Published in J Biochem Mol Toxicol on January 01, 2005
TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure. Invest Ophthalmol Vis Sci (2008) 1.54
Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Invest Ophthalmol Vis Sci (2008) 1.20
Absence of transient receptor potential vanilloid-1 accelerates stress-induced axonopathy in the optic projection. J Neurosci (2014) 1.06
Transient receptor potential (TRP) channels in the airway: role in airway disease. Br J Pharmacol (2014) 1.05
Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP. Chem Res Toxicol (2011) 1.04
Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria. J Med Chem (2011) 1.02
Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. J Pharmacol Exp Ther (2007) 1.01
TRPV1 antagonists elevate cell surface populations of receptor protein and exacerbate TRPV1-mediated toxicities in human lung epithelial cells. Toxicol Sci (2005) 0.96
Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation. J Neurosci (2014) 0.95
Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material. Mol Pharmacol (2011) 0.92
Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity. J Pharmacol Exp Ther (2011) 0.88
Emerging mechanistic targets in lung injury induced by combustion-generated particles. Toxicol Sci (2013) 0.88
Metabolism of capsaicinoids by P450 enzymes: a review of recent findings on reaction mechanisms, bio-activation, and detoxification processes. Drug Metab Rev (2006) 0.86
Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury. Am J Physiol Lung Cell Mol Physiol (2011) 0.84
A synergistic effect of simultaneous TRPA1 and TRPV1 activations on vagal pulmonary C-fiber afferents. J Appl Physiol (1985) (2014) 0.83
Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress. Channels (Austin) (2015) 0.78
TRPV1 activation exacerbates hypoxia/reoxygenation-induced apoptosis in H9C2 cells via calcium overload and mitochondrial dysfunction. Int J Mol Sci (2014) 0.78
Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia. J Neuroinflammation (2012) 0.78
TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli. Curr Neuropharmacol (2015) 0.78
TRP channels and traffic-related environmental pollution-induced pulmonary disease. Semin Immunopathol (2016) 0.77
Interaction between TRPA1 and TRPV1: Synergy on pulmonary sensory nerves. Pulm Pharmacol Ther (2015) 0.76
The role of stretch-activated ion channels in acute respiratory distress syndrome: finally a new target? Am J Physiol Lung Cell Mol Physiol (2016) 0.75
A study to investigate capsaicin-induced pressure response in vagotomized rats. Indian J Pharmacol (2013) 0.75
Characterization of Transient Receptor Potential Vanilloid-1 (TRPV1) Variant Activation by Coal Fly Ash Particles and Associations with Altered Transient Receptor Potential Ankyrin-1 (TRPA1) Expression and Asthma. J Biol Chem (2016) 0.75
The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59
Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev (1999) 7.20
Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A (2000) 3.55
A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science (2003) 3.51
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci U S A (2003) 2.58
Analysis of the native quaternary structure of vanilloid receptor 1. J Biol Chem (2001) 2.55
Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J Neurosci (1988) 2.18
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. Pain (2000) 2.11
Ca2+/calmodulin modulates TRPV1 activation by capsaicin. J Gen Physiol (2004) 1.91
Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. J Biol Chem (2004) 1.85
TRPV channels as temperature sensors. Cell Calcium (2003) 1.63
Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1. J Biol Chem (2000) 1.59
Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors. Toxicol Sci (2003) 1.34
Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes. J Pharmacol Exp Ther (2003) 1.25
Characterization of functional vanilloid receptors expressed by mast cells. Blood (1998) 1.21
Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther (2002) 1.16
TRPV1 receptors mediate particulate matter-induced apoptosis. Am J Physiol Lung Cell Mol Physiol (2003) 1.13
Activation of protein kinase C sensitizes human VR1 to capsaicin and to moderate decreases in pH at physiological temperatures in Xenopus oocytes. Pain (2002) 1.10
Particulate matter initiates inflammatory cytokine release by activation of capsaicin and acid receptors in a human bronchial epithelial cell line. Toxicol Appl Pharmacol (1999) 1.09
Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. Neuropeptides (1999) 1.06
Protein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways. J Biol Chem (2002) 1.05
High affinity antagonists of the vanilloid receptor. Mol Pharmacol (2002) 1.00
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor. J Med Chem (2003) 0.99
Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. Am J Physiol Lung Cell Mol Physiol (2000) 0.98
Enhancement of potency and efficacy of NADA by PKC-mediated phosphorylation of vanilloid receptor. J Neurophysiol (2004) 0.98
