Published in Antimicrob Agents Chemother on March 01, 2006
Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo. Antimicrob Agents Chemother (2010) 0.94
Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide. Bioorg Med Chem (2007) 0.87
Synthesis of a highly water-soluble derivative of amphotericin B with attenuated proinflammatory activity. Mol Pharm (2009) 0.85
Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines. Curr Drug Targets (2012) 0.82
Antibacterial activities of Groebke-Blackburn-Bienaymé-derived imidazo[1,2-a]pyridin-3-amines. Bioorg Med Chem (2012) 0.81
Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Antimicrob Agents Chemother (2010) 0.81
Structure-activity relationships of antimicrobial and lipoteichoic acid-sequestering properties in polyamine sulfonamides. Antimicrob Agents Chemother (2008) 0.81
Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii. Curr Drug Deliv (2015) 0.77
Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin. Mol Pharm (2010) 0.76
Bactericidal Effects and Mechanism of Action of Olanexidine Gluconate, a New Antiseptic. Antimicrob Agents Chemother (2015) 0.75
N-terminally modified linear and branched spermine backbone dipeptidomimetics against planktonic and sessile methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2014) 0.75
Efficacy of the combination of tachyplesin III and clarithromycin in rat models of Escherichia coli sepsis. Antimicrob Agents Chemother (2008) 0.75
A High-Throughput Approach To Identify Compounds That Impair Envelope Integrity in Escherichia coli. Antimicrob Agents Chemother (2016) 0.75
Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. Gene (1977) 114.87
Molecular basis of bacterial outer membrane permeability. Microbiol Rev (1985) 17.75
Agents that increase the permeability of the outer membrane. Microbiol Rev (1992) 7.52
Peptide antibiotics. Lancet (1997) 6.76
Peptide antibiotics. Antimicrob Agents Chemother (1999) 5.76
Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J (1994) 5.70
Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry (1976) 5.43
Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest (1989) 5.21
Polymyxin and related peptide antibiotics. Annu Rev Biochem (1977) 4.53
Polycations sensitize enteric bacteria to antibiotics. Antimicrob Agents Chemother (1983) 3.33
Polycations as outer membrane-disorganizing agents. Antimicrob Agents Chemother (1983) 3.06
EUCAST Definitive Document E.DEF 3.1, June 2000: Determination of minimum inhibitory concentrations (MICs) of antibacterial agents by agar dilution. Clin Microbiol Infect (2000) 3.05
Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide. Nature (1983) 2.84
Action of polymyxin B on bacterial membranes: morphological changes in the cytoplasm and in the outer membrane of Salmonella typhimurium and Escherichia coli B. Antimicrob Agents Chemother (1975) 2.69
Compounds which increase the permeability of the Pseudomonas aeruginosa outer membrane. Antimicrob Agents Chemother (1984) 2.37
Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry. J Immunol Methods (1988) 2.31
Antibiotic-supersusceptible mutants of Escherichia coli and Salmonella typhimurium. Antimicrob Agents Chemother (1993) 2.00
Interactions of bacterial cationic peptide antibiotics with outer and cytoplasmic membranes of Pseudomonas aeruginosa. Antimicrob Agents Chemother (2000) 1.99
Antimicrobial peptides: properties and applicability. Biol Chem (2001) 1.89
Antibiotic-induced release of endotoxin: a reappraisal. Clin Infect Dis (1992) 1.82
Salt-resistant alpha-helical cationic antimicrobial peptides. Antimicrob Agents Chemother (1999) 1.78
Gemini Surfactants. Angew Chem Int Ed Engl (2000) 1.76
Group of peptides that act synergistically with hydrophobic antibiotics against gram-negative enteric bacteria. Antimicrob Agents Chemother (1996) 1.75
Multiparameter flow cytometric analysis of antibiotic effects on membrane potential, membrane permeability, and bacterial counts of Staphylococcus aureus and Micrococcus luteus. Antimicrob Agents Chemother (2000) 1.75
Rapid membrane permeabilization and inhibition of vital functions of gram-negative bacteria by bactenecins. Infect Immun (1990) 1.64
Disruption of the Escherichia coli outer membrane permeability barrier by immobilized polymyxin B. J Antibiot (Tokyo) (1977) 1.62
