Published in PLoS Comput Biol on June 24, 2005
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Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
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Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
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The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev (2007) 5.16
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Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov (2010) 4.25
Systematic identification of microRNA functions by combining target prediction and expression profiling. Nucleic Acids Res (2006) 3.29
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Widespread regulatory activity of vertebrate microRNA* species. RNA (2010) 2.97
The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature (2012) 2.94
Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. Blood (2007) 2.83
Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes Dev (2008) 2.35
Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis. Genes Dev (2008) 2.34
Drosophila lacking microRNA miR-278 are defective in energy homeostasis. Genes Dev (2006) 2.26
A biophysical miRNA-mRNA interaction model infers canonical and noncanonical targets. Nat Methods (2013) 2.16
Revealing posttranscriptional regulatory elements through network-level conservation. PLoS Comput Biol (2005) 2.04
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The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings. Genes Dev (2005) 2.04
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MicroRNA regulation of human protein protein interaction network. RNA (2007) 1.82
Diverse set of microRNAs are responsive to powdery mildew infection and heat stress in wheat (Triticum aestivum L.). BMC Plant Biol (2010) 1.80
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MicroRNAs shape the neuronal landscape. Neuron (2012) 1.64
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A role for microRNAs in the Drosophila circadian clock. Genes Dev (2009) 1.56
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Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology. PLoS One (2008) 1.49
Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder. Biol Psychiatry (2011) 1.49
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Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. Science (2008) 1.41
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Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nat Protoc (2008) 1.38
MicroRNAs: regulating a change of heart. Circulation (2009) 1.37
Sequence variation of MicroRNAs and their binding sites in Arabidopsis. Plant Physiol (2008) 1.35
Finding microRNA regulatory modules in human genome using rule induction. BMC Bioinformatics (2008) 1.32
Small regulatory RNAs may sharpen spatial expression patterns. PLoS Comput Biol (2007) 1.32
Concise review: MicroRNA expression in multipotent mesenchymal stromal cells. Stem Cells (2007) 1.32
Adaptive evolution of newly emerged micro-RNA genes in Drosophila. Mol Biol Evol (2008) 1.31
miRTar: an integrated system for identifying miRNA-target interactions in human. BMC Bioinformatics (2011) 1.30
Clustered microRNAs' coordination in regulating protein-protein interaction network. BMC Syst Biol (2009) 1.28
Computational methods to identify miRNA targets. Semin Cell Dev Biol (2010) 1.21
mRNA turnover rate limits siRNA and microRNA efficacy. Mol Syst Biol (2010) 1.21
Regulatory circuit of human microRNA biogenesis. PLoS Comput Biol (2007) 1.21
Origins and evolution of microRNA genes in plant species. Genome Biol Evol (2012) 1.20
An expanded seed sequence definition accounts for full regulation of the hid 3' UTR by bantam miRNA. RNA (2009) 1.17
Involvement of microRNAs in physiological and pathological processes in the lung. Respir Res (2010) 1.17
Computational and transcriptional evidence for microRNAs in the honey bee genome. Genome Biol (2007) 1.15
Insect microRNAs: biogenesis, expression profiling and biological functions. Insect Biochem Mol Biol (2012) 1.15
Identification and characteristics of microRNAs from Bombyx mori. BMC Genomics (2008) 1.14
Invited review: decoding the microRNA response to hypoxia. Pflugers Arch (2011) 1.12
MicroRNAs in C. elegans Aging: Molecular Insurance for Robustness? Curr Genomics (2009) 1.11
MicroRNA levels are modulated in Aedes aegypti after exposure to Dengue-2. Insect Mol Biol (2013) 1.10
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk. Mol Neurodegener (2012) 1.08
Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data. Genome Biol (2009) 1.08
Evidence for conserved post-transcriptional roles of unitary pseudogenes and for frequent bifunctionality of mRNAs. Genome Biol (2012) 1.07
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Identification of microRNAs from Amur grape (Vitis amurensis Rupr.) by deep sequencing and analysis of microRNA variations with bioinformatics. BMC Genomics (2012) 1.04
Let-7-complex microRNAs regulate the temporal identity of Drosophila mushroom body neurons via chinmo. Dev Cell (2012) 1.03
Evidence for the complexity of microRNA-mediated regulation in ovarian cancer: a systems approach. PLoS One (2011) 1.02
Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome. BMC Genomics (2008) 1.02
Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. Mol Cell Biol (2010) 1.00
microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein. EMBO Rep (2012) 0.99
