Published in Exp Neurol on January 10, 2006
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest (2007) 2.99
Nuclear factor-kappa B signaling in skeletal muscle atrophy. J Mol Med (Berl) (2008) 1.86
Immune-mediated mechanisms potentially regulate the disease time-course of duchenne muscular dystrophy and provide targets for therapeutic intervention. PM R (2009) 1.22
Increased resting intracellular calcium modulates NF-κB-dependent inducible nitric-oxide synthase gene expression in dystrophic mdx skeletal myotubes. J Biol Chem (2012) 1.13
Emerging drugs for Duchenne muscular dystrophy. Expert Opin Emerg Drugs (2012) 1.11
Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Mol Med (2011) 1.09
Wasting mechanisms in muscular dystrophy. Int J Biochem Cell Biol (2013) 1.07
Exacerbation of pathology by oxidative stress in respiratory and locomotor muscles with Duchenne muscular dystrophy. J Physiol (2011) 1.05
Novel approach to meta-analysis of microarray datasets reveals muscle remodeling-related drug targets and biomarkers in Duchenne muscular dystrophy. PLoS Comput Biol (2012) 1.02
NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases. J Mol Med (Berl) (2008) 1.01
Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice. Gene Ther (2010) 1.00
Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice. Clin Nutr (2009) 0.99
Pre-clinical drug tests in the mdx mouse as a model of dystrophinopathies: an overview. Acta Myol (2012) 0.94
Protein-DNA array-based identification of transcription factor activities differentially regulated in skeletal muscle of normal and dystrophin-deficient mdx mice. Mol Cell Biochem (2008) 0.93
L-type Ca2+ channel function is linked to dystrophin expression in mammalian muscle. PLoS One (2008) 0.92
Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2. EMBO Mol Med (2014) 0.92
Reduced resting potentials in dystrophic (mdx) muscle fibers are secondary to NF-κB-dependent negative modulation of ouabain sensitive Na+-K+ pump activity. J Neurol Sci (2011) 0.90
Therapeutic targeting of signaling pathways in muscular dystrophy. J Mol Med (Berl) (2009) 0.90
Activation of NF-kappaB pathway in Duchenne muscular dystrophy: relation to age. Acta Myol (2011) 0.89
Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials. ILAR J (2014) 0.88
Bortezomib (PS-341) treatment decreases inflammation and partially rescues the expression of the dystrophin-glycoprotein complex in GRMD dogs. PLoS One (2013) 0.85
PKC theta ablation improves healing in a mouse model of muscular dystrophy. PLoS One (2012) 0.85
Soluble activin receptor type IIB increases forward pulling tension in the mdx mouse. Muscle Nerve (2011) 0.85
Sarcopenia: a major challenge in elderly patients with end-stage renal disease. J Aging Res (2012) 0.85
Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice. J Pathol (2013) 0.82
Roles and potential therapeutic targets of the ubiquitin proteasome system in muscle wasting. BMC Biochem (2007) 0.78
Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice. Hum Mol Genet (2012) 0.78
Pharmacological Inhibition of PKCθ Counteracts Muscle Disease in a Mouse Model of Duchenne Muscular Dystrophy. EBioMedicine (2017) 0.78
Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice. Hum Mol Genet (2015) 0.77
Oxidative Stress-Mediated Skeletal Muscle Degeneration: Molecules, Mechanisms, and Therapies. Oxid Med Cell Longev (2015) 0.76
The effect of specific IKKβ inhibitors on the cytosolic expression of IκB-α and the nuclear expression of p65 in dystrophic (MDX) muscle. Am J Transl Res (2015) 0.76
Life or death by NFκB, Losartan promotes survival in dy2J/dy2J mouse of MDC1A. Cell Death Dis (2015) 0.76
Effect of the IL-1 Receptor Antagonist Kineret® on Disease Phenotype in mdx Mice. PLoS One (2016) 0.75
NO may prompt calcium leakage in dystrophic muscle. Nat Med (2009) 0.75
High throughput screening in duchenne muscular dystrophy: from drug discovery to functional genomics. Biology (Basel) (2014) 0.75
Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in ApcMin/+ mice. Oncotarget (2016) 0.75
D-Amino Acid Substitution of Peptide-Mediated NF-κB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity. Mol Med (2015) 0.75
Ascorbic Acid Protects against Hypertension through Downregulation of ACE1 Gene Expression Mediated by Histone Deacetylation in Prenatal Inflammation-Induced Offspring. Sci Rep (2016) 0.75
Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice. Sci Rep (2017) 0.75
Effect of nuclear factor κB inhibition on serotype 9 adeno-associated viral (AAV9) minidystrophin gene transfer to the mdx mouse. Mol Med (2012) 0.75
