Published in Blood on June 28, 2005
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Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo. Blood (2006) 1.22
An important role for Akt3 in platelet activation and thrombosis. Blood (2011) 1.19
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood (2008) 1.11
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ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β. Arterioscler Thromb Vasc Biol (2012) 0.91
LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis. Blood (2013) 0.88
The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation. J Biol Chem (2012) 0.85
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A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood (2005) 2.90
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Evidence for activation of tissue factor by an allosteric disulfide bond. Biochemistry (2006) 1.99
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High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
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Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin. Blood (2011) 1.54
The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface. J Biol Chem (2003) 1.49
Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol Cell Biol (2006) 1.48
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Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa. Blood (2011) 1.44
Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. J Biol Chem (2002) 1.39
Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood (2008) 1.39
P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface. Blood (2003) 1.34
Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo. Blood (2006) 1.22
A critical role for 14-3-3zeta protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications. Blood (2005) 1.20
Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene. J Biol Chem (2006) 1.12
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood (2008) 1.11
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Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. Blood (2002) 1.09
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Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V. Arthritis Rheum (2006) 1.09
The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood (2002) 1.07
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Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa. Blood (2007) 1.06
Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. Blood (2004) 1.04
BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation. Blood (2002) 1.04
Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor. J Biol Chem (2006) 1.03
Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. J Biol Chem (2011) 1.01
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Platelet adhesion: a game of catch and release. J Clin Invest (2008) 1.00
Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha. Blood (2004) 0.99
Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets. Thromb Haemost (2005) 0.98
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The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large. J Biol Chem (2004) 0.96
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Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain. J Biol Chem (2003) 0.93
Platelet receptor proteolysis: a mechanism for downregulating platelet reactivity. Arterioscler Thromb Vasc Biol (2007) 0.92
The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation. Arterioscler Thromb Vasc Biol (2012) 0.92
Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor. J Biol Chem (2008) 0.92
Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood. J Biol Chem (2012) 0.92
ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β. Arterioscler Thromb Vasc Biol (2012) 0.91
The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling. Blood (2005) 0.90
Platelet receptor redox regulation. Platelets (2008) 0.88
LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis. Blood (2013) 0.88
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Roles of purinergic receptor P2Y, G protein-coupled 12 in the development of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2012) 0.88
Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI. Blood (2002) 0.87
Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation. Blood (2009) 0.87
Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels. Blood (2012) 0.87
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The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation. J Biol Chem (2012) 0.85
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Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane. J Biol Chem (2007) 0.84
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Snake venom probes of platelet adhesion receptors and their ligands. Toxicon (2005) 0.83
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Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding. Platelets (2009) 0.83
Integrin αIIb-mediated PI3K/Akt activation in platelets. PLoS One (2012) 0.82
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Characterization of a myeloma patient with a life-threatening hemorrhagic diathesis: presence of a lambda dimer protein inhibiting shear-induced platelet aggregation by binding to the A1 domain of von Willebrand factor. Thromb Haemost (2005) 0.81
Purinergic P2Y12 receptor blockade inhibits shear-induced platelet phosphatidylinositol 3-kinase activation. Mol Pharmacol (2003) 0.80
Cadherin 6 has a functional role in platelet aggregation and thrombus formation. Arterioscler Thromb Vasc Biol (2012) 0.80
GPIbalpha-selective activation of platelets induces platelet signaling events comparable to GPVI activation events. Platelets (2010) 0.80
The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIa. Biochem J (2004) 0.80
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The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism. PLoS One (2012) 0.78
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Measuring soluble platelet glycoprotein VI in human plasma by ELISA. Platelets (2009) 0.78
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