Published in Proc Natl Acad Sci U S A on December 14, 2005
A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia. Blood (2007) 2.19
Threshold-free high-power methods for the ontological analysis of genome-wide gene-expression studies. Genome Biol (2007) 1.54
Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2010) 1.37
Investigating the efficacy of nonlinear dimensionality reduction schemes in classifying gene and protein expression studies. IEEE/ACM Trans Comput Biol Bioinform (2008) 1.18
Integrative analysis of gene expression and copy number alterations using canonical correlation analysis. BMC Bioinformatics (2010) 1.10
Genes overexpressed in different human solid cancers exhibit different tissue-specific expression profiles. Proc Natl Acad Sci U S A (2007) 1.02
The leukemia-specific fusion gene ETV6/RUNX1 perturbs distinct key biological functions primarily by gene repression. PLoS One (2011) 1.01
Improving missing value imputation of microarray data by using spot quality weights. BMC Bioinformatics (2006) 0.95
Germinal and Somatic Trisomy 21 Mosaicism: How Common is it, What are the Implications for Individual Carriers and How Does it Come About? Curr Genomics (2010) 0.94
Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia. Mol Cancer (2010) 0.92
Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies. BMC Med Genomics (2010) 0.88
Predicting interactome network perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia. Mol Biol Cell (2014) 0.85
HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia. Leuk Lymphoma (2013) 0.84
Role of the erythropoietin receptor in ETV6/RUNX1-positive acute lymphoblastic leukemia. Clin Cancer Res (2008) 0.83
The coregulator Alien. Nucl Recept Signal (2007) 0.77
Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes. PLoS One (2013) 0.77
PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease. Cancer Res (2016) 0.76
TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells. PLoS One (2016) 0.76
Specific expression of novel long non-coding RNAs in high-hyperdiploid childhood acute lymphoblastic leukemia. PLoS One (2017) 0.75
Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression. Mol Cancer (2008) 0.75
Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. Oncotarget (2016) 0.75
High hyperdiploid childhood acute lymphoblastic leukemia: Chromosomal gains as the main driver event. Mol Cell Oncol (2015) 0.75
The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia. PLoS One (2016) 0.75
Designing Dietary Recommendations Using System Level Interactomics Analysis and Network-Based Inference. Front Physiol (2017) 0.75
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science (1999) 83.27
Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res (2002) 40.03
TM4: a free, open-source system for microarray data management and analysis. Biotechniques (2003) 38.02
Identifying biological themes within lists of genes with EASE. Genome Biol (2003) 31.72
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet (2001) 13.79
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell (2002) 11.83
Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med (2004) 11.61
Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med (2004) 9.81
Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. Cancer Res (2002) 7.29
BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data. Genome Biol (2002) 6.35
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A (2000) 6.30
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood (2003) 4.54
Gene expression profiling of pediatric acute myelogenous leukemia. Blood (2004) 3.77
Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. Nat Med (2005) 2.36
Global approach to the diagnosis of leukemia using gene expression profiling. Blood (2005) 1.76
Identification of a gene expression signature associated with pediatric AML prognosis. Blood (2003) 1.71
HMG-I/Y, a new c-Myc target gene and potential oncogene. Mol Cell Biol (2000) 1.71
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin. Blood (2002) 1.65
Protein tyrosine phosphatases and signalling. J Endocrinol (2005) 1.58
Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia. Blood (2003) 1.52
Surface antigen phenotype can predict TEL-AML1 rearrangement in childhood B-precursor ALL: a Pediatric Oncology Group study. Leukemia (1998) 1.43
New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genes. Leukemia (2005) 1.32
p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells. Genes Dev (2000) 1.29
Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1. Oncogene (2001) 1.25
Treatment stratification based on initial in vivo response in acute myeloid leukaemia in children without Down's syndrome: results of NOPHO-AML trials. Br J Haematol (2003) 1.22
Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study. Blood (1990) 1.20
Two distinct gene expression signatures in pediatric acute lymphoblastic leukemia with MLL rearrangements. Cancer Res (2003) 1.16
The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia. Best Pract Res Clin Haematol (2001) 1.10
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations. Leukemia (2005) 1.07
Newly diagnosed childhood acute lymphoblastic leukemia: update on prognostic factors and treatment. Curr Opin Hematol (2003) 1.03
Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia. Ann Med (2004) 1.02
Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group. J Clin Oncol (1998) 1.02
Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins. Oncogene (2002) 1.00
Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis. Blood (2004) 0.98
Cytogenetic abnormalities in childhood acute myeloid leukaemia: a Nordic series comprising all children enrolled in the NOPHO-93-AML trial between 1993 and 2001. Br J Haematol (2003) 0.89
Femtosecond X-ray protein nanocrystallography. Nature (2011) 14.34
Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med (2011) 9.90
The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer (2007) 9.81
Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nat Genet (2004) 5.75
Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med (2011) 5.24
Single mimivirus particles intercepted and imaged with an X-ray laser. Nature (2011) 4.63
