Periodontal diseases.

Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe (2011) 5.06

The keystone-pathogen hypothesis. Nat Rev Microbiol (2012) 4.18

Pathogens and host immunity in the ancient human oral cavity. Nat Genet (2014) 3.19

Toothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish Health Survey. BMJ (2010) 3.04

Human gut microbiome and risk for colorectal cancer. J Natl Cancer Inst (2013) 2.76

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol (2012) 2.48

Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol (2015) 2.44

Cannabis smoking and periodontal disease among young adults. JAMA (2008) 2.30

Periodontitis and diabetes: a two-way relationship. Diabetologia (2011) 2.27

Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum (2012) 2.24

The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders. Clin Exp Immunol (2007) 2.22

The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol (2008) 2.21

Periodontal diagnosis affected by variation in terminology. J Periodontol (2012) 2.13

Relationship between Type 2 Diabetic Retinopathy and Periodontal Disease in Iranian Adults. N Am J Med Sci (2014) 2.08

A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17. J Dent Res (2008) 2.05

Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol (2011) 2.01

Association between chronic periodontal disease and obesity: a systematic review and meta-analysis. J Periodontol (2010) 1.96

Microbial hijacking of complement-toll-like receptor crosstalk. Sci Signal (2010) 1.91

Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. PLoS Genet (2009) 1.80

Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function. Proc Natl Acad Sci U S A (2008) 1.77

A review of the relationship between tooth loss, periodontal disease, and cancer. Cancer Causes Control (2008) 1.76

Bacterial community shift in treated periodontitis patients revealed by ion torrent 16S rRNA gene amplicon sequencing. PLoS One (2012) 1.68

Periodontal disease and incident type 2 diabetes: results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study. Diabetes Care (2008) 1.67

The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J Immunol (2010) 1.64

Identification of essential genes of the periodontal pathogen Porphyromonas gingivalis. BMC Genomics (2012) 1.55

Cigarette smoking and periodontal disease among 32-year-olds: a prospective study of a representative birth cohort. J Clin Periodontol (2007) 1.53

Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease. Clinics (Sao Paulo) (2011) 1.50

Association of environmental cadmium exposure with periodontal disease in U.S. adults. Environ Health Perspect (2009) 1.50

Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. Carcinogenesis (2012) 1.50

Tooth loss and lack of regular oral hygiene are associated with higher risk of esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev (2008) 1.47

Breaking bad: manipulation of the host response by Porphyromonas gingivalis. Eur J Immunol (2014) 1.47

Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol (2010) 1.44

Review of osteoimmunology and the host response in endodontic and periodontal lesions. J Oral Microbiol (2011) 1.42

Oxidative stress, systemic inflammation, and severe periodontitis. J Dent Res (2010) 1.41

Topical HPMC/S-Nitrosoglutathione Solution Decreases Inflammation and Bone Resorption in Experimental Periodontal Disease in Rats. PLoS One (2016) 1.39

Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist. J Immunol (2012) 1.35

Hyperactivity and reactivity of peripheral blood neutrophils in chronic periodontitis. Clin Exp Immunol (2007) 1.27

Animal models for periodontal disease. J Biomed Biotechnol (2011) 1.26

Differential activation of NF-kappaB and gene expression in oral epithelial cells by periodontal pathogens. Clin Exp Immunol (2007) 1.26

Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis. J Immunol (2014) 1.25

Optimization of the ligature-induced periodontitis model in mice. J Immunol Methods (2013) 1.23

Diabetes and tooth loss in a national sample of dentate adults reporting annual dental visits. Prev Chronic Dis (2007) 1.22

Quantitative analysis of three hydrogenotrophic microbial groups, methanogenic archaea, sulfate-reducing bacteria, and acetogenic bacteria, within plaque biofilms associated with human periodontal disease. J Bacteriol (2008) 1.21

Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses. J Innate Immun (2010) 1.21

Tetra- and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-κB signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts. PLoS One (2013) 1.21

Complement and periodontitis. Biochem Pharmacol (2010) 1.20

Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000 (2014) 1.20

Buccal alterations in diabetes mellitus. Diabetol Metab Syndr (2010) 1.19

Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol (2012) 1.18

Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice. J Immunol (2008) 1.16

Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol 2000 (2010) 1.15

Social stress enhances IL-1beta and TNF-alpha production by Porphyromonas gingivalis lipopolysaccharide-stimulated CD11b+ cells. Physiol Behav (2009) 1.15

Detection of multiple pathogenic species in saliva is associated with periodontal infection in adults. J Clin Microbiol (2008) 1.15

