Published in Bioorg Med Chem Lett on November 15, 2005
Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem (2014) 1.36
A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium. Arthritis Rheum (2005) 1.36
Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. J Med Chem (2012) 1.12
Exploiting structural information in patent specifications for key compound prediction. J Chem Inf Model (2012) 0.97
The pivotal role of hepatocytes in drug discovery. Chem Biol Interact (2006) 0.92
Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium. Arthritis Rheum (2008) 0.92
Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis. Drug Metab Dispos (2005) 0.90
Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells. J Pharmacol Exp Ther (2004) 0.90
The influence of DMPK as an integrated partner in modern drug discovery. Curr Drug Metab (2002) 0.88
Time-dependent CYP inhibition. Expert Opin Drug Metab Toxicol (2007) 0.88
Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes. Drug Metab Dispos (2006) 0.88
Endovascular coiling of an internal mammary artery pseudoaneurysm following placement of an internal jugular central venous catheter. Mil Med (2010) 0.88
Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo. Drug Metab Dispos (2007) 0.87
Optimisation of DMPK by the inhaled route: challenges and approaches. Curr Drug Metab (2012) 0.84
Restenosis in gold-coated renal artery stents. J Vasc Surg (2005) 0.82
Lead optimisation of pyrazoles as novel FPR1 antagonists. Bioorg Med Chem Lett (2011) 0.79
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity. Bioorg Med Chem Lett (2012) 0.78
Phototoxicity and fluorotoxicity combine to alter the behavior of neutrophils in fluorescence microscopy based flow adhesion assays. Microsc Res Tech (2006) 0.78
The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD. Bioorg Med Chem Lett (2013) 0.78
The development of a cocktail CYP2B6, CYP2C8, and CYP3A5 inhibition assay and a preliminary assessment of utility in a drug discovery setting. Drug Metab Dispos (2006) 0.77
Predicting metabolic clearance for drugs that are actively transported into hepatocytes: incubational binding as a consequence of in vitro hepatocyte concentration is a key factor. Drug Metab Dispos (2013) 0.77
Structure-based design of peptidomimetic antagonists of p56(lck) SH2 domain. Bioorg Med Chem Lett (2002) 0.77
P-glycoprotein potentiates CYP3A4-mediated drug disappearance during Caco-2 intestinal secretory detoxification. J Drug Target (2004) 0.76
Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett (2012) 0.75
Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas. Bioorg Med Chem Lett (2005) 0.75
A general synthesis of macrocyclic pi-electron-acceptor systems. Org Lett (2009) 0.75
Training an old-timer as a GP in Britain. S Afr Med J (2008) 0.75
Searching for the tooth. J Ir Dent Assoc (2014) 0.75
A system for encoding and searching Markush structures. J Chem Inf Model (2012) 0.75
A novel matrix for the short-term storage of cells: utility in drug metabolism and drug transporter studies with rat, dog and human hepatocytes. Xenobiotica (2012) 0.75
Better compounds faster: the development and exploitation of a desktop predictive chemistry toolkit. Drug Discov Today (2012) 0.75
Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. J Med Chem (2017) 0.75
CONTROL OF THE POROUS STRUCTURE OF POLYSTYRENE PARTICLES OBTAINED BY NON-SOLVENT INDUCED PHASE SEPARATION. Langmuir (2017) 0.75
Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides. Bioorg Med Chem Lett (2006) 0.75
The discovery of AZD9164, a novel muscarinic M3 antagonist. Bioorg Med Chem Lett (2011) 0.75