Published in J Clin Invest on March 01, 2006
The role of liver-derived insulin-like growth factor-I. Endocr Rev (2009) 1.87
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Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study. Br J Cancer (2008) 1.05
Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors. J Biol Chem (2011) 1.01
High constitutive activity is an intrinsic feature of ghrelin receptor protein: a study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs. J Biol Chem (2011) 0.99
Ghrelin: central and peripheral implications in anorexia nervosa. Front Endocrinol (Lausanne) (2013) 0.90
Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor. Mol Pharmacol (2009) 0.89
Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications. Int J Pept (2010) 0.88
An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3. Endocrinology (2007) 0.86
The growth hormone secretagogue receptor: its intracellular signaling and regulation. Int J Mol Sci (2014) 0.84
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GHS-R1a constitutive activity and its physiological relevance. Front Neurosci (2013) 0.81
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity. PLoS One (2010) 0.77
The influence of estrogens on the biological and therapeutic actions of growth hormone in the liver. Pharmaceuticals (Basel) (2012) 0.77
Estrogens regulate the hepatic effects of growth hormone, a hormonal interplay with multiple fates. Front Endocrinol (Lausanne) (2013) 0.76
Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. Br J Pharmacol (2014) 0.75
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes (2001) 7.54
Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest (2005) 3.92
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev (2004) 3.79
Molecular mechanism of 7TM receptor activation--a global toggle switch model. Annu Rev Pharmacol Toxicol (2006) 3.33
Absence of ghrelin protects against early-onset obesity. J Clin Invest (2005) 2.53
High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist. Mol Endocrinol (2003) 1.97
Ghrelin--a hormone with multiple functions. Front Neuroendocrinol (2004) 1.88
Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin. J Neurosci (2004) 1.79
Constitutive endocytic cycle of the CB1 cannabinoid receptor. J Biol Chem (2004) 1.70
Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab (2004) 1.58
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest (2004) 1.55
Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem (2004) 1.49
Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature. J Clin Invest (2006) 1.44
Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature. J Clin Endocrinol Metab (2004) 1.17
Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Trends Pharmacol Sci (2004) 1.15
Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors. Trends Pharmacol Sci (2005) 1.09
Clinical endocrinology and metabolism. Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach. Best Pract Res Clin Endocrinol Metab (2004) 0.97
Is ghrelin a signal for the development of metabolic systems? J Clin Invest (2005) 0.92
Inverse agonism gains weight. Trends Pharmacol Sci (2003) 0.90
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
Ligand binding and micro-switches in 7TM receptor structures. Trends Pharmacol Sci (2009) 2.33
High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist. Mol Endocrinol (2003) 1.97
GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Endocrinology (2013) 1.89
High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3. Mol Pharmacol (2005) 1.86
The chemokine system -- a major regulator of angiogenesis in health and disease. APMIS (2004) 1.72
Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes. Traffic (2002) 1.65
GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology (2006) 1.60
Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities. J Virol (2002) 1.56
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. J Biol Chem (2003) 1.50
Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem (2004) 1.49
Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor. Biochemistry (2003) 1.40
Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation. J Biol Chem (2006) 1.35
The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma. J Immunol (2005) 1.35
The minor binding pocket: a major player in 7TM receptor activation. Trends Pharmacol Sci (2010) 1.35
A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab (2008) 1.35
Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity. J Biol Chem (2006) 1.32
A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology (2012) 1.31
A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors. J Biol Chem (2009) 1.25
Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s). J Pharmacol Exp Ther (2007) 1.22
Structural biology: A moving story of receptors. Nature (2008) 1.22
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biol Chem (2003) 1.20
GPR119 as a fat sensor. Trends Pharmacol Sci (2012) 1.20
Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Trends Pharmacol Sci (2004) 1.15
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab (2013) 1.14
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. J Biol Chem (2007) 1.13
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol (2005) 1.11
NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype. Mol Pharmacol (2002) 1.08
Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor. Mol Endocrinol (2007) 1.07
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol Endocrinol (2005) 1.07
Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74. Virology (2004) 1.06
CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor. J Biol Chem (2004) 1.01
Enteroendocrine cell types revisited. Curr Opin Pharmacol (2013) 1.00
Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. J Biol Chem (2008) 0.99
Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation. J Biol Chem (2010) 0.99
Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype. Mol Endocrinol (2004) 0.97
Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem (2007) 0.96
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. Endocrinology (2009) 0.96
Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors. J Biol Chem (2002) 0.94
Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation. J Med Chem (2011) 0.94
Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe. Ann N Y Acad Sci (2003) 0.93
Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor. Mol Pharmacol (2008) 0.93
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem (2011) 0.92
GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors. Curr Top Med Chem (2006) 0.91
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. FEBS Lett (2008) 0.90
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry. FEBS Lett (2003) 0.90
GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue. Mol Endocrinol (2007) 0.89
Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. J Biