High activity of acid sphingomyelinase in major depression.

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases. FASEB J (2008) 1.73

Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nat Med (2013) 1.36

Mechanisms of amine accumulation in, and egress from, lysosomes. Bioanalysis (2009) 1.03

Quantitative modeling of selective lysosomal targeting for drug design. Eur Biophys J (2008) 0.99

Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases. J Alzheimers Dis (2012) 0.98

The role of ceramide in major depressive disorder. Eur Arch Psychiatry Clin Neurosci (2009) 0.96

Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One (2011) 0.91

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons. Front Physiol (2014) 0.91

Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology (2012) 0.87

The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior. Psychopharmacology (Berl) (2008) 0.87

Acid sphingomyelinase in macrophage biology. Cell Mol Life Sci (2011) 0.84

Functional implications of novel human acid sphingomyelinase splice variants. PLoS One (2012) 0.83

The Acid Sphingomyelinase Sequence Variant p.A487V Is Not Associated With Decreased Levels of Enzymatic Activity. JIMD Rep (2012) 0.83

Elevated plasma ceramides in depression. J Neuropsychiatry Clin Neurosci (2011) 0.82

Sphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimer's disease. PLoS One (2015) 0.78

ALTERED BLOOD SPHINGOLIPIDOMICS AND ELEVATED PLASMA INFLAMMATORY CYTOKINES IN COMBAT VETERANS WITH POST-TRAUMATIC STRESS DISORDER. Neurobiol Lipids (2012) 0.76

Alleged Detrimental Mutations in the SMPD1 Gene in Patients with Niemann-Pick Disease. Int J Mol Sci (2015) 0.76

Characterization of acid sphingomyelinase activity in human cerebrospinal fluid. PLoS One (2013) 0.76

Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling. Mol Pharmacol (2017) 0.75

Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory. PLoS One (2016) 0.75

Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis. Acta Neuropathol (2016) 0.75

Harnessing the power of yeast to elucidate the role of sphingolipids in metabolic and signaling processes pertinent to psychiatric disorders. Clin Lipidol (2014) 0.75

Interferon-Beta Increases Plasma Ceramides of Specific Chain Length in Multiple Sclerosis Patients, Unlike Fingolimod or Natalizumab. Front Pharmacol (2016) 0.75

Functional rafts in cell membranes. Nature (1997) 38.89

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (1992) 12.18

The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment. Arch Gen Psychiatry (1998) 4.83

The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem (1994) 4.21

CD95 signaling via ceramide-rich membrane rafts. J Biol Chem (2001) 2.48

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity (1995) 2.19

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid. EMBO J (1995) 2.14

Kinase suppressor of Ras is ceramide-activated protein kinase. Cell (1997) 2.05

Signal transduction abnormalities in melancholic depression. Int J Neuropsychopharmacol (2004) 1.73

Sphingomyelinase treatment induces ATP-independent endocytosis. J Cell Biol (1998) 1.72

Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem (1992) 1.72

Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells. Cell (1997) 1.47

Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem (2003) 1.47

Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids (1996) 1.44

Omega-3 fatty acids--the missing link? Arch Gen Psychiatry (1999) 1.41

Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix. Arterioscler Thromb Vasc Biol (1999) 1.33

Ceramide activates the stress-activated protein kinases. J Biol Chem (1995) 1.33

Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine. FEBS Lett (2004) 1.19

Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids. Proc Natl Acad Sci U S A (1999) 1.15

Ceramide as an activator lipid of cathepsin D. Adv Exp Med Biol (2000) 1.08

Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944. Science (1977) 1.07

Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity. J Biol Chem (1998) 1.06

Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases. Proc Natl Acad Sci U S A (1997) 1.06

Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release. FASEB J (2000) 1.05

Enzyme activities and phospholipid storage patterns in brain and spleen samples from Niemann-Pick disease variants: a comparison of neuropathic and non-neuropathic forms. J Inherit Metab Dis (1986) 0.96

Sphingomyelin metabolites in vascular cell signaling and atherogenesis. Prog Lipid Res (2000) 0.96

Decreased catalytic activity and expression of protein kinase C isozymes in teenage suicide victims: a postmortem brain study. Arch Gen Psychiatry (2004) 0.95

Elevated PLA2 activity in schizophrenics and other psychiatric patients. Biol Psychiatry (1993) 0.92

Observation of topical catalysis by sphingomyelinase coupled to microspheres. J Am Chem Soc (2002) 0.89

Protein kinase C in the postmortem brain of teenage suicide victims. Neurosci Lett (1997) 0.88

Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines. Life Sci (1986) 0.87

Ceramides increase the activity of the secretory phospholipase A2 and alter its fatty acid specificity. Biochem J (2002) 0.86

