Published in Proc Natl Acad Sci U S A on June 30, 2005
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol (2006) 2.57
Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia. J Clin Invest (2009) 2.13
Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene (2008) 1.95
Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood (2010) 1.84
Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev (2010) 1.64
Notch signaling in the vasculature. Curr Top Dev Biol (2010) 1.62
VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis. Br J Cancer (2008) 1.55
Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice. Proc Natl Acad Sci U S A (2008) 1.53
Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis. Development (2008) 1.43
Interaction between alk1 and blood flow in the development of arteriovenous malformations. Development (2011) 1.42
Sustained endothelial expression of HoxA5 in vivo impairs pathological angiogenesis and tumor progression. PLoS One (2015) 1.41
An artery-specific fluorescent dye for studying neurovascular coupling. Nat Methods (2012) 1.31
Loss of unc45a precipitates arteriovenous shunting in the aortic arches. Dev Biol (2008) 1.17
Novel insights into the differential functions of Notch ligands in vascular formation. J Angiogenes Res (2009) 1.16
Notch-1 signalling is activated in brain arteriovenous malformations in humans. Brain (2009) 1.15
Notch4 normalization reduces blood vessel size in arteriovenous malformations. Sci Transl Med (2012) 1.14
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease. Lab Invest (2009) 1.12
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol (2012) 1.08
Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature. Proc Natl Acad Sci U S A (2007) 1.07
Brothers and sisters: molecular insights into arterial-venous heterogeneity. Circ Res (2008) 1.03
Biology of cerebral arteriovenous malformations with a focus on inflammation. J Cereb Blood Flow Metab (2014) 1.03
Distinct Notch signaling outputs pattern the developing arterial system. Development (2014) 1.02
Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol (2008) 0.99
Fbxw7 controls angiogenesis by regulating endothelial Notch activity. PLoS One (2012) 0.97
Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations. Circ Res (2008) 0.97
BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II. Angiogenesis (2012) 0.95
BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development (2013) 0.94
Line-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animals. PLoS One (2012) 0.93
Notch signaling in developmental and tumor angiogenesis. Genes Cancer (2011) 0.93
Signaling required for blood vessel maintenance: molecular basis and pathological manifestations. Int J Vasc Med (2011) 0.91
Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. Am J Physiol Lung Cell Mol Physiol (2009) 0.90
Brain arteriovenous malformation modeling, pathogenesis, and novel therapeutic targets. Transl Stroke Res (2014) 0.90
Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9. J Cereb Blood Flow Metab (2009) 0.88
Dll4-Notch signaling in regulation of tumor angiogenesis. J Cancer Res Clin Oncol (2013) 0.86
3-dimensional resin casting and imaging of mouse portal vein or intrahepatic bile duct system. J Vis Exp (2012) 0.86
Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis. Transgenic Res (2012) 0.86
Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels. Proc Natl Acad Sci U S A (2014) 0.84
Genetic mouse models to study blood-brain barrier development and function. Fluids Barriers CNS (2013) 0.83
Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation. Mol Cell Biol (2007) 0.83
Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice. Development (2014) 0.82
Notch signaling in ocular vasculature development and diseases. Mol Med (2012) 0.82
Notch4 is activated in endothelial and smooth muscle cells in human brain arteriovenous malformations. J Cell Mol Med (2013) 0.82
Notch signaling and neurogenesis in normal and stroke brain. Int J Physiol Pathophysiol Pharmacol (2009) 0.82
Regulation of signaling interactions and receptor endocytosis in growing blood vessels. Cell Adh Migr (2014) 0.82
Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy. Dev Dyn (2010) 0.80
Zebrafish models of cerebrovascular disease. J Cereb Blood Flow Metab (2014) 0.80
Notch1 and 4 signaling responds to an increasing vascular wall shear stress in a rat model of arteriovenous malformations. Biomed Res Int (2014) 0.80
Endothelial signaling and the molecular basis of arteriovenous malformation. Cell Mol Life Sci (2013) 0.79
Cell-cell interactions influence vascular reprogramming by Prox1 during embryonic development. PLoS One (2013) 0.79
Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations. Cardiovasc Res (2015) 0.78
Temporal expression analysis of angiogenesis-related genes in brain development. Vasc Cell (2012) 0.77
Notch regulation of hematopoiesis, endothelial precursor cells, and blood vessel formation: orchestrating the vasculature. Stem Cells Int (2012) 0.77
Oncogenic role of the Notch pathway in primary liver cancer. Oncol Lett (2016) 0.77
Overexpression of Notch1 ectodomain in myeloid cells induces vascular malformations through a paracrine pathway. Am J Pathol (2007) 0.77
Rosuvastatin counteracts vessel arterialisation and sinusoid capillarisation, reduces tumour growth, and prolongs survival in murine hepatocellular carcinoma. Gastroenterol Res Pract (2011) 0.76
Endothelial notch signaling is essential to prevent hepatic vascular malformations in mice. Hepatology (2016) 0.76
