Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.

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Published in Proc Natl Acad Sci U S A on December 12, 2005

Authors

Eiichi Sato1, Sara H Olson, Jiyoung Ahn, Brian Bundy, Hiroyoshi Nishikawa, Feng Qian, Achim A Jungbluth, Denise Frosina, Sacha Gnjatic, Christine Ambrosone, James Kepner, Tosin Odunsi, Gerd Ritter, Shashikant Lele, Yao-Tseng Chen, Haruo Ohtani, Lloyd J Old, Kunle Odunsi

Author Affiliations

1: Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Associated clinical trials:

Phase II: Pembrolizumab/Carboplatin/Taxol in Epithelial Ovary Cancer | NCT02766582

Phenotypic Characterization Tumor-infiltrating Lymphocytes at Diagnosis and After Chemotherapy in Ovarian Cancer (TILsOV-1805) | NCT03922776

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