Published in Structure on August 01, 2005
A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation. J Cell Biol (2006) 2.08
Folding versus aggregation: polypeptide conformations on competing pathways. Arch Biochem Biophys (2007) 1.97
Prevention of amyloid-like aggregation as a driving force of protein evolution. EMBO Rep (2007) 1.78
Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival. PLoS Biol (2008) 1.61
Mapping the structural transition in an amyloidogenic apolipoprotein A-I. Biochemistry (2007) 1.03
A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information. PLoS One (2008) 1.02
Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at residue 20. J Mol Biol (2011) 1.00
Natural selection against protein aggregation on self-interacting and essential proteins in yeast, fly, and worm. Mol Biol Evol (2008) 0.99
Hexafluoroisopropanol induces amyloid fibrils of islet amyloid polypeptide by enhancing both hydrophobic and electrostatic interactions. J Biol Chem (2011) 0.96
Self-assembly of functional, amphipathic amyloid monolayers by the fungal hydrophobin EAS. Proc Natl Acad Sci U S A (2012) 0.94
VnD: a structure-centric database of disease-related SNPs and drugs. Nucleic Acids Res (2010) 0.78
A GLYmmer of insight into fibril formation. Structure (2005) 0.77
The importance of a gatekeeper residue on the aggregation of transthyretin: implications for transthyretin-related amyloidoses. J Biol Chem (2014) 0.75
Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem (2006) 22.87
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A (2010) 15.22
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature (2002) 10.81
Simultaneous determination of protein structure and dynamics. Nature (2005) 5.28
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution. J Mol Med (Berl) (2003) 5.15
Rationalization of the effects of mutations on peptide and protein aggregation rates. Nature (2003) 4.98
The protofilament structure of insulin amyloid fibrils. Proc Natl Acad Sci U S A (2002) 4.08
Long-range interactions within a nonnative protein. Science (2002) 4.06
Protein structure determination from NMR chemical shifts. Proc Natl Acad Sci U S A (2007) 3.96
An analytical solution to the kinetics of breakable filament assembly. Science (2009) 3.87
Amyloid formation by globular proteins under native conditions. Nat Chem Biol (2009) 3.72
High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy. Proc Natl Acad Sci U S A (2004) 3.58
Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell (2012) 3.39
Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases. J Mol Biol (2005) 3.18
Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations. J Am Chem Soc (2005) 3.13
Role of intermolecular forces in defining material properties of protein nanofibrils. Science (2007) 2.94
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Proc Natl Acad Sci U S A (2013) 2.89
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR. Nature (2004) 2.84
The importance of sequence diversity in the aggregation and evolution of proteins. Nature (2005) 2.70
De novo designed peptide-based amyloid fibrils. Proc Natl Acad Sci U S A (2002) 2.59
The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation. EMBO J (2002) 2.59
Prediction of aggregation-prone regions in structured proteins. J Mol Biol (2008) 2.56
A causative link between the structure of aberrant protein oligomers and their toxicity. Nat Chem Biol (2010) 2.48
Characterization of the nanoscale properties of individual amyloid fibrils. Proc Natl Acad Sci U S A (2006) 2.46
Molecular recycling within amyloid fibrils. Nature (2005) 2.39
Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth. Mol Cell Biol (2005) 2.38
Kinetic partitioning of protein folding and aggregation. Nat Struct Biol (2002) 2.37
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS Biol (2007) 2.35
Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril. Proc Natl Acad Sci U S A (2002) 2.18
Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy. J Mol Biol (2009) 2.14
Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains. J Mol Biol (2004) 2.14
Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J Cell Biol (2003) 2.05
Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments. Proc Natl Acad Sci U S A (2003) 1.93
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Sci (2005) 1.91
Prefibrillar amyloid aggregates could be generic toxins in higher organisms. J Neurosci (2006) 1.89
Life on the edge: a link between gene expression levels and aggregation rates of human proteins. Trends Biochem Sci (2007) 1.88
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. Proc Natl Acad Sci U S A (2004) 1.83
Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases. Proc Natl Acad Sci U S A (2002) 1.80
The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. FASEB J (2007) 1.79
Prefibrillar amyloid protein aggregates share common features of cytotoxicity. J Biol Chem (2004) 1.79
Prevention of amyloid-like aggregation as a driving force of protein evolution. EMBO Rep (2007) 1.78
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75
Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering. Proc Natl Acad Sci U S A (2010) 1.72
From macroscopic measurements to microscopic mechanisms of protein aggregation. J Mol Biol (2012) 1.71
Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils. PLoS Comput Biol (2007) 1.71
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature (2003) 1.66
Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme. Nat Struct Biol (2002) 1.64
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide. Nat Struct Mol Biol (2011) 1.62
Direct characterization of amyloidogenic oligomers by single-molecule fluorescence. Proc Natl Acad Sci U S A (2008) 1.56
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. J Mol Biol (2013) 1.56
Insight into the structure of amyloid fibrils from the analysis of globular proteins. PLoS Comput Biol (2006) 1.55
Exploring amyloid formation by a de novo design. Proc Natl Acad Sci U S A (2004) 1.55
Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR. J Am Chem Soc (2011) 1.54
Metastability of native proteins and the phenomenon of amyloid formation. J Am Chem Soc (2011) 1.53
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments. J Chem Phys (2011) 1.52
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy. Biochemistry (2010) 1.50
ANS binding reveals common features of cytotoxic amyloid species. ACS Chem Biol (2010) 1.48
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species. J Biol Chem (2005) 1.48
Determination of a transition state at atomic resolution from protein engineering data. J Mol Biol (2002) 1.47
A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction. Structure (2008) 1.45
Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein. J Am Chem Soc (2004) 1.44
Observation of sequence specificity in the seeding of protein amyloid fibrils. Protein Sci (2004) 1.44
Proliferation versus migration in platelet-derived growth factor signaling: the key role of endocytosis. J Biol Chem (2008) 1.42
Protein misfolded oligomers: experimental approaches, mechanism of formation, and structure-toxicity relationships. Chem Biol (2012) 1.41
In situ measurements of the formation and morphology of intracellular β-amyloid fibrils by super-resolution fluorescence imaging. J Am Chem Soc (2011) 1.37
The formation of spherulites by amyloid fibrils of bovine insulin. Proc Natl Acad Sci U S A (2004) 1.36
Protein misfolding and disease: from the test tube to the organism. Curr Opin Chem Biol (2008) 1.35
Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J (2002) 1.35
Redox regulation of beta-actin during integrin-mediated cell adhesion. J Biol Chem (2006) 1.31
Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes. Proc Natl Acad Sci U S A (2004) 1.31
Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin. Proc Natl Acad Sci U S A (2005) 1.31
Structural biology. Dynamic visions of enzymatic reactions. Science (2006) 1.30
Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy. Proc Natl Acad Sci U S A (2007) 1.30
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass. Proc Natl Acad Sci U S A (2007) 1.29
A highly amyloidogenic region of hen lysozyme. J Mol Biol (2004) 1.29
Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange. J Am Chem Soc (2003) 1.27
Calculation of mutational free energy changes in transition states for protein folding. Biophys J (2003) 1.27
Formation of native and non-native interactions in ensembles of denatured ACBP molecules from paramagnetic relaxation enhancement studies. J Mol Biol (2005) 1.27
EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to rho-dependent actino/myosin contractility. J Biol Chem (2007) 1.26
Protein folding on the ribosome. Curr Opin Struct Biol (2010) 1.25
Amyloid fibril formation can proceed from different conformations of a partially unfolded protein. Biophys J (2005) 1.25
Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation. J Biol Chem (2003) 1.25