Asymmetric localization of lipopolysaccharides on the outer membrane of Salmonella typhimurium. J Bacteriol (1980) 1.53
The outer membrane permeability-increasing action of deacylpolymyxins. J Antibiot (Tokyo) (1991) 1.52
Cutting edge: cationic antimicrobial peptides block the binding of lipopolysaccharide (LPS) to LPS binding protein. J Immunol (2000) 1.51
Improvement of outer membrane-permeabilizing and lipopolysaccharide-binding activities of an antimicrobial cationic peptide by C-terminal modification. Antimicrob Agents Chemother (1994) 1.51
Clinical relevance of antibiotic-induced endotoxin release. Antimicrob Agents Chemother (1994) 1.48
Molecular mechanisms of polymyxin B-membrane interactions: direct correlation between surface charge density and self-promoted transport. J Membr Biol (1998) 1.43
Interaction of cationic peptides with lipoteichoic acid and gram-positive bacteria. Infect Immun (1999) 1.40
The pharmacophore of short cationic antibacterial peptides. J Med Chem (2003) 1.35
Cationic peptides: distribution and mechanisms of resistance. Curr Pharm Des (2002) 1.35
Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria. J Med Chem (2000) 1.25
The lipopolysaccharide barrier: correlation of antibiotic susceptibility with antibiotic permeability and fluorescent probe binding kinetics. Biochemistry (2000) 1.21
Towards a rational development of anti-endotoxin agents: novel approaches to sequestration of bacterial endotoxins with small molecules. J Mol Recognit (2001) 1.19
Antibiotic-induced endotoxin release in patients with gram-negative urosepsis: a double-blind study comparing imipenem and ceftazidime. J Infect Dis (1995) 1.16
Antibiotic-induced release of endotoxin. A therapeutic paradox. Drug Saf (1995) 1.16
Correlation of the antibacterial activities of cationic peptide antibiotics and cationic steroid antibiotics. J Med Chem (2002) 1.16
Lipopolysaccharide sequestrants: structural correlates of activity and toxicity in novel acylhomospermines. J Med Chem (2005) 1.10
Lipopolyamines: novel antiendotoxin compounds that reduce mortality in experimental sepsis caused by gram-negative bacteria. Antimicrob Agents Chemother (1999) 1.05
Influence of preformed alpha-helix and alpha-helix induction on the activity of cationic antimicrobial peptides. J Pept Res (1998) 1.04
Surface plasmon resonance studies resolve the enigmatic endotoxin neutralizing activity of polymyxin B. J Biol Chem (1999) 1.04
Interaction of cationic peptides with bacterial membranes. Methods Mol Biol (1997) 1.03
Interaction of melittin with endotoxic lipid A. Biochim Biophys Acta (1992) 1.00
Phase separation induced by melittin in negatively-charged phospholipid bilayers as detected by fluorescence polarization and differential scanning calorimetry. Biochim Biophys Acta (1982) 0.97
Structure-function relationships in novel peptide dodecamerswith broad-spectrum bactericidal and endotoxin-neutralizing activities. Biochem J (2000) 0.96
Bacterial resistance to antibiotics as a function of outer membrane permeability. J Antimicrob Chemother (1988) 0.95
Analysis of the binding of polymyxin B to endotoxic lipid A and core glycolipid using a fluorescent displacement probe. Biochim Biophys Acta (1992) 0.88
Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide. Bioorg Med Chem Lett (2000) 0.86
Mode of action of novel polyamines increasing the permeability of bacterial outer membrane. Int J Antimicrob Agents (2004) 0.84
Activities of cholic acid-derived antimicrobial agents against multidrug-resistant bacteria. J Antimicrob Chemother (2001) 0.84
Failure of Padac test strips to detect staphylococcal beta-lactamase. Antimicrob Agents Chemother (1982) 0.84
Origins of cell selectivity of cationic steroid antibiotics. J Am Chem Soc (2004) 0.83
Structure activity relationship study of polymyxin B nonapeptide. Adv Exp Med Biol (2000) 0.80
Maximum bubble pressure tensiometry--an analysis of experimental constraints. Adv Colloid Interface Sci (2004) 0.78
Influence of antibiotic class and concentration on the percentage of release of lipopolysaccharide from Escherichia coli. J Infect Dis (1994) 0.78
Combination of antimicrobial and endotoxin-neutralizing activities of novel oleoylamines. Antimicrob Agents Chemother (2005) 0.76