Cytogenetic and molecular genetic evolution of chronic myeloid leukemia. Acta Haematol (2002) 3.34
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nat Med (2010) 3.32
Comparing functional annotation analyses with Catmap. BMC Bioinformatics (2004) 2.92
Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays. Genome Biol (2008) 2.67
Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios. BMC Bioinformatics (2008) 2.66
National Inventory of Landscapes in Sweden (NILS)--scope, design, and experiences from establishing a multiscale biodiversity monitoring system. Environ Monit Assess (2010) 2.48
Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis (2005) 2.47
A molecular taxonomy for urothelial carcinoma. Clin Cancer Res (2012) 2.37
Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. Nat Med (2005) 2.36
High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization. Genes Chromosomes Cancer (2007) 2.34
Models from experiments: combinatorial drug perturbations of cancer cells. Mol Syst Biol (2008) 2.33
Persistent malignant stem cells in del(5q) myelodysplasia in remission. N Engl J Med (2010) 2.11
MiRNA expression in urothelial carcinomas: important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31. Int J Cancer (2009) 2.06
Combined gene expression and genomic profiling define two intrinsic molecular subtypes of urothelial carcinoma and gene signatures for molecular grading and outcome. Cancer Res (2010) 1.99
Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab Chip (2010) 1.97
"Good Old" clinical markers have similar power in breast cancer prognosis as microarray gene expression profilers. Eur J Cancer (2004) 1.88
Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer. Genes Chromosomes Cancer (2002) 1.81
Expression profiling to predict outcome in breast cancer: the influence of sample selection. Breast Cancer Res (2002) 1.72
Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential. BMC Genomics (2007) 1.71
The breakpoint region of the most common isochromosome, i(17q), in human neoplasia is characterized by a complex genomic architecture with large, palindromic, low-copy repeats. Am J Hum Genet (2003) 1.70
Antithymocyte globulin and cyclosporine A as combination therapy for low-risk non-sideroblastic myelodysplastic syndromes. Haematologica (2006) 1.64
Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity. Proc Natl Acad Sci U S A (2005) 1.61
Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected patients with neoplastic disorders. Genes Chromosomes Cancer (2005) 1.57
Integrated genomic and gene expression profiling identifies two major genomic circuits in urothelial carcinoma. PLoS One (2012) 1.56
MLL/GRAF fusion in an infant acute monocytic leukemia (AML M5b) with a cytogenetically cryptic ins(5;11)(q31;q23q23). Genes Chromosomes Cancer (2004) 1.55
Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Clin Cancer Res (2007) 1.54
Threshold-free high-power methods for the ontological analysis of genome-wide gene-expression studies. Genome Biol (2007) 1.54
Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia. Blood (2003) 1.52
Coping with complexity. multivariate analysis of tumor karyotypes. Cancer Genet Cytogenet (2002) 1.50
High hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer (2009) 1.49
Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines. Cancer Res (2004) 1.49
Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. Int J Cancer (2003) 1.45
Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12). Br J Haematol (2007) 1.44
ISCN (2005) is not acceptable for describing clonal evolution in cancer. Genes Chromosomes Cancer (2007) 1.44
Independent component analysis reveals new and biologically significant structures in micro array data. BMC Bioinformatics (2006) 1.44
Gene expression profiling indicates that immunohistochemical expression of CD40 is a marker of an inflammatory reaction in the tumor stroma of diffuse large B-cell lymphoma. Leuk Lymphoma (2012) 1.43
Trisomy 8 as the sole chromosomal aberration in myelocytic malignancies: a multicolor and locus-specific fluorescence in situ hybridization study. Cancer Genet Cytogenet (2003) 1.42
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer (2008) 1.39
Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2010) 1.37
Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation. Blood (2014) 1.36
The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes. Blood (2007) 1.35
Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study. Blood (2007) 1.30
Network modeling of the transcriptional effects of copy number aberrations in glioblastoma. Mol Syst Biol (2011) 1.26
Isolation and characterization of human myeloid progenitor populations--TpoR as discriminator between common myeloid and megakaryocyte/erythroid progenitors. Exp Hematol (2006) 1.26
Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein. Proc Natl Acad Sci U S A (2010) 1.24
Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors. BMC Med Genomics (2008) 1.24
The DNA methylome of pediatric acute lymphoblastic leukemia. Hum Mol Genet (2009) 1.23
Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8. Blood (2002) 1.22
Acute leukaemia in children with Down syndrome: a population-based Nordic study. Br J Haematol (2005) 1.22
A systematic study of gene mutations in urothelial carcinoma; inactivating mutations in TSC2 and PIK3R1. PLoS One (2011) 1.21
Response-guided induction therapy in pediatric acute myeloid leukemia with excellent remission rate. J Clin Oncol (2010) 1.21
Dissecting karyotypic patterns in malignant melanomas: temporal clustering of losses and gains in melanoma karyotypic evolution. Int J Cancer (2004) 1.18
Spatially resolved Hall effect measurement in a single semiconductor nanowire. Nat Nanotechnol (2012) 1.17
Molecular profiling reveals low- and high-grade forms of primary melanoma. Clin Cancer Res (2012) 1.17
Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances. Cancer Res (2002) 1.16
Characterization of bone marrow-derived mesenchymal stromal cells (MSC) based on gene expression profiling of functionally defined MSC subsets. Cytotherapy (2009) 1.14
MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene. Hum Mol Genet (2006) 1.13