Published in J Biol Chem on October 27, 2005
TRP channels. Annu Rev Biochem (2007) 8.09
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A (2007) 1.99
Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella. J Cell Biol (2007) 1.94
Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. J Biol Chem (2006) 1.90
Autophagic dysfunction in mucolipidosis type IV patients. Hum Mol Genet (2008) 1.66
The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci Signal (2014) 1.58
Mucolipins: Intracellular TRPML1-3 channels. FEBS Lett (2010) 1.49
The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic (2009) 1.44
Neurologic, gastric, and opthalmologic pathologies in a murine model of mucolipidosis type IV. Am J Hum Genet (2007) 1.44
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases. EMBO J (2014) 1.43
Transient receptor potential channelopathies. Pflugers Arch (2010) 1.40
TRP channels and Ca2+ signaling. Cell Calcium (2006) 1.35
Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem (2009) 1.32
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J Biol Chem (2011) 1.32
Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis. J Exp Med (2008) 1.31
TRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+ release channel in coronary arterial myocytes. J Cell Mol Med (2008) 1.28
Lysosomal trafficking functions of mucolipin-1 in murine macrophages. BMC Cell Biol (2007) 1.27
Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. Am J Physiol Renal Physiol (2010) 1.27
TRPMLs: in sickness and in health. Am J Physiol Renal Physiol (2009) 1.26
Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation. J Biol Chem (2010) 1.16
Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae. PLoS One (2011) 1.13
The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway. Traffic (2009) 1.12
Macroautophagy is defective in mucolipin-1-deficient mouse neurons. Neurobiol Dis (2010) 1.07
Cellular and mitochondrial iron homeostasis in vertebrates. Biochim Biophys Acta (2012) 1.05
Mucolipidosis type IV: an update. Mol Genet Metab (2011) 1.05
TRPpathies. J Physiol (2006) 1.04
The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1. Pflugers Arch (2009) 1.04
Drosophila TRP channels and animal behavior. Life Sci (2012) 1.04
The varitint-waddler mouse phenotypes and the TRPML3 ion channel mutation: cause and consequence. Pflugers Arch (2008) 1.04
A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice. Gastroenterology (2010) 1.01
Constitutive activity of the human TRPML2 channel induces cell degeneration. J Biol Chem (2009) 1.00
The role of TRPMLs in endolysosomal trafficking and function. Cell Calcium (2014) 0.99
Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1. J Biol Chem (2009) 0.99
Role of TRP channels in the regulation of the endosomal pathway. Physiology (Bethesda) (2011) 0.98
LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV. J Cell Sci (2011) 0.96
Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy. J Cell Sci (2010) 0.94
A model of lysosomal pH regulation. J Gen Physiol (2013) 0.94
The intracellular Ca²⁺ channels of membrane traffic. Channels (Austin) (2012) 0.93
TRP channels as candidates for hearing and balance abnormalities in vertebrates. Biochim Biophys Acta (2007) 0.92
Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes. Messenger (Los Angel) (2012) 0.92
Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC. J Biol Chem (2010) 0.91
N-glycosylation determines the abundance of the transient receptor potential channel TRPP2. J Biol Chem (2014) 0.91
Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis. J Biol Chem (2012) 0.88
TRPML: transporters of metals in lysosomes essential for cell survival? Cell Calcium (2011) 0.88
Mitochondrial Ca2+ homeostasis in lysosomal storage diseases. Cell Calcium (2008) 0.84
Transient receptor potential channels and regulation of lung endothelial permeability. Pulm Circ (2013) 0.82
The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase. Biochem J (2015) 0.82
Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathol Commun (2014) 0.82
The cation channel mucolipin-1 is a bifunctional protein that facilitates membrane remodeling via its serine lipase domain. Exp Cell Res (2011) 0.82
Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV. Dis Model Mech (2015) 0.79
Cyclic ADP-Ribose and NAADP in Vascular Regulation and Diseases. Messenger (Los Angel) (2013) 0.78
Systematic screens for proteins that interact with the mucolipidosis type IV protein TRPML1. PLoS One (2013) 0.78
Role of protein kinase d in Golgi exit and lysosomal targeting of the transmembrane protein, Mcoln1. Traffic (2012) 0.77
Zinc-permeable ion channels: effects on intracellular zinc dynamics and potential physiological/pathophysiological significance. Curr Med Chem (2015) 0.76
Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel. Nat Struct Mol Biol (2017) 0.75
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. J Exp Med (2016) 0.75
Retinal Dystrophy and Optic Nerve Pathology in the Mouse Model of Mucolipidosis IV. Am J Pathol (2015) 0.75
STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol (2006) 5.68
A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc (2007) 5.15
SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73
Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest (2002) 4.64
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol (2007) 3.47
Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol (2004) 3.43
Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis. J Bacteriol (2006) 3.23
Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell (2003) 3.11
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat Med (2011) 2.87
Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA (2012) 2.85
Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol (2008) 2.74
Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes (2006) 2.53
Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene (2002) 2.41
STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell (2008) 2.30
A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis. EMBO J (2002) 2.11
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest (2008) 2.11
TRPC channels as STIM1-regulated store-operated channels. Cell Calcium (2007) 2.04
NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. Mol Cell (2004) 2.02
Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol Cancer Res (2002) 1.96
TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96
Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells. Gastroenterology (2002) 1.91
Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. Proc Natl Acad Sci U S A (2012) 1.88
Regulation of osteogenic differentiation during skeletal development. Front Biosci (2008) 1.88
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis. Gastroenterology (2010) 1.86
Seed size, more than nutrient or tannin content, affects seed caching behavior of a common genus of Old World rodents. Ecology (2009) 1.85
EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci (2004) 1.82
The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev (2002) 1.80
Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol Cell Proteomics (2003) 1.77
Recent advances in tumor-targeting anticancer drug conjugates. Bioorg Med Chem (2005) 1.77
The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda) (2008) 1.76
Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol (2006) 1.73
Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol Biol Cell (2004) 1.73
The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus. Nat Med (2012) 1.72
Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis. Gastroenterology (2004) 1.72
Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev (2012) 1.71
Hypoxia reprograms calcium signaling and regulates myoglobin expression. Am J Physiol Cell Physiol (2008) 1.69
Molecular and cellular approaches for the detection of protein-protein interactions: latest techniques and current limitations. Plant J (2008) 1.62
Mitochondrial aberrations in mucolipidosis Type IV. J Biol Chem (2006) 1.61
Monte Carlo based method for fluorescence tomographic imaging with lifetime multiplexing using time gates. Biomed Opt Express (2011) 1.61
Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. FASEB J (2005) 1.61
A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene (2005) 1.59
RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem (2010) 1.58
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J (2006) 1.56
Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J Biol Chem (2007) 1.56
Autophagy, mitochondria and cell death in lysosomal storage diseases. Autophagy (2007) 1.55
Eph receptor tyrosine kinases in angiogenesis: from development to disease. Angiogenesis (2004) 1.55
EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics. Curr Cancer Drug Targets (2005) 1.54
BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. J Cell Mol Med (2008) 1.54
Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. Lab Invest (2008) 1.54
Wnt signaling and human diseases: what are the therapeutic implications? Lab Invest (2007) 1.51
Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo. Am J Physiol Cell Physiol (2013) 1.51
Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem (2006) 1.50
Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism. J Cell Sci (2008) 1.48
Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. J Biol Chem (2008) 1.48
A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype. EMBO J (2008) 1.47
Combining Usability Techniques to Design Geovisualization Tools for Epidemiology. Cartogr Geogr Inf Sci (2005) 1.46
Homer proteins in Ca2+ signaling by excitable and non-excitable cells. Cell Calcium (2007) 1.45
High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome. Metabolism (2007) 1.45
Kidney transplantation in mice using left and right kidney grafts. J Surg Res (2010) 1.44
The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic (2009) 1.44
Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion. Cell Host Microbe (2013) 1.44
Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. J Exp Med (2012) 1.44
Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res (2009) 1.44
TRPC channels as STIM1-regulated SOCs. Channels (Austin) (2009) 1.43
Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3. J Biol Chem (2008) 1.43
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases. EMBO J (2014) 1.43
Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation. J Biol Chem (2006) 1.41
The complete genome sequence of Bacillus thuringiensis Al Hakam. J Bacteriol (2007) 1.40
The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct. J Physiol (2008) 1.40
Mitochondria and calcium in health and disease. Cell Calcium (2008) 1.39
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39
Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels. Proc Natl Acad Sci U S A (2009) 1.38
Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Mol Cell Biol (2006) 1.37
Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. Gastroenterology (2009) 1.37
Predicting mating patterns from pollination syndromes: the case of "sapromyiophily" in Tacca chantrieri (Taccaceae). Am J Bot (2005) 1.36
Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis. J Cell Sci (2002) 1.36
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol (2005) 1.36
Diverse transport modes by the solute carrier 26 family of anion transporters. J Physiol (2008) 1.35
Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1. J Biol Chem (2009) 1.34
Eph receptor tyrosine kinases in tumor and tumor microenvironment. Curr Pharm Des (2004) 1.33
SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol (2007) 1.33
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest (2008) 1.32