Published in J Physiol on November 10, 2005
TRPC channels function independently of STIM1 and Orai1. J Physiol (2009) 1.83
Activation and regulation of store-operated calcium entry. J Cell Mol Med (2010) 1.70
Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1. Nature (2010) 1.63
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol (2009) 1.51
Multiple activation mechanisms of store-operated TRPC channels in smooth muscle cells. J Physiol (2007) 1.37
STIM and Orai: the long-awaited constituents of store-operated calcium entry. Trends Pharmacol Sci (2009) 1.20
Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. Mol Biol Cell (2008) 1.17
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
Organization and function of TRPC channelosomes. Pflugers Arch (2007) 1.01
Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels. J Biol Chem (2012) 0.97
Myosin light chain kinase-independent inhibition by ML-9 of murine TRPC6 channels expressed in HEK293 cells. Br J Pharmacol (2007) 0.90
TRP Channels as Sensors and Signal Integrators of Redox Status Changes. Front Pharmacol (2011) 0.88
Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca(2+) influx. J Neurochem (2015) 0.78
Myosin light chain kinase controls voltage-dependent calcium channels in vascular smooth muscle. Pflugers Arch (2013) 0.77
Calcium permeability of transient receptor potential canonical (TRPC) 4 channels measured by TRPC4-GCaMP6s. Korean J Physiol Pharmacol (2016) 0.75
Regulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinase. Channels (Austin) (2014) 0.75
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60
Inositol trisphosphate and calcium signalling. Nature (1993) 25.57
Calcium signaling. Cell (1995) 8.87
Capacitative calcium entry revisited. Cell Calcium (1991) 7.73
Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol (1997) 7.14
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature (1999) 6.85
Capacitative calcium entry. Biochem J (1995) 6.16
Inhibition of myosin light chain kinase by p21-activated kinase. Science (1999) 5.41
Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels. Science (2000) 5.04
The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu Rev Pharmacol Toxicol (1985) 4.80
Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. J Cell Biol (2000) 4.34
Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques (1994) 4.24
Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol (2004) 4.19
Dedicated myosin light chain kinases with diverse cellular functions. J Biol Chem (2000) 3.89
Calmodulin. Adv Protein Chem (1982) 3.89
TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron (2001) 3.74
Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature (1998) 3.68
Receptor-activated Ca2+ influx: how many mechanisms for how many channels? Trends Pharmacol Sci (1994) 3.63
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J Biol Chem (1987) 3.20
The elemental principles of calcium signaling. Cell (1995) 3.18
trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell (1996) 3.14
Neuronal Ca2+/calmodulin-dependent protein kinases. Annu Rev Biochem (1992) 2.99
Store-operated Ca2+ entry: evidence for a secretion-like coupling model. Cell (1999) 2.67
TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci U S A (1995) 2.56
On the molecular basis and regulation of cellular capacitative calcium entry: roles for Trp proteins. Proc Natl Acad Sci U S A (1996) 2.44
Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein. J Biol Chem (1997) 2.33
Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry. J Biol Chem (1998) 2.32
Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J Biol Chem (2003) 2.26
Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem (2000) 2.22
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol (2001) 2.13
Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate. Nature (1984) 2.11
Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. J Biol Chem (2001) 1.99
Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. Neuron (1996) 1.99
Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell (1997) 1.97
Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J Cell Biol (1997) 1.96
A novel capacitative calcium entry channel expressed in excitable cells. EMBO J (1998) 1.95
PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nat Neurosci (2004) 1.93
Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cells. J Cell Biol (1998) 1.91
Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. J Biol Chem (2002) 1.91
Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J Biol Chem (1998) 1.90
A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL. EMBO J (1996) 1.82
The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence. J Biol Chem (1987) 1.72
Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain. Proc Natl Acad Sci U S A (2001) 1.70
Human TRPC5 channel activated by a multiplicity of signals in a single cell. J Physiol (2004) 1.63
Signal transduction in Drosophila photoreceptors. Annu Rev Neurosci (1995) 1.62
Production and characterization of an antibody to myosin light chain kinase and intracellular localization of the enzyme. Cell (1981) 1.48
Rapid endocytosis of the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A (1994) 1.47
Exocytotic insertion of TRPC6 channel into the plasma membrane upon Gq protein-coupled receptor activation. J Biol Chem (2003) 1.45
