Published in Methods Enzymol on January 01, 2005
Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein. J Neurosci (2011) 2.53
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Mol Cell (2010) 2.24
RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature (2012) 2.11
Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97. Curr Biol (2014) 2.01
Cancer vulnerabilities unveiled by genomic loss. Cell (2012) 1.95
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry (2009) 1.78
Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons. J Neurosci (2010) 1.77
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature (2012) 1.75
Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins. Cell (2013) 1.74
Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II. J Biol Chem (2009) 1.55
An inducible chaperone adapts proteasome assembly to stress. Mol Cell (2014) 1.49
Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites. Chem Biol (2009) 1.47
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. J Clin Invest (2017) 1.40
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease. Brain (2010) 1.38
Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations. J Mol Cell Cardiol (2006) 1.28
Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload. Am J Physiol Heart Circ Physiol (2008) 1.23
Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity. J Biol Chem (2010) 1.14
Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J Neurosci (2009) 1.13
Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib. Chem Biol (2011) 1.13
Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. Elife (2015) 1.12
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution. Front Mol Neurosci (2014) 1.10
Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration. Proc Natl Acad Sci U S A (2013) 1.10
UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Proc Natl Acad Sci U S A (2011) 1.09
Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide. Mol Cell Proteomics (2008) 1.07
CCP1/Nna1 functions in protein turnover in mouse brain: Implications for cell death in Purkinje cell degeneration mice. FASEB J (2010) 1.06
Targeting the UPS as therapy in multiple myeloma. BMC Biochem (2008) 1.05
Cryo-electron tomography reveals a critical role of RIM1α in synaptic vesicle tethering. J Cell Biol (2013) 1.05
Carfilzomib: a novel second-generation proteasome inhibitor. Future Oncol (2011) 1.03
Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Chem Biol (2010) 1.01
Molecular, physiological, and motor performance defects in DMSXL mice carrying >1,000 CTG repeats from the human DM1 locus. PLoS Genet (2012) 1.01
Methamphetamine oxidatively damages parkin and decreases the activity of 26S proteasome in vivo. J Neurochem (2011) 1.00
Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition. J Infect Dis (2009) 1.00
Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment. Proc Natl Acad Sci U S A (2009) 0.98
Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo. J Biol Chem (2008) 0.96
Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS. Nat Protoc (2013) 0.96
Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency. Endocrinology (2008) 0.95
Heat shock proteins in neurodegenerative disorders and aging. J Cell Commun Signal (2014) 0.93
XIAP reduces muscle proteolysis induced by CKD. J Am Soc Nephrol (2010) 0.93
Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging. J Gerontol A Biol Sci Med Sci (2014) 0.92
Simultaneous fluorescent monitoring of proteasomal subunit catalysis. J Am Chem Soc (2010) 0.92
Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol (2015) 0.92
Lysosomal membrane permeability stimulates protein aggregate formation in neurons of a lysosomal disease. J Neurosci (2013) 0.91
Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones. J Biol Chem (2008) 0.91
Inhibition of proteasome activity impairs centrosome-dependent microtubule nucleation and organization. Mol Biol Cell (2007) 0.91
Autophagy contributes to degradation of Hirano bodies. Autophagy (2009) 0.89
PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity. PLoS One (2013) 0.88
The ubiquitin-proteasome system regulates the stability of neuronal nicotinic acetylcholine receptors. J Mol Neurosci (2009) 0.86
Measuring activity in the ubiquitin-proteasome system: from large scale discoveries to single cells analysis. Cell Biochem Biophys (2013) 0.85
Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol. PLoS One (2008) 0.85
Proteomic identification of immunoproteasome accumulation in formalin-fixed rodent spinal cords with experimental autoimmune encephalomyelitis. J Proteome Res (2012) 0.85
Bortezomib Amplifies Effect on Intracellular Proteasomes by Changing Proteasome Structure. EBioMedicine (2015) 0.85
Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132. PLoS One (2013) 0.84
The origin of proteasome-inhibitor resistant HLA class I peptidomes: a study with HLA-A*68:01. Mol Cell Proteomics (2011) 0.84
Skeletal muscle myotubes in severe obesity exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux. Obesity (Silver Spring) (2015) 0.83
Regulation of the calpain and ubiquitin-proteasome systems in a canine model of muscular dystrophy. Muscle Nerve (2011) 0.83
BU-32: a novel proteasome inhibitor for breast cancer. Breast Cancer Res (2009) 0.83
Sequence-specific alterations of epitope production by HIV protease inhibitors. J Immunol (2014) 0.83
