Published in Infect Immun on August 01, 2005
A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Mol Biol Cell (2006) 1.86
Mitogen-activated protein kinase pathways and fungal pathogenesis. Eukaryot Cell (2007) 1.71
Master and commander in fungal pathogens: the two-component system and the HOG signaling pathway. Eukaryot Cell (2008) 1.50
The response regulator RRG-1 functions upstream of a mitogen-activated protein kinase pathway impacting asexual development, female fertility, osmotic stress, and fungicide resistance in Neurospora crassa. Mol Biol Cell (2007) 1.34
Nitrosative and oxidative stress responses in fungal pathogenicity. Curr Opin Microbiol (2009) 1.28
Signalling pathways in the pathogenesis of Cryptococcus. Cell Microbiol (2008) 1.26
Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis. Infect Immun (2010) 1.22
Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. Eukaryot Cell (2006) 1.21
The link between morphotype transition and virulence in Cryptococcus neoformans. PLoS Pathog (2012) 1.07
The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. Infect Immun (2008) 1.03
Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa. Curr Genet (2007) 0.99
Two-component response regulators Ssk1p and Skn7p additively regulate high-osmolarity adaptation and fungicide sensitivity in Cochliobolus heterostrophus. Eukaryot Cell (2006) 0.95
Involvement of putative response regulator genes of the rice blast fungus Magnaporthe oryzae in osmotic stress response, fungicide action, and pathogenicity. Curr Genet (2008) 0.94
Two-component signal transduction proteins as potential drug targets in medically important fungi. Infect Immun (2008) 0.92
Oxidative stress function of the Saccharomyces cerevisiae Skn7 receiver domain. Eukaryot Cell (2009) 0.91
Cryptococcus neoformans induces IL-8 secretion and CXCL1 expression by human bronchial epithelial cells. Respir Res (2008) 0.91
Fungal Skn7 stress responses and their relationship to virulence. Eukaryot Cell (2010) 0.86
Stress Response and Pathogenicity of the Necrotrophic Fungal Pathogen Alternaria alternata. Scientifica (Cairo) (2012) 0.86
STAT1 signaling is essential for protection against Cryptococcus neoformans infection in mice. J Immunol (2014) 0.85
Characterization of a flocculation-like phenotype in Cryptococcus neoformans and its effects on pathogenesis. Cell Microbiol (2006) 0.83
Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major quantitative trait nucleotide. Genetics (2011) 0.83
STAT1 Signaling within Macrophages Is Required for Antifungal Activity against Cryptococcus neoformans. Infect Immun (2015) 0.81
Transcriptional profiling of the Candida albicans Ssk1p receiver domain point mutants and their virulence. FEMS Yeast Res (2008) 0.80
Protective immunity against cryptococcus neoformans infection. Mcgill J Med (2007) 0.80
Characterization of the conserved phosphorylation site in the Aspergillus nidulans response regulator SrrA. Curr Genet (2011) 0.79
A case for two-component signaling systems as antifungal drug targets. PLoS Pathog (2015) 0.79
Aimless mutants of Cryptococcus neoformans: failure to disseminate. Fungal Biol Rev (2012) 0.78
Cryptococcus neoformans Yap1 is required for normal fluconazole and oxidative stress resistance. Fungal Genet Biol (2014) 0.78
MrSkn7 controls sporulation, cell wall integrity, autolysis, and virulence in Metarhizium robertsii. Eukaryot Cell (2015) 0.78
Rapid mapping of insertional mutations to probe cell wall regulation in Cryptococcus neoformans. Fungal Genet Biol (2015) 0.76
Transcriptomic analysis of Ustilago maydis infecting Arabidopsis reveals important aspects of the fungus pathogenic mechanisms. Plant Signal Behav (2013) 0.75
Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans. Genetics (2016) 0.75
The transcription factor SKN7 regulates conidiation, thermotolerance, apoptotic-like cell death and parasitism in the nematode endoparasitic fungus Hirsutella minnesotensis. Sci Rep (2016) 0.75
Regulatory roles of phosphorylation in model and pathogenic fungi. Med Mycol (2015) 0.75
Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol (2000) 128.08
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol (2002) 82.19
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans. Clin Microbiol Rev (1995) 8.81
Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell (1988) 7.06
Isolation of the gene encoding the S. cerevisiae heat shock transcription factor. Cell (1988) 4.23
Oxidative stress responses of the yeast Saccharomyces cerevisiae. Yeast (1998) 3.86