Evidence for myosin light chain kinase mediating noradrenaline-evoked cation current in rabbit portal vein myocytes. J Physiol (2000) 1.39
Dynamics of myosin light chain phosphorylation at Ser19 and Thr18/Ser19 in smooth muscle cells in culture. Am J Physiol (1998) 1.35
Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na(+) channel to the cell surface. J Clin Invest (2000) 1.32
Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1. Mol Cell (2002) 1.32
Localization and activity of myosin light chain kinase isoforms during the cell cycle. J Cell Biol (2000) 1.29
Ca(2+)-calmodulin regulates receptor-operated Ca(2+) entry activity of TRPC6 in HEK-293 cells. Cell Calcium (2002) 1.26
Regulation of cytoskeletal mechanics and cell growth by myosin light chain phosphorylation. Am J Physiol (1998) 1.23
Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues. Biochem J (1995) 1.21
Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation. J Biol Chem (2005) 1.15
Direct activation of trpl cation channels by G alpha11 subunits. EMBO J (1996) 1.09
Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors. J Biol Chem (2005) 1.07
Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse. J Physiol (2004) 1.06
Calcium/calmodulin-dependent protein kinases. Semin Cancer Biol (1994) 1.01
Secretagogue-induced exocytosis recruits G protein-gated K+ channels to plasma membrane in endocrine cells. J Biol Chem (1999) 1.00
An essential role of myosin light-chain kinase in the regulation of agonist- and fluid flow-stimulated Ca2+ influx in endothelial cells. FASEB J (1998) 0.99
Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channels. Mol Pharmacol (2001) 0.96
ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation. Mol Pharmacol (1988) 0.96
The p38 mitogen-activated protein kinase pathway negatively regulates Ca2+-activated K+ channel trafficking in developing parasympathetic neurons. J Neurochem (2005) 0.95
Spontaneous single-channel activity of neuronal TRP5 channel recombinantly expressed in HEK293 cells. Neurosci Lett (2000) 0.94
Effects of myosin light chain kinase inhibitors on carbachol-activated nonselective cationic current in guinea-pig gastric myocytes. Pflugers Arch (1997) 0.93
Synthesis, insertion into the plasma membrane, and turnover of alpha-bungarotoxin receptors in chick sympathetic neurons. J Cell Biol (1979) 0.91
Activation of calcium/calmodulin regulated kinases. Cell Mol Biol (Noisy-le-grand) (2000) 0.90
The transient receptor potential, TRP4, cation channel is a novel member of the family of calmodulin binding proteins. Biochem J (2001) 0.90
Acid secretagogues induce Ca2+ mobilization coupled to K+ conductance activation in rat parietal cells in tissue culture. Biochim Biophys Acta (1989) 0.86
Phenothiazines mimic the action of cAMP in potentiating slow inward current in a bursting molluscan neuron. Brain Res (1983) 0.79
Involvement of myosin light-chain kinase in chloride-sensitive Ca2+ influx in porcine aortic endothelial cells. Cardiovasc Res (1999) 0.77
Germinal-center organization and cellular dynamics. Immunity (2007) 5.62
Imaging of germinal center selection events during affinity maturation. Science (2006) 4.86
Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat Immunol (2007) 4.46
Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol (2006) 3.66
Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2006) 3.47
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell (2002) 3.36
S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity (2007) 3.05
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Ca2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res (2003) 2.85
TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med (2008) 2.77
Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell (2011) 2.62
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev (2006) 2.62
Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity (2011) 2.60
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell (2002) 2.31
TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J (2006) 2.28
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21
TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A (2009) 2.20
Upregulation of TRPC1 in the development of cardiac hypertrophy. J Mol Cell Cardiol (2006) 2.17
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke (2005) 2.13
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A (2009) 2.08
Fatty liver predicts impaired fasting glucose and type 2 diabetes mellitus in Japanese undergoing a health checkup. J Gastroenterol Hepatol (2009) 2.04
Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nat Genet (2004) 1.98
Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. Nat Immunol (2008) 1.96
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci (2007) 1.95
Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol (2004) 1.91
Rho kinase (ROCK) inhibitors. J Cardiovasc Pharmacol (2007) 1.89
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors. Circ J (2008) 1.89
Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. J Immunol (2011) 1.77
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nat Neurosci (2009) 1.75
Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes. J Exp Med (2002) 1.73
TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal (2009) 1.71
STIM protein coupling in the activation of Orai channels. Proc Natl Acad Sci U S A (2009) 1.70
The activation of exocytotic sites by the formation of phosphatidylinositol 4,5-bisphosphate microdomains at syntaxin clusters. J Biol Chem (2005) 1.70
Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation: a nationwide retrospective study. Blood (2011) 1.65
Increased aggregation response of platelets in patients with inflammatory bowel disease. J Gastroenterol (2006) 1.59
FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood (2009) 1.59
Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Channels (Austin) (2008) 1.59
Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J (2009) 1.58
Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci (2004) 1.56
Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Proc Natl Acad Sci U S A (2006) 1.55
The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. J Mol Biol (2006) 1.54
Association of Ureaplasma urealyticum (biovar 2) with nongonococcal urethritis. Sex Transm Dis (2004) 1.54
Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial. J Neurol Sci (2005) 1.52
Prominent gelatinous bone marrow transformation presenting prior to myelodysplastic syndrome: a case report with review of the literature. Int J Clin Exp Pathol (2013) 1.50
Long-term low-dose spironolactone therapy is safe in oligoanuric hemodialysis patients. Cardiology (2009) 1.49
TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol (2011) 1.47
Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Sci Signal (2010) 1.44
Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors. Proc Natl Acad Sci U S A (2008) 1.42
Differentiation capacity of endothelial progenitor cells correlates with endothelial function in healthy young men. Circ J (2009) 1.40
TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci U S A (2007) 1.37
Primary amenorrhea accompanied by adrenal adenoma: start of menarche soon after tumor resection. Intern Med (2002) 1.37
Methotrexate-related Epstein-Barr virus-associated lymphoproliferative disorder occurring in the gingiva of a patient with rheumatoid arthritis. Int J Clin Exp Pathol (2013) 1.36
Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: a multicenter, retrospective analysis in Japan. Cancer Sci (2011) 1.33
Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. J Immunol (2008) 1.32
TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun (2013) 1.32
A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci (2006) 1.31
Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models. Circulation (2012) 1.30
A novel optical assay system for the quantitative measurement of chemotaxis. J Immunol Methods (2003) 1.30
Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes (2010) 1.29
Occurrence of anaplastic large cell lymphoma following IgG4-related autoimmune pancreatitis and cholecystitis and diffuse large B-cell lymphoma. Int J Clin Exp Pathol (2013) 1.28
Roles of TRPM2 in oxidative stress. Cell Calcium (2011) 1.26
Anaplastic lymphoma kinase-positive large B-cell lymphoma: a case report with emphasis on the cytological features of the pleural effusion. Int J Clin Exp Pathol (2013) 1.25
Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells. Nat Methods (2013) 1.25
Antibacterial activity of hydrolyzable tannins derived from medicinal plants against Helicobacter pylori. Microbiol Immunol (2004) 1.24
Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways. Circ Res (2009) 1.23
Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A (2004) 1.22
Dynamics of microcystin-producing and non-microcystin-producing Microcystis populations is correlated with nitrate concentration in a Japanese lake. FEMS Microbiol Lett (2007) 1.21
BANK negatively regulates Akt activation and subsequent B cell responses. Immunity (2006) 1.21
Systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood: Report of a case with review of the literature. Oncol Lett (2012) 1.21
Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domain. J Biol Chem (2009) 1.21
Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation. J Biol Chem (2007) 1.21
Similarity of visual selectivity among clonally related neurons in visual cortex. Neuron (2012) 1.21
Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. J Physiol (2009) 1.19
Molecular epidemiological analyses of Japanese encephalitis virus isolates from swine in Japan from 2002 to 2004. J Gen Virol (2007) 1.19
Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6. J Physiol (2008) 1.19
Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis. J Gen Physiol (2007) 1.19
Alveolar bone marrow as a cell source for regenerative medicine: differences between alveolar and iliac bone marrow stromal cells. J Bone Miner Res (2004) 1.19
The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction. Circulation (2006) 1.19
Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice. J Neurosci (2002) 1.17
Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels. Proc Natl Acad Sci U S A (2007) 1.17
Three-dimensional reconstruction using transmission electron microscopy reveals a swollen, bell-shaped structure of transient receptor potential melastatin type 2 cation channel. J Biol Chem (2007) 1.16
SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming. Neuron (2010) 1.16
Impact of a single intracoronary administration of adiponectin on myocardial ischemia/reperfusion injury in a pig model. Circ Cardiovasc Interv (2010) 1.15
Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study. Clin Infect Dis (2013) 1.14
TRPM1: a vertebrate TRP channel responsible for retinal ON bipolar function. Cell Calcium (2010) 1.13