The activation sequence of cellular protein handling systems after proteasomal inhibition in dopaminergic cells. Chem Biol Interact (2013) 0.82
Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease. J Neurochem (2014) 0.82
Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism. J Neurochem (2008) 0.81
Structural analysis of spiro beta-lactone proteasome inhibitors. J Am Chem Soc (2008) 0.80
Selective immunoproteasome inhibitors with non-peptide scaffolds identified from structure-based virtual screening. Bioorg Med Chem Lett (2014) 0.80
A simple methodology to assess endolysosomal protease activity involved in antigen processing in human primary cells. BMC Cell Biol (2013) 0.79
Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. J Clin Invest (2016) 0.79
Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription. PLoS Biol (2015) 0.78
Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. J Biol Chem (2014) 0.78
Timely activation of budding yeast APCCdh1 involves degradation of its inhibitor, Acm1, by an unconventional proteolytic mechanism. PLoS One (2014) 0.78
Development of two novel high-throughput assays to quantify ubiquitylated proteins in cell lysates: application to screening of new anti-malarials. Malar J (2015) 0.77
A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity. Mol Pharmacol (2015) 0.77
Mechanistic insights into the cure of prion disease by novel antiprion compounds. J Virol (2007) 0.77
Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms. PLoS One (2014) 0.77
Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction. Mol Cell Proteomics (2016) 0.77
Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction. PLoS One (2015) 0.76
Proteasome Activity Is Affected by Fluctuations in Insulin-Degrading Enzyme Distribution. PLoS One (2015) 0.76
The proteasome complex and the maintenance of pluripotency: sustain the fate by mopping up? Stem Cell Res Ther (2014) 0.76
Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol (2016) 0.76
Mediation of organismal aging and somatic proteostasis by the germline. Front Mol Biosci (2015) 0.76
Proteasome inhibition in hypertrophied myocardium. Am J Physiol Heart Circ Physiol (2008) 0.76
Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis. Cell Rep (2017) 0.75
Nano-liquid chromatography-orbitrap MS -based quantitative proteomics reveals differences between the mechanisms of action of carnosic acid and carnosol in colon cancer cells. Mol Cell Proteomics (2016) 0.75
Evaluating age-associated phenotypes in a mouse model of protein dyshomeostasis. Methods (2010) 0.75
Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine. PLoS One (2017) 0.75
Multicolor monitoring of the proteasome's catalytic signature. ACS Chem Biol (2014) 0.75
The effects of proteasomal inhibition on synaptic proteostasis. EMBO J (2016) 0.75
An assay for 26S proteasome activity based on fluorescence anisotropy measurements of dye-labeled protein substrates. Anal Biochem (2016) 0.75
Elucidating the catalytic subunit composition of distinct proteasome subtypes: a crosslinking approach employing bifunctional activity-based probes. Chembiochem (2014) 0.75
The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. Acta Neuropathol Commun (2016) 0.75
Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol (2016) 0.75
Proteostasis of Huntingtin in Health and Disease. Int J Mol Sci (2017) 0.75
Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation. PLoS One (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell (2004) 11.33
FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab (2007) 8.90
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab (2007) 8.05
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J (2004) 7.02
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A (2006) 5.28
Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell (2010) 5.23
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell (2007) 4.54
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol (2006) 4.01
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. J Biol Chem (2007) 3.68
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell (2008) 3.49
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol (2002) 3.45
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases. FASEB J (2006) 3.27
An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol (2002) 3.22
ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation. Mol Cell (2003) 3.14
During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol (2009) 3.03
Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol Cell (2004) 2.89
IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab (2004) 2.82
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell (2005) 2.82
Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate. J Biol Chem (2006) 2.59
The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. Proc Natl Acad Sci U S A (2005) 2.47
The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J Biol Chem (2005) 2.44
hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J (2006) 2.35
Patterns of gene expression in atrophying skeletal muscles: response to food deprivation. FASEB J (2002) 2.29
ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle. Cell (2011) 2.27
Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol (2002) 2.17
Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening. Mol Cell (2009) 2.10
Cancer vulnerabilities unveiled by genomic loss. Cell (2012) 1.95
