Published in Proc Natl Acad Sci U S A on January 13, 2006
Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell (2008) 4.20
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol (2012) 3.15
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell (2010) 2.29
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. Blood (2011) 1.88
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood (2013) 1.60
Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias. J Biol Chem (2010) 1.56
In search of tumor suppressing functions of menin. Mol Cell Endocrinol (2007) 1.28
Clinical and molecular genetics of parathyroid neoplasms. Best Pract Res Clin Endocrinol Metab (2010) 1.27
Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10. Blood (2012) 1.21
Menin: a scaffold protein that controls gene expression and cell signaling. Trends Biochem Sci (2013) 1.21
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein. J Biol Chem (2011) 1.16
Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. Blood (2009) 1.15
Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells. PLoS One (2006) 1.09
Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin. Oncogene (2009) 1.05
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1. Cancer Res (2009) 1.05
Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells. J Clin Invest (2015) 1.00
Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells. Oncogene (2008) 1.00
The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis. Nat Commun (2014) 1.00
Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome. Cancer Res (2013) 0.97
Novel insight into mutational landscape of head and neck squamous cell carcinoma. PLoS One (2014) 0.97
Regression analysis of combined gene expression regulation in acute myeloid leukemia. PLoS Comput Biol (2014) 0.94
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective. Curr Mol Med (2008) 0.94
Regulation of cyclin B2 expression and cell cycle G2/m transition by menin. J Biol Chem (2010) 0.90
Menin mediates epigenetic regulation via histone H3 lysine 9 methylation. Cell Death Dis (2013) 0.89
PAFc, a key player in MLL-rearranged leukemogenesis. Oncotarget (2010) 0.89
Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia (2007) 0.89
High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction. J Med Chem (2014) 0.89
Parathyroid tumor development involves deregulation of homeobox genes. Endocr Relat Cancer (2008) 0.87
Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. J Biol Chem (2007) 0.87
The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia. Haematologica (2013) 0.86
In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is mediated by Hoxa9. Mech Dev (2009) 0.85
Menin represses tumorigenesis via repressing cell proliferation. Am J Cancer Res (2011) 0.85
Menin as a hub controlling mixed lineage leukemia. Bioessays (2012) 0.85
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. Cancer Discov (2016) 0.85
The role of menin in hematopoiesis. Adv Exp Med Biol (2009) 0.82
Menin directly represses Gli1 expression independent of canonical Hedgehog signaling. Mol Cancer Res (2013) 0.81
Modulation by miR-29b of intestinal epithelium homoeostasis through the repression of menin translation. Biochem J (2015) 0.81
Menin induces endodermal differentiation in aggregated P19 stem cells by modulating the retinoic acid receptors. Mol Cell Biochem (2011) 0.79
Challenges and opportunities in targeting the menin-MLL interaction. Future Med Chem (2014) 0.79
Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia. Blood (2013) 0.78
Menin and bone metabolism. J Bone Miner Metab (2012) 0.78
Tumor Suppressors and Endodermal Differentiation of P19 Embryonic Stem Cells. Cell Dev Biol (2015) 0.75
MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches. Front Pediatr (2017) 0.75
Menin and Daxx Interact to Control Neuroendocrine Tumors via Epigenetic Regulation of Membrane Metallo-Endopeptidase. Cancer Res (2016) 0.75
Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin. Oncotarget (2016) 0.75
Menin localization in cell membrane compartment. Cancer Biol Ther (2016) 0.75
The roles of SNF2/SWI2 nucleosome remodeling enzymes in blood cell differentiation and leukemia. Biomed Res Int (2015) 0.75
Epigenetic regulation by the menin pathway. Endocr Relat Cancer (2017) 0.75
Translating the histone code. Science (2001) 56.77
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol (2003) 8.82
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (1997) 7.95
Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun (1997) 7.87
Acute lymphoblastic leukemia. N Engl J Med (2004) 7.83
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell (2002) 6.72
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol (2004) 6.55
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell (2004) 6.08
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature (2005) 5.15
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci U S A (2004) 4.85
Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J (1997) 4.03
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev (2003) 4.00
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell (2005) 3.70
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol Cell Biol (2004) 3.62
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A (2005) 3.37
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell (1999) 3.16
Multiple tumor suppressor pathways negatively regulate telomerase. Cell (2003) 2.82
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci U S A (2001) 2.57
Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood (1997) 2.55
Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. Hum Mol Genet (1997) 2.45
Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol (2003) 2.12
Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell (2004) 2.09
Defects in yolk sac hematopoiesis in Mll-null embryos. Blood (1997) 2.06
In vivo protein-protein and protein-DNA crosslinking for genomewide binding microarray. Methods (2003) 1.92
Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res (2003) 1.78
The role of chromosome translocations in leukemogenesis. Semin Hematol (1999) 1.76
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene (2001) 1.69
MLL: how complex does it get? J Cell Biochem (2005) 1.61
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Cancer Res (2003) 1.54
Identification of a new family of Pbx-related homeobox genes. Oncogene (1996) 1.52
Hematopoiesis: how does it happen? Curr Opin Cell Biol (1995) 1.52
Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol Cell Biol (2004) 1.29
Menin molecular interactions: insights into normal functions and tumorigenesis. Horm Metab Res (2005) 1.28
Menin induces apoptosis in murine embryonic fibroblasts. J Biol Chem (2003) 1.25
Functional studies of the MEN1 gene. J Intern Med (2003) 1.25
Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mech Dev (2003) 1.22
Menin interacting proteins as clues toward the understanding of multiple endocrine neoplasia type 1. Cancer Lett (2003) 1.21
