Published in J Immunol on August 01, 2005
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell (2008) 4.32
Targeting Toll-like receptors: emerging therapeutics? Nat Rev Drug Discov (2010) 3.35
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85
Flagellin as an adjuvant: cellular mechanisms and potential. J Immunol (2010) 2.68
TLR-based immune adjuvants. Vaccine (2010) 2.10
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity (2006) 2.04
An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. J Exp Med (2006) 1.94
Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology (2012) 1.88
Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis. PLoS One (2008) 1.83
The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J Immunol (2008) 1.75
A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood (2008) 1.69
TLR7 induces anergy in human CD4(+) T cells. Nat Immunol (2014) 1.56
Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR. Blood (2010) 1.55
TLR2-independent induction and regulation of chronic intestinal inflammation. Eur J Immunol (2010) 1.55
Innate immune recognition and activation during HIV infection. Retrovirology (2010) 1.45
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol (2010) 1.43
T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A (2008) 1.43
CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock. Proc Natl Acad Sci U S A (2007) 1.40
A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.39
Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. J Clin Invest (2009) 1.35
NOD2 regulates hematopoietic cell function during graft-versus-host disease. J Exp Med (2009) 1.30
The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome. Proc Natl Acad Sci U S A (2009) 1.28
Toll-like receptors in the skin. Semin Immunopathol (2007) 1.27
The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology (2008) 1.23
Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. Respir Res (2006) 1.20
Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. FASEB J (2008) 1.19
Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. J Immunol (2010) 1.18
TLR agonists: our best frenemy in cancer immunotherapy. J Leukoc Biol (2013) 1.18
IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J Exp Med (2016) 1.17
Antigen-dependent and -independent mechanisms of T and B cell hyperactivation during chronic HIV-1 infection. J Virol (2011) 1.17
Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells. Immunology (2007) 1.16
FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression. J Biol Chem (2015) 1.09
Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure. J Pharmacol Exp Ther (2012) 1.09
When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function. Blood (2010) 1.08
Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2). PLoS One (2012) 1.07
The expression and functions of toll-like receptors in atherosclerosis. Mediators Inflamm (2010) 1.07
Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2. Infect Immun (2010) 1.07
TLR9 engagement on CD4 T lymphocytes represses gamma-radiation-induced apoptosis through activation of checkpoint kinase response elements. Blood (2007) 1.01
The multiple facets of toll-like receptors in transplantation biology. Transplantation (2008) 0.99
Altering cell death pathways as an approach to cure HIV infection. Cell Death Dis (2013) 0.99
Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide. Trends Immunol (2010) 0.97
The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice. Cell Mol Immunol (2010) 0.97
Lung CD8+ T cells in COPD have increased expression of bacterial TLRs. Respir Res (2013) 0.97
Amplifying TLR-MyD88 signals within tumor-specific T cells enhances antitumor activity to suboptimal levels of weakly immunogenic tumor antigens. Cancer Res (2010) 0.97
Modulation of immune responses through direct activation of Toll-like receptors to T cells. Clin Exp Immunol (2010) 0.96
A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int J Cancer (2014) 0.95
Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation. AIDS Res Hum Retroviruses (2007) 0.94
Regulatory T cells and Toll-like receptors: what is the missing link? Int Immunopharmacol (2009) 0.94
The contribution of direct TLR signaling to T cell responses. Immunol Res (2009) 0.94
Activation requirements and responses to TLR ligands in human CD4+ T cells: comparison of two T cell isolation techniques. J Immunol Methods (2009) 0.92
Translational mini-review series on Toll-like receptors: Toll-like receptor ligands as novel pharmaceuticals for allergic disorders. Clin Exp Immunol (2007) 0.92
Signaling via TLR2 and TLR4 Directly Down-Regulates T Cell Effector Functions: The Regulatory Face of Danger Signals. Front Immunol (2013) 0.90
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun (2015) 0.90
Inducible resistance of fish bacterial pathogens to the antimicrobial peptide cecropin B. Antimicrob Agents Chemother (2008) 0.89
HIV type 1 infection up-regulates TLR2 and TLR4 expression and function in vivo and in vitro. AIDS Res Hum Retroviruses (2012) 0.89
Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies. J Clin Invest (2015) 0.89
15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. J Clin Immunol (2008) 0.89
NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells. PLoS One (2012) 0.88
HIV-1 replication activates CD4+ T cells with specificities for persistent herpes viruses. EMBO Mol Med (2010) 0.88
Toll-like receptor 7 inhibits early acute retroviral infection through rapid lymphocyte responses. J Virol (2013) 0.88
TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity. Cancer Res (2015) 0.87
Targeting of TLRs inhibits CD4+ regulatory T cell function and activates lymphocytes in human peripheral blood mononuclear cells. J Immunol (2014) 0.86
Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia. Thorax (2015) 0.86
Association pattern of interleukin-1 receptor-associated kinase-4 gene polymorphisms with allergic rhinitis in a Han Chinese population. PLoS One (2011) 0.85
Antigenic experience dictates functional role of glycogen synthase kinase-3 in human CD4+ T cell responses. J Immunol (2008) 0.85
Bacterial infections, alloimmunity, and transplantation tolerance. Transplant Rev (Orlando) (2011) 0.85
Lactobacillus gasseri OLL2809 and its RNA suppress proliferation of CD4(+) T cells through a MyD88-dependent signalling pathway. Immunology (2011) 0.84
TLR5 risk-associated haplotype for canine inflammatory bowel disease confers hyper-responsiveness to flagellin. PLoS One (2012) 0.84
The therapeutic potential of Toll-like receptor 7 stimulation in asthma. Inflamm Allergy Drug Targets (2012) 0.83
Toll-like receptor mediated modulation of T cell response by commensal intestinal microbiota as a trigger for autoimmune arthritis. J Immunol Res (2015) 0.83
Burkholderia pseudomallei infection of T cells leads to T-cell costimulation partially provided by flagellin. Infect Immun (2008) 0.82
Positive T cell co-stimulation by TLR7/8 ligands is dependent on the cellular environment. Immunobiology (2010) 0.82
Insights into the Relationship between Toll Like Receptors and Gamma Delta T Cell Responses. Front Immunol (2014) 0.82
Vaccines against respiratory viral pathogens for use in neonates: opportunities and challenges. J Immunol (2014) 0.82
Innate immunity and transplantation tolerance: the potential role of TLRs/NLRs in GVHD. Korean J Hematol (2011) 0.82
CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection. J Immunol (2013) 0.81
Toll-like receptor ligands induce the expression of interferon-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res Notes (2012) 0.81
Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells. Cell Signal (2012) 0.81
Recent advances in the role of toll-like receptors and TLR agonists in immunotherapy for human glioma. Protein Cell (2014) 0.80
Characterization of long-term mixed donor-donor chimerism after double cord blood transplantation. Clin Exp Immunol (2010) 0.80
Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production. Mol Immunol (2013) 0.80
Effects of Toll-like receptor signals in T-cell neoplasms. Future Oncol (2011) 0.79
The combination of early and rapid type I IFN, IL-1α, and IL-1β production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses. PLoS One (2011) 0.79
Small Wonders-The Use of Nanoparticles for Delivering Antigen. Vaccines (Basel) (2015) 0.79
Flagellin a toll-like receptor 5 agonist as an adjuvant in chicken vaccines. Clin Vaccine Immunol (2014) 0.79
Oral Typhoid Vaccination With Live-Attenuated Salmonella Typhi Strain Ty21a Generates Ty21a-Responsive and Heterologous Influenza Virus-Responsive CD4+ and CD8+ T Cells at the Human Intestinal Mucosa. J Infect Dis (2016) 0.78
TLR5 signaling enhances the proliferation of human allogeneic CD40-activated B cell induced CD4hiCD25+ regulatory T cells. PLoS One (2013) 0.78
Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates. J Virol (2015) 0.78
Mycobacterial phosphatidylinositol mannoside 6 (PIM6) up-regulates TCR-triggered HIV-1 replication in CD4+ T cells. PLoS One (2013) 0.78
Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system. PLoS One (2012) 0.78
Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses. Cancer Immunol Res (2016) 0.77
Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections. Sci Rep (2014) 0.77
Flagellin Encoded in Gene-Based Vector Vaccines Is a Route-Dependent Immune Adjuvant. PLoS One (2016) 0.77
MyD88 in donor bone marrow cells is critical for protection from acute intestinal graft-vs.-host disease. Mucosal Immunol (2015) 0.77
Differential Effect of MyD88 Signal in Donor T Cells on Graft-versus-Leukemia Effect and Graft-versus-Host Disease after Experimental Allogeneic Stem Cell Transplantation. Mol Cells (2015) 0.77
A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model. J Immunol (2016) 0.76
Attenuation of Hepatic Graft-versus-host Disease in Allogeneic Recipients of MyD88-deficient Donor Bone Marrow. Immune Netw (2015) 0.76
Antigen-free adjuvant assists late effector CD4 T cells to transit to memory in lymphopenic hosts. J Immunol (2013) 0.76
Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol (2008) 3.03
Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling. Nat Immunol (2003) 2.99
The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med (2007) 2.71
Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity (2002) 2.47
Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products. Appl Environ Microbiol (2003) 2.19
Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors. Immunity (2005) 1.86
Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood (2007) 1.83
Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production. Blood (2004) 1.71
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol (2012) 1.68
Neutrophils efficiently cross-prime naive T cells in vivo. Blood (2007) 1.67
Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int J Cancer (2009) 1.62
Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J Exp Med (2012) 1.50
Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling. Development (2005) 1.44
Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice. PLoS One (2010) 1.43
Interferon-gamma switches monocyte differentiation from dendritic cells to macrophages. Blood (2002) 1.37
Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation. J Immunol (2007) 1.36
