Published in Genes Dev on February 15, 2006
MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev (2006) 6.30
MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74
Isolation of microRNA targets by miRNP immunopurification. RNA (2007) 5.50
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res (2007) 4.28
MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes (2009) 3.02
Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila. Cell Metab (2007) 2.99
Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol Genet Metab (2007) 2.52
A role of miR-27 in the regulation of adipogenesis. FEBS J (2009) 2.27
MicroRNA regulation of lipid metabolism. Metabolism (2012) 2.15
microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila. Genes Dev (2007) 1.80
Deep sequencing of small RNA libraries reveals dynamic regulation of conserved and novel microRNAs and microRNA-stars during silkworm development. BMC Genomics (2010) 1.68
Polycomb preferentially targets stalled promoters of coding and noncoding transcripts. Genome Res (2010) 1.63
The silkworm (Bombyx mori) microRNAs and their expressions in multiple developmental stages. PLoS One (2008) 1.48
Differential expression of microRNAs in mouse liver under aberrant energy metabolic status. J Lipid Res (2009) 1.43
microRNAs: a new emerging class of players for disease diagnostics and gene therapy. J Cell Mol Med (2007) 1.43
microRNAs in the regulation of adipogenesis and obesity. Curr Mol Med (2011) 1.39
SH2B regulation of growth, metabolism, and longevity in both insects and mammals. Cell Metab (2010) 1.34
microRNA control of cell-cell signaling during development and disease. Cell Cycle (2008) 1.32
d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila. Aging Cell (2009) 1.31
Insect-Specific microRNA Involved in the Development of the Silkworm Bombyx mori. PLoS One (2009) 1.31
Role of microRNAs in diabetes. Biochim Biophys Acta (2008) 1.31
Role of microRNAs in diabetes and its cardiovascular complications. Cardiovasc Res (2011) 1.30
Identification of novel Drosophila melanogaster microRNAs. PLoS One (2007) 1.28
Method for microRNA isolation from clinical serum samples. Anal Biochem (2012) 1.23
MicroRNAs in adipogenesis and as therapeutic targets for obesity. Expert Opin Ther Targets (2011) 1.22
The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans. Nucleic Acids Res (2010) 1.22
miRNAs: effectors of environmental influences on gene expression and disease. Toxicol Sci (2008) 1.21
Lessons from microRNA mutants in worms, flies and mice. Cell Cycle (2008) 1.20
Identification and differential expression of microRNAs during metamorphosis of the Japanese flounder (Paralichthys olivaceus). PLoS One (2011) 1.16
Insect microRNAs: biogenesis, expression profiling and biological functions. Insect Biochem Mol Biol (2012) 1.15
Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction. Front Physiol (2013) 1.14
Targeting microRNAs in obesity. Expert Opin Ther Targets (2009) 1.14
A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways. Mol Cell Biol (2008) 1.13
Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe. Genes Dev (2010) 1.10
Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element. BMC Cell Biol (2010) 1.09
Use of target protector morpholinos to analyze the physiological roles of specific miRNA-mRNA pairs in vivo. Nat Protoc (2011) 1.07
Complex genetics of obesity in mouse models. Annu Rev Nutr (2008) 1.06
A Drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling. Genetics (2008) 0.99
Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells. Development (2009) 0.97
Ageing and the small, non-coding RNA world. Ageing Res Rev (2012) 0.93
MicroRNAs as genetic sculptors: fishing for clues. Semin Cell Dev Biol (2010) 0.93
Regulation of Adipocyte Differentiation via MicroRNAs. Endocrinol Metab (Seoul) (2014) 0.92
Characterization of host microRNAs that respond to DNA virus infection in a crustacean. BMC Genomics (2012) 0.90
MicroRNA-375 promotes 3T3-L1 adipocyte differentiation through modulation of extracellular signal-regulated kinase signalling. Clin Exp Pharmacol Physiol (2011) 0.90
Predicting kissing interactions in microRNA-target complex and assessment of microRNA activity. Nucleic Acids Res (2012) 0.90
Post-transcriptional regulation in metabolic diseases. RNA Biol (2012) 0.88
miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2. Mol Cell (2014) 0.88
MicroRNAs: a new ray of hope for diabetes mellitus. Protein Cell (2012) 0.87
MicroRNAs as newer therapeutic targets: A big hope from a tiny player. J Pharmacol Pharmacother (2012) 0.87
Characterization and comparative analysis of small RNAs in three small RNA libraries of the brown planthopper (Nilaparvata lugens). PLoS One (2012) 0.87
MicroRNA in carcinogenesis & cancer diagnostics: a new paradigm. Indian J Med Res (2013) 0.86
Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster. G3 (Bethesda) (2013) 0.86
Exploiting Drosophila genetics to understand microRNA function and regulation. Curr Top Dev Biol (2012) 0.85
MiR-278-3p regulates pyrethroid resistance in Culex pipiens pallens. Parasitol Res (2014) 0.84
MicroRNAs influence reproductive responses by females to male sex peptide in Drosophila melanogaster. Genetics (2014) 0.84
Discovery of novel and differentially expressed microRNAs between fetal and adult backfat in cattle. PLoS One (2014) 0.80
Modulation of methuselah expression targeted to Drosophila insulin-producing cells extends life and enhances oxidative stress resistance. Aging Cell (2012) 0.80
Expression profiling analysis of the microRNA response of Cynoglossus semilaevis to Vibrio anguillarum and other stimuli. Mar Biotechnol (NY) (2015) 0.78
Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Genetics (2016) 0.77
MicroRNA Signature of Human Microvascular Endothelium Infected with Rickettsia rickettsii. Int J Mol Sci (2017) 0.76