Factors influencing killing of Cryptococcus neoformans by human leukocytes in vitro. J Infect Dis (1972) 3.75
Urease as a virulence factor in experimental cryptococcosis. Infect Immun (2000) 3.53
YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides. EMBO J (1994) 3.44
Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins. Genes Dev (1989) 3.40
Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast. J Biol Chem (1999) 3.12
Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans. Mol Microbiol (2001) 3.02
Phagocytes and oxidative stress. Am J Med (2000) 3.00
Bacterial defenses against oxidative stress. Trends Genet (1990) 2.89
The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae. EMBO J (1997) 2.25
A new dominant selectable marker for use in Cryptococcus neoformans. Med Mycol (2001) 2.16
Cytokine enhancement of complement-dependent phagocytosis by macrophages: synergy of tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor for phagocytosis of Cryptococcus neoformans. Eur J Immunol (1992) 2.16
Cryptococcal meningitis and AIDS. Clin Infect Dis (1993) 2.03
Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages. Infect Immun (2003) 2.00
Cell wall perturbation in yeast results in dual phosphorylation of the Slt2/Mpk1 MAP kinase and in an Slt2-mediated increase in FKS2-lacZ expression, glucanase resistance and thermotolerance. Microbiology (2000) 1.96
Cryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcome. Emerg Infect Dis (2001) 1.91
SKN7, a yeast multicopy suppressor of a mutation affecting cell wall beta-glucan assembly, encodes a product with domains homologous to prokaryotic two-component regulators and to heat shock transcription factors. J Bacteriol (1993) 1.85
The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol Microbiol (2003) 1.81
Free radicals and antioxidants: a personal view. Nutr Rev (1994) 1.76
Enzymes that counteract nitrosative stress promote fungal virulence. Curr Biol (2003) 1.75
Redox control of AP-1-like factors in yeast and beyond. Oncogene (2001) 1.72
The Skn7 response regulator of Saccharomyces cerevisiae interacts with Hsf1 in vivo and is required for the induction of heat shock genes by oxidative stress. Mol Biol Cell (2000) 1.69
The response regulator-like protein Pos9/Skn7 of Saccharomyces cerevisiae is involved in oxidative stress resistance. Curr Genet (1996) 1.65
Molecular cloning and analysis of the yeast flocculation gene FLO1. Yeast (1994) 1.64
Intracellular fate of Cryptococcus neoformans. Infect Immun (1972) 1.63
A new antioxidant with alkyl hydroperoxide defense properties in yeast. J Biol Chem (1999) 1.50
Antibody-dependent leukocyte killing of Cryptococcus neoformans. J Immunol (1983) 1.47
Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide. J Clin Microbiol (2003) 1.39
Genetic analysis reveals that FLO11 upregulation and cell polarization independently regulate invasive growth in Saccharomyces cerevisiae. Genetics (2000) 1.33
Regulation of the transcriptional response to oxidative stress in fungi: similarities and differences. Eukaryot Cell (2003) 1.32
Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans. Microbiology (1999) 1.31
AP-1 transcription factors in yeast. Curr Opin Genet Dev (1999) 1.31
Domains of the SFL1 protein of yeasts are homologous to Myc oncoproteins or yeast heat-shock transcription factor. Gene (1989) 1.28
Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans. Mol Microbiol (2004) 1.27
Characterization of Cu,Zn superoxide dismutase (SOD1) gene knock-out mutant of Cryptococcus neoformans var. gattii: role in biology and virulence. Mol Microbiol (2003) 1.23
Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans. Infect Immun (2003) 1.22
SKN7 of Candida albicans: mutant construction and phenotype analysis. Infect Immun (2004) 1.22
Mutants of Saccharomyces cerevisiae sensitive to oxidative and osmotic stress. Curr Genet (1995) 1.18
Thioredoxin peroxidase is required for the transcriptional response to oxidative stress in budding yeast. Mol Biol Cell (2000) 1.13
Antioxidant function of cytosolic sources of NADPH in yeast. Free Radic Biol Med (2001) 1.09
Recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) expressing mouse IL-18 augments Th1 immunity and macrophage cytotoxicity. Clin Exp Immunol (2004) 1.04
A reverse transcription comparative real-time PCR method for quantitative detection of angiogenic growth factors in head and neck cancer patients. Clin Biochem (2002) 0.92