Multiple endocrine neoplasia type 1. Endocr Relat Cancer (1999) 1.21
Direct binding of DNA by tumor suppressor menin. J Biol Chem (2004) 1.16
Origins of mammalian hematopoiesis: in vivo paradigms and in vitro models. Curr Top Dev Biol (2004) 1.02
Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. Hum Mol Genet (2004) 0.95
Multiple endocrine neoplasia--introduction. J Intern Med (2005) 0.93
Chromosome abnormalities in lymphocytes and fibroblasts of subjects with multiple endocrine neoplasia type 1. Cancer Genet Cytogenet (1991) 0.92
The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells. Endocrinology (2002) 0.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature (2005) 7.18
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 6.19
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell (2004) 6.08
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell (2007) 6.02
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol Cell Biol (2004) 3.62
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood (2007) 3.60
Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol (2005) 3.58
A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol (2004) 3.53
Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A (2005) 3.37
Notch signaling controls the generation and differentiation of early T lineage progenitors. Nat Immunol (2005) 3.26
Notch signaling in leukemia. Annu Rev Pathol (2008) 3.21
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol (2004) 3.20
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol (2012) 3.15
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell (2008) 3.08
The multifaceted role of Notch in cancer. Curr Opin Genet Dev (2006) 3.07
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood (2004) 2.90
Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity (2007) 2.88
Notch signaling is an important regulator of type 2 immunity. J Exp Med (2005) 2.87
MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A (2005) 2.87
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood (2007) 2.77
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. J Clin Invest (2008) 2.73
C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science (2006) 2.72
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J (2007) 2.61
Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J Pathol (2010) 2.58
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell (2010) 2.50
Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications. Cancer Res (2005) 2.45
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest (2005) 2.38
Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility. J Exp Med (2003) 2.30
Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution. PLoS One (2011) 2.29
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell (2010) 2.29
Notch signaling in cancer. Cancer Biol Ther (2002) 2.20
Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A (2011) 2.16
An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest (2007) 2.09
The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. J Exp Med (2006) 2.02
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell (2011) 2.01
ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection. Cell Microbiol (2008) 2.01
A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. PLoS Pathog (2007) 2.00
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation. Blood (2011) 1.99
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A (2007) 1.98
Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog (2009) 1.96
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood (2005) 1.96
Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol (2003) 1.95
The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol (2011) 1.95
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood (2010) 1.92
Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy. Mol Microbiol (2003) 1.91
Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. Blood (2009) 1.90
PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep (2009) 1.89
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell (2013) 1.86
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res (2010) 1.82
Interaction of MLL amino terminal sequences with menin is required for transformation. Cancer Res (2007) 1.82
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J (2005) 1.79
Dimerization of MLL fusion proteins immortalizes hematopoietic cells. Cancer Cell (2003) 1.79
Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol (2004) 1.78
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res (2003) 1.78
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell (2010) 1.76
Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell (2006) 1.76
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev (2009) 1.76
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol (2006) 1.75
T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity (2013) 1.72
Notch signaling represses myocardin-induced smooth muscle cell differentiation. J Biol Chem (2005) 1.71
Notch and the immune system. Immunity (2003) 1.66
Macrophage complement receptors and pathogen clearance. Cell Microbiol (2007) 1.65
The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin. Oncogene (2005) 1.64
Identification and characterization of Hoxa9 binding sites in hematopoietic cells. Blood (2011) 1.63
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature (2012) 1.62
Notch 1 signaling regulates peripheral T cell activation. Immunity (2004) 1.61
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A (2009) 1.59
Transposon mutagenesis of Mycobacterium marinum identifies a locus linking pigmentation and intracellular survival. Infect Immun (2003) 1.59
Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell (2008) 1.58
Notch and cancer: best to avoid the ups and downs. Cancer Cell (2003) 1.56
Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity (2002) 1.55
Atg5-independent sequestration of ubiquitinated mycobacteria. PLoS Pathog (2009) 1.55
ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem (2008) 1.55
RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Rep (2013) 1.53
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53. Nat Genet (2009) 1.51
Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest (2009) 1.50
Interactions between CD47 and thrombospondin reduce inflammation. J Immunol (2007) 1.46
Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. J Virol (2005) 1.46
Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR. J Clin Invest (2011) 1.46
Mycobacterium marinum: the generalization and specialization of a pathogenic mycobacterium. Microbes Infect (2004) 1.43
Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning. Development (2003) 1.41
The advent of targeted therapeutics and implications for pathologists. Am J Clin Pathol (2002) 1.38
Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. Mol Cell Biol (2008) 1.37
Active Notch1 confers a transformed phenotype to primary human melanocytes. Cancer Res (2009) 1.36
Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. Cancer Res (2006) 1.36