Necrotizing enterocolitis in full-term infants. J Pediatr Surg (2003) 1.85
Establishment and characterization of cell lines from a novel mouse model of poorly differentiated thyroid carcinoma: powerful tools for basic and preclinical research. Thyroid (2011) 1.47
Structure-activity relationships in human toll-like receptor 7-active imidazoquinoline analogues. J Med Chem (2010) 1.26
The unique paradigm of spirochete motility and chemotaxis. Annu Rev Microbiol (2012) 1.26
Potential adjuvantic properties of innate immune stimuli. Hum Vaccin (2009) 1.25
Embryonic mouse blood flow and oxygen correlate with early pancreatic differentiation. Dev Biol (2010) 1.17
Lipopolysaccharide sequestrants: structural correlates of activity and toxicity in novel acylhomospermines. J Med Chem (2005) 1.10
Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline. Bioorg Med Chem Lett (2009) 1.09
Single cannula technique and robotic telescopic assistance in infants and children who require laparoscopic Nissen fundoplication. J Pediatr Surg (2003) 1.09
Comparison of the immunostimulatory and proinflammatory activities of candidate Gram-positive endotoxins, lipoteichoic acid, peptidoglycan, and lipopeptides, in murine and human cells. Immunol Lett (2008) 1.08
Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett (2010) 1.08
Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides. J Med Chem (2010) 1.06
Toward self-adjuvanting subunit vaccines: model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines. Bioorg Med Chem Lett (2011) 1.05
Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer. PLoS One (2012) 1.04
Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines. J Med Chem (2012) 1.02
Cryoelectron tomography reveals the sequential assembly of bacterial flagella in Borrelia burgdorferi. Proc Natl Acad Sci U S A (2013) 1.02
Identification of Vibrio cholerae type III secretion system effector proteins. Infect Immun (2011) 1.01
Bound to shock: protection from lethal endotoxemic shock by a novel, nontoxic, alkylpolyamine lipopolysaccharide sequestrant. Antimicrob Agents Chemother (2007) 1.01
Ischemia/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation. J Pediatr Surg (2005) 1.00
Lysine-spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants. Bioorg Med Chem (2005) 0.99
Effective Nissen fundoplication length and bougie diameter size in young children undergoing laparoscopic Nissen fundoplication. J Pediatr Surg (2002) 0.98
Anti-endotoxin agents. 1. Development of a fluorescent probe displacement method optimized for the rapid identification of lipopolysaccharide-binding agents. Comb Chem High Throughput Screen (2004) 0.97
Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models. Hum Vaccin (2010) 0.97
Laparoscopic patch repair of diaphragmatic hernias with Surgisis. J Pediatr Surg (2005) 0.94
IL-10 is not protective in intestinal ischemia reperfusion injury. J Surg Res (2002) 0.94
Structure-activity relationships in nucleotide oligomerization domain 1 (Nod1) agonistic γ-glutamyldiaminopimelic acid derivatives. J Med Chem (2011) 0.94
Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides. J Med Chem (2011) 0.93
Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists. Bioorg Med Chem (2011) 0.93
Complex peptidyl nucleoside antibiotics: efficient syntheses of the glycosyl nucleoside amino acid cores. J Org Chem (2004) 0.92
The parental perspective regarding the contralateral inguinal region in a child with a known unilateral inguinal hernia. J Pediatr Surg (2004) 0.91
Controlling plasma protein binding: structural correlates of interactions of hydrophobic polyamine endotoxin sequestrants with human serum albumin. Mol Pharm (2009) 0.91
Structure-activity relationships in human Toll-like receptor 2-specific monoacyl lipopeptides. J Med Chem (2012) 0.90
High-resolution solution structure of a designed peptide bound to lipopolysaccharide: transferred nuclear Overhauser effects, micelle selectivity, and anti-endotoxic activity. Biochemistry (2007) 0.90
Structure-activity relationships in lipopolysaccharide neutralizers: design, synthesis, and biological evaluation of a 540-membered amphipathic bisamide library. J Comb Chem (2006) 0.89
Potent adjuvantic activity of a CCR1-agonistic bis-quinoline. Bioorg Med Chem Lett (2011) 0.88
