend or foe? Inflamm Bowel Dis (2008) 1.33
Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo. J Immunol (2008) 1.32
Think small: zebrafish as a model system of human pathology. J Biomed Biotechnol (2012) 1.30
Multiple facets of macrophages in renal injury. Kidney Int (2004) 1.28
Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide. J Immunol (2007) 1.22
Stochastic changes over time and not founder effects drive cage effects in microbial community assembly in a mouse model. ISME J (2013) 1.21
The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis. Arthritis Res Ther (2010) 1.20
Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition. PLoS One (2012) 1.19
Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis. Inflamm Bowel Dis (2011) 1.16
The induction of macrophage hemeoxygenase-1 is protective during acute kidney injury in aging mice. Kidney Int (2011) 1.16
Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis. Invest Ophthalmol Vis Sci (2002) 1.16
High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis. J Am Soc Nephrol (2012) 1.15
The struggle within: microbial influences on colorectal cancer. Inflamm Bowel Dis (2011) 1.15
Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. Gastroenterology (2009) 1.15
Gut microbiota and probiotics in colon tumorigenesis. Cancer Lett (2011) 1.12
The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Immunology (2005) 1.10
Interaction between resident luminal bacteria and the host: can a healthy relationship turn sour? J Pediatr Gastroenterol Nutr (2004) 1.10
Impact of a focussed teaching programme on practical prescribing skills among final year medical students. Br J Clin Pharmacol (2011) 1.09
Macrophages expressing heme oxygenase-1 improve renal function in ischemia/reperfusion injury. Mol Ther (2010) 1.08
Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. PLoS One (2009) 1.07
Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis. PLoS One (2012) 1.06
Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancer. Mol Pharmacol (2008) 1.06
Serum amyloid A activates NF-kappaB and proinflammatory gene expression in human and murine intestinal epithelial cells. Eur J Immunol (2005) 1.06
Urinary endothelin-1 in chronic kidney disease and as a marker of disease activity in lupus nephritis. Am J Physiol Renal Physiol (2009) 1.06
Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice. J Biol Chem (2008) 1.04
Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. Oncogene (2005) 1.04
Macrophages and the kidney. Curr Opin Nephrol Hypertens (2004) 1.04
Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation. Sci Rep (2013) 1.02
Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells. J Cell Physiol (2004) 1.02
Gnotobiotic IL-10; NF-kappaB mice develop rapid and severe colitis following Campylobacter jejuni infection. PLoS One (2009) 1.02
Inflammatory cells in renal injury and repair. Semin Nephrol (2007) 1.02
Toll-like receptor 9-dependent macrophage activation by Entamoeba histolytica DNA. Infect Immun (2007) 1.01
Bone-marrow-derived macrophages genetically modified to produce IL-10 reduce injury in experimental glomerulonephritis. Mol Ther (2002) 1.01
Hemeoxygenase-1 and renal ischaemia-reperfusion injury. Nephron Exp Nephrol (2010) 1.01
Nitric oxide is an important mediator of renal tubular epithelial cell death in vitro and in murine experimental hydronephrosis. Am J Pathol (2006) 0.99
Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling. Gastroenterology (2011) 0.98
The complex interplay between inflammation, the microbiota and colorectal cancer. Gut Microbes (2013) 0.98
Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda. Inflamm Bowel Dis (2013) 0.97
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity (2012) 0.97
Mu opioid signaling protects against acute murine intestinal injury in a manner involving Stat3 signaling. Am J Pathol (2011) 0.96
Healthy individuals have Goodpasture autoantigen-reactive T cells. J Am Soc Nephrol (2008) 0.96
PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response. PLoS One (2011) 0.96
Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis. PLoS One (2009) 0.95
Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A. Cell Microbiol (2014) 0.95
Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling. Am J Pathol (2013) 0.94
A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo. Immunology (2014) 0.94
Pretreatment with the probiotic VSL#3 delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer. Am J Physiol Gastrointest Liver Physiol (2011) 0.93
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock (2011) 0.93
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One (2012) 0.92
Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes. J Cell Physiol (2006) 0.91
NF-kappaB-inducing kinase restores defective IkappaB kinase activity and NF-kappaB signaling in intestinal epithelial cells. Cell Signal (2004) 0.91
Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses. Dis Model Mech (2012) 0.91
Diet, microbiome, and the intestinal epithelium: an essential triumvirate? Biomed Res Int (2013) 0.91
The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. PLoS One (2007) 0.89
Macrophage heterogeneity in renal inflammation. Nephrol Dial Transplant (2003) 0.89
Adenosine is a negative regulator of NF-kappaB and MAPK signaling in human intestinal epithelial cells. Cell Immunol (2005) 0.88
Endothelin-1 and the kidney--beyond BP. Br J Pharmacol (2012) 0.88
Could a swimming creature inform us on intestinal diseases? Lessons from zebrafish. Inflamm Bowel Dis (2014) 0.88
VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer. Sci Rep (2013) 0.87
Colorectal cancer: CRC--all about microbial products and barrier function? Nat Rev Gastroenterol Hepatol (2012) 0.87
Genotypic diversity of complement component C4 does not predict kidney transplant outcome. J Am Soc Nephrol (2010) 0.86
Immunosuppression for membranous nephropathy. Lancet (2013) 0.86
Characterisation of tumour-infiltrating macrophages: impact on response and survival in patients receiving primary chemotherapy for breast cancer. Breast Cancer Res Treat (2012) 0.85
Computed tomography angiography in the diagnosis of ANCA-associated small- and medium-vessel vasculitis. Am J Kidney Dis (2013) 0.85
Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci (2012) 0.85