Ceramide-induced alterations in dopamine transporter function. Eur J Pharmacol (2003) 0.82

Altered brain protein kinase C in depression: a post-mortem study. Eur Neuropsychopharmacol (2000) 0.81

Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide. Eur J Biochem (2003) 0.81

Ceramide promotes calpain-mediated proteolysis of protein kinase C beta in murine polymorphonuclear leukocytes. Biochem Biophys Res Commun (1998) 0.80

Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorder. J Affect Disord (2004) 0.77

Ceramide-induced vasorelaxation: An inhibitory action on protein kinase C. Gen Pharmacol (1999) 0.75

Functional significance of cell volume regulatory mechanisms. Physiol Rev (1998) 4.59

Growth and transplantation of a custom vascularised bone graft in a man. Lancet (2004) 3.01

Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF. Neurology (1999) 2.74

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat Med (2003) 2.60

CD95 signaling via ceramide-rich membrane rafts. J Biol Chem (2001) 2.48

Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease. Ann Neurol (1998) 2.35

Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study. BMJ (1998) 2.15

Chronic granulomatous disease in adults. Lancet (1996) 1.97

Different preparation methods to obtain platelet components as a source of growth factors for local application. Transfusion (2001) 1.92

Ceramide enables fas to cap and kill. J Biol Chem (2001) 1.88

Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease. Neurology (2002) 1.84

Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease. Neurology (2012) 1.78

CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa. Science (2000) 1.77

Morbidity of harvesting of bone grafts from the iliac crest for preprosthetic augmentation procedures: a prospective study. Int J Oral Maxillofac Surg (2004) 1.76

The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB J (2003) 1.75

Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neurosci Lett (1997) 1.71

Ion channels in cell proliferation and apoptotic cell death. J Membr Biol (2005) 1.69

A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease. Ann Clin Biochem (2009) 1.66

Portosystemic hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis: clinical, laboratory, psychometric, and electroencephalographic investigations. Hepatology (1998) 1.65

Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias. Mol Psychiatry (2003) 1.58

Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry (2008) 1.54

Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment. Mol Psychiatry (2004) 1.53

CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway. EMBO J (1998) 1.53

Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J Biol Chem (1997) 1.51

Prospective evaluation of malignant cell seeding after percutaneous endoscopic gastrostomy in patients with oropharyngeal/esophageal cancers. Endoscopy (2013) 1.49

Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells. Cell (1997) 1.47

Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study. Neurology (2004) 1.45

Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism. J Neural Transm (Vienna) (2006) 1.43

[Nature meets nurture: the importance of epigenetics for the aetiology of psychiatric diseases]. Fortschr Neurol Psychiatr (2013) 1.40

Avoidance of implicit hazards: the realignment of maxillary and mandibular arches in comminuted and facial fractures. J Craniofac Surg (1998) 1.38

Long-term follow-up and outcome of 39 patients with chronic granulomatous disease. J Pediatr (2000) 1.37

Molecular mechanisms of bacteria induced apoptosis. Apoptosis (2001) 1.36

Cell volume in the regulation of cell proliferation and apoptotic cell death. Cell Physiol Biochem (2000) 1.34

Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism. J Neural Transm (Vienna) (2004) 1.33

The tyrosine kinase p56lck mediates activation of swelling-induced chloride channels in lymphocytes. J Cell Biol (1998) 1.30

Ca2+-activated K channel of the BK-type in the inner mitochondrial membrane of a human glioma cell line. Biochem Biophys Res Commun (1999) 1.29

Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes. Gene Ther (2003) 1.23

Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulation. J Biol Chem (1996) 1.23

Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes. Proc Natl Acad Sci U S A (1998) 1.22

Social cognition in attention-deficit hyperactivity disorder (ADHD). Neurosci Biobehav Rev (2009) 1.22

L-selectin activates the Ras pathway via the tyrosine kinase p56lck. Proc Natl Acad Sci U S A (1996) 1.20

Electrophoretic separation of betaA4 peptides (1-40) and (1-42). Anal Biochem (1996) 1.20

Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease. Ann Neurol (2001) 1.18

TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis. Oncogene (2006) 1.18

Molecular mechanisms of ceramide-mediated CD95 clustering. Biochem Biophys Res Commun (2001) 1.17

Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing. Exp Neurol (2009) 1.17

Okadaic acid disrupts clusters of synaptic vesicles in frog motor nerve terminals. J Cell Biol (1994) 1.17

Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids. Proc Natl Acad Sci U S A (1999) 1.15

Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes. J Biol Chem (2000) 1.14

Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway. Proc Natl Acad Sci U S A (1994) 1.14

Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo. Oncogene (2006) 1.13

Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis. Cell Death Differ (2010) 1.09

Dictyostelium myosin IK is involved in the maintenance of cortical tension and affects motility and phagocytosis. J Cell Sci (2000) 1.09

