Published in J Biol Chem on April 25, 1977
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Analysis of bilirubin and bilirubin mono- and di-conjugates. Determination of their relative amounts in biological samples. Biochem J (1980) 1.26
Distribution of UDPglucuronosyltransferase in rat tissue. Proc Natl Acad Sci U S A (1985) 1.15
Bilirubin diglucuronide synthesis by a UDP-glucuronic acid-dependent enzyme system in rat liver microsomes. Proc Natl Acad Sci U S A (1979) 1.14
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Bilirubin diglucuronide formation in intact rats and in isolated Gunn rat liver. J Clin Invest (1982) 0.91
Mechanism of bilirubin diglucuronide formation in intact rats: bilirubin diglucuronide formation in vivo. J Clin Invest (1980) 0.89
Twenty-five years of progress in bilirubin metabolism (1952-77). Gut (1978) 0.88
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New insights into the classification and mechanisms of hereditary, chronic, non-haemolytic hyperbilirubinaemias. Gut (1978) 0.83
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The formation and distribution of bilirubin monoglucuronide and diglucuronide in rat liver slices. Biochem J (1979) 0.80
The photoinduced isomerization of bilirubin in cationic detergent solutions. Biochem J (1980) 0.75
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Sexual transmission of hepatitis C virus. Lancet (1993) 4.27
Ligandin: a hepatic protein which binds steroids, bilirubin, carcinogens and a number of exogenous organic anions. Nature (1971) 3.93
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Nitrite and nitrate determinations in plasma: a critical evaluation. Clin Chem (1995) 3.33
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Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci U S A (1991) 2.19
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Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and cholestasis. J Clin Invest (1971) 1.97
Immunological studies of Y protein. A major cytoplasmic organic anion-binding protein in rat liver. J Clin Invest (1972) 1.71
Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem (1994) 1.69
Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes. Science (1986) 1.61
Phylogenetic study of organic anion transfer from plasma into the liver. Nat New Biol (1971) 1.60
Treatment of experimental colitis by oral tolerance induction: a central role for suppressor lymphocytes. Am J Gastroenterol (2000) 1.59
Hepatocyte transplantation for the treatment of human disease. Semin Liver Dis (1999) 1.57
A mutation in bilirubin uridine 5'-diphosphate-glucuronosyltransferase isoform 1 causing Crigler-Najjar syndrome type II. Gastroenterology (1993) 1.57
Taurocholate transport by rat liver sinusoidal membrane vesicles: evidence of sodium cotransport. Hepatology (1982) 1.57
Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits. J Biol Chem (1992) 1.55
Regulation of protein turnover in mammalian tissues. Fed Proc (1968) 1.55
Familial intrahepatic cholestasis 1: studies of localization and function. Hepatology (2001) 1.54
The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J Biol Chem (1989) 1.52
Rat liver canalicular membrane vesicles. Isolation and topological characterization. J Biol Chem (1983) 1.51
A meningococcal endocarditis in a patient with Sweet's syndrome. Int J Cardiol (2007) 1.50
Insulin-like growth factor-I in liver cirrhosis. J Hepatol (1997) 1.50
Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes. Hepatology (1995) 1.43
Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I. Hepatology (1992) 1.42
Deficiency of hepatic organic anion-binding protein as a possible cause of non-haemolytic unconjugated hyperbilirubinaemia in the newborn. Lancet (1969) 1.41
Pathogenesis and medical therapy of primary sclerosing cholangitis. Any news? Eur J Gastroenterol Hepatol (1999) 1.40
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Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology (1985) 1.39
The binding of fatty acids to cytoplasmic proteins: binding to Z protein in liver and other tissues of the rat. Biochem Biophys Res Commun (1972) 1.38
Deficiency of hepatic organic anion-binding protein, impaired organic amnion uptake by liver and "physiologic" jaundice in newborn monkeys. N Engl J Med (1970) 1.38
Organic anion-binding protein in rat liver: drug induction and its physiologic consequence. Proc Natl Acad Sci U S A (1969) 1.38
Interactions of bilirubin and other ligands with ligandin. Biochemistry (1975) 1.38
Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression. Proc Natl Acad Sci U S A (1997) 1.37
Electrophysiological properties of gap junctions between dissociated pairs of rat hepatocytes. J Cell Biol (1986) 1.37
Transporters on demand: intrahepatic pools of canalicular ATP binding cassette transporters in rat liver. J Biol Chem (2000) 1.37
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim Biophys Acta (1995) 1.35
The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence. DNA Cell Biol (1991) 1.35
Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia. Proc Natl Acad Sci U S A (1990) 1.33
Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats. Gastroenterology (1997) 1.33
Inositol 1,4,5-trisphosphate and calcium regulate the calcium channel function of the hepatic inositol 1,4,5-trisphosphate receptor. J Biol Chem (1997) 1.33
Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system. Proc Natl Acad Sci U S A (1991) 1.29
Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia. J Clin Invest (1989) 1.29
Role of ligandin in transfer of bilirubin from plasma into liver. Am J Physiol (1979) 1.27
Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase. J Clin Invest (1994) 1.26
Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease. J Pathol (1998) 1.24
Taurocholate transport by rat liver canalicular membrane vesicles. Evidence for the presence of an Na+-independent transport system. J Clin Invest (1984) 1.24
Structural and functional studies of ligandin, a major renal organic anion-binding protein. J Clin Invest (1975) 1.23
Molecular aspects of hepatobiliary transport. Am J Physiol (1997) 1.23
Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. J Biol Chem (2000) 1.23
Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion. Hepatology (1987) 1.19
ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. Br J Pharmacol (1999) 1.17
Studies on subunit structure and evidence that ligandin is a heterodimer. J Biol Chem (1978) 1.16
Distribution of UDPglucuronosyltransferase in rat tissue. Proc Natl Acad Sci U S A (1985) 1.15
Isolation of a potent cholesterol nucleation-promoting activity from human gallbladder bile: role in the pathogenesis of gallstone disease. Hepatology (1990) 1.14
Ligandin. Bilirubin binding and glutathione-S-transferase activity are independent processes. J Biol Chem (1978) 1.14
Bilirubin mono- and diglucuronide formation by human liver in vitro: assay by high-pressure liquid chromatography. Hepatology (1982) 1.13
Australia antigen: detection and transmission in shellfish. Science (1974) 1.13
The isomerisation of bilirubin monoglucuronide. Clin Chim Acta (1973) 1.12
Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter. J Biol Chem (1995) 1.12
Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology (1998) 1.12
Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo. Prolonged persistence in cytoplasmic vesicles after partial hepatectomy. J Biol Chem (1993) 1.11
Transplantation of microcarrier-attached hepatocytes into 90% partially hepatectomized rats. Hepatology (1988) 1.11
Conjugation and excretion of bilirubin. Semin Liver Dis (1983) 1.11
Delipidation and reactivation of UDPglucuronosyltransferase from rat liver. Biochim Biophys Acta (1975) 1.11
The value of Doppler ultrasound in cirrhosis and portal hypertension. Scand J Gastroenterol Suppl (1999) 1.10
Morphological and biochemical studies of benign recurrent cholestasis. Gastroenterology (1967) 1.10
Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation. Hepatology (1991) 1.10
Ligandinuria in nephrotoxic acute tubular necrosis. Kidney Int (1977) 1.10
Small bowel absorption of sulfasalazine and its hepatic metabolism in human beings, cats, and rats. Gastroenterology (1979) 1.09
Circular dichroism studies of Y protein (ligandin), a major organic anion binding protein in liver, kidney, and small intestine. Ann N Y Acad Sci (1973) 1.09
Recombinant immunoblot assay reaction patterns and hepatitis C virus RNA in blood donors and non-A, non-B hepatitis patients. Transfusion (1993) 1.09
Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes. Proc Natl Acad Sci U S A (1990) 1.09
A nucleoside transporter is functionally linked to ectonucleotidases in rat liver canalicular membrane. J Biol Chem (1992) 1.08
Subunit composition, organic anion binding, catalytic and immunological properties of ligandin from rat testis. J Biol Chem (1980) 1.08
ATP-dependent efflux of GSSG and GS-conjugate from isolated rat hepatocytes. Am J Physiol (1990) 1.08
Studies on fenestral contraction in rat liver endothelial cells in culture. Am J Pathol (1996) 1.07
Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide. Proc Natl Acad Sci U S A (1999) 1.07
Regulation of growth and differentiation of a rat hepatoma cell line by the synergistic interactions of hormones and collagenous substrata. J Cell Biol (1983) 1.07
Bile acid secretion and direct targeting of mdr1-green fluorescent protein from Golgi to the canalicular membrane in polarized WIF-B cells. J Cell Sci (1999) 1.07
The role of the canalicular multispecific organic anion transporter in the disposal of endo- and xenobiotics. Pharmacol Ther (1994) 1.06
Characterization and tissue specificity of a monoclonal antibody against human uridine 5'-diphosphate-glucuronosyltransferase. Gastroenterology (1987) 1.06
Hepatic intracellular distribution of tritium-labeled unconjugated and conjugated bilirubin in normal and Gunn rats. J Clin Invest (1966) 1.06
Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I. FASEB J (1992) 1.06