Trehalose synthesis is induced upon exposure of Escherichia coli to cold and is essential for viability at low temperatures. Proc Natl Acad Sci U S A (2002) 1.85
Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway. Proc Natl Acad Sci U S A (2011) 1.85
Post-proteasomal antigen processing for major histocompatibility complex class I presentation. Nat Immunol (2004) 1.83
TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k. FASEB J (2003) 1.83
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry (2009) 1.78
Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins. Cell (2013) 1.74
Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins. J Cell Biol (2008) 1.71
ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation. Mol Cell (2010) 1.68
Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes. EMBO J (2002) 1.68
BMP signaling controls muscle mass. Nat Genet (2013) 1.68
Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. Proc Natl Acad Sci U S A (2002) 1.68
Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy. J Biol Chem (2010) 1.66
Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions. EMBO J (2009) 1.60
Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. PLoS Pathog (2012) 1.60
Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? EMBO J (2013) 1.53
Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases. J Biol Chem (2004) 1.50
Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor. Autophagy (2008) 1.47
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem (2003) 1.46
Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J (2004) 1.46
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol (2011) 1.42
Yeast adapt to near-freezing temperatures by STRE/Msn2,4-dependent induction of trehalose synthesis and certain molecular chaperones. Mol Cell (2004) 1.37
The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity (2003) 1.36
S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains. EMBO J (2009) 1.36
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell (2013) 1.35
Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings. J Biol Chem (2002) 1.32
Myostatin/activin pathway antagonism: molecular basis and therapeutic potential. Int J Biochem Cell Biol (2013) 1.32
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring. EMBO J (2012) 1.31
Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway. J Biol Chem (2010) 1.28
Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech (2013) 1.28
Identification of a novel pool of extracellular pro-myostatin in skeletal muscle. J Biol Chem (2008) 1.23
The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1. PLoS One (2008) 1.23
Getting to first base in proteasome assembly. Cell (2009) 1.22
The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. J Biol Chem (2004) 1.21
Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs. J Biol Chem (2013) 1.20
Characterization of the Brain 26S Proteasome and its Interacting Proteins. Front Mol Neurosci (2010) 1.19
Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy. J Cell Biol (2012) 1.17
ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea. J Biol Chem (2007) 1.15
The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins. EMBO J (2012) 1.15
Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. J Immunol (2006) 1.14
The influence of skeletal muscle on systemic aging and lifespan. Aging Cell (2013) 1.13
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. EMBO J (2011) 1.13
Not just research tools--proteasome inhibitors offer therapeutic promise. Nat Med (2002) 1.12
The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. J Biol Chem (2009) 1.10
SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth. J Biol Chem (2013) 1.09
Mechanisms of muscle growth and atrophy in mammals and Drosophila. Dev Dyn (2013) 1.09
Bacterial proteolytic complexes as therapeutic targets. Nat Rev Drug Discov (2012) 1.08
The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome. J Biol Chem (2013) 1.04
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism. J Biol Chem (2011) 1.01
A conserved F box regulatory complex controls proteasome activity in Drosophila. Cell (2011) 0.98
Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. Hum Mol Genet (2010) 0.94
The direction of protein entry into the proteasome determines the variety of products and depends on the force needed to unfold its two termini. Mol Cell (2012) 0.94
New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis. Chang Gung Med J (2008) 0.92
Preparation of hybrid (19S-20S-PA28) proteasome complexes and analysis of peptides generated during protein degradation. Methods Enzymol (2005) 0.89
Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation. J Cell Biol (2014) 0.83
Slowing muscle atrophy: putting the brakes on protein breakdown. J Physiol (2002) 0.81
Affinity purification of mammalian 26S proteasomes using an ubiquitin-like domain. Methods Mol Biol (2012) 0.80
Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes. J Biol Chem (2012) 0.80
Keeping proteasomes under control--a role for phosphorylation in the nucleus. Proc Natl Acad Sci U S A (2011) 0.80
Formation of nondegradable forked ubiquitin conjugates by ring-finger ligases and its prevention by S5a. Methods Mol Biol (2012) 0.78
S5a/Rpn10, a UIM-protein, as a universal substrate for ubiquitination. Methods Mol Biol (2012) 0.77
Hsp104 is essential for the selective degradation in yeast of polyglutamine expanded ataxin-1 but not most misfolded proteins generally. Biochem Biophys Res Commun (2009) 0.77