Published in Am J Physiol Renal Physiol on July 26, 2005
The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ (2008) 4.31
Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol (2006) 2.25
Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Mol Med (2008) 1.72
Pathophysiology of acute kidney injury. Compr Physiol (2012) 1.56
Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism. Diabetes (2011) 1.32
Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. J Am Soc Nephrol (2011) 1.05
Differential roles of Epac in regulating cell death in neuronal and myocardial cells. J Biol Chem (2010) 1.02
Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury. Am J Physiol Renal Physiol (2012) 0.93
The influence of different microenvironments on melanoma invasiveness and microcirculation patterns: an animal experiment study in the mouse model. J Cancer Res Clin Oncol (2007) 0.85
Tubular Epithelial NF-κB Activity Regulates Ischemic AKI. J Am Soc Nephrol (2016) 0.77
EGF regulation of proximal tubule cell proliferation and VEGF-A secretion. Physiol Rep (2017) 0.75
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest (2007) 4.80
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest (2004) 3.90
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest (2007) 3.76
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest (2007) 3.61
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest (2007) 3.40
Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res (2006) 3.04
Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN. Kidney Int (2005) 2.58
Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood (2010) 2.57
Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54
Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest (2010) 2.42
Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol (2005) 2.25
Concern Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest (2012) 2.23
Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol (2004) 2.19
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood (2006) 2.16
AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab (2011) 2.03
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol (2003) 1.99
Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol Cell Biol (2009) 1.88
Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury. J Am Soc Nephrol (2010) 1.82
Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet (2008) 1.66
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene (2008) 1.61
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (2004) 1.58
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology (2008) 1.57
Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol (2008) 1.54
Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy. Am J Kidney Dis (2009) 1.51
Inflammatory hypoxia: role of hypoxia-inducible factor. Cell Cycle (2005) 1.50
Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J Clin Invest (2016) 1.49
Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis. Circulation (2009) 1.49
Hypoxia-inducible factor signaling in the development of tissue fibrosis. Cell Cycle (2008) 1.49
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol (2004) 1.48
Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol (2005) 1.47
A case of autoimmune hepatitis exacerbated by the administration of etanercept in the patient with rheumatoid arthritis. Clin Rheumatol (2008) 1.43
Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. J Clin Invest (2016) 1.42
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest (2009) 1.40
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A (2005) 1.38
Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest (2012) 1.35
Elevated levels of fractalkine expression and accumulation of CD16+ monocytes in glomeruli of active lupus nephritis. Am J Kidney Dis (2007) 1.34
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia (2010) 1.31
Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J Am Soc Nephrol (2010) 1.31
Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion. Kidney Int (2012) 1.19
pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol (2006) 1.18
Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J Clin Invest (2014) 1.16
Sirtuins and their relevance to the kidney. J Am Soc Nephrol (2010) 1.15
Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression. J Am Soc Nephrol (2006) 1.11
Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. J Immunol (2012) 1.09
Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease. Am J Physiol Renal Physiol (2007) 1.08
Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Carcinogenesis (2009) 1.05
Prognostic value of increased plasma levels of brain natriuretic peptide in patients with septic shock. Shock (2006) 0.99
von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase. Int J Oncol (2007) 0.94
Primary systemic amyloidosis presenting as angina pectoris due to intramyocardial coronary artery involvement: a case report. Heart Vessels (2002) 0.93
Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury. Am J Physiol Renal Physiol (2012) 0.93
Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress. Mol Cell Biol (2010) 0.93
Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int (2012) 0.91
Expression of glomerular plasminogen activator inhibitor type 1 in glomerulonephritis. Am J Kidney Dis (2002) 0.89
VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am J Pathol (2010) 0.87
Transferrinuria in type 2 diabetic patients with early nephropathy and tubulointerstitial injury. Eur J Intern Med (2002) 0.85
Mutant α-galactosidase A with M296I does not cause elevation of the plasma globotriaosylsphingosine level. Mol Genet Metab (2012) 0.85
Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy. J Am Heart Assoc (2013) 0.84
Prediction of corticosteroid responsiveness based on fibroblast-specific protein 1 (FSP1) in patients with IgA nephropathy. Nephrol Dial Transplant (2008) 0.83
Prognostic value of urinary interleukin 6 in patients with IgA nephropathy: an 8-year follow-up study. Nephron (2002) 0.82
Prognostic Impact of Placental Growth Factor on Mortality and Cardiovascular Events in Dialysis Patients. Am J Nephrol (2015) 0.80
Relationship between the accuracy of glycemic markers and the chronic kidney disease stage in patients with type 2 diabetes mellitus. Clin Nephrol (2014) 0.79
Hemoglobin in the kidney: breaking with traditional dogma. J Am Soc Nephrol (2008) 0.79
Clinical significance of fibroblast-specific protein-1 expression on podocytes in patients with focal segmental glomerulosclerosis. Nephron Clin Pract (2011) 0.78
Association of interleukin-1 receptor antagonist gene polymorphism with IgA nephropathy. Nephron (2002) 0.78
Low-dose aspirin therapy in patients with type 2 diabetes and reduced glomerular filtration rate: subanalysis from the JPAD trial. Diabetes Care (2011) 0.77
Validation of simple indices to assess insulin sensitivity and pancreatic Beta-cell function in patients with renal dysfunction. Nephron (2002) 0.77
Urinary FSP1 is a biomarker of crescentic GN. J Am Soc Nephrol (2011) 0.75
HO-1 in control of a self-eating kidney. J Am Soc Nephrol (2010) 0.75
Hepatic cyst infection in a healthy older male. BMJ Case Rep (2012) 0.75
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest (2017) 0.75
Using imaging mass spectrometry to accurately diagnose Fabry's disease. Circ J (2010) 0.75
[Case Report; Polyuria and polydipsia as presenting symptoms of sarcoidosis, an elderly case]. Nihon Naika Gakkai Zasshi (2016) 0.75
Inflamed fat and mitochondrial dysfunction in end-stage renal disease links to hypoxia-could curcumin be of benefit? Nephrol Dial Transplant (2017) 0.75
[An elderly case of advanced gastric cancer with gynecomastia and high serum levels of hCG]. Nihon Ronen Igakkai Zasshi (2002) 0.75
[A case of MPO-ANCA-related microscopic polyangiitis with mixed cryoglobulinemia]. Nihon Jinzo Gakkai Shi (2006) 0.75
Insulin resistance and pancreatic beta-cell function in patients with hypertensive kidney disease. Nephrol Dial Transplant (2004) 0.75