Published in Proc Natl Acad Sci U S A on August 12, 2005
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Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
A MicroRNA feedback circuit in midbrain dopamine neurons. Science (2007) 8.33
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev (2008) 7.07
Control of the embryonic stem cell state. Cell (2011) 6.89
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med (2008) 5.91
MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74
Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell (2008) 5.47
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet (2008) 5.26
RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2007) 5.26
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature (2010) 5.10
Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis. Cell Stem Cell (2010) 4.97
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev (2006) 4.97
MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. J Clin Invest (2007) 4.76
MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell (2008) 4.70
Epigenetic inheritance during the cell cycle. Nat Rev Mol Cell Biol (2009) 4.43
Critical roles for Dicer in the female germline. Genes Dev (2007) 4.23
Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol (2008) 4.07
Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90
Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle (2009) 3.68
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Intersection of the RNA interference and X-inactivation pathways. Science (2008) 3.43
Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet (2011) 3.36
MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries. Stem Cells (2008) 3.14
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A (2008) 3.10
On the origin and functions of RNA-mediated silencing: from protists to man. Curr Genet (2006) 3.05
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03
MicroRNA sponges: progress and possibilities. RNA (2010) 2.96
Retracted RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells. PLoS Genet (2013) 2.91
Antiviral RNA interference in mammalian cells. Science (2013) 2.89
MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS One (2008) 2.82
Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell (2011) 2.73
Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev (2009) 2.73
Mammalian microRNAs: a small world for fine-tuning gene expression. Mamm Genome (2006) 2.64
miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development (2008) 2.59
MicroRNA function is globally suppressed in mouse oocytes and early embryos. Curr Biol (2010) 2.57
microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. J Cell Biol (2010) 2.57
MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci U S A (2010) 2.53
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci (2008) 2.50
DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A (2008) 2.49
MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev (2009) 2.44
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A (2008) 2.42
MicroRNA regulation of cardiovascular development. Circ Res (2009) 2.42
Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol (2008) 2.39
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32
MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Proc Natl Acad Sci U S A (2007) 2.16
ATP-dependent human RISC assembly pathways. Nat Struct Mol Biol (2009) 2.04
MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler Thromb Vasc Biol (2010) 2.00
Accumulation of small murine minor satellite transcripts leads to impaired centromeric architecture and function. Proc Natl Acad Sci U S A (2006) 1.98
Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J (2009) 1.94
Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo. Cell Death Differ (2009) 1.92
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. J Clin Invest (2010) 1.91
Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets. Mamm Genome (2007) 1.88
Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology (2009) 1.86
SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin. Nat Genet (2011) 1.85
Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. Br J Cancer (2009) 1.85
Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev Dyn (2009) 1.83
A new class of retroviral and satellite encoded small RNAs emanates from mammalian centromeres. Chromosoma (2008) 1.79
SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control. Nat Struct Mol Biol (2010) 1.78
MicroRNAs in gene regulation: when the smallest governs it all. J Biomed Biotechnol (2006) 1.76
Targeting breast cancer stem cells. Mol Oncol (2010) 1.72
Cell cycle regulation by MicroRNAs in embryonic stem cells. Cancer Res (2009) 1.69
Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev (2010) 1.67
MicroRNA expression pattern of undifferentiated and differentiated human embryonic stem cells. Stem Cells Dev (2007) 1.65
Characterization of microRNAs involved in embryonic stem cell states. Stem Cells Dev (2010) 1.62
Proliferation-dependent and cell cycle regulated transcription of mouse pericentric heterochromatin. J Cell Biol (2007) 1.59
microRNAs regulate human embryonic stem cell division. Cell Cycle (2009) 1.58
Structure of C3PO and mechanism of human RISC activation. Nat Struct Mol Biol (2011) 1.55
microRNA and stem cell function. Cell Tissue Res (2007) 1.54
Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression. Proc Natl Acad Sci U S A (2008) 1.54
