Published in Curr Pharm Des on January 01, 2006
Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med (2011) 3.09
Role of microglia in neurotrauma. Neurotherapeutics (2010) 2.53
PPARs and molecular mechanisms of transrepression. Biochim Biophys Acta (2007) 2.10
Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. Annu Rev Nutr (2011) 1.88
Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. PLoS One (2011) 1.45
PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics (2008) 1.36
New perspectives on central and peripheral immune responses to acute traumatic brain injury. J Neuroinflammation (2012) 1.34
Intrathecal rosiglitazone acts at peroxisome proliferator-activated receptor-gamma to rapidly inhibit neuropathic pain in rats. J Pain (2008) 1.14
Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt. J Neuroinflammation (2008) 1.08
Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease. J Neuroinflammation (2012) 1.06
Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury. Exp Neurol (2010) 1.04
Microglia and Astrocyte Activation by Toll-Like Receptor Ligands: Modulation by PPAR-gamma Agonists. PPAR Res (2008) 0.97
Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinson's Disease. Curr Neuropharmacol (2007) 0.94
Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats. Neurosci Lett (2008) 0.94
New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury. PPAR Res (2012) 0.94
Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines. PPAR Res (2007) 0.93
The synthetic peroxisome proliferator-activated receptor-gamma agonist ciglitazone attenuates neuroinflammation and accelerates encapsulation in bacterial brain abscesses. J Immunol (2008) 0.91
Activation of peroxisome proliferator-activated receptor gamma in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema. Neuropharmacology (2009) 0.91
Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: an endocrine-disruption theory of schizophrenia. Schizophr Bull (2008) 0.91
Peroxisome proliferator-activated receptors: "key" regulators of neuroinflammation after traumatic brain injury. PPAR Res (2008) 0.90
The PPAR-γ agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function. J Neuroinflammation (2012) 0.90
Peroxisome proliferator-activated receptor-gamma activation suppresses HIV-1 replication in an animal model of encephalitis. AIDS (2008) 0.90
Mechanisms and potential therapeutic applications of microglial activation after brain injury. CNS Neurosci Ther (2014) 0.89
PPARs in Alzheimer's Disease. PPAR Res (2008) 0.88
Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology (2012) 0.88
Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. PPAR Res (2008) 0.87
Expression of peroxisome proliferator-activated receptor-gamma in the substantia nigra of hemiparkinsonian nonhuman primates. Neurol Res (2013) 0.86
PPAR-gamma, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches. PPAR Res (2008) 0.85
Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy? Parkinsons Dis (2011) 0.85
Peroxisome proliferator activated receptor-γ and traumatic brain injury. Int J Clin Exp Med (2010) 0.84
Potential Therapeutic Targets for PPARgamma after Spinal Cord Injury. PPAR Res (2008) 0.84
Ginsenoside Rg1 suppressed inflammation and neuron apoptosis by activating PPARγ/HO-1 in hippocampus in rat model of cerebral ischemia-reperfusion injury. Int J Clin Exp Pathol (2015) 0.83
Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy. Exp Neurol (2016) 0.83
Impact and Therapeutic Potential of PPARs in Alzheimer's Disease. Curr Neuropharmacol (2011) 0.82
Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. PLoS One (2011) 0.81
Analgesic tolerance to morphine is regulated by PPARγ. Br J Pharmacol (2014) 0.79
PPARγ and PGC-1α as therapeutic targets in Parkinson's. Neurochem Res (2014) 0.79
Activation of central PPAR-γ attenuates angiotensin II-induced hypertension. Hypertension (2015) 0.78
Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality. J Neuroinflammation (2014) 0.78
Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake. Front Neurosci (2015) 0.77
The endocytic pathway in microglia during health, aging and Alzheimer's disease. Ageing Res Rev (2016) 0.77
Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions. Pharmaceuticals (Basel) (2010) 0.76
Roles of PPAR transcription factors in the energetic metabolic switch occurring during adult neurogenesis. Cell Cycle (2016) 0.75
Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets. Pharmaceuticals (Basel) (2009) 0.75
PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease. Free Radic Biol Med (2016) 0.75
Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors. PPAR Res (2008) 0.75
Increased levels of acute-phase inflammatory proteins in plasma of patients with sporadic CJD. Neurology (2012) 1.49
Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures. J Neuroinflammation (2005) 1.36
Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration. J Neuropathol Exp Neurol (2004) 1.20
Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus. J Neurochem (2005) 1.15
Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation, and differentiation. Dev Neurobiol (2012) 1.10
Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen. J Neurochem (2005) 1.02
TGF-β and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. J Neurochem (2010) 0.99
Role of neuroinflammation in hypertension-induced brain amyloid pathology. Neurobiol Aging (2010) 0.99
Microglial polarization and plasticity: evidence from organotypic hippocampal slice cultures. Glia (2013) 0.99
Apoptotic PC12 cells exposing phosphatidylserine promote the production of anti-inflammatory and neuroprotective molecules by microglial cells. J Neuropathol Exp Neurol (2003) 0.99
Minocycline in phenotypic models of Huntington's disease. Neurobiol Dis (2005) 0.98
Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice. Exp Gerontol (2006) 0.98
Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity. PLoS One (2011) 0.97
Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase. J Neurosci Res (2003) 0.97
Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction. Mol Neurobiol (2004) 0.92
Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. J Neurosci Res (2011) 0.92
Expression of phosphatidylserine receptor and down-regulation of pro-inflammatory molecule production by its natural ligand in rat microglial cultures. J Neuropathol Exp Neurol (2002) 0.92
Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1. Aging Cell (2013) 0.90
Isoprostanes in clinically isolated syndrome and early multiple sclerosis as biomarkers of tissue damage and predictors of clinical course. Mult Scler (2012) 0.90
Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. PPAR Res (2008) 0.87
15-deoxy-delta12,14-prostaglandin J2 regulates the functional state and the survival of microglial cells through multiple molecular mechanisms. J Neurochem (2003) 0.87
Differential lipid peroxidation, Mn superoxide, and bcl-2 expression contribute to the maturation-dependent vulnerability of oligodendrocytes to oxidative stress. J Neuropathol Exp Neurol (2003) 0.86
Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity. J Neurochem (2004) 0.85
Isoprostanes as biomarkers and mediators of oxidative injury in infant and adult central nervous system diseases. Curr Neurovasc Res (2004) 0.85
PPAR-gamma, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches. PPAR Res (2008) 0.85
Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats. Exp Neurol (2004) 0.85
Pro-gliogenic effect of IL-1alpha in the differentiation of embryonic neural precursor cells in vitro. J Neurochem (2010) 0.84
Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases. Neurobiol Dis (2005) 0.84
Modulation of PGE(2) and TNFalpha by nitric oxide and LPS-activated RAW 264.7 cells. Cytokine (2002) 0.84
Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. J Neuropathol Exp Neurol (2009) 0.82
Branched-chain amino acids influence the immune properties of microglial cells and their responsiveness to pro-inflammatory signals. Biochim Biophys Acta (2013) 0.82
Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats. Rev Neurosci (2014) 0.81
Striatal 6-OHDA lesion in mice: Investigating early neurochemical changes underlying Parkinson's disease. Behav Brain Res (2009) 0.81
Microglia in development and disease. Clin Dev Immunol (2013) 0.80
Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine. PLoS One (2013) 0.80
Plasma levels of 15-F(2t)-isoprostane in newborn infants are affected by mode of delivery. Clin Biochem (2007) 0.80
Cerebrospinal fluid isoprostanes are not related to inflammatory activity in relapsing-remitting multiple sclerosis. J Neurol Sci (2004) 0.80
Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence. Aging Cell (2012) 0.80
The matrix metalloproteinase inhibitor marimastat promotes neural progenitor cell differentiation into neurons by gelatinase-independent TIMP-2-dependent mechanisms. Stem Cells Dev (2012) 0.80
Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons. Neurobiol Dis (2006) 0.79
Altered expression of cyclooxygenase-2, presenilins and oxygen radical scavenging enzymes in a rat model of global perinatal asphyxia. Exp Neurol (2007) 0.78
The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves. Biol Chem (2013) 0.78
Increased brain levels of F2-isoprostane are an early marker of behavioral sequels in a rat model of global perinatal asphyxia. Pediatr Res (2003) 0.78
Adenosine A2A receptor antagonism and neuroprotection: mechanisms, lights, and shadows. Crit Rev Neurobiol (2004) 0.78
Peroxisome proliferator-activated receptor γ agonists accelerate oligodendrocyte maturation and influence mitochondrial functions and oscillatory Ca(2+) waves. J Neuropathol Exp Neurol (2011) 0.77
Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice. Exp Gerontol (2010) 0.77
Non steroidal anti-inflammatory drugs and neurogenesis in the adult mammalian brain. Curr Pharm Des (2008) 0.76
The stimulation of adenosine A2A receptors ameliorates the pathological phenotype of fibroblasts from Niemann-Pick type C patients. J Neurosci (2013) 0.75
Cyclooxygenases and cyclooxygenase inhibitors in neurological and psychiatric diseases. Curr Pharm Des (2008) 0.75