A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform.

PubWeight™: 1.53‹?› | Rank: Top 4%

🔗 View Article (PMID 16271896)

Published in Structure on November 01, 2005

Authors

Xinchao Yu1, Devrim Acehan, Jean-François Ménétret, Christopher R Booth, Steven J Ludtke, Stefan J Riedl, Yigong Shi, Xiaodong Wang, Christopher W Akey

Author Affiliations

1: Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

Articles citing this

The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu Rev Immunol (2007) 3.59

Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol (2008) 2.63

Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell (2007) 2.48

TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol (2007) 2.42

Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci (2010) 1.91

Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation. Cell Host Microbe (2011) 1.83

NLR functions in plant and animal immune systems: so far and yet so close. Nat Immunol (2011) 1.82

The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J (2009) 1.57

Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine. Mol Cell (2006) 1.46

Structure of an apoptosome-procaspase-9 CARD complex. Structure (2010) 1.42

Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin. J Biol Chem (2012) 1.41

Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC). J Biol Chem (2009) 1.33

Apoptosome structure, assembly, and procaspase activation. Structure (2013) 1.33

Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p. J Mol Biol (2008) 1.33

The mitochondrial death pathway: a promising therapeutic target in diseases. J Cell Mol Med (2009) 1.30

Structure of the Drosophila apoptosome at 6.9 å resolution. Structure (2011) 1.22

Molecular cell death platforms and assemblies. Curr Opin Cell Biol (2010) 1.20

The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3. Structure (2011) 1.15

Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome. Proc Natl Acad Sci U S A (2014) 1.07

A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome. J Biol Chem (2009) 1.04

Genomic clustering and homology between HET-S and the NWD2 STAND protein in various fungal genomes. PLoS One (2012) 1.03

Modular software platform for low-dose electron microscopy and tomography. J Microsc (2007) 0.95

Changes in Apaf-1 conformation that drive apoptosome assembly. Biochemistry (2013) 0.95

Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1. Genes Dev (2015) 0.91

Structural and functional analysis of novel human cytochrome C targets in apoptosis. Mol Cell Proteomics (2014) 0.91

cIAP1 cooperatively inhibits procaspase-3 activation by the caspase-9 apoptosome. J Biol Chem (2010) 0.91

New Arabidopsis thaliana cytochrome c partners: a look into the elusive role of cytochrome c in programmed cell death in plants. Mol Cell Proteomics (2013) 0.90

Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila. Genes Dev (2015) 0.88

The apoptosome: emerging insights and new potential targets for drug design. Pharm Res (2007) 0.87

WD-repeat instability and diversification of the Podospora anserina hnwd non-self recognition gene family. BMC Evol Biol (2010) 0.87

Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death. PLoS Pathog (2016) 0.84

Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation. PLoS One (2011) 0.84

The apoptotic function analysis of p53, Apaf1, Caspase3 and Caspase7 during the spermatogenesis of the Chinese fire-bellied newt Cynops orientalis. PLoS One (2012) 0.84

Structure of the Fas/FADD complex: a conditional death domain complex mediating signaling by receptor clustering. Cell Cycle (2009) 0.83

Natural variation of heterokaryon incompatibility gene het-c in Podospora anserina reveals diversifying selection. Mol Biol Evol (2014) 0.83

Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch. J Biol Inorg Chem (2011) 0.80

Mathematical modeling of the formation of apoptosome in intrinsic pathway of apoptosis. Syst Synth Biol (2009) 0.79

A near atomic structure of the active human apoptosome. Elife (2016) 0.78

The apoptosome at high resolution. Cell (2010) 0.76

Modeling of interaction between cytochrome c and the WD domains of Apaf-1: bifurcated salt bridges underlying apoptosome assembly. Biol Direct (2015) 0.76

Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions. J Biol Chem (2011) 0.76

A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation. Structure (2016) 0.75

Structural biology of the intrinsic cell death pathway: what do we know and what is missing? Comput Struct Biotechnol J (2012) 0.75

Articles by these authors

EMAN2: an extensible image processing suite for electron microscopy. J Struct Biol (2006) 14.70

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell (2009) 11.36

R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (2003) 9.53

The BioGRID Interaction Database: 2011 update. Nucleic Acids Res (2010) 8.46

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods (2013) 8.12

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell (2005) 6.86

TNF-alpha induces two distinct caspase-8 activation pathways. Cell (2008) 6.81

Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol (2004) 6.76

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell (2005) 6.47

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev (2003) 6.17

Cytochrome C-mediated apoptosis. Annu Rev Biochem (2004) 5.38

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell (2005) 5.37

PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell (2006) 5.28

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem (2007) 5.21

WormBase: a comprehensive resource for nematode research. Nucleic Acids Res (2009) 5.20