Study on Genetic Variance of miR-541 in Type 1 Diabetes. ISRN Endocrinol (2012) 0.76
Expression Profile Analysis of miR-221 and miR-222 in Different Tissues and Head Kidney Cells of Cynoglossus semilaevis, Following Pathogen Infection. Mar Biotechnol (NY) (2015) 0.76
MicroRNAs Circulate in the Hemolymph of Drosophila and Accumulate Relative to Tissue microRNAs in an Age-Dependent Manner. Genomics Insights (2016) 0.75
Identification and characterization of microRNAs expressed in the African malaria vector Anopheles funestus life stages using high throughput sequencing. Malar J (2016) 0.75
miRNAs: Miracle or Mirage?: The Limes Against the Barbaric Floods of Leaky and Undesired Transcripts. Organogenesis (2007) 0.75
Infections of virulent and avirulent viruses differentially influenced the expression of dicer-1, ago-1, and microRNAs in Bombus terrestris. Sci Rep (2017) 0.75
Comparative analysis of miRNA expression during the development of insects of different metamorphosis modes and germ-band types. BMC Genomics (2017) 0.75
Pervasive Behavioural Effects of microRNA Regulation in Drosophila. Genetics (2017) 0.75
Potential miRNA involvement in the anti-adipogenic effect of resveratrol and its metabolites. PLoS One (2017) 0.75
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62
Combinatorial microRNA target predictions. Nat Genet (2005) 50.48
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60
Principles of microRNA-target recognition. PLoS Biol (2005) 23.70
bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell (2003) 22.14
Upstream and downstream of mTOR. Genes Dev (2004) 21.61
The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science (2005) 20.51
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature (2005) 17.17
Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet (2005) 15.96
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Cell (2005) 15.38
A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24
A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature (2003) 12.93
The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Curr Biol (2003) 11.23
MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16
MicroRNA functions in animal development and human disease. Development (2005) 8.41
microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol (2005) 6.77
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature (2004) 6.38
Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science (2002) 6.35
Ends-out, or replacement, gene targeting in Drosophila. Proc Natl Acad Sci U S A (2003) 5.55
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell (1999) 5.38
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A (2005) 5.34
Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr Biol (2002) 5.12
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev (2003) 5.10
Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth. Genes Dev (2005) 4.34
Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin. Genes Dev (2005) 3.59
Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster. Genetics (2004) 3.32
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature (2004) 3.29
4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev (2005) 2.28
Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev (2005) 1.84
The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. Development (2000) 1.78
Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. Proc Natl Acad Sci U S A (2003) 1.75
Insulin receptor knockout mice. Annu Rev Physiol (2002) 1.70
Drosophila Melted modulates FOXO and TOR activity. Dev Cell (2005) 1.59
Interplay between growth factor and nutrient signaling: lessons from Drosophila TOR. Curr Top Microbiol Immunol (2004) 1.32
Recent advances in the regulation of the TOR pathway by insulin and nutrients. Curr Opin Clin Nutr Metab Care (2005) 1.28
Expanded functions in the apical cell domain to regulate the growth rate of imaginal discs. Dev Genet (1997) 1.28
Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E. Curr Biol (2005) 1.14
Expanded, a negative regulator of cell proliferation in Drosophila, shows homology to the NF2 tumor suppressor. Mech Dev (1993) 1.11
Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development. Curr Biol (2005) 1.05
The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development. Mech Dev (2000) 1.01
Principles of microRNA-target recognition. PLoS Biol (2005) 23.70
bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell (2003) 22.14
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Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Cell (2005) 15.38
Identification of Drosophila MicroRNA targets. PLoS Biol (2003) 12.72
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Delineation of a Fat tumor suppressor pathway. Nat Genet (2006) 5.06
Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev Cell (2002) 4.85
The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Cell (2007) 4.00
The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell (2006) 3.81
Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Mol Cell Biol (2006) 3.80
Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev Cell (2005) 2.81
On the mechanism of wing size determination in fly development. Proc Natl Acad Sci U S A (2007) 2.62
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature (2008) 2.54
MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev (2010) 2.51
Temporal reciprocity of miRNAs and their targets during the maternal-to-zygotic transition in Drosophila. Curr Biol (2008) 2.47
A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands. Genes Dev (2008) 2.45
Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab (2008) 2.32
4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev (2005) 2.28
Regulation of tissue growth through nutrient sensing. Annu Rev Genet (2009) 2.18
HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient. Dev Cell (2002) 2.03