Electrostatic charge activates inflammatory vanilloid (VR1) receptors. Neurotoxicology (2003) 0.94
Simultaneous intracellular calcium and sodium flux imaging in human vanilloid receptor 1 (VR1)-transfected human embryonic kidney cells: a method to resolve ionic dependence of VR1-mediated cell death. J Pharmacol Exp Ther (2002) 0.93
Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells. Toxicol Appl Pharmacol (2003) 0.93
Induction of prostaglandin H synthase 2 in human airway epithelial cells exposed to residual oil fly ash. Toxicol Appl Pharmacol (1996) 0.85
Cytotoxicity and genotoxicity of capsaicin in human neuroblastoma cells SHSY-5Y. Arch Toxicol (1999) 0.84
Increased expression of cyclooxygenase 2 mediates oil fly ash-induced lung injury. Exp Lung Res (2000) 0.84
Implications of oxidative stress and inflammatory process in the cytotoxicity of capsaicin in human endothelial cells: lack of DNA strand breakage. Toxicology (2000) 0.83
Cytotoxicity of capsaicin in monkey kidney cells: lack of antagonistic effects of capsazepine and Ruthenium red. Arch Toxicol (2000) 0.82
Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity. Bioorg Med Chem Lett (2004) 0.81
Tyrosine prevents capsaicin-induced protein synthesis inhibition in cultured cells. Toxicology (1997) 0.77
Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1. J Neurophysiol (2008) 2.99
Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors. Toxicol Sci (2003) 1.34
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. J Biol Chem (2001) 1.21
Cytokine responses of human lung cells (BEAS-2B) treated with micron-sized and nanoparticles of metal oxides compared to soil dusts. Part Fibre Toxicol (2007) 1.16
Human lung epithelial cells express a functional cold-sensing TRPM8 variant. Am J Respir Cell Mol Biol (2008) 1.12
Inflammatory cytokines and cell death in BEAS-2B lung cells treated with soil dust, lipopolysaccharide, and surface-modified particles. Toxicol Sci (2004) 1.10
Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Neurobiol Aging (2003) 1.08
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones. Org Lett (2004) 1.05
2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region. Eur J Med Chem (2013) 1.05
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem (2008) 1.04
Correlation of in vitro cytokine responses with the chemical composition of soil-derived particulate matter. Environ Health Perspect (2006) 1.04
Quantum mechanically derived AMBER-compatible heme parameters for various states of the cytochrome P450 catalytic cycle. J Comput Chem (2011) 1.04
Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP. Chem Res Toxicol (2011) 1.04
Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents. J Med Chem (2005) 1.02
Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. J Pharmacol Exp Ther (2007) 1.01
Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. Life Sci (2005) 1.01
High affinity antagonists of the vanilloid receptor. Mol Pharmacol (2002) 1.00
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor. J Med Chem (2003) 0.99
Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies. J Comput Aided Mol Des (2011) 0.99
Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae). Oncol Res (2002) 0.97
Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease. J Alzheimers Dis (2012) 0.97
Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol (2003) 0.97
TRPV1 antagonists elevate cell surface populations of receptor protein and exacerbate TRPV1-mediated toxicities in human lung epithelial cells. Toxicol Sci (2005) 0.96
Metabolic activation of a novel 3-substituted indole-containing TNF-alpha inhibitor: dehydrogenation and inactivation of CYP3A4. Chem Res Toxicol (2007) 0.95
3-methylindole-induced toxicity to human bronchial epithelial cell lines. Toxicol Sci (2003) 0.95
Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures. Am J Physiol Lung Cell Mol Physiol (2008) 0.95
Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action. Regul Toxicol Pharmacol (2007) 0.93
Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control. J Pediatr (2013) 0.92
Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material. Mol Pharmacol (2011) 0.92
High-affinity partial agonists of the vanilloid receptor. Mol Pharmacol (2003) 0.91
Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues. J Med Chem (2007) 0.91
The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract. Drug Metab Dispos (2009) 0.91
Improved cytochrome P450 3A4 molecular models accurately predict the Phe215 requirement for raloxifene dehydrogenation selectivity. Biochemistry (2010) 0.90
Synthesis and evaluation of fluorine-substituted 1H-pyrrolo[2,3-b]pyridine derivatives for dopamine D4 receptor imaging. Bioorg Med Chem (2004) 0.89
Kinetics of penetration influence the apparent potency of vanilloids on TRPV1. Mol Pharmacol (2006) 0.89
Dehydrogenation of indoline by cytochrome P450 enzymes: a novel "aromatase" process. J Pharmacol Exp Ther (2007) 0.88
Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase. Biochemistry (2008) 0.88
Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity. J Pharmacol Exp Ther (2011) 0.88
Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Drug Metab Dispos (2008) 0.88
Effects of the differentiated keratinocyte phenotype on expression levels of CYP1-4 family genes in human skin cells. Toxicol Appl Pharmacol (2005) 0.87
Effects of cell type and culture media on Interleukin-6 secretion in response to environmental particles. Toxicol In Vitro (2007) 0.87
Metabolism and bioactivation of 3-methylindole by human liver microsomes. Chem Res Toxicol (2007) 0.87
2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. Eur J Med Chem (2008) 0.87
Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.86
3-Methylindole is mutagenic and a possible pulmonary carcinogen. Toxicol Sci (2009) 0.86
Metabolism of capsaicinoids by P450 enzymes: a review of recent findings on reaction mechanisms, bio-activation, and detoxification processes. Drug Metab Rev (2006) 0.86
Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain. J Med Chem (2003) 0.86
Determination of capsaicin, nonivamide, and dihydrocapsaicin in blood and tissue by liquid chromatography-tandem mass spectrometry. J Anal Toxicol (2002) 0.86
Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists. Bioorg Med Chem Lett (2005) 0.86
Characterization of the human lung CYP2F1 gene and identification of a novel lung-specific binding motif. J Biol Chem (2003) 0.86
Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors. J Mol Med (Berl) (2014) 0.85
Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorg Med Chem (2007) 0.85
Sp1 and Sp3 regulate basal transcription of the human CYP2F1 gene. Drug Metab Dispos (2005) 0.84
Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury. Am J Physiol Lung Cell Mol Physiol (2011) 0.84
Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme. Chem Res Toxicol (2005) 0.84
3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively. Chem Res Toxicol (2010) 0.84
Mechanism-based inactivation of lung-selective cytochrome P450 CYP2F enzymes. Drug Metab Dispos (2007) 0.84
Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models. Drug Metab Dispos (2012) 0.84
Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther (2013) 0.84
Benzene metabolism in human lung cell lines BEAS-2B and A549 and cells overexpressing CYP2F1. J Biochem Mol Toxicol (2004) 0.83
Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding. Bioorg Med Chem (2004) 0.83
Structural and enzymatic parameters that determine alkyl dehydrogenation/hydroxylation of capsaicinoids by cytochrome p450 enzymes. Drug Metab Dispos (2005) 0.83
Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK. Chem Res Toxicol (2010) 0.82
CYP3A4-Mediated oxygenation versus dehydrogenation of raloxifene. Biochemistry (2010) 0.82
Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos (2012) 0.82
The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme. Chem Res Toxicol (2010) 0.82
Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen. Biochim Biophys Acta (2012) 0.81
Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors. Bioorg Med Chem Lett (2006) 0.81
Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity. Bioorg Med Chem Lett (2004) 0.81
N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region. Bioorg Med Chem (2011) 0.81
Transcription factor binding to a putative double E-box motif represses CYP3A4 expression in human lung cells. Mol Pharmacol (2007) 0.81
Aminopropyl carbazole analogues as potent enhancers of neurogenesis. Bioorg Med Chem (2013) 0.81
Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists. Bioorg Med Chem (2008) 0.81
Characterization of pulmonary CYP4B2, specific catalyst of methyl oxidation of 3-methylindole. Mol Pharmacol (2003) 0.81
TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation. Curr Top Med Chem (2011) 0.81
Ligand-based design, synthesis, and biological evaluation of 2-aminopyrimidines, a novel series of receptor for advanced glycation end products (RAGE) inhibitors. J Med Chem (2012) 0.81
Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template. Bioorg Med Chem (2013) 0.81
3D-QSAR analysis of conformationally constrained diacylglycerol (DAG) analogues as potent protein kinase C (PK-C) ligands. Bioorg Med Chem (2004) 0.80
N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure-activity relationships for the "C-Region". Bioorg Med Chem (2004) 0.80
Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects. Bioorg Med Chem Lett (2003) 0.80
Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes. Chem Res Toxicol (2012) 0.79
Inhibition of glutaminyl cyclase ameliorates amyloid pathology in an animal model of Alzheimer's disease via the modulation of γ-secretase activity. J Alzheimers Dis (2015) 0.79
3-D-QSAR study and molecular docking of methionyl-tRNA synthetase inhibitors. Bioorg Med Chem (2003) 0.79
N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity. Bioorg Med Chem Lett (2004) 0.79
Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin. Bioorg Med Chem (2010) 0.79
Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin. Bioorg Med Chem Lett (2006) 0.79