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A Drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling. Genetics (2008) 0.99
Control of antagonistic components of the hedgehog signaling pathway by microRNAs in Drosophila. Genetics (2008) 0.99
A microRNA repertoire for functional genome research in rainbow trout (Oncorhynchus mykiss). Mar Biotechnol (NY) (2009) 0.98
miR-1279, miR-548j, miR-548m, and miR-548d-5p binding sites in CDSs of paralogous and orthologous PTPN12, MSH6, and ZEB1 Genes. Biomed Res Int (2013) 0.98
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Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells. Development (2009) 0.97
Adverse interactions between micro-RNAs and target genes from different species. Proc Natl Acad Sci U S A (2010) 0.97
Investigation of miRNA biology by bioinformatic tools and impact of miRNAs in colorectal cancer--regulatory relationship of c-Myc and p53 with miRNAs. Cancer Inform (2007) 0.96
The Drosophila nerfin-1 mRNA requires multiple microRNAs to regulate its spatial and temporal translation dynamics in the developing nervous system. Dev Biol (2007) 0.95
OMIT: dynamic, semi-automated ontology development for the microRNA domain. PLoS One (2014) 0.94
A computational-based update on microRNAs and their targets in barley (Hordeum vulgare L.). BMC Genomics (2010) 0.94
A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. Genetics (2008) 0.93
Fast-evolving microRNAs are highly expressed in the early embryo of Drosophila virilis. RNA (2014) 0.93
Computational prediction of rice (Oryza sativa) miRNA targets. Genomics Proteomics Bioinformatics (2007) 0.92
Identifications of conserved 7-mers in 3'-UTRs and microRNAs in Drosophila. BMC Bioinformatics (2007) 0.91
MicroRNA: A matter of life or death. World J Biol Chem (2010) 0.91
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Predicting kissing interactions in microRNA-target complex and assessment of microRNA activity. Nucleic Acids Res (2012) 0.90
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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95
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bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell (2003) 22.14
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
Fast and effective prediction of microRNA/target duplexes. RNA (2004) 18.10
Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet (2002) 17.20
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Incorporating structure to predict microRNA targets. Proc Natl Acad Sci U S A (2005) 5.68
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Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity. Dev Biol (2003) 4.63
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Computational detection of genomic cis-regulatory modules applied to body patterning in the early Drosophila embryo. BMC Bioinformatics (2002) 3.61
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A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
Regulation of the germinal center response by microRNA-155. Science (2007) 12.25
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Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17
A genome-wide map of conserved microRNA targets in C. elegans. Curr Biol (2006) 10.14
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell (2007) 9.33
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Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53
Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo): genome assembly and analysis. PLoS Biol (2010) 5.39
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet (2007) 4.69
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Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol Cell (2011) 4.15
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The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol (2010) 2.53
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Nat Methods (2009) 2.50
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Deciphering the porcine intestinal microRNA transcriptome. BMC Genomics (2010) 1.30
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RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing. J Clin Invest (2014) 0.99
miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol (2015) 0.98
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Select microRNAs are essential for early development in the sea urchin. Dev Biol (2011) 0.95
The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. EMBO J (2011) 0.95
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Screening of pathogenic genes in Chinese patients with arrhythmogenic right ventricular cardiomyopathy. Chin Med J (Engl) (2013) 0.80
DevStaR: high-throughput quantification of C. elegans developmental stages. IEEE Trans Med Imaging (2013) 0.79
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Rational design of temperature-sensitive alleles using computational structure prediction. PLoS One (2011) 0.78
Microvesicles derived from hypoxia/reoxygenation-treated human umbilical vein endothelial cells impair relaxation of rat thoracic aortic rings. Zhongguo Ying Yong Sheng Li Xue Za Zhi (2014) 0.77
Myocardial bridging as a common phenotype of hypertrophic cardiomyopathy has no effect on prognosis. Am J Med Sci (2014) 0.75
MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb. Cell (2016) 0.75