Published in FASEB J on January 09, 2006
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J (2010) 2.35
Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans. Proc Natl Acad Sci U S A (2011) 1.67
ADAM-17: the enzyme that does it all. Crit Rev Biochem Mol Biol (2010) 1.62
Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. PLoS One (2011) 1.45
The role of G protein-coupled receptors in the pathology of Alzheimer's disease. Nat Rev Neurosci (2011) 1.30
Obesity, leptin, and Alzheimer's disease. Ann N Y Acad Sci (2011) 1.09
Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo. J Neurosci (2011) 1.04
Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice. FASEB J (2011) 1.00
Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid β fragment in rats. Am J Pathol (2011) 0.98
The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein. J Biol Chem (2010) 0.96
Induction of RAGE shedding by activation of G protein-coupled receptors. PLoS One (2012) 0.87
5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10. ACS Chem Neurosci (2012) 0.86
Regulation of α-secretase ADAM10 expression and activity. Exp Brain Res (2011) 0.85
Proteolytic remodeling of the synaptic cell adhesion molecules (CAMs) by metzincins in synaptic plasticity. Neurochem Res (2012) 0.84
The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding. J Biol Chem (2015) 0.83
STC1 induction by PACAP is mediated through cAMP and ERK1/2 but not PKA in cultured cortical neurons. J Mol Neurosci (2012) 0.83
Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity. Front Endocrinol (Lausanne) (2013) 0.82
Neurobiology of memory and anxiety: from genes to behavior. Neural Plast (2007) 0.82
Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP. Cell Death Dis (2012) 0.82
PACAP38 protects rat cortical neurons against the neurotoxicity evoked by sodium nitroprusside and thrombin. Regul Pept (2008) 0.80
Viable mouse gene ablations that robustly alter brain Aβ levels are rare. BMC Neurosci (2010) 0.79
Synaptic therapy in Alzheimer's disease: a CREB-centric approach. Neurotherapeutics (2015) 0.79
G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs. Front Aging Neurosci (2016) 0.78
The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease. Cell Mol Neurobiol (2015) 0.76
Neuroprotective roles of pituitary adenylate cyclase-activating polypeptide in neurodegenerative diseases. BMB Rep (2014) 0.76
New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer's disease. BMC Neurosci (2012) 0.76
Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα. Front Mol Neurosci (2017) 0.75
Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo. Mol Neurodegener (2016) 0.75
Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately? Open Neurol J (2009) 0.75
Light-Triggerable Liposomes for Enhanced Endolysosomal Escape and Gene Silencing in PC12 Cells. Mol Ther Nucleic Acids (2017) 0.75
Pituitary adenylate cyclase-activating polypeptide (PACAP) protects against mitoxantrone-induced cardiac injury in mice. Peptides (2017) 0.75
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood (2003) 3.51
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J Clin Invest (2004) 2.52
Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases. J Biol Chem (2008) 1.52
Genomic structure and functional characterization of the human ADAM10 promoter. FASEB J (2005) 1.31
Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin. FASEB J (2009) 1.28
Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs. EMBO J (2002) 1.22
Cholesterol reporter molecules. Biosci Rep (2007) 1.20
Analysis of DHHC acyltransferases implies overlapping substrate specificity and a two-step reaction mechanism. Traffic (2009) 1.14
The non-amyloidogenic pathway: structure and function of alpha-secretases. Subcell Biochem (2005) 1.11
Cholesterol as stabilizer of the oxytocin receptor. Biochim Biophys Acta (2002) 1.10
The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity. J Biol Chem (2005) 1.09
ADAM-10 over-expression increases cortical synaptogenesis. Neurobiol Aging (2006) 1.08
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. J Biol Chem (2009) 1.06
Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia. J Neurosci (2006) 1.05
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. Cell Mol Life Sci (2012) 1.05
Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation. Eur J Biochem (2003) 1.04
Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice. FASEB J (2011) 1.00
Upregulation of the alpha-secretase ADAM10--risk or reason for hope? FEBS J (2010) 1.00
Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases. FEBS J (2005) 1.00
Ectodomain shedding of the receptor for advanced glycation end products: a novel therapeutic target for Alzheimer's disease. Cell Mol Life Sci (2009) 0.98
Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region. J Biol Chem (2010) 0.94
Probes for studying cholesterol binding and cell biology. Steroids (2010) 0.93
Alpha-secretase activation--an approach to Alzheimer's disease therapy. Neurodegener Dis (2006) 0.93
Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo. Neurobiol Dis (2009) 0.92
Statins stimulate the production of a soluble form of the receptor for advanced glycation end products. J Lipid Res (2013) 0.91
Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in mice. Behav Brain Res (2006) 0.90
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease. FASEB J (2013) 0.90
Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice. BMC Genomics (2009) 0.88
The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1. FEBS J (2009) 0.88
Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein. FASEB J (2003) 0.87
Gradient-echo and CRAZED imaging for minute detection of Alzheimer plaques in an APPV717I x ADAM10-dn mouse model. Magn Reson Med (2007) 0.87
Induction of RAGE shedding by activation of G protein-coupled receptors. PLoS One (2012) 0.87
Regulated proteolysis of RAGE and AbetaPP as possible link between type 2 diabetes mellitus and Alzheimer's disease. J Alzheimers Dis (2009) 0.86
Regulation of α-secretase ADAM10 expression and activity. Exp Brain Res (2011) 0.85
A cellular metalloproteinase activates Vibrio cholerae pro-cytolysin. J Biol Chem (2004) 0.85
Cholesterol and steroid hormones: modulators of oxytocin receptor function. Prog Brain Res (2002) 0.85
CSF APPs alpha and phosphorylated tau protein levels in mild cognitive impairment and dementia of Alzheimer's type. J Geriatr Psychiatry Neurol (2008) 0.84
The Role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins. Curr Alzheimer Res (2012) 0.84
A closer look at the cholesterol sensor. Trends Biochem Sci (2002) 0.83
Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease. J Alzheimers Dis (2009) 0.82
Cholesterol interaction with the related steroidogenic acute regulatory lipid-transfer (START) domains of StAR (STARD1) and MLN64 (STARD3). FEBS J (2008) 0.81
Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17. J Pineal Res (2014) 0.80
Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis. J Alzheimers Dis (2010) 0.80
DHEA-Bodipy--a functional fluorescent DHEA analog for live cell imaging. Mol Cell Endocrinol (2009) 0.79
Intestinal cholesterol absorption: identification of different binding proteins for cholesterol and cholesterol absorption inhibitors in the enterocyte brush border membrane. Biochim Biophys Acta (2003) 0.78
Effects of copper on CHO cells: insights from gene expression analyses. Biotechnol Prog (2014) 0.78
Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Eur J Pharmacol (2005) 0.78
Acitretin, an enhancer of alpha-secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein. Neurodegener Dis (2012) 0.76
Photo-DHEA--a functional photoreactive dehydroepiandrosterone (DHEA) analog. Steroids (2011) 0.76
Amphiphilic HPMA-LMA copolymers increase the transport of Rhodamine 123 across a BBB model without harming its barrier integrity. J Control Release (2012) 0.76
Synthesis of maleimide-functionalyzed HPMA-copolymers and in vitro characterization of the aRAGE- and human immunoglobulin (huIgG)-polymer conjugates. Macromol Biosci (2012) 0.75