Oral microbiome and oral and gastrointestinal cancer risk. Cancer Causes Control (2012) 1.15

Too old to fight? Aging and its toll on innate immunity. Mol Oral Microbiol (2010) 1.15

Endogenous modulators of inflammatory cell recruitment. Trends Immunol (2012) 1.14

Tooth loss, systemic inflammation, and prevalent stroke among participants in the reasons for geographic and racial difference in stroke (REGARDS) study. Atherosclerosis (2008) 1.13

Phylogenetic and functional gene structure shifts of the oral microbiomes in periodontitis patients. ISME J (2014) 1.12

Tissue engineering bone-ligament complexes using fiber-guiding scaffolds. Biomaterials (2011) 1.12

Oral microbiome of deep and shallow dental pockets in chronic periodontitis. PLoS One (2013) 1.11

Statin use is associated with fewer periodontal lesions: A retrospective study. BMC Oral Health (2008) 1.09

Translational and clinical applications of salivary diagnostics. Adv Dent Res (2011) 1.08

Evaluation of Total Antioxidant Capacity of Saliva in Type 2 Diabetic Patients with and without Periodontal Disease: A Case-Control Study. N Am J Med Sci (2013) 1.08

Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease. PLoS One (2014) 1.08

Oral inflammatory diseases and systemic inflammation: role of the macrophage. Front Immunol (2012) 1.07

Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial. Cell Transplant (2013) 1.07

Maternal periodontitis and the causes of preterm birth: the case-control Epipap study. J Clin Periodontol (2010) 1.05

Cellular and molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin. Cell Death Dis (2011) 1.04

Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies. PLoS One (2012) 1.04

Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes. Proc Natl Acad Sci U S A (2013) 1.03

Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro. Mech Ageing Dev (2009) 1.03

Biomimetic hybrid scaffolds for engineering human tooth-ligament interfaces. Biomaterials (2010) 1.03

Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir. Br J Cancer (2013) 1.03

Investigation of the effect of type 2 diabetes mellitus on subgingival plaque microbiota by high-throughput 16S rDNA pyrosequencing. PLoS One (2013) 1.03

Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol (2012) 1.02

Effects of smoking on non-AIDS-related morbidity in HIV-infected patients. Clin Infect Dis (2013) 1.01

A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A. J Biol Chem (2007) 1.01

Anatomically shaped tooth and periodontal regeneration by cell homing. J Dent Res (2010) 1.01

Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies. PLoS One (2013) 1.00

Aggregatibacter actinomycetemcomitans leukotoxin: a powerful tool with capacity to cause imbalance in the host inflammatory response. Toxins (Basel) (2011) 0.99

Hyaluronic Acid: a boon in periodontal therapy. N Am J Med Sci (2013) 0.99

Immune evasion strategies of Porphyromonas gingivalis. J Oral Biosci (2011) 0.99

Diabetes and periodontal disease: a two-way relationship. Br Dent J (2014) 0.98

Biomaterial selection for tooth regeneration. Tissue Eng Part B Rev (2011) 0.98

An exploratory qualitative interview study about collaboration between medicine and dentistry in relation to diabetes management. BMJ Open (2013) 0.97

Subversion of innate immunity by periodontopathic bacteria via exploitation of complement receptor-3. Adv Exp Med Biol (2008) 0.97

Epigenetic regulation of human β-defensin 2 and CC chemokine ligand 20 expression in gingival epithelial cells in response to oral bacteria. Mucosal Immunol (2011) 0.97

Signal pathways JNK and NF-kappaB, identified by global gene expression profiling, are involved in regulation of TNFalpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts. BMC Genomics (2010) 0.97

Periodontal therapy and systemic inflammation in type 2 diabetes mellitus: a meta-analysis. PLoS One (2015) 0.96

Influence of mast cells in drug-induced gingival overgrowth. Mediators Inflamm (2013) 0.96

Periodontal status and bacteremia with oral viridans streptococci and coagulase negative staphylococci in allogeneic hematopoietic stem cell transplantation recipients: a prospective observational study. Support Care Cancer (2013) 0.96

Infection and Atherosclerosis Development. Arch Med Res (2015) 0.96

Sialidase and sialoglycoproteases can modulate virulence in Porphyromonas gingivalis. Infect Immun (2011) 0.96

Oral Manifestations and Complications of Diabetes Mellitus: A review. Sultan Qaboos Univ Med J (2011) 0.96

The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases. Mol Microbiol (2010) 0.95

The riboswitch regulates a thiamine pyrophosphate ABC transporter of the oral spirochete Treponema denticola. J Bacteriol (2011) 0.95