Identification of sister chromatids by DNA template strand sequences. Nature (2009) 1.53
The contradictory definitions of heterochromatin: transcription and silencing. Chromosoma (2006) 1.52
Small RNAs: keeping stem cells in line. Cell (2008) 1.51
myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation (2010) 1.50
The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells. Genome Biol (2007) 1.49
Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells. Dev Biol (2010) 1.47
Dicer controls CD8+ T-cell activation, migration, and survival. Proc Natl Acad Sci U S A (2010) 1.43
MicroRNA-302 increases reprogramming efficiency via repression of NR2F2. Stem Cells (2013) 1.41
Novel functions for small RNA molecules. Curr Opin Mol Ther (2009) 1.39
A natural antisense transcript at the Huntington's disease repeat locus regulates HTT expression. Hum Mol Genet (2011) 1.39
Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization. Proc Natl Acad Sci U S A (2010) 1.38
Biogenesis of mammalian microRNAs by a non-canonical processing pathway. Nucleic Acids Res (2012) 1.37
MicroRNAs of the immune system: roles in inflammation and cancer. Ann N Y Acad Sci (2010) 1.37
MicroRNAs: regulating a change of heart. Circulation (2009) 1.37
miR-34a regulates mouse neural stem cell differentiation. PLoS One (2011) 1.37
Cohesin regulation: fashionable ways to wear a ring. Chromosoma (2007) 1.34
RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells. J Cell Sci (2010) 1.33
Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by a DNA methylation-independent mechanism. J Biol Chem (2010) 1.33
Small RNAs in early mammalian development: from gametes to gastrulation. Development (2011) 1.33
Concise review: MicroRNA expression in multipotent mesenchymal stromal cells. Stem Cells (2007) 1.32
Piecing together the mosaic of early mammalian development through microRNAs. J Biol Chem (2008) 1.32
siRNA repositioning for guide strand selection by human Dicer complexes. Mol Cell (2011) 1.31
A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. PLoS Genet (2011) 1.31
Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells. Genes Chromosomes Cancer (2010) 1.27
MicroRNAs in embryonic stem cell function and fate. Genes Dev (2010) 1.27
Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75
RNA interference. Nature (2002) 22.28
Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18
Functional siRNAs and miRNAs exhibit strand bias. Cell (2003) 19.15
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04
Dicer is essential for mouse development. Nat Genet (2003) 15.87
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell (2004) 13.51
Embryonic stem cell-specific MicroRNAs. Dev Cell (2003) 13.05
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell (2001) 11.39
MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16
R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (2003) 9.53
Establishment and maintenance of a heterochromatin domain. Science (2002) 9.34
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13
RNAi-mediated targeting of heterochromatin by the RITS complex. Science (2004) 8.73
Single processing center models for human Dicer and bacterial RNase III. Cell (2004) 8.19
A protein sensor for siRNA asymmetry. Science (2004) 7.77
The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10
Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J (2002) 6.65
Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science (2004) 6.35
Small RNAs correspond to centromere heterochromatic repeats. Science (2002) 5.96
Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nat Cell Biol (2004) 5.92
Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell (2002) 5.78
A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell (2004) 5.69
T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med (2005) 5.26
Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A (2002) 5.05
The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet (2003) 4.97
Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc Natl Acad Sci U S A (2001) 4.79
Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem (2004) 4.40
RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol (2004) 4.01
Cytosine methylation and mammalian development. Genes Dev (1999) 3.82
Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol (2004) 3.67
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64
RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast. Proc Natl Acad Sci U S A (2002) 3.52
RNA interference is required for normal centromere function in fission yeast. Chromosome Res (2003) 3.46
Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr Biol (2003) 3.37
RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. Science (2004) 2.80
A Dicer-like protein in Tetrahymena has distinct functions in genome rearrangement, chromosome segregation, and meiotic prophase. Genes Dev (2004) 2.75
Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells. Mol Cell Biol (2001) 2.40
Dicer is required for chromosome segregation and gene silencing in fission yeast cells. Proc Natl Acad Sci U S A (2002) 1.97
Transcripts from opposite strands of gamma satellite DNA are differentially expressed during mouse development. Mamm Genome (1995) 1.70
DNA methylation is independent of RNA interference in Neurospora. Science (2004) 1.66
RNAi-dependent and RNAi-independent mechanisms contribute to the silencing of RIPed sequences in Neurospora crassa. Nucleic Acids Res (2004) 1.38
