Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department.

PubWeight™: 5.31‹?› | Rank: Top 1%

🔗 View Article (PMID 16478835)

Published in Chest on February 01, 2006

Authors

Stephen Trzeciak1, R Phillip Dellinger, Nicole L Abate, Robert M Cowan, Mary Stauss, J Hope Kilgannon, Sergio Zanotti, Joseph E Parrillo

Author Affiliations

1: Division of Cardiovascular Disease and Critical Care Medicine, UMDNJ-Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza, D363, Camden, NJ 08103, USA. TRZECIAK-STEPHEN@cooperhealth.edu

Articles citing this

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33

Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09

Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock. Chest (2007) 4.60

Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82

The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73

Factors associated with nonadherence to early goal-directed therapy in the ED. Chest (2010) 3.23

Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14

Bundled care for septic shock: an analysis of clinical trials. Crit Care Med (2010) 2.57

Increased fluid administration in the first three hours of sepsis resuscitation is associated with reduced mortality: a retrospective cohort study. Chest (2014) 2.39

Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. Acad Emerg Med (2007) 1.95

Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87

The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands. Crit Care (2008) 1.81

Cost-effectiveness of an emergency department-based early sepsis resuscitation protocol. Crit Care Med (2011) 1.65

One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study. Crit Care (2009) 1.57

Early goal-directed therapy in severe sepsis and septic shock: converting science to reality. Chest (2006) 1.54

Etiology of illness in patients with severe sepsis admitted to the hospital from the emergency department. Clin Infect Dis (2010) 1.44

A survey of Canadian intensivists' resuscitation practices in early septic shock. Crit Care (2007) 1.37

Decreasing mortality in severe sepsis and septic shock patients by implementing a sepsis bundle in a hospital setting. PLoS One (2011) 1.35

Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med (2012) 1.24

Out-of-hospital fluid in severe sepsis: effect on early resuscitation in the emergency department. Prehosp Emerg Care (2010) 1.16

Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study. Crit Care (2007) 1.12

Shock index and early recognition of sepsis in the emergency department: pilot study. West J Emerg Med (2013) 1.12

Healthcare professionals' intentions to use wiki-based reminders to promote best practices in trauma care: a survey protocol. Implement Sci (2010) 1.06

Adherence to guidelines and protocols in the prehospital and emergency care setting: a systematic review. Scand J Trauma Resusc Emerg Med (2013) 1.06

Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Crit Care (2016) 1.04

Diagnosis and treatment of severe sepsis. Crit Care (2007) 1.01

Effects on management and outcome of severe sepsis and septic shock patients admitted to the intensive care unit after implementation of a sepsis program: a pilot study. Crit Care (2009) 1.01

Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O 2 content difference ratio as markers of resuscitation in patients with septic shock. Intensive Care Med (2015) 0.96

Clinical review: use of venous oxygen saturations as a goal - a yet unfinished puzzle. Crit Care (2011) 0.96

The impact of nationwide education program on clinical practice in sepsis care and mortality of severe sepsis: a population-based study in Taiwan. PLoS One (2013) 0.95

Early goal-directed resuscitation of patients with septic shock: current evidence and future directions. Crit Care (2015) 0.95

Severe sepsis and septic shock: management and performance improvement. Virulence (2013) 0.94

Critical care in the emergency department: an assessment of the length of stay and invasive procedures performed on critically ill ED patients. Scand J Trauma Resusc Emerg Med (2009) 0.91

The impact of duration of organ dysfunction on the outcome of patients with severe sepsis and septic shock. Clinics (Sao Paulo) (2008) 0.91

Early goal-directed therapy: a UK perspective. Emerg Med J (2006) 0.89

Implementing a collaborative protocol in a sepsis intervention program: lessons learned. Lung (2010) 0.88

Implementation of modified early-goal directed therapy for sepsis in the emergency center of a comprehensive cancer center. Support Care Cancer (2012) 0.88

Meta-analysis of protocolized goal-directed hemodynamic optimization for the management of severe sepsis and septic shock in the Emergency Department. West J Emerg Med (2014) 0.87

The outcome of patients presenting to the emergency department with severe sepsis or septic shock. Crit Care (2006) 0.82