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell (2007) 5.09

China's research culture. Science (2010) 5.08

Jaundice Constrain or Indication? Response. Radiology (2017) 5.07

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science (2004) 4.95

SPARX, a new environment for Cryo-EM image processing. J Struct Biol (2006) 4.66

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell (2012) 4.37

Outcome of the first electron microscopy validation task force meeting. Structure (2012) 4.35

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33

Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell (2003) 4.07

WormBase: new content and better access. Nucleic Acids Res (2006) 4.01

WormBase 2012: more genomes, more data, new website. Nucleic Acids Res (2011) 3.87

WormBase 2007. Nucleic Acids Res (2007) 3.69

Structural basis for sequence-specific recognition of DNA by TAL effectors. Science (2012) 3.64

Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc Natl Acad Sci U S A (2004) 3.63

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science (2003) 3.59

EMDataBank.org: unified data resource for CryoEM. Nucleic Acids Res (2010) 3.32

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol (2007) 3.23

Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14

Structure of the protein phosphatase 2A holoenzyme. Cell (2006) 3.07

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell (2002) 3.06

Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol (2006) 3.00

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99

The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell (2010) 2.97

Mechanism of folding chamber closure in a group II chaperonin. Nature (2010) 2.85

Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 2.75

Indirect emissions from biofuels: how important? Science (2009) 2.71

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A (2011) 2.64

Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature (2005) 2.63

Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro (2005) 2.60

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Nat Struct Biol (2002) 2.60

Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice. Hepatology (2013) 2.42

Structure and mechanism of an amino acid antiporter. Science (2009) 2.40

WormBase 2014: new views of curated biology. Nucleic Acids Res (2013) 2.39

Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science (2002) 2.36

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35

Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol Cell (2004) 2.31

Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis. Structure (2004) 2.30

XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. EMBO J (2005) 2.27

The role of oxygen during fracture healing. Bone (2012) 2.21

Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1. Proc Natl Acad Sci U S A (2005) 2.18

Whole-exome-sequencing-based discovery of human FADD deficiency. Am J Hum Genet (2010) 2.17

4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement. Proc Natl Acad Sci U S A (2010) 2.17

tRNA binds to cytochrome c and inhibits caspase activation. Mol Cell (2010) 2.14

The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature (2008) 2.11

Structure of the mammalian 80S ribosome at 8.7 A resolution. Structure (2008) 2.11

Structure of a site-2 protease family intramembrane metalloprotease. Science (2007) 2.08

Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature (2005) 2.08

Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature (2009) 2.07

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci U S A (2011) 2.06

An expanded conformation of single-ring GroEL-GroES complex encapsulates an 86 kDa substrate. Structure (2006) 2.04

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat Struct Mol Biol (2004) 2.03

The Nod-like receptor (NLR) family: a tale of similarities and differences. PLoS One (2008) 1.99

Architecture of the ribosome-channel complex derived from native membranes. J Mol Biol (2005) 1.97

The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus. Structure (2004) 1.96

Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. Mol Cell (2008) 1.93

Mechanism of substrate recognition and transport by an amino acid antiporter. Nature (2010) 1.92

Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology (2008) 1.90

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell (2006) 1.88

Structural basis of ultraviolet-B perception by UVR8. Nature (2012) 1.86

Automatic particle selection: results of a comparative study. J Struct Biol (2004) 1.82

Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol Cell Biol (2004) 1.77

Anisotropic self-assembly of spherical polymer-grafted nanoparticles. Nat Mater (2009) 1.77

Structure of a presenilin family intramembrane aspartate protease. Nature (2012) 1.76

HIV/STD prevalence among men who have sex with men in Chengdu, China and associated risk factors for HIV infection. J Acquir Immune Defic Syndr (2010) 1.76

Cytokines in alcoholic liver disease. Arch Toxicol (2012) 1.74

Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell (2010) 1.73

A 9 angstroms single particle reconstruction from CCD captured images on a 200 kV electron cryomicroscope. J Struct Biol (2004) 1.70

Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci U S A (2008) 1.68

Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure (2008) 1.68

Silica encapsulation of n-octadecane via sol-gel process: a novel microencapsulated phase-change material with enhanced thermal conductivity and performance. J Colloid Interface Sci (2009) 1.67

Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell (2008) 1.67

Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins. Nat Struct Mol Biol (2007) 1.67

Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature (2013) 1.66

Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology. Trends Biochem Sci (2004) 1.66

Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. Mol Cell (2005) 1.65

Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res (2012) 1.64

Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature (2008) 1.64

Caspase mechanisms. Adv Exp Med Biol (2008) 1.64

C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nat Cell Biol (2007) 1.63