A pilot study of the discontinuation of antifungal therapy for disseminated cryptococcal disease in patients with acquired immunodeficiency syndrome, following immunologic response to antiretroviral therapy. J Infect Dis (2002) 0.82
On the doublet formation in the flocculation process of the yeast cells. Biosystems (2001) 0.78
Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature (1979) 11.83
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans. Clin Microbiol Rev (1995) 8.81
An improved algorithm for nucleic acid secondary structure display. Comput Appl Biosci (1988) 5.91
Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America. Clin Infect Dis (2000) 5.53
Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J Bacteriol (1993) 5.14
Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med (2000) 4.98
Chronic cryptococcal meningitis: a new experimental model in rabbits. Am J Pathol (1980) 4.28
Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes Dev (1997) 4.28
Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy. Clin Infect Dis (2001) 4.01
Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. J Clin Invest (1985) 3.98
Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1. Antimicrob Agents Chemother (1993) 3.79
Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. J Exp Med (1996) 3.76
Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages. J Clin Invest (1988) 3.69
Urease as a virulence factor in experimental cryptococcosis. Infect Immun (2000) 3.53
Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits. Antimicrob Agents Chemother (1986) 3.38
In vitro and in vivo efficacies of the azole SCH56592 against Cryptococcus neoformans. Antimicrob Agents Chemother (1996) 3.20
Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Mol Cell Biol (2001) 3.11
Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases. Clin Infect Dis (1998) 3.09
Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans. Mol Microbiol (2001) 3.02
Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. J Clin Invest (1990) 2.91
Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review. Rev Infect Dis (1989) 2.89
In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds. Antimicrob Agents Chemother (1997) 2.76
Karyotyping of Cryptococcus neoformans as an epidemiological tool. J Clin Microbiol (1993) 2.50
Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and are heterozygous at the mating-type locus. Infect Immun (2001) 2.39
Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains. J Exp Med (1984) 2.33
Morphologic criteria for the preliminary identification of Fusarium, Paecilomyces, and Acremonium species by histopathology. Am J Clin Pathol (1998) 2.30
RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. Mol Microbiol (2000) 2.30
The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis. Clin Infect Dis (2001) 2.25
The effect on blood-pressure of organ extracts. J Physiol (1911) 2.24
Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem (1986) 2.22
Zygomycosis: the re-emerging fungal infection. Eur J Clin Microbiol Infect Dis (2006) 2.17
A new dominant selectable marker for use in Cryptococcus neoformans. Med Mycol (2001) 2.16
Cryptococcemia. Medicine (Baltimore) (1983) 2.10
Fluorescent treponemal antibodies in fractionated syphilitic sera. The immunoglobulin class. Arch Dermatol (1969) 2.06
Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity. J Immunol (1986) 2.06
The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans. Mol Cell Biol (2000) 2.03
Penetration of imidazoles and triazoles into cerebrospinal fluid of rabbits. J Antimicrob Chemother (1985) 2.02
Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. Proc Natl Acad Sci U S A (2000) 1.96
In vivo chemosensitivity-adapted preoperative chemotherapy in patients with early-stage breast cancer: the GEPARTRIO pilot study. Ann Oncol (2005) 1.89
Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Mol Microbiol (2001) 1.87
Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. J Infect Dis (1987) 1.85
pepM is an essential gene in Salmonella typhimurium. J Bacteriol (1989) 1.85
Synthesis of polymerized melanin by Cryptococcus neoformans in infected rodents. Infect Immun (2000) 1.79
Comparison of amphotericin B and N-D-ornithyl amphotericin B methyl ester in experimental cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis. Antimicrob Agents Chemother (1985) 1.78
Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. EMBO J (2000) 1.76
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. Genetics (1999) 1.75
Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans. Proc Natl Acad Sci U S A (1994) 1.72
Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. Genes Dev (2001) 1.72
Combination photoimmunotherapy and cisplatin: effects on human ovarian cancer ex vivo. J Natl Cancer Inst (1999) 1.71
Anti-thyroid peroxidase antibody in patients with autoimmune thyroid disease: possible identity with anti-microsomal antibody. J Clin Endocrinol Metab (1985) 1.69
N-terminal methionine-specific peptidase in Salmonella typhimurium. Proc Natl Acad Sci U S A (1987) 1.66
Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Antimicrob Agents Chemother (2000) 1.66
A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function. J Bacteriol (1999) 1.65
Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol Cell Biol (1999) 1.64
Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches. Drugs (1997) 1.63
Effect of speaking rate on the perceptual structure of a phonetic category. Percept Psychophys (1989) 1.59
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. Genes Dev (1995) 1.59
Treatment of experimental cryptococcal meningitis with amphotericin B, 5-fluorocytosine, and ketoconazole. J Infect Dis (1982) 1.58
Processing of the N termini of nascent polypeptide chains requires deformylation prior to methionine removal. J Mol Biol (1999) 1.57
Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis. Ann Intern Med (1983) 1.56
Dominant selection system for use in Cryptococcus neoformans. J Med Vet Mycol (1997) 1.54
Articulation rate and its variability in spontaneous speech: a reanalysis and some implications. Phonetica (1984) 1.52
The nucleotide sequence of the B gene of bacteriophage Mu. Nucleic Acids Res (1984) 1.51
Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonization. J Infect Dis (1999) 1.51
Serum androgens and depression in women with facial hirsutism. J Am Acad Dermatol (1992) 1.50
The TPI and FTA-ABS tests in treated late syphilis. JAMA (1968) 1.50
Fungal meningitis. Semin Neurol (2000) 1.50
Cryptococcus neoformans gene expression during experimental cryptococcal meningitis. Eukaryot Cell (2003) 1.49
A direct relationship between the partitioning of the pathogenic prion protein and transmissible spongiform encephalopathy infectivity during the purification of plasma proteins. Transfusion (2001) 1.49
Some effects of later-occurring information on the perception of stop consonant and semivowel. Percept Psychophys (1979) 1.47
Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. Infect Immun (2000) 1.46
Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. EMBO Rep (2001) 1.46
Involvement of the mannose receptor in infection of macrophages by influenza virus. J Virol (2000) 1.45
Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone. J Biol Chem (1984) 1.45
Disseminated zygomycosis: report of four cases and review. Rev Infect Dis (1989) 1.45
Continuous growth of mitogen-reactive B lymphocytes. Scand J Immunol (1975) 1.43
Amplification and purification of the bacteriophage Mu encoded B transposition protein. J Biol Chem (1985) 1.43
Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. Antimicrob Agents Chemother (2000) 1.42
The North American experience with photopheresis. Ther Apher (1999) 1.42
Epidurals redefined in analgesia and anesthesia: a distinction with a difference. J Obstet Gynecol Neonatal Nurs (1996) 1.42
Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans. Fungal Genet Biol (1998) 1.41
GnRH agonists: gonadorelin, leuprolide and nafarelin. Am Fam Physician (1991) 1.40
Marrow aplasia and sulindac. Ann Intern Med (1980) 1.40
GFPcre fusion vectors with enhanced expression. Anal Biochem (1999) 1.39
Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector. J Clin Invest (1994) 1.39
Finasteride for benign prostatic hyperplasia. Am Fam Physician (1992) 1.38
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR. Antimicrob Agents Chemother (2001) 1.37
Modulation of metarhodopsin formation by cholesterol-induced ordering of bilayer lipids. Biochemistry (1990) 1.36
Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons. Am J Psychiatry (1997) 1.36
Phonetic prototypes: influence of place of articulation and speaking rate on the internal structure of voicing categories. J Acoust Soc Am (1992) 1.35
Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon. J Biol Chem (1984) 1.34
The epidemiology of myasthenia gravis in central and western Virginia. Neurology (1992) 1.31
Segmental genomic replacement in embryonic stem cells by double lox targeting. Nucleic Acids Res (1999) 1.31
Combined therapy with amphotericin B and 5-fluorocytosine for Candida meningitis. Rev Infect Dis (1985) 1.31