Small interfering RNAs that trigger posttranscriptional gene silencing are not required for the histone H3 Lys9 methylation necessary for transgenic tandem repeat stabilization in Neurospora crassa. Mol Cell Biol (2005) 1.17
Arabidopsis epigenetics: when RNA meets chromatin. Curr Opin Plant Biol (2005) 1.05
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet (2004) 37.83
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
Genome-wide in situ exon capture for selective resequencing. Nat Genet (2007) 19.97
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Dicer is essential for mouse development. Nat Genet (2003) 15.87
Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev (2006) 15.20
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature (2006) 9.88
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet (2005) 8.99
Small RNAs as guardians of the genome. Cell (2009) 8.88
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Developmentally regulated piRNA clusters implicate MILI in transposon control. Science (2007) 7.68
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell (2007) 7.66
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev (2002) 7.61
A role for the P-body component GW182 in microRNA function. Nat Cell Biol (2005) 7.54
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90
Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol (2005) 6.64
Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37
A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science (2010) 5.84
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Alta-Cyclic: a self-optimizing base caller for next-generation sequencing. Nat Methods (2008) 5.70
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell (2008) 5.47
Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41
microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer (2007) 5.38
RNA interference in adult mice. Nature (2002) 5.33
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29
A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16
Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A (2002) 5.05
An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05
A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95
miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature (2006) 4.68
The CRISPR system: small RNA-guided defense in bacteria and archaea. Mol Cell (2010) 4.60
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57
Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51
Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing. Nat Protoc (2009) 4.45
A molecular roadmap of reprogramming somatic cells into iPS cells. Cell (2012) 4.41
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res (2007) 4.28
Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet (2010) 4.27
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24
Critical roles for Dicer in the female germline. Genes Dev (2007) 4.23
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol (2004) 4.01
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00
Biochemical specialization within Arabidopsis RNA silencing pathways. Mol Cell (2005) 3.92
miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol (2004) 3.82
A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell (2011) 3.69
A micrococcal nuclease homologue in RNAi effector complexes. Nature (2003) 3.67
Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol (2004) 3.67
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A (2004) 3.42
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell (2011) 3.39
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol (2010) 3.33
Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Res (2009) 3.08
DNA Sudoku--harnessing high-throughput sequencing for multiplexed specimen analysis. Genome Res (2009) 3.05
RNAi: an ever-growing puzzle. Trends Biochem Sci (2003) 3.01
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis. Nat Methods (2004) 3.01
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev (2009) 2.95
The guardian's little helper: microRNAs in the p53 tumor suppressor network. Cancer Res (2007) 2.92
Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res (2011) 2.89
Evolutionary flux of canonical microRNAs and mirtrons in Drosophila. Nat Genet (2010) 2.84
The structure of human argonaute-2 in complex with miR-20a. Cell (2012) 2.83
RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos. Dev Biol (2004) 2.82
Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell (2011) 2.82
Lessons from Nature: microRNA-based shRNA libraries. Nat Methods (2006) 2.80
Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science (2011) 2.78
An alternative mode of microRNA target recognition. Nat Struct Mol Biol (2012) 2.77
Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment. Mol Cell (2011) 2.77
Patient-derived tumor xenografts: transforming clinical samples into mouse models. Cancer Res (2013) 2.74
Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol (2008) 2.67
Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Methods (2004) 2.62
Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol (2002) 2.61
Design of 240,000 orthogonal 25mer DNA barcode probes. Proc Natl Acad Sci U S A (2009) 2.61
miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development (2008) 2.59
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell (2009) 2.54
Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet (2007) 2.54