Dystrophic phenotype improvement in the diaphragm muscle of mdx mice by diacerhein. PLoS One (2017) 0.75
Pharmacological therapeutics targeting the secondary defects and downstream pathology of Duchenne muscular dystrophy. Expert Opin Orphan Drugs (2016) 0.75
Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial. Lancet Neurol (2011) 2.44
North Star Ambulatory Assessment, 6-minute walk test and timed items in ambulant boys with Duchenne muscular dystrophy. Neuromuscul Disord (2010) 2.14
Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock. Circulation (2003) 2.03
Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats. Crit Care Med (2005) 1.96
Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Ann Intern Med (2007) 1.76
The effect of PDRN, an adenosine receptor A2A agonist, on the healing of chronic diabetic foot ulcers: results of a clinical trial. J Clin Endocrinol Metab (2014) 1.75
Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res (2002) 1.69
miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors. J Neurooncol (2009) 1.68
Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia. Endocrinology (2005) 1.63
Microsurgical arterovenous loops and biological templates: a novel in vivo chamber for tissue engineering. Microsurgery (2007) 1.54
Effect of recombinant adeno-associated virus vector-mediated vascular endothelial growth factor gene transfer on wound healing after burn injury. Crit Care Med (2003) 1.50
Protective effects of melanocortins on short-term changes in a rat model of traumatic brain injury*. Crit Care Med (2012) 1.45
Effectiveness of skeletal scintigraphy in transthyretin-related amyloidosis. Int J Cardiol (2013) 1.43
Melanocortin 4 receptor stimulation decreases pancreatitis severity in rats by activation of the cholinergic anti-inflammatory pathway. Crit Care Med (2011) 1.43
Beta-arrestin 2 negatively regulates sepsis-induced inflammation. Immunology (2010) 1.33
Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther (2003) 1.29
Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetes (2004) 1.29
Lipid peroxidation inhibition blunts nuclear factor-kappaB activation, reduces skeletal muscle degeneration, and enhances muscle function in mdx mice. Am J Pathol (2006) 1.24
VEGF overexpression via adeno-associated virus gene transfer promotes skeletal muscle regeneration and enhances muscle function in mdx mice. FASEB J (2007) 1.18
Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab (2007) 1.18
Importance of SPP1 genotype as a covariate in clinical trials in Duchenne muscular dystrophy. Neurology (2012) 1.17
Adrenocorticotropin reverses hemorrhagic shock in anesthetized rats through the rapid activation of a vagal anti-inflammatory pathway. Cardiovasc Res (2004) 1.15
Sleep disorders in children with Attention-Deficit/Hyperactivity Disorder (ADHD) recorded overnight by video-polysomnography. Sleep Med (2009) 1.13
Nuclear factor-kappaB activation and differential expression of survivin and Bcl-2 in human grade 2-4 astrocytomas. Cancer (2008) 1.13
Effect of genistein on endothelial function in postmenopausal women: a randomized, double-blind, controlled study. Am J Med (2003) 1.12
Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds. Crit Care Med (2006) 1.12
Serum levels of osteoprotegerin and RANKL in patients with ST elevation acute myocardial infarction. Clin Sci (Lond) (2005) 1.12
Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study. J Clin Endocrinol Metab (2008) 1.10
Attenuated cerulein-induced pancreatitis in nuclear factor-kappaB-deficient mice. Lab Invest (2003) 1.10
Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse. Wound Repair Regen (2008) 1.08
The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis (2002) 1.08
Motor function-muscle strength relationship in spinal muscular atrophy. Muscle Nerve (2004) 1.07
Drug-induced TINU syndrome and genetic characterization. Clin Nephrol (2012) 1.05
Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: a comparison study with methylprednisolone. Exp Neurol (2009) 1.04
Muscle fat-fraction and mapping in Duchenne muscular dystrophy: evaluation of disease distribution and correlation with clinical assessments. Preliminary experience. Skeletal Radiol (2011) 1.02
Cardiovascular autonomic control in myotonic dystrophy type 1: a correlative study with clinical and genetic data. Neuromuscul Disord (2004) 1.01
Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis. Life Sci (2004) 1.00
OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration. J Bone Miner Res (2008) 1.00