BMP signaling modulation attenuates cerebral arteriovenous malformation formation in a vertebrate model. J Cereb Blood Flow Metab (2014) 0.76
Vascular patterning sets the stage for macro and micro hepatic architecture. Dev Dyn (2014) 0.76
Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nat Cell Biol (2017) 0.75
Molecular, Cellular, and Genetic Determinants of Sporadic Brain Arteriovenous Malformations. Neurosurgery (2016) 0.75
Mouse Models of Cerebral Arteriovenous Malformation. Stroke (2015) 0.75
Conservative therapy with a gonadotropin-releasing hormone agonist for a uterine arteriovenous malformation in a patient with congenital heart disease. Clin Case Rep (2015) 0.75
ALK1 signaling in development and disease: new paradigms. Cell Mol Life Sci (2017) 0.75
Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell (1998) 10.61
Heart failure. N Engl J Med (2003) 9.75
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. Proc Natl Acad Sci U S A (1926) 6.61
Notch signaling: control of cell communication and cell fate. Development (2004) 5.95
Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development (2001) 5.46
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev (2003) 4.89
Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science (2003) 4.56
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet (1999) 4.55
Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc Natl Acad Sci U S A (1997) 4.52
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev (2004) 4.41
Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A (2004) 4.06
Notch1 is essential for postimplantation development in mice. Genes Dev (1994) 4.06
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development (1996) 3.84
Increased vascularization in mice overexpressing angiopoietin-1. Science (1998) 3.67
Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat Biotechnol (1999) 3.04
Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J (2002) 2.74
Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mech Dev (2001) 2.69
Notch function in the vasculature: insights from zebrafish, mouse and man. Bioessays (2004) 2.59
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A (2001) 2.56
Flow regulates arterial-venous differentiation in the chick embryo yolk sac. Development (2003) 2.43
Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations. Development (2004) 2.35
Arteries and veins: making a difference with zebrafish. Nat Rev Genet (2002) 2.31
Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res (2004) 2.10
Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases. Am J Physiol Cell Physiol (2003) 2.00
Heart diseases affecting the liver and liver diseases affecting the heart. Am Heart J (2000) 1.94
Time course of endothelial cell proliferation and microvascular remodeling in chronic inflammation. Am J Pathol (2001) 1.67
Cellular mechanics and gene expression in blood vessels. J Biomech (2003) 1.63
Notch receptor expression in adult human liver: a possible role in bile duct formation and hepatic neovascularization. Hepatology (2001) 1.30
Notch signaling in primary endothelial cells. Ann N Y Acad Sci (2003) 1.29
Arterial enlargement, tortuosity, and intimal thickening in response to sequential exposure to high and low wall shear stress. J Vasc Surg (2004) 1.27
Liver disease in hereditary hemorrhagic telangiectasia. J Clin Gastroenterol (2003) 1.01
Molecular basis of vascular anomalies. Trends Cardiovasc Med (1998) 0.98
New technique for measurement of left ventricular pressure in conscious mice. Am J Physiol Heart Circ Physiol (2003) 0.94
Inflammation and cancer. Nature (2002) 53.78
New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer (2002) 24.71
Matrix metalloproteinases: regulators of the tumor microenvironment. Cell (2010) 12.90
Lifeact: a versatile marker to visualize F-actin. Nat Methods (2008) 12.23
Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol (2007) 10.17
Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nat Biotechnol (2006) 9.95
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell (2002) 9.36
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature (2012) 8.13
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell (2008) 8.01
Immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med (2002) 7.35
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med (2009) 6.72
The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol (2012) 6.07
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell (2002) 5.56
Seeding and propagation of untransformed mouse mammary cells in the lung. Science (2008) 5.33
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med (2006) 5.22
Stromal effects on mammary gland development and breast cancer. Science (2002) 5.22
GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell (2006) 4.98
Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem (2004) 4.89
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A (2003) 4.69
The need for a public proteomics repository. Nat Biotechnol (2004) 4.60
PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol (2005) 4.57
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Dev Cell (2008) 4.18
Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol (2004) 4.16
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer (2011) 4.12
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med (2002) 4.00
Tumors as organs: complex tissues that interface with the entire organism. Dev Cell (2010) 3.98
Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell (2003) 3.68
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development (2004) 3.45
GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell (2008) 3.44
Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathog (2005) 3.44
Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol (2011) 3.36
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest (2012) 3.09
Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem (2002) 2.86
Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol Cell Biol (2006) 2.85
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nat Immunol (2002) 2.83
Derivation and validation of a practical risk score for prediction of mortality after open repair of ruptured abdominal aortic aneurysms in a US regional cohort and comparison to existing scoring systems. J Vasc Surg (2012) 2.78
Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J Biol Chem (2004) 2.76
Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results. Hum Gene Ther (2011) 2.75
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (2005) 2.73
The effect of postoperative myocardial ischemia on long-term survival after vascular surgery. J Vasc Surg (2013) 2.72
Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev Cell (2003) 2.70
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol (2003) 2.68
Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Am J Hum Genet (2004) 2.66
Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus. Cell Host Microbe (2010) 2.64
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell (2012) 2.61
Hormonal and local control of mammary branching morphogenesis. Differentiation (2006) 2.60
Seminal plasma reduces the effectiveness of topical polyanionic microbicides. J Infect Dis (2007) 2.57
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol (2006) 2.57
Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A (2007) 2.56
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci (2005) 2.48
Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cancer Res (2007) 2.41
Altered fracture repair in the absence of MMP9. Development (2003) 2.41
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest (2005) 2.38
Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J (2003) 2.34
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech (2008) 2.34
Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40. Hum Mutat (2006) 2.29
Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell (2008) 2.24
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood (2008) 2.24
Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer Cell (2013) 2.22
Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci (2002) 2.21
ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proc Natl Acad Sci U S A (2012) 2.20
Peripheral arterial interventions: trends in market share and outcomes by specialty, 1998-2005. J Vasc Surg (2009) 2.20
Purification and characterization of the human gamma-secretase complex. Biochemistry (2004) 2.18
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras. Proc Natl Acad Sci U S A (2008) 2.14
Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev (2007) 2.14
Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Curr Biol (2008) 2.13
Identification of mutations in CUL7 in 3-M syndrome. Nat Genet (2005) 2.10
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC Biochem (2006) 2.09
Enhanced tumor formation in mice heterozygous for Blm mutation. Science (2002) 2.07
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis (2005) 2.05
Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn (2006) 2.03
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol (2013) 2.03
Direct and potent regulation of gamma-secretase by its lipid microenvironment. J Biol Chem (2008) 2.00
Patterning mechanisms of branched organs. Science (2008) 2.00
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol (2002) 1.99
The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Dev Biol (2007) 1.98
Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia (2005) 1.98
Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis. Dev Biol (2008) 1.97
Matrix remodeling during endochondral ossification. Trends Cell Biol (2004) 1.97
Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell (2012) 1.95
Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. Mol Cancer Ther (2008) 1.95
Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy. Cold Spring Harb Protoc (2011) 1.95
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization. J Exp Med (2005) 1.93
Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein. Proc Natl Acad Sci U S A (2005) 1.91
Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. FASEB J (2005) 1.90
Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: a comparison with a high-dose simvastatin therapy. Am J Physiol Heart Circ Physiol (2009) 1.90
CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Proc Natl Acad Sci U S A (2002) 1.89
The relationship between alcohol use and cigarette smoking in a sample of undergraduate college students. Addict Behav (2006) 1.89
Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA. PLoS Pathog (2009) 1.89
The Bacillus subtilis spore coat protein interaction network. Mol Microbiol (2006) 1.88
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol (2002) 1.88
Phospholipase dalpha1 and phosphatidic acid regulate NADPH oxidase activity and production of reactive oxygen species in ABA-mediated stomatal closure in Arabidopsis. Plant Cell (2009) 1.88
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell (2013) 1.86
Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression. Cancer Res (2005) 1.85
Vascular development of the brain requires beta8 integrin expression in the neuroepithelium. J Neurosci (2005) 1.85