PubRank

Thomas Quertermous

Author PubWeight™ 269.40‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010 28.21
2 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010 23.08
3 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010 20.01
4 Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 2011 13.25
5 Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010 7.94
6 Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2012 7.59
7 Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet 2011 5.26
8 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
9 Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet 2010 3.15
10 Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 2013 2.92
11 Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One 2010 2.86
12 Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. Hum Mol Genet 2008 2.71
13 Pathway analysis of coronary atherosclerosis. Physiol Genomics 2005 2.59
14 CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature 2016 2.53
15 Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes 2010 2.44
16 Network analysis of human in-stent restenosis. Circulation 2006 2.27
17 The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc Res 2005 2.24
18 Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol 2010 2.17
19 Endothelial lipase is a major determinant of HDL level. J Clin Invest 2003 2.12
20 Differences in vascular bed disease susceptibility reflect differences in gene expression response to atherogenic stimuli. Circ Res 2005 2.10
21 Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science 2008 2.10
22 A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes 2011 2.09
23 Characterizing the admixed African ancestry of African Americans. Genome Biol 2009 2.01
24 Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest 2008 1.89
25 Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 2013 1.72
26 Statin and beta-blocker therapy and the initial presentation of coronary heart disease. Ann Intern Med 2006 1.72
27 Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res 2013 1.68
28 Hepatic proprotein convertases modulate HDL metabolism. Cell Metab 2007 1.68
29 Therapeutic lymphangiogenesis with human recombinant VEGF-C. FASEB J 2002 1.67
30 Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation 2003 1.66
31 MicroRNA-26a is a novel regulator of vascular smooth muscle cell function. J Cell Physiol 2011 1.64
32 Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet 2013 1.57
33 In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Am J Physiol Heart Circ Physiol 2007 1.54
34 Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J Biol Chem 2004 1.54
35 The negative correlation between plasma adiponectin and blood pressure depends on obesity: a family-based association study in SAPPHIRe. Am J Hypertens 2008 1.44
36 Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development. Cardiovasc Res 2013 1.40
37 Metabolic syndrome and early-onset coronary artery disease: is the whole greater than its parts? J Am Coll Cardiol 2006 1.40
38 Identification of endothelial cell genes by combined database mining and microarray analysis. Physiol Genomics 2003 1.39
39 Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J Biol Chem 2005 1.34
40 Endogenous regulation of cardiovascular function by apelin-APJ. Am J Physiol Heart Circ Physiol 2009 1.34
41 Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program. Hypertension 2005 1.32
42 Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vasc Biol 2011 1.30
43 Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp. Metabolism 2012 1.28
44 Insulin resistance independently predicts the progression of coronary artery calcification. Am Heart J 2009 1.26
45 Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 t. Magn Reson Med 2006 1.25
46 Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes 2013 1.25
47 Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease. Physiol Genomics 2005 1.22
48 Genome-wide expression profiling of a cardiac pressure overload model identifies major metabolic and signaling pathway responses. J Mol Cell Cardiol 2004 1.21
49 Apelin is necessary for the maintenance of insulin sensitivity. Am J Physiol Endocrinol Metab 2009 1.19
50 Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes 2005 1.19
51 Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. Am J Physiol Heart Circ Physiol 2009 1.19
52 Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. J Biol Chem 2004 1.18
53 Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease. Am Heart J 2007 1.18
54 Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest 2003 1.17
55 Tree-structured supervised learning and the genetics of hypertension. Proc Natl Acad Sci U S A 2004 1.17