Interleukin-33 overexpression is associated with liver fibrosis in mice and humans. J Cell Mol Med (2009) 1.36
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci U S A (2004) 1.36
The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling. J Immunol (2009) 1.34
CCR7 is involved in the migration of neutrophils to lymph nodes. Blood (2010) 1.34
Pattern recognition receptors in the immune response against dying cells. Curr Opin Immunol (2008) 1.29
Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling. Stem Cells (2012) 1.29
The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection. J Immunol (2002) 1.28
Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. J Biol Chem (2001) 1.20
Outer membrane protein A (OmpA): a new pathogen-associated molecular pattern that interacts with antigen presenting cells-impact on vaccine strategies. Vaccine (2002) 1.20
SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. J Biol Chem (2004) 1.17
Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells. Immunology (2006) 1.10
Expression of recombinant proteins in a lipid A mutant of Escherichia coli BL21 with a strongly reduced capacity to induce dendritic cell activation and maturation. J Immunol Methods (2003) 1.10
IL-34 induces the differentiation of human monocytes into immunosuppressive macrophages. antagonistic effects of GM-CSF and IFNγ. PLoS One (2013) 1.09
Acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance. BMC Evol Biol (2004) 1.08
Deficiency or blockade of angiotensin II type 2 receptor delays tumorigenesis by inhibiting malignant cell proliferation and angiogenesis. Int J Cancer (2010) 1.07
Pentraxins as a key component of innate immunity. Curr Opin Immunol (2005) 1.07
Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. Proc Natl Acad Sci U S A (2006) 1.05
Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. Eur Cytokine Netw (2005) 1.04
GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor. J Biol Chem (2003) 1.02
Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression. J Biol Chem (2002) 1.01
Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects. Clin Chem (2008) 0.98
Scavenger receptors in human airway epithelial cells: role in response to double-stranded RNA. PLoS One (2012) 0.97
Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture. Cytokine (2002) 0.96
The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1β, IL-23, and TNF-like 1A expression by monocytes. J Immunol (2011) 0.95
Complement dependent amplification of the innate response to a cognate microbial ligand by the long pentraxin PTX3. J Immunol (2007) 0.94
PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta. Eur J Immunol (2009) 0.93
Measurement of nuclear factor-kappa B translocation on lipopolysaccharide-activated human dendritic cells by confocal microscopy and flow cytometry. Cytometry (2002) 0.93
IL-6 and leukemia-inhibitory factor are involved in the generation of tumor-associated macrophage: regulation by IFN-γ. Immunotherapy (2011) 0.93
Heat shock proteins 70 and 60 share common receptors which are expressed on human monocyte-derived but not epidermal dendritic cells. Eur J Immunol (2002) 0.92
IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells. Hepatology (2014) 0.91
Outer membrane protein A renders dendritic cells and macrophages responsive to CCL21 and triggers dendritic cell migration to secondary lymphoid organs. Eur J Immunol (2003) 0.90
Dog bite wound infection by Pasteurella dagmatis misidentified as Pasteurella pneumotropica by automated system Vitek 2. Diagn Microbiol Infect Dis (2009) 0.90
Mycobacterial phosphatidylinositol mannosides negatively regulate host Toll-like receptor 4, MyD88-dependent proinflammatory cytokines, and TRIF-dependent co-stimulatory molecule expression. J Biol Chem (2009) 0.90
The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells. J Hepatol (2010) 0.89
Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor. J Biol Chem (2003) 0.89
Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor. J Biol Chem (2006) 0.88
Impact of bronchial epithelium on dendritic cell migration and function: modulation by the bacterial motif KpOmpA. J Immunol (2006) 0.88
Definition and characterization of an inhibitor for interleukin-31. J Biol Chem (2010) 0.88
Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines. J Biol Chem (2004) 0.87
Outer membrane protein A from Klebsiella pneumoniae activates bronchial epithelial cells: implication in neutrophil recruitment. J Immunol (2003) 0.86
Invariant NKT cells drive hepatic cytokinic microenvironment favoring efficient granuloma formation and early control of Leishmania donovani infection. PLoS One (2012) 0.86
IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants. Proc Natl Acad Sci U S A (2010) 0.86
Neonatal and adult microglia cross-present exogenous antigens. Glia (2008) 0.84
Routine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples. BMC Med Genomics (2012) 0.83
Reversal of some viral IL-6 electrostatic properties compared to IL-6 contributes to a loss of alpha receptor component recruitment. Proteins (2005) 0.83
The outer membrane protein X from Escherichia coli exhibits immune properties. Vaccine (2003) 0.83
clc is co-expressed with clf or cntfr in developing mouse muscles. Cell Commun Signal (2005) 0.83
Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain. J Biol Chem (2008) 0.83
Expression of biologically active mouse ciliary neutrophic factor (CNTF) and soluble CNTFRalpha in Escherichia coli and characterization of their functional specificities. Eur Cytokine Netw (2004) 0.83
Septic shock sera containing circulating histones induce dendritic cell-regulated necrosis in fatal septic shock patients. Crit Care Med (2015) 0.82