Published in J Cell Sci on August 09, 2005
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes (2008) 2.71
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest (2008) 2.58
The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response. J Lipid Res (2009) 1.90
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proc Natl Acad Sci U S A (2009) 1.84
High glucose induces adipogenic differentiation of muscle-derived stem cells. Proc Natl Acad Sci U S A (2008) 1.84
Glucolipotoxicity of the pancreatic beta cell. Biochim Biophys Acta (2009) 1.69
Beta-cell failure as a complication of diabetes. Rev Endocr Metab Disord (2008) 1.60
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. Proc Natl Acad Sci U S A (2008) 1.39
Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries. Nat Med (2009) 1.36
NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways. PLoS One (2010) 1.23
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol (2013) 1.23
Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish. Hepatology (2011) 1.21
The vascular contribution to Alzheimer's disease. Clin Sci (Lond) (2010) 1.21
Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice. Diabetes (2009) 1.17
The endoplasmic reticulum stress response and diabetic kidney disease. Am J Physiol Renal Physiol (2011) 1.16
Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. Am J Physiol Endocrinol Metab (2008) 1.15
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes. J Biol Chem (2009) 1.15
Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency. Proc Natl Acad Sci U S A (2010) 1.12
Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts. J Biol Chem (2008) 1.09
Pdx1 and other factors that regulate pancreatic beta-cell survival. Diabetes Obes Metab (2009) 1.09
Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. J Virol (2010) 1.08
Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation. Cold Spring Harb Perspect Biol (2012) 1.06
Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. J Biol Chem (2009) 1.05
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets. Diabetes (2009) 1.02
Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP. Semin Liver Dis (2013) 1.02
Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice. Toxicol Lett (2006) 0.99
Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity. Diabetologia (2012) 0.99
Imaging of beta-cell mass and function. J Nucl Med (2010) 0.98
A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. Am J Physiol Endocrinol Metab (2012) 0.98
Protection of pancreatic beta-cells from various stress conditions is mediated by DJ-1. J Biol Chem (2010) 0.97
Calcium-independent phospholipases A2 and their roles in biological processes and diseases. J Lipid Res (2015) 0.97
Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells. Mol Cell Proteomics (2009) 0.95
Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech (2009) 0.95
Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. PLoS One (2009) 0.93
Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation. PLoS One (2011) 0.93
Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells. Proc Natl Acad Sci U S A (2014) 0.93
Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: protection by nifedipine. Biochem Pharmacol (2013) 0.92
Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. J Biol Chem (2011) 0.91
SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat. Genes Dev (2015) 0.90
Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells. J Lipid Res (2011) 0.89
Endoplasmic reticulum stress and insulin biosynthesis: a review. Exp Diabetes Res (2012) 0.89
Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells. J Biol Chem (2013) 0.88
Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes. Exp Diabetes Res (2011) 0.87
A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β). Diabetes Obes Metab (2010) 0.86
Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation. Rev Diabet Stud (2011) 0.86
A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance. J Biol Chem (2013) 0.86
Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells. Apoptosis (2014) 0.85
Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation? Aging (Albany NY) (2010) 0.85
Loss of sugar detection by GLUT2 affects glucose homeostasis in mice. PLoS One (2007) 0.84
Autophagy contributes to retardation of cardiac growth in diabetic rats. Lab Anim Res (2012) 0.84
Nutrigenomics, beta-cell function and type 2 diabetes. Curr Genomics (2007) 0.84
Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment. J Biomed Sci (2012) 0.84
Genetic modulation of islet β-cell iPLA₂β expression provides evidence for its impact on β-cell apoptosis and autophagy. Islets (2013) 0.83
Diosgenin, 4-hydroxyisoleucine, and fiber from fenugreek: mechanisms of actions and potential effects on metabolic syndrome. Adv Nutr (2015) 0.82