56 Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization. Circ Res 2006 1.16
57 Endothelial lipase: a new lipase on the block. J Lipid Res 2002 1.15
58 Transcriptional profiling of the heart reveals chamber-specific gene expression patterns. Circ Res 2003 1.13
59 Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arterioscler Thromb Vasc Biol 2012 1.12
60 Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. Am Heart J 2007 1.11
61 Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. J Biol Chem 2003 1.11
62 An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program. Nutr Metab (Lond) 2005 1.09
63 Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology. Arterioscler Thromb Vasc Biol 2007 1.09
64 Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes: distinct responses to stimuli. Arterioscler Thromb Vasc Biol 2006 1.07
65 Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes 2013 1.06
66 The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation. Microvasc Res 2002 1.06
67 Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease. Physiol Genomics 2007 1.05
68 The adhesion molecule esam1 is a novel hematopoietic stem cell marker. Stem Cells 2009 1.05
69 Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. Am Heart J 2007 1.05
70 Admixture mapping of quantitative trait loci for blood lipids in African-Americans. Hum Mol Genet 2009 1.04
71 Increased expression of endothelial lipase in rat models of hypertension. Cardiovasc Res 2005 1.03
72 Biethnic comparisons of autosomal genomic scan for loci linked to plasma adiponectin in populations of Chinese and Japanese origin. J Clin Endocrinol Metab 2004 1.03
73 A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. Atherosclerosis 2007 1.01
74 Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia. Circulation 2004 1.01
75 Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. Circ Res 2010 1.00
76 HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. Am J Physiol Endocrinol Metab 2007 1.00
77 Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease. Arterioscler Thromb Vasc Biol 2004 0.99
78 Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3). Am J Physiol Heart Circ Physiol 2002 0.99
79 Genome-wide expression dynamics during mouse embryonic development reveal similarities to Drosophila development. Dev Biol 2005 0.98
80 Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages. J Atheroscler Thromb 2007 0.98
81 Apelin decreases lipolysis via G(q), G(i), and AMPK-Dependent Mechanisms. Endocrinology 2010 0.98
82 Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort. Clin Endocrinol (Oxf) 2012 0.97
83 Apelin enhances directed cardiac differentiation of mouse and human embryonic stem cells. PLoS One 2012 0.97
84 Myocardial restoration with embryonic stem cell bioartificial tissue transplantation. J Heart Lung Transplant 2005 0.96
85 Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. PLoS Genet 2013 0.95
86 Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activation. Physiol Genomics 2004 0.94
87 Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation. J Biol Chem 2004 0.94
88 Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. Proc Natl Acad Sci U S A 2009 0.94
89 Dissecting the causal genetic mechanisms of coronary heart disease. Curr Atheroscler Rep 2014 0.93
90 Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. Hum Genet 2008 0.93
91 Inducible and selective transgene expression in murine vascular endothelium. Physiol Genomics 2002 0.93
92 Opposing cardiovascular roles for the angiotensin and apelin signaling pathways. J Mol Cell Cardiol 2006 0.93
93 The impact of data quality on the identification of complex disease genes: experience from the Family Blood Pressure Program. Eur J Hum Genet 2006 0.93
94 Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Cardiovasc Res 2003 0.92
95 Proteomic profiles of serum inflammatory markers accurately predict atherosclerosis in mice. Physiol Genomics 2006 0.90
96 In vivo bioluminescence imaging of inducible nitric oxide synthase gene expression in vascular inflammation. Mol Imaging Biol 2011 0.90
97 Transcriptome alteration in the diabetic heart by rosiglitazone: implications for cardiovascular mortality. PLoS One 2008 0.90
98 Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest 2015 0.90
99 Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption. BMC Cardiovasc Disord 2012 0.89
100 Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD. BMC Med Genet 2008 0.89
101 FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells. Arterioscler Thromb Vasc Biol 2012 0.89
102 Endothelial cell-selective adhesion molecule modulates atherosclerosis through plaque angiogenesis and monocyte-endothelial interaction. Microvasc Res 2010 0.89
103 Targeted inactivation of endothelial lipase attenuates lung allergic inflammation through raising plasma HDL level and inhibiting eosinophil infiltration. Am J Physiol Lung Cell Mol Physiol 2009 0.87
104 Physical inactivity is an important lifestyle determinant of insulin resistance in hypertensive patients. Blood Press 2004 0.87
105 The angiogenic factor Del1 prevents apoptosis of endothelial cells through integrin binding. Surgery 2011 0.86
106 An "almost exhaustive" search-based sequential permutation method for detecting epistasis in disease association studies. Genet Epidemiol 2010 0.86
107 Peroxisome proliferator-activated receptor gamma polymorphisms and coronary heart disease. PPAR Res 2009 0.86
108 Cardiac pressure overload hypertrophy is differentially regulated by β-adrenergic receptor subtypes. Am J Physiol Heart Circ Physiol 2011 0.85
109 An autosomal genome-wide scan for loci linked to pre-diabetic phenotypes in nondiabetic Chinese subjects from the Stanford Asia-Pacific Program of Hypertension and Insulin Resistance Family Study. Diabetes 2005 0.85
110 Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice. J Lipid Res 2004 0.84
111 In vivo molecular MRI of cell survival and teratoma formation following embryonic stem cell transplantation into the injured murine myocardium. Magn Reson Med 2011 0.84
112 Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arterioscler Thromb Vasc Biol 2015 0.83
113 Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia. J Atheroscler Thromb 2009 0.83
114 Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis. Microvasc Res 2010 0.83
115 Heritability of left ventricular mass in Japanese families living in Hawaii: the SAPPHIRe Study. J Hypertens 2007 0.83
116 Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population. Diabetologia 2013 0.83
117 Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery. Anat Rec A Discov Mol Cell Evol Biol 2005 0.83
118 Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. J Clin Invest 2014 0.82
119 A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation. PLoS One 2013 0.82
120 Apelin-APJ signaling in retinal angiogenesis. Arterioscler Thromb Vasc Biol 2008 0.81
121 Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300. PLoS One 2010 0.81
122 Ontogeny of apelin and its receptor in the rodent gastrointestinal tract. Regul Pept 2009 0.80
123 Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse. Cardiovasc Res 2010 0.80
124 Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms. Genomics 2004 0.80
125 Comparison of developmental endothelial locus-1 angiogenic factor with vascular endothelial growth factor in a porcine model of cardiac ischemia. Ann Thorac Surg 2003 0.79
126 Racial variation in lipoprotein-associated phospholipase A₂ in older adults. BMC Cardiovasc Disord 2011 0.79
127 Increased bone mass in mice lacking the adipokine apelin. Endocrinology 2013 0.78
128 FGF-1 enhanced cardiogenesis in differentiating embryonal carcinoma cell cultures, which was opposite to the effect of FGF-2. J Mol Cell Cardiol 2003 0.78
129 Do plasma biomarkers of coagulation and fibrinolysis differ between patients who have experienced an acute myocardial infarction versus stable exertional angina? Am Heart J 2007 0.78
130 Genetic variation in the carbonyl reductase 3 gene confers risk of type 2 diabetes and insulin resistance: a potential regulator of adipogenesis. J Mol Med (Berl) 2012 0.78
131 Use of high throughput genomic tools for the study of endothelial cell biology. Lymphat Res Biol 2003 0.77
132 The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model. Vasc Med 2013 0.77
133 Frontiers in nephrology: genomic approaches to understanding the molecular basis of atherosclerosis. J Am Soc Nephrol 2007 0.76
134 Increased rate of hair regrowth in mice with constitutive overexpression of Del1. J Surg Res 2007 0.76
135 Distribution of the number of false discoveries in large-scale family-based association testing with application to the association between PTPN1 and hypertension and obesity. Hum Genet 2010 0.76
136 Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest 2016 0.76
137 Pancreatitis activates pancreatic apelin-APJ axis in mice. Am J Physiol Gastrointest Liver Physiol 2013 0.75
138 Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet 2016 0.75
139 Clinical utility of a novel coronary heart disease risk-assessment test to further classify intermediate-risk patients. Clin Cardiol 2013 0.75
140 The effects of the renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance in hypertensive families. J Renin Angiotensin Aldosterone Syst 2012 0.75
141 Absence of evidence for an association between resistin gene variants and insulin resistance in an Asian population with low and high blood pressure. Diabetes Res Clin Pract 2008 0.75