Periodontal disease is associated with gestational diabetes mellitus: a case-control study. J Periodontol (2009) 0.95

Periodontal disease and diabetes mellitus. J Appl Oral Sci (2013) 0.94

Complement and dysbiosis in periodontal disease. Immunobiology (2012) 0.94

From Phenotype to Genotype: Enter Genomics and Transformation of Primary Health Care around the World. J Dent Res (2014) 0.94

Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med (2007) 4.72

Utility of panoramic radiographs in detecting cervical calcified carotid atheroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2006) 4.32

Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J Am Dent Assoc (2015) 3.41

Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res (2004) 2.35

Poor oral hygiene as a risk factor for infective endocarditis-related bacteremia. J Am Dent Assoc (2009) 2.23

Evidence-based clinical practice guideline on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J Am Dent Assoc (2015) 2.06

An analysis of risk factors for oral cancer in young people: a case-control study. Oral Oncol (2004) 1.90

Advanced dental disease in people with severe mental illness: systematic review and meta-analysis. Br J Psychiatry (2011) 1.63

Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: a multicenter trial. J Periodontol (2004) 1.59

Dental procedures and subsequent prosthetic joint infections: findings from the Medicare Current Beneficiary Survey. J Am Dent Assoc (2011) 1.44

Squamous cell carcinoma and precursor lesions of the oral cavity: epidemiology and aetiology. Periodontol 2000 (2011) 1.27

Bisphosphonate-related osteonecrosis of the jaw: clinical features, risk factors, management, and treatment outcomes of 26 patients. J Oral Maxillofac Surg (2009) 1.19

Epithelial-mesenchymal transition in oral squamous cell carcinoma triggered by transforming growth factor-beta1 is Snail family-dependent and correlates with matrix metalloproteinase-2 and -9 expressions. Int J Oncol (2010) 1.16

Greater severity and extent of periodontal breakdown in 136 south Indian human immunodeficiency virus seropositive patients than in normal controls: a comparative study using community periodontal index of treatment needs. Indian J Dent Res (2007) 1.10

Oral cancer in India continues in epidemic proportions: evidence base and policy initiatives. Int Dent J (2012) 1.07

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms. Cancer Metastasis Rev (2012) 1.06

Periodontal disease, tooth loss and incident rheumatoid arthritis: results from the First National Health and Nutrition Examination Survey and its epidemiological follow-up study. J Clin Periodontol (2011) 1.02

The influence of anti-infective periodontal treatment on C-reactive protein: a systematic review and meta-analysis of randomized controlled trials. PLoS One (2013) 0.99

Periodontal bacterial profiles in pregnant women: response to treatment and associations with birth outcomes in the obstetrics and periodontal therapy (OPT) study. J Periodontol (2008) 0.96

A pilot study of glycosylated hemoglobin levels in periodontitis cases and healthy controls. J Periodontol (2009) 0.94

Disclosure of a stem cell phenotype in an oral squamous cell carcinoma cell line induced by BMP-4 via an epithelial-mesenchymal transition. Oncol Rep (2011) 0.91

The application of multilevel modeling in the analysis of longitudinal periodontal data--part I: absolute levels of disease. J Periodontol (2004) 0.90

Health state valuation in low- and middle-income countries: a systematic review of the literature. Value Health (2013) 0.90

Transforming growth factor-β1 treatment of oral cancer induces epithelial-mesenchymal transition and promotes bone invasion via enhanced activity of osteoclasts. Clin Exp Metastasis (2013) 0.90

Quantitative measures of aggressive periodontitis show substantial heritability and consistency with traditional diagnoses. J Periodontol (2005) 0.88

Systemic immune responses in pregnancy and periodontitis: relationship to pregnancy outcomes in the Obstetrics and Periodontal Therapy (OPT) study. J Periodontol (2009) 0.88

Public awareness of oral cancer, of oral potentially malignant disorders and of their risk factors in some rural populations in Sri Lanka. Community Dent Oral Epidemiol (2010) 0.87

Oral and oropharyngeal cancer: what are the next steps? J Am Dent Assoc (2011) 0.86

Trends of lip, oral cavity and oropharyngeal cancers in Australia 1982-2008: overall good news but with rising rates in the oropharynx. BMC Cancer (2013) 0.86

Step-wise analysis of the dental implant insertion process using the finite element technique. Clin Oral Implants Res (2007) 0.85

Successful treatment of an HIV-positive patient with unmasking Kaposi's sarcoma immune reconstitution inflammatory syndrome. J Clin Virol (2013) 0.85

