PubRank

Arlene H Sharpe

Author PubWeight™ 266.63‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2005 28.04
2 PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008 19.24
3 The B7 family revisited. Annu Rev Immunol 2005 13.51
4 Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007 8.94
5 PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009 6.80
6 The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010 5.99
7 The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 2008 5.92
8 Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 2006 5.88
9 PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A 2004 4.75
10 Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 2004 4.65
11 TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 2007 4.49
12 Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med 2006 4.17
13 Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 2002 3.80
14 PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol 2010 3.51
15 Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol 2006 3.42
16 Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Eur J Immunol 2003 3.37
17 Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol 2009 3.05
18 Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. Eur J Immunol 2003 2.91
19 PD-1 and its ligands in T-cell immunity. Curr Opin Immunol 2007 2.86
20 Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med 2008 2.81
21 The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo. J Immunol 2011 2.69
22 Interaction of human PD-L1 and B7-1. Mol Immunol 2008 2.48
23 Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity 2012 2.47
24 Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A 2007 2.39
25 Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol 2004 2.38
26 The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol 2011 2.34
27 PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. J Immunol 2007 2.34
28 The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat Immunol 2012 2.17
29 The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol 2003 2.17
30 An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity 2004 2.00
31 IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proc Natl Acad Sci U S A 2008 1.84
32 TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection. Blood 2008 1.82
33 CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol 2002 1.78
34 Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. J Immunol 2011 1.77
35 Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood 2010 1.77
36 The cell surface receptor SLAM controls T cell and macrophage functions. J Exp Med 2004 1.77
37 Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation 2006 1.77
38 CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J Immunol 2002 1.73
39 CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. J Immunol 2010 1.71
40 B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J Immunol 2002 1.69
41 Negative co-receptors on lymphocytes. Curr Opin Immunol 2002 1.66
42 Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity. J Immunol 2009 1.66
43 Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. J Immunol 2005 1.62
44 Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc Natl Acad Sci U S A 2011 1.62
45 B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections]. J Immunol 2004 1.60
46 The B7/CD28 costimulatory family in autoimmunity. Immunol Rev 2005 1.57
47 The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat Immunol 2003 1.57
48 PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest 2010 1.53
49 SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell 2013 1.52
50 Role of PD-1 in regulating acute infections. Curr Opin Immunol 2010 1.51
51 Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood 2013 1.44
52 Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes. J Immunol 2005 1.40
53 PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. Eur J Immunol 2006 1.38
54 Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart. Circulation 2007 1.37
55 Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. J Immunol 2009 1.37
56 Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM). Blood 2004 1.34
57 T-cell costimulation and coinhibition in atherosclerosis. Circ Res 2008 1.32
58 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. J Immunol 2004 1.30
59 B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation 2004 1.30
60 Physiologic control of IDO competence in splenic dendritic cells. J Immunol 2011 1.29
61 Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood 2005 1.28
62 The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity. J Clin Invest 2003 1.26
63 Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. J Immunol 2009 1.25
64 PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis. J Immunol 2012 1.24
65 Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation. Eur J Immunol 2002 1.19
66 Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity 2012 1.19
67 The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J Virol 2011 1.18
68 Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles. J Immunol 2007 1.17
69 The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival. J Immunol 2007 1.17
70 The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus. J Immunol 2003 1.17
71 A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection. J Immunol 2003 1.16
72 Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation. Immunity 2012 1.15
73 ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol 2008 1.14
74 The ICOS molecule plays a crucial role in the development of mucosal tolerance. J Immunol 2005 1.13
75 Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice. J Immunol 2002 1.13
76 BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes. Oncoimmunology 2013 1.13
77 Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1). Proc Natl Acad Sci U S A 2013 1.10
78 Cutting edge: inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis. J Immunol 2002 1.10
79 RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med 2014 1.09
80 CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo. J Immunol 2005 1.06
81 Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation. J Am Soc Nephrol 2004 1.05
82 Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J Immunol 2012 1.04
83 Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients. Blood 2003 1.03
84 Circulating T follicular regulatory and helper cells have memory-like properties. J Clin Invest 2014 1.03
85 Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. J Immunol 2008 1.03
86 CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation. J Immunol 2012 1.02
87 Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arterioscler Thromb Vasc Biol 2011 1.02
88 Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo. J Immunol 2002 1.02
89 Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation. Proc Natl Acad Sci U S A 2007 1.02
90 Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease. Proc Natl Acad Sci U S A 2009 0.96
91 Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice. Eur J Immunol 2003 0.96
92 Inducible co-stimulator null MRL-Faslpr mice: uncoupling of autoantibodies and T cell responses in lupus. J Am Soc Nephrol 2005 0.94
93 B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. Eur J Immunol 2009 0.93
94 SnapShot: B7/CD28 costimulation. Cell 2009 0.92
95 Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity. J Immunol 2011 0.91
96 Cutting edge: a crucial role for B7-CD28 in transmitting T help from APC to CTL. J Immunol 2002 0.91
97 Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo. J Immunol 2005 0.91
98 Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest 2008 0.91
99 Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity. J Immunol 2011 0.91
100 Modulation of surgical fibrosis by microbial zwitterionic polysaccharides. Proc Natl Acad Sci U S A 2005 0.90
101 Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis. Ocul Immunol Inflamm 2009 0.89
102 Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells. Nat Immunol 2010 0.88
103 Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation. Invest Ophthalmol Vis Sci 2009 0.88
104 Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice. Int Immunol 2011 0.87
105 The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules. J Virol 2002 0.87
106 ICOS contributes to T cell expansion in CTLA-4 deficient mice. J Immunol 2005 0.87
107 An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice. J Immunol 2005 0.87
108 A novel function for programmed death ligand-1 regulation of angiogenesis. Am J Pathol 2011 0.87
109 T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania major. Eur J Immunol 2002 0.87
110 The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1β. J Immunol 2011 0.86
111 Development of autoimmunity in mice lacking DNA topoisomerase 3beta. Proc Natl Acad Sci U S A 2007 0.85
112 Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite. J Immunol 2002 0.84
113 B7h (ICOS-L) maintains tolerance at the fetomaternal interface. Am J Pathol 2013 0.84
114 Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. Curr Dir Autoimmun 2002 0.84
115 The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis. J Autoimmun 2011 0.83
116 Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest 2016 0.83
117 Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. Eur J Immunol 2002 0.82
118 Mitochondrial metabolism in T cell activation and senescence: a mini-review. Gerontology 2014 0.81
119 Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells. Invest Ophthalmol Vis Sci 2009 0.81
120 A new therapeutic strategy for malaria: targeting T cell exhaustion. Nat Immunol 2012 0.81
121 Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse. J Immunol 2013 0.80
122 CD28 costimulation regulates genome-wide effects on alternative splicing. PLoS One 2012 0.79
123 In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses. Methods Mol Biol 2015 0.79
124 Protect the killer: CTLs need defenses against the tumor. Nat Med 2002 0.77
125 Dendritic cells giveth and taketh away. Nat Immunol 2005 0.77
126 Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice. J Neuroophthalmol 2012 0.77
127 Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. Arthritis Rheum 2013 0.76
128 Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. PLoS One 2013 0.76
129 CD28 ligation increases macrophage suppression of T-cell proliferation. Cell Mol Immunol 2012 0.76
130 Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditis. Clin Immunol 2011 0.75
131 Erratum: The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection. Nat Immunol 2017 0.75