The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway. Cell Microbiol (2011) 0.82
Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c. J Biomed Sci (2011) 0.81
Gamma-tocotrienol reduces the triacylglycerol level in rat primary hepatocytes through regulation of fatty acid metabolism. J Clin Biochem Nutr (2012) 0.81
In vivo beta-cell imaging with VMAT 2 ligands--current state-of-the-art and future perspective. Curr Pharm Des (2010) 0.81
The role of the unfolded protein response in diabetes mellitus. Semin Immunopathol (2013) 0.81
In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing study. Histochem Cell Biol (2008) 0.80
Role of unfolded protein response in lipogenesis. World J Hepatol (2010) 0.80
Inefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes. J Biol Chem (2014) 0.80
Proteasome dysfunction mediates high glucose-induced apoptosis in rodent beta cells and human islets. PLoS One (2014) 0.80
ChREBP Regulates Itself and Metabolic Genes Implicated in Lipid Accumulation in β-Cell Line. PLoS One (2016) 0.79
Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids. PLoS One (2013) 0.79
Increased protein aggregation in Zucker diabetic fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide. BMC Cell Biol (2014) 0.79
Role of the unfolded protein response in β cell compensation and failure during diabetes. J Diabetes Res (2014) 0.79
Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly. J Clin Med (2015) 0.79
Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D development. Endocrinology (2014) 0.78
Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA. Am J Physiol Endocrinol Metab (2016) 0.77
Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress. Mol Cell Proteomics (2012) 0.77
CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell Apoptosis. Mol Endocrinol (2016) 0.77
Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor α. J Biol Chem (2014) 0.77
Adaptive responses by mouse fetus to a maternal HLE diet by downregulating SREBP1: a microarray- and bio-analytic-based study. J Lipid Res (2013) 0.76
TRB3 is involved in free fatty acid-induced INS-1-derived cell apoptosis via the protein kinase C δ pathway. PLoS One (2014) 0.76
Behavioral stress reduces RIP140 expression in astrocyte and increases brain lipid accumulation. Brain Behav Immun (2015) 0.76
Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity. Regul Pept (2010) 0.76
Nutritional modulation of insulin resistance. Scientifica (Cairo) (2012) 0.76
Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion. Proteome Sci (2009) 0.75
UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid. Nutr Metab (Lond) (2011) 0.75
Dietary Cocoa Powder Improves Hyperlipidemia and Reduces Atherosclerosis in apoE Deficient Mice through the Inhibition of Hepatic Endoplasmic Reticulum Stress. Mediators Inflamm (2016) 0.75
Glucose plus metformin compared with glucose alone on β-cell function in mouse pancreatic islets. Biomed Rep (2015) 0.75
Vanadyl bisacetylacetonate protects β cells from palmitate-induced cell death through the unfolded protein response pathway. J Biol Inorg Chem (2011) 0.75
Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev (2007) 3.86
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology (2003) 2.86
Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol (2003) 2.55
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes. Cell Metab (2012) 2.46
Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release. Diabetes (2005) 2.24
Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes (2005) 2.04
Minireview: implication of mitochondria in insulin secretion and action. Endocrinology (2006) 1.93
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab (2012) 1.93
MicroRNAs: 'ribo-regulators' of glucose homeostasis. Nat Med (2006) 1.90
Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation. EMBO J (2009) 1.85
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab (2005) 1.72
The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets. J Cell Biol (2004) 1.64
Mitochondrial GTP regulates glucose-stimulated insulin secretion. Cell Metab (2007) 1.61
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J (2003) 1.51
Concern Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets. Diabetes (2006) 1.47
Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells. Endocrinology (2005) 1.35
Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes. Mol Endocrinol (2012) 1.35
ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells. J Biol Chem (2002) 1.31
Proteomics analysis of insulin secretory granules. Mol Cell Proteomics (2007) 1.31
Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. Diabetes (2011) 1.26
Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. J Biol Chem (2008) 1.25
PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression. Cell Metab (2009) 1.21
Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem (2007) 1.21
Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell. Cell Calcium (2008) 1.18
Synaptotagmins bind calcium to release insulin. Am J Physiol Endocrinol Metab (2008) 1.14
Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets. J Biol Chem (2004) 1.14
Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis. FASEB J (2007) 1.12
Mitochondrial signals drive insulin secretion in the pancreatic β-cell. Mol Cell Endocrinol (2011) 1.12
Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. J Biol Chem (2002) 1.12
GABA in the endocrine pancreas: its putative role as an islet cell paracrine-signalling molecule. J Gen Physiol (2004) 1.11
Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis. Int J Biochem Cell Biol (2008) 1.10
Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion. Endocrinology (2008) 1.09
Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. J Biol Chem (2002) 1.09
The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci U S A (2007) 1.08
Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis. J Cell Sci (2004) 1.08
Mitochondrial matrix calcium is an activating signal for hormone secretion. Cell Metab (2011) 1.06
The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction. J Biol Chem (2003) 1.06
Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas. Diabetes (2002) 1.06
Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death. J Biol Chem (2001) 1.05
Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets. J Biol Chem (2009) 1.03
Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors. PLoS One (2010) 1.02
Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells. FEBS Lett (2002) 0.99
Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha. J Biol Chem (2002) 0.99
Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets. Diabetes (2003) 0.98
Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells. Diabetes (2002) 0.98
In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice. Diabetes (2011) 0.98
INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. Diabetes (2010) 0.97
TRIB3 [corrected] is implicated in glucotoxicity- and endoplasmic reticulum-stress-induced [corrected] beta-cell apoptosis. J Endocrinol (2008) 0.97
SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment. J Cell Sci (2005) 0.96
Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion. Biochem J (2002) 0.95
Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells. FASEB J (2010) 0.94
The MODY1 gene for hepatocyte nuclear factor 4alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells. Mol Cell Biol (2008) 0.94
Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets. FEBS Lett (2005) 0.94
AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF. J Biol Chem (2010) 0.94
Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release. Biochem J (2013) 0.93
Experimental models of transcription factor-associated maturity-onset diabetes of the young. Diabetes (2002) 0.91
DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets. BMC Med Genet (2013) 0.89
Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells. J Lipid Res (2011) 0.89
The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {beta}-cells against stress-induced apoptosis. Hum Mol Genet (2011) 0.89
Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells. J Biol Chem (2008) 0.88
Improved characterization of the insulin secretory granule proteomes. J Proteomics (2012) 0.88
Evidence against a direct role of klotho in insulin resistance. Pflugers Arch (2009) 0.87
Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells. Mol Cell Endocrinol (2011) 0.86
Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation. Biochim Biophys Acta (2009) 0.84
Does chasing selected 'Fox' to the nucleus prevent diabetes? Trends Mol Med (2005) 0.84
Double trisomy (48,XXY,+21) in monozygotic twins: case report and review of the literature. Ann Genet (2004) 0.83
Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells. Proteomics (2010) 0.82
Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells. Biochim Biophys Acta (2012) 0.81
Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation. J Biol Chem (2011) 0.79
Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress. J Biol Chem (2011) 0.78
Defective mitochondrial function and motility due to mitofusin 1 overexpression in insulin secreting cells. Korean J Physiol Pharmacol (2012) 0.78
Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress. Mol Cell Proteomics (2012) 0.77
Linking fatty acid stress to beta-cell mitochondrial dynamics. Diabetes (2009) 0.76
Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells. Mol Cell Endocrinol (2013) 0.76
Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box. Mol Cell Endocrinol (2012) 0.76
[Glucose homeostasis ribo-regulated by microRNA]. Med Sci (Paris) (2006) 0.75
[Pax4, islet plasticity and diabetes]. Med Sci (Paris) (2005) 0.75