Periodontal disease as a risk factor for bisphosphonate-related osteonecrosis of the jaw. J Periodontol (2013) 0.85

No association between selected candidate gene polymorphisms and severe chronic periodontitis. J Periodontol (2006) 0.84

Betel-quid chewing with or without tobacco is a major risk factor for oral potentially malignant disorders in Sri Lanka: a case-control study. Oral Oncol (2010) 0.83

Basic consideration of research strategies for head and neck cancer. Front Med (2012) 0.83

Traditional and interprofessional curricula for dental technology: perceptions of students in two programs in Australia. J Dent Educ (2013) 0.81

Factors associated with delay in presentation among younger patients with oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2004) 0.81

Study protocol for valuing EQ-5D-3L and EORTC-8D health states in a representative population sample in Sri Lanka. Health Qual Life Outcomes (2013) 0.81

A systematic review and meta-analysis of the association between poor oral health and severe mental illness. Psychosom Med (2015) 0.81

Dental students' reflections on clinical placement in a rural and indigenous community in Australia. J Dent Educ (2013) 0.81

Mutations of the cell cycle arrest gene p21WAF1, but not the metastasis-inducing gene S100A4, are frequent in oral squamous cell carcinomas from Sudanese toombak dippers and non-snuff-dippers from the Sudan, Scandinavia, USA and UK. Anticancer Res (2002) 0.81

Molecular pathways involved in crosstalk between cancer cells, osteoblasts and osteoclasts in the invasion of bone by oral squamous cell carcinoma. Pathology (2012) 0.81

The application of multilevel modeling in the analysis of longitudinal periodontal data--part II: changes in disease levels over time. J Periodontol (2004) 0.80

A preliminary study of intra-pocket topical versus injected anaesthetic for scaling and root planing. J Clin Periodontol (2007) 0.80

Improving assessment in dental education through a paradigm of comprehensive care: a case report. J Dent Educ (2010) 0.80

Oral Health Status of the Veddas-Sri Lankan Indigenous People. J Health Care Poor Underserved (2016) 0.79

Global Epidemiology of Head and Neck Cancers: A Continuing Challenge. Oncology (2016) 0.79

Correlation of the expression of human kallikrein-related peptidases 4 and 7 with the prognosis in oral squamous cell carcinoma. Head Neck (2011) 0.79

Valuing EQ-5D health states for Sri Lanka. Qual Life Res (2014) 0.79

The epidemic of oral cancer in India continues unabated: need for new policy initiatives. Oral Oncol (2012) 0.78

Dental care provision by students on a remote rural clinical placement. Aust N Z J Public Health (2013) 0.78

Teriparatide therapy for bisphosphonate-related osteonecrosis of the jaw: a case report and narrative review. Northwest Dent (2013) 0.77

MCP-1 as a potential target to inhibit the bone invasion by oral squamous cell carcinoma. J Cell Biochem (2014) 0.76

Detection of human herpesvirus 8 by quantitative polymerase chain reaction: development and standardisation of methods. BMC Infect Dis (2012) 0.76

Diet and risk of oral potentially malignant disorders in rural Sri Lanka. J Oral Pathol Med (2013) 0.75

The authors respond. SADJ (2013) 0.75

Re: Issues and early evidence for the economic evaluation of the effects of periodontal therapy on pregnancy outcomes. Quinonez R, Stearns SC. (J Periodontol 2008;79:203-206). J Periodontol (2008) 0.75

Periodontal status and sulcular Candida albicans colonization in patients with primary Sjögren's Syndrome. Quintessence Int (2005) 0.75

Improvements in methods of periodontal probing: comparison of relative attachment level data selected by outlier reduction protocols from Florida disc probe measurements. J Clin Periodontol (2002) 0.75

Oral Health Status of the Veddas-Sri Lankan Indigenous People. J Health Care Poor Underserved (2016) 0.75

A finite element study of short dental implants in the posterior maxilla. Int J Oral Maxillofac Implants (2014) 0.75

Relationship of Lifetime Exposure to Tobacco, Alcohol and Second Hand Tobacco Smoke with Upper aero-digestive tract cancers in India: a Case-Control Study with a Life-Course Perspective Asian Pac J Cancer Prev (2017) 0.75

Dental procedures and risk of experiencing a second vascular event in a Medicare population. J Am Dent Assoc (2012) 0.75

Emerging and established global life-style risk factors for cancer of the upper aero-digestive tract. Asian Pac J Cancer Prev (2014) 0.75

Association between low-dose aspirin and periodontal disease: results from the continuous national health and nutrition examination survey (NHANES) 2011-2012. J Clin Periodontol (2015) 0.75