Decreased beta-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neurology (2000) 1.08

Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells. Apoptosis (2001) 1.08

Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growth in vivo. Gene Ther (1998) 1.07

Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence. Hum Mol Genet (2005) 1.07

Invasion of human epithelial cells by Pseudomonas aeruginosa involves src-like tyrosine kinases p60Src and p59Fyn. Infect Immun (2001) 1.07

A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI. Neurology (2009) 1.05

Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias. Mol Psychiatry (2007) 1.05

Evolution of Abeta42 and Abeta40 levels and Abeta42/Abeta40 ratio in plasma during progression of Alzheimer's disease: a multicenter assessment. J Nutr Health Aging (2009) 1.04

Gas-phase sequencing after electroblotting on polyvinylidene difluoride membranes assigns correct molecular weights to myoglobin molecular weight markers. Anal Biochem (1989) 1.03

Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases. Cell Death Differ (1998) 1.02

Vitamin deficiency and hyperhomocysteinemia in pseudoexfoliation glaucoma. J Neural Transm (Vienna) (2007) 1.02

Sample preparation technique and white cell content influence the detectable levels of growth factors in platelet concentrates. Vox Sang (2003) 1.02

The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways. Oncogene (2008) 1.01

Pseudomonas aeruginosa-induced apoptosis involves mitochondria and stress-activated protein kinases. Infect Immun (2001) 1.01

Improved specificity of RT-PCR amplifications using nested cDNA primers. Nucleic Acids Res (1993) 1.00

Epac inhibits migration and proliferation of human prostate carcinoma cells. Br J Cancer (2009) 0.99

Ion channels and membrane rafts in apoptosis. Pflugers Arch (2004) 0.99

Antibacterial essential oils in malodorous cancer patients: clinical observations in 30 patients. Phytomedicine (2005) 0.99

Boxing and running lead to a rise in serum levels of S-100B protein. Int J Sports Med (2000) 0.99

Biological markers to predict previous alcohol withdrawal seizures: a risk assessment. J Neural Transm (Vienna) (2006) 0.98

Persistence of haloperidol in human brain tissue. Am J Psychiatry (1999) 0.98

Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease. J Neural Transm (Vienna) (2004) 0.97

Paracetamol as a test drug to determine glucuronide formation in man. Effects of inducers and of smoking. Eur J Clin Pharmacol (1987) 0.95

CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release. Oncogene (2001) 0.94

Evaluation of oxidative stress measurements in obstructive sleep apnea syndrome. J Neural Transm (Vienna) (2005) 0.94

Selective potentiation of drug cytotoxicity by NSAID in human glioma cells: the role of COX-1 and MRP. Biochem Biophys Res Commun (1999) 0.94

CD95-mediated apoptosis in vivo involves acid sphingomyelinase. J Biol Chem (2000) 0.93

Plasma lipoprotein beta-amyloid in subjects with Alzheimer's disease or mild cognitive impairment. Ann Clin Biochem (2008) 0.93

Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae. FEBS Lett (2000) 0.93

Elevated homocysteine levels in alcohol withdrawal. Alcohol Alcohol (2000) 0.93

Current application of neurochemical biomarkers in the prediction and differential diagnosis of Alzheimer's disease and other neurodegenerative dementias. Eur Arch Psychiatry Clin Neurosci (2012) 0.93

Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases. Biochem Biophys Res Commun (1997) 0.92

Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking. J Immunol (1994) 0.92

Homocysteine induces cell death of rat astrocytes in vitro. Neurosci Lett (2003) 0.92

Langerhans cell granulomatosis: a case report of polyostotic manifestation in the jaw. Int J Oral Maxillofac Surg (2001) 0.92

Hertel exophthalmometry versus computed tomography and optical 3D imaging for the determination of the globe position in zygomatic fractures. Int J Oral Maxillofac Surg (2004) 0.91

The interleukin-8 (-251A/T) polymorphism is associated with increased risk for oral squamous cell carcinoma. Eur J Surg Oncol (2006) 0.91

The involvement of caspases in the CD95(Fas/Apo-1)- but not swelling-induced cellular taurine release from Jurkat T-lymphocytes. Pflugers Arch (2000) 0.91

Neurophysiological assessment of early hepatic encephalopathy. Electroencephalogr Clin Neurophysiol (1990) 0.91

Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia. Leukemia (2013) 0.91

Inhibition of Jurkat-T-lymphocyte Na+/H+-exchanger by CD95(Fas/Apo-1)-receptor stimulation. Pflugers Arch (2000) 0.91

Bright basal ganglia in T1-weighted magnetic resonance images are frequent in patients with portal vein thrombosis without liver cirrhosis and not suggestive of hepatic encephalopathy. J Hepatol (1998) 0.90