A Computerized Alert Screening for Severe Sepsis in Emergency Department Patients Increases Lactate Testing but does not Improve Inpatient Mortality. Appl Clin Inform (2010) 0.81

Do clinical guidelines improve management of sepsis in critically ill elderly patients? A before-and-after study of the implementation of a sepsis protocol. Wien Klin Wochenschr (2012) 0.80

Suspicion and treatment of severe sepsis. An overview of the prehospital chain of care. Scand J Trauma Resusc Emerg Med (2012) 0.80

Early goal-directed resuscitation for patients with severe sepsis and septic shock: a meta-analysis and trial sequential analysis. Scand J Trauma Resusc Emerg Med (2016) 0.79

Metabolic support of the enterocutaneous fistula patient. Clin Colon Rectal Surg (2010) 0.79

Development and validation of questionnaires exploring health care professionals' intention to use wiki-based reminders to promote best practices in trauma. JMIR Res Protoc (2014) 0.79

Conservative fluid therapy in septic shock: an example of targeted therapeutic minimization. Crit Care (2014) 0.79

Could a protocol based on early goal-directed therapy improve outcomes in patients with severe sepsis and septic shock in the Intensive Care Unit setting? Indian J Crit Care Med (2015) 0.76

Results from using a new dyadic-dependence model to analyze sociocentric physician networks. Soc Sci Med (2014) 0.76

Success of applying early goal-directed therapy for septic shock patients in the emergency department. Open Access Emerg Med (2016) 0.75

Implementing sepsis bundles. Ann Transl Med (2016) 0.75

Commentary: Trzeciak S et al. (2006). Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Nurs Crit Care (2007) 0.75

Implementing a collaborative sepsis protocol on the time to antibiotics in an emergency department of a saudi hospital: quasi randomized study. Crit Care Res Pract (2014) 0.75

Early management of sepsis with emphasis on early goal directed therapy: AME evidence series 002. J Thorac Dis (2017) 0.75

The outcomes of severe sepsis and septic shock in the UK. Crit Care (2006) 0.75

The association of prior statin use in septic shock treated with early goal directed therapy. Eur J Emerg Med (2012) 0.75

Severe sepsis bundles. Indian J Crit Care Med (2010) 0.75

Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia. J Anesth (2008) 0.75

Articles by these authors

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med (2006) 23.62

The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69

Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med (2014) 5.70

The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64

Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit. Crit Care Med (2007) 4.54

Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest (2009) 4.51

Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA (2010) 4.37

Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis. Crit Care Med (2014) 4.11

Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis (2012) 4.07

Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med (2015) 3.55

Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med (2006) 3.36

The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17

Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14

Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA (2004) 3.07

Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Crit Care Med (2015) 2.81

A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med (2013) 2.68

Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med (2009) 2.68

Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67

Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65

Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59

Point: Are the best patient outcomes achieved when ICU bundles are rigorously adhered to? Yes. Chest (2013) 2.59

An international survey: Public awareness and perception of sepsis. Crit Care Med (2009) 2.40

Activated protein C and septic shock: a propensity-matched cohort study*. Crit Care Med (2012) 2.39

Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects. Crit Care Med (2004) 2.35

Utility of history, physical examination, electrocardiogram, and chest radiograph for differentiating normal from decreased systolic function in patients with heart failure. Am J Med (2002) 2.34

Association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome. Circulation (2013) 2.22

Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17

Critical care medicine training and certification for emergency physicians. Crit Care Med (2005) 2.12

Transfusion of packed red blood cells is not associated with improved central venous oxygen saturation or organ function in patients with septic shock. J Emerg Med (2012) 2.02

Sepsis change bundles: converting guidelines into meaningful change in behavior and clinical outcome. Crit Care Med (2004) 1.96

Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med (2008) 1.93

Serum lactate as a predictor of mortality in patients with infection. Intensive Care Med (2007) 1.88

Clinical review: Myocardial depression in sepsis and septic shock. Crit Care (2002) 1.74

Interaction between fluids and vasoactive agents on mortality in septic shock: a multicenter, observational study. Crit Care Med (2014) 1.72

Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61

The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels. J Infect Dis (2005) 1.60

Effect of large volume infusion on left ventricular volumes, performance and contractility parameters in normal volunteers. Intensive Care Med (2004) 1.59

A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsis. Crit Care Med (2013) 1.58

Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-α fragment antibody AZD9773 in adult patients with severe sepsis and/or septic shock: randomized, double-blind, placebo-controlled phase IIb study*. Crit Care Med (2014) 1.56

Myocardial dysfunction in the patient with sepsis. Curr Opin Crit Care (2002) 1.47

Use of a standardized order set for achieving target temperature in the implementation of therapeutic hypothermia after cardiac arrest: a feasibility study. Acad Emerg Med (2008) 1.46

Sepsis severity score: an internationally derived scoring system from the surviving sepsis campaign database*. Crit Care Med (2014) 1.46

Randomized controlled trial of inhaled nitric oxide for the treatment of microcirculatory dysfunction in patients with sepsis*. Crit Care Med (2014) 1.42

Drotrecogin alfa (activated) in an infant with gram-negative septic shock. J Intensive Care Med (2004) 1.42

Inhaled nitric oxide: should it be used in acute respiratory distress syndrome? Crit Care Med (2006) 1.39

Incidence and mortality of sepsis, severe sepsis, and septic shock in intensive care unit patients with candidemia. Infect Dis (Lond) (2015) 1.39

Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Intensive Care Med (2014) 1.38

Regional distribution of acoustic-based lung vibration as a function of mechanical ventilation mode. Crit Care (2007) 1.36

Clinical characteristics and outcomes of septic patients with new-onset atrial fibrillation. J Crit Care (2008) 1.35

Eosinophilic myocarditis. Heart Fail Clin (2005) 1.34

Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis. Crit Care Med (2002) 1.32

Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study. Crit Care (2013) 1.31

Dynamic visualization of lung sounds with a vibration response device: a case series. Respiration (2007) 1.24

Evolution of critical care cardiology: transformation of the cardiovascular intensive care unit and the emerging need for new medical staffing and training models: a scientific statement from the American Heart Association. Circulation (2012) 1.23

Advances in pathogenesis and management of sepsis. Curr Opin Infect Dis (2007) 1.23

Vasopressor and inotropic support in septic shock: an evidence-based review. Crit Care Med (2004) 1.23

Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med (2009) 1.16

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Crit Care Med (2017) 1.15

Fluid resuscitation influences cardiovascular performance and mortality in a murine model of sepsis. Intensive Care Med (2008) 1.14

Septic shock--vasopressin, norepinephrine, and urgency. N Engl J Med (2008) 1.12

The EUPHRATES trial (Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock): study protocol for a randomized controlled trial. Trials (2014) 1.12

Infections and severe sepsis in solid-organ transplant patients admitted from a university-based ED. Am J Emerg Med (2004) 1.10

Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity. J Biol Chem (2002) 1.09

The pathophysiology of septic shock. Crit Care Clin (2009) 1.08

Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock. Crit Care (2008) 1.07

Cardiogenic shock. Crit Care Med (2008) 1.06

Timing of vasopressor initiation and mortality in septic shock: a cohort study. Crit Care (2014) 1.05

Multiple organ dysfunction after return of spontaneous circulation in postcardiac arrest syndrome. Crit Care Med (2013) 1.05

Reducing mortality in severe sepsis: the Surviving Sepsis Campaign. Clin Chest Med (2008) 1.01

Human serum from patients with septic shock activates transcription factors STAT1, IRF1, and NF-kappaB and induces apoptosis in human cardiac myocytes. J Biol Chem (2005) 1.00

Lactate as a hemodynamic marker in the critically ill. Curr Opin Crit Care (2012) 0.99

Adenosine deaminase inhibition attenuates microvascular dysfunction and improves survival in sepsis. Am J Respir Crit Care Med (2002) 0.97

The Surviving Sepsis Campaign: a history and a perspective. Surg Infect (Larchmt) (2010) 0.97

Moving some articles to electronic (online) only publication. Crit Care Med (2013) 0.96

Sepsis and septic shock: a history. Crit Care Clin (2009) 0.96

Discordance between microvascular permeability and leukocyte dynamics in septic inducible nitric oxide synthase deficient mice. Crit Care (2007) 0.96

Early arterial hypotension is common in the post-cardiac arrest syndrome and associated with increased in-hospital mortality. Resuscitation (2008) 0.96

Interleukin-10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response. Crit Care Med (2005) 0.95