Molecular modeling analysis of the interaction of novel bis-cationic ligands with the lipid A moiety of lipopolysaccharide. Bioorg Med Chem Lett (2005) 0.87
Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide. Bioorg Med Chem (2007) 0.87
Total synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B). Org Lett (2005) 0.87
Polycationic sulfonamides for the sequestration of endotoxin. J Med Chem (2007) 0.87
Novel endotoxin-sequestering compounds with terephthalaldehyde-bis-guanylhydrazone scaffolds. Bioorg Med Chem Lett (2006) 0.87
Pharmacokinetics of DS-96, an alkylpolyamine lipopolysaccharide sequestrant, in rodents. J Pharm Sci (2008) 0.87
Structural correlation between lipophilicity and lipopolysaccharide-sequestering activity in spermine-sulfonamide analogs. Bioorg Med Chem Lett (2006) 0.86
Synthesis of a highly water-soluble derivative of amphotericin B with attenuated proinflammatory activity. Mol Pharm (2009) 0.85
Anti-endotoxin agents. 2. Pilot high-throughput screening for novel lipopolysaccharide-recognizing motifs in small molecules. Comb Chem High Throughput Screen (2004) 0.85
Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system. Bioorg Med Chem Lett (2003) 0.85
Structure-activity relationships in Toll-like receptor 7 agonistic 1H-imidazo[4,5-c]pyridines. Org Biomol Chem (2013) 0.85
Design and development of stable, water-soluble, human Toll-like receptor 2 specific monoacyl lipopeptides as candidate vaccine adjuvants. J Med Chem (2013) 0.84
Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines. J Med Chem (2013) 0.84
Structure-activity relationships in human Toll-like receptor 8-active 2,3-diamino-furo[2,3-c]pyridines. J Med Chem (2012) 0.83
Structure-based design of novel human Toll-like receptor 8 agonists. ChemMedChem (2014) 0.83
Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity relationship (QSAR) of diverse heterocyclic scaffolds. J Med Chem (2014) 0.83
Toll-like receptor-8 agonistic activities in C2, C4, and C8 modified thiazolo[4,5-c]quinolines. Org Biomol Chem (2013) 0.83
Synthetic studies on amipurimycin: total synthesis of a thymine nucleoside analogue. J Org Chem (2008) 0.83
Anti-endotoxin agents. 3. Rapid identification of high-affinity lipopolysaccharide-binding compounds in a substituted polyamine library. Comb Chem High Throughput Screen (2006) 0.82
Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines. Curr Drug Targets (2012) 0.82
Structure-activity relationships of lipopolysaccharide sequestration in guanylhydrazone-bearing lipopolyamines. Bioorg Med Chem (2008) 0.82
From dioxin to drug lead--the development of 2,3,7,8-tetrachlorophenothiazine. ChemMedChem (2007) 0.81
Structure-activity relationships of antimicrobial and lipoteichoic acid-sequestering properties in polyamine sulfonamides. Antimicrob Agents Chemother (2008) 0.81
Antibacterial activities of Groebke-Blackburn-Bienaymé-derived imidazo[1,2-a]pyridin-3-amines. Bioorg Med Chem (2012) 0.81
Thyroid transcription factor-1 expression in the human neonatal tracheoesophageal fistula. J Pediatr Surg (2002) 0.81
Interactions of a designed peptide with lipopolysaccharide: Bound conformation and anti-endotoxic activity. Biochem Biophys Res Commun (2008) 0.80
Intramolecular azide-alkyne [3 + 2] cycloaddition: versatile route to new heterocyclic structural scaffolds. Org Biomol Chem (2009) 0.80
Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines. J Med Chem (2014) 0.79
Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin. J Org Chem (2010) 0.79
Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells. Bioorg Med Chem Lett (2005) 0.79
Sledding injuries: a rationale for helmet usage. J Trauma (2010) 0.79
Structure-activity relationships of lipopolysaccharide sequestration in N-alkylpolyamines. Bioorg Med Chem Lett (2009) 0.78
De novo synthetic route to a combinatorial library of peptidyl nucleosides. Nucleosides Nucleotides Nucleic Acids (2008) 0.78
An efficient and highly stereocontrolled route to bulgecinine hydrochloride. J Org Chem (2004) 0.77
Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines. Open Biochem J (2013) 0.77
Functionalized dendrimers as endotoxin sponges. Bioorg Med Chem Lett (2005) 0.77
Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin. Mol Pharm (2010) 0.76