Connecting proliferation and apoptosis in development and disease. Nat Rev Mol Cell Biol (2004) 1.97
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev (2007) 1.83
microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila. Genes Dev (2007) 1.80
Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development. Development (2003) 1.72
Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity. Dev Cell (2004) 1.69
The bantam gene regulates Drosophila growth. Genetics (2002) 1.62
MicroRNAs in neurodegeneration. Curr Opin Neurobiol (2008) 1.62
Drosophila Melted modulates FOXO and TOR activity. Dev Cell (2005) 1.59
Short-range cell interactions and cell survival in the Drosophila wing. Dev Cell (2002) 1.57
Towards a complete description of the microRNA complement of animal genomes. Genome Biol (2003) 1.49
Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth. Genes Dev (2004) 1.38
Identification of novel Drosophila melanogaster microRNAs. PLoS One (2007) 1.28
Recombinase-mediated cassette exchange provides a versatile platform for gene targeting: knockout of miR-31b. Genetics (2009) 1.26
Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Proc Natl Acad Sci U S A (2009) 1.26
Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis. PLoS Biol (2010) 1.26
MAP4K3 regulates body size and metabolism in Drosophila. Dev Biol (2010) 1.24
On the role of glypicans in the process of morphogen gradient formation. Dev Biol (2006) 1.18
TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells. BMC Cancer (2008) 1.18
A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway. Genetics (2005) 1.14
Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe. Genes Dev (2010) 1.10
Drosophila miR-124 regulates neuroblast proliferation through its target anachronism. Development (2012) 1.04
MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet (2011) 1.03
Gain-of-function screen for genes that affect Drosophila muscle pattern formation. PLoS Genet (2005) 1.02
Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan. Dev Dyn (2005) 1.01
The Drosophila sterile-20 kinase slik controls cell proliferation and apoptosis during imaginal disc development. PLoS Biol (2003) 1.00
Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing. Development (2011) 0.99
Distal antenna and distal antenna related encode nuclear proteins containing pipsqueak motifs involved in antenna development in Drosophila. Development (2003) 0.99
A naturally occurring alternative product of the mastermind locus that represses notch signalling. Mech Dev (2002) 0.98
Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. Curr Biol (2012) 0.98
Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complex. Development (2004) 0.98
A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing. Development (2003) 0.98
Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. Genes Dev (2012) 0.97
Repression of Teashirt marks the initiation of wing development. Development (2002) 0.97
molting defective is required for ecdysone biosynthesis. Dev Biol (2005) 0.97
The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. EMBO J (2010) 0.97
MicroRNA transgene overexpression complements deficiency-based modifier screens in Drosophila. Genetics (2011) 0.96
Drosophila egghead encodes a beta 1,4-mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for brainiac. J Biol Chem (2002) 0.94
Protocols for use of homologous recombination gene targeting to produce microRNA mutants in Drosophila. Methods Mol Biol (2011) 0.94
Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivo. J Biol Chem (2004) 0.92
Not miR-ly muscular: microRNAs and muscle development. Genes Dev (2005) 0.92
Structural insights into the Notch-modifying glycosyltransferase Fringe. Nat Struct Mol Biol (2006) 0.92
The Drosophila gene brainiac encodes a glycosyltransferase putatively involved in glycosphingolipid synthesis. J Biol Chem (2002) 0.91
ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation. Genes Dev (2013) 0.90
The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs. Cell Metab (2012) 0.90
Spatial and temporal regulation of the homeotic selector gene Antennapedia is required for the establishment of leg identity in Drosophila. Dev Biol (2004) 0.89
An evaluation of the efficacy of a cyclosporine-based dry eye therapy when used with marketed artificial tears as supportive therapy in dry eye. Eye Contact Lens (2006) 0.89
Glycosphingolipids with extended sugar chain have specialized functions in development and behavior of Drosophila. Dev Biol (2007) 0.89
Osa modulates the expression of Apterous target genes in the Drosophila wing. Mech Dev (2004) 0.87
Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster. G3 (Bethesda) (2013) 0.86
Perspective: follow the money: the implications of medical schools' funds flow models. Acad Med (2012) 0.85
Drosophila Minus is required for cell proliferation and influences Cyclin E turnover. Genes Dev (2009) 0.84
The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth. Biol Open (2013) 0.83
miR-989 is required for border cell migration in the Drosophila ovary. PLoS One (2013) 0.82
miR-124 controls male reproductive success in Drosophila. Elife (2013) 0.82
Glycosphingolipids control the extracellular gradient of the Drosophila EGFR ligand Gurken. Development (2009) 0.81
TORCing up metabolic control in the brain. Cell Metab (2008) 0.80
Time is of the essence: microRNAs and age-associated neurodegeneration. Cell Res (2012) 0.80
Ligand-binding and signaling properties of the Ax[M1] form of Notch. Mech Dev (2005) 0.79
Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11. Glycoconj J (2010) 0.78
Notch signaling: filopodia dynamics confer robustness. Curr Biol (2010) 0.76
Developmental biology: long-range signalling by touch. Nature (2003) 0.75
The secret life of Smoothened. Dev Cell (2003) 0.75