Published in Korean J Biol Sci on March 01, 2003
Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal (2010) 1.40
Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore. J Biol Chem (2008) 0.90
Mechanisms of neutrophil death in human immunodeficiency virus-infected patients: role of reactive oxygen species, caspases and map kinase pathways. Clin Exp Immunol (2007) 0.87
Combining 2-deoxy-D-glucose with electron transport chain blockers: a double-edged sword. Cancer Biol Ther (2009) 0.78
Escaping Death: Mitochondrial Redox Homeostasis in Cancer Cells. Front Oncol (2017) 0.75
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Apoptosis in the pathogenesis and treatment of disease. Science (1995) 20.24
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell (1996) 16.73
The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer (2002) 14.94
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90
Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell (1993) 10.83
The expanding role of mitochondria in apoptosis. Genes Dev (2001) 9.91
The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat Cell Biol (2000) 9.87
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J (1998) 9.36
Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol (1997) 9.18
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature (1999) 8.70
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell (1997) 8.61
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35
The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins. Annu Rev Genet (1993) 7.60
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J (1973) 7.01
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science (2003) 6.66
Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med (2000) 6.25
Endonuclease G is an apoptotic DNase when released from mitochondria. Nature (2001) 6.20
Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem (1997) 5.95
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell (2002) 5.47
Superoxide activates mitochondrial uncoupling proteins. Nature (2002) 5.43
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet (2000) 5.42
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol (2000) 5.24
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (2001) 5.07
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science (1998) 4.84
Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer (2002) 4.76
Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol (1999) 4.76
Mitochondrial control of apoptosis. Immunol Today (1997) 4.74
Conversion of Bcl-2 to a Bax-like death effector by caspases. Science (1997) 4.55
A caspase-related protease regulates apoptosis in yeast. Mol Cell (2002) 4.43
A matter of life and death. Cancer Cell (2002) 4.07
Structural basis of IAP recognition by Smac/DIABLO. Nature (2001) 3.66
Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem J (2000) 3.62
Cytochrome c release from mitochondria proceeds by a two-step process. Proc Natl Acad Sci U S A (2002) 3.57
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci U S A (1997) 3.21
Fas-induced caspase denitrosylation. Science (1999) 3.21
Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol (1999) 3.17
Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol (2000) 3.08
Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol (2000) 3.05
Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity (1999) 2.84
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J (1998) 2.84
VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol (2001) 2.80
Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc Natl Acad Sci U S A (2001) 2.63
The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol (1998) 2.60
Heat shock proteins: endogenous modulators of apoptotic cell death. Biochem Biophys Res Commun (2001) 2.56
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol (2003) 2.47
The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ (2000) 2.29
Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process. J Cell Biol (2001) 2.29
Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol (1996) 2.22
Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim Biophys Acta (2001) 2.21
HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB J (1999) 2.16
The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event. J Cell Biol (1999) 2.12
Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. J Biol Chem (1999) 2.12
Redox control of cell death. Antioxid Redox Signal (2002) 2.08
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem (2002) 2.04
Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection. Proc Natl Acad Sci U S A (2001) 2.03
Stress management - heat shock protein-70 and the regulation of apoptosis. Trends Cell Biol (2001) 2.02
The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death. Proc Natl Acad Sci U S A (2000) 1.96
BCL-2 and glutathione: alterations in cellular redox state that regulate apoptosis sensitivity. Free Radic Biol Med (1999) 1.95
Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release. Cell Death Differ (2000) 1.92
Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J Biol Chem (2000) 1.83
Mechanisms of apoptosis avoidance in cancer. Curr Opin Oncol (1999) 1.81
Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J Biol Chem (1999) 1.81
Cytochrome c in the apoptotic and antioxidant cascades. FEBS Lett (1998) 1.80
Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem (1999) 1.78
Aponecrosis: morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis. J Cell Physiol (2000) 1.76
The voltage-dependent anion channel: an essential player in apoptosis. Biochimie (2002) 1.75
Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis. Cell Death Differ (2000) 1.71
Necrotic death pathway in Fas receptor signaling. J Cell Biol (2000) 1.68
Mitochondrial control of apoptosis: the role of cytochrome c. Biochim Biophys Acta (1998) 1.65
Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proc Natl Acad Sci U S A (2000) 1.60
Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae. FEBS Lett (1996) 1.59
Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J Cell Biol (2001) 1.57
Regulation and measurement of oxidative stress in apoptosis. J Immunol Methods (2002) 1.56
Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma. Blood (2001) 1.54
Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: cooperation with exonuclease and DNase I. J Biol Chem (2001) 1.53
Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line. Cell Death Differ (2002) 1.48
Cytochrome c release from mitochondria: all or nothing. Nat Cell Biol (2000) 1.47
Caspase-independent cell deaths. Curr Opin Cell Biol (2002) 1.46
Apoptosis in yeast: a new model system with applications in cell biology and medicine. Curr Genet (2002) 1.43
Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes. J Biol Chem (2001) 1.43
And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis. Biochimie (2002) 1.39
Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c. Gene Expr (2001) 1.38
The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction. Cell Death Differ (2003) 1.32
Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells. FASEB J (2002) 1.30
Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production. J Neurosci (2000) 1.29
Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL-X(L). Mol Cell Biol (2000) 1.29
Signalling apoptosis: a radical approach. Redox Rep (2001) 1.29
Apoptosis in yeast--a monocellular organism exhibits altruistic behaviour. FEBS Lett (2000) 1.28
Apoptosis in human disease: a new skin for the old ceremony? Biochem Biophys Res Commun (1999) 1.28
Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc Natl Acad Sci U S A (1998) 1.23
Signalling mechanisms and oxidative stress in apoptosis. Toxicol Lett (1995) 1.23
Mitochondrial ROS metabolism: modulation by uncoupling proteins. IUBMB Life (2002) 1.20
Caspases disrupt mitochondrial membrane barrier function. FEBS Lett (1998) 1.19
Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo. Cancer Res (1997) 1.17
Evidence for redox regulation of cytochrome C release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition. J Neurosci (2001) 1.17
Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts. Biochem J (1998) 1.15
Redox regulation of caspase-3(-like) protease activity: regulatory roles of thioredoxin and cytochrome c. J Immunol (1998) 1.13
Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD. J Neuroimmunol (1999) 1.10
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One (2010) 2.05
Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. Oncogene (2004) 1.57
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. Oncogene (2002) 1.18
Apoptosis induction in prostate cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand and CPT-11. Cancer Res (2003) 1.16
Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis. Am J Physiol Endocrinol Metab (2012) 1.12
Suppression of NF-kappa B survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL. J Biol Chem (2003) 1.04
The evolving role of radiation therapy in the management of malignant melanoma. Int J Radiat Oncol Biol Phys (2011) 1.04
Retracted Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand. J Gen Virol (2005) 1.00
Requirement of catalytically active Tyk2 and accessory signals for the induction of TRAIL mRNA by IFN-beta. J Interferon Cytokine Res (2007) 0.95
Future of radiation therapy for malignant melanoma in an era of newer, more effective biological agents. Onco Targets Ther (2011) 0.88
Retracted Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines. J Virol (2005) 0.86
HDAC inhibitors potentiate the apoptotic effect of enzastaurin in lymphoma cells. Apoptosis (2011) 0.82
p53 binding to target sites is dynamically regulated before and after ionizing radiation-mediated DNA damage. J Environ Pathol Toxicol Oncol (2004) 0.81
Sustained apoptosis in human cardiac allografts despite histologic resolution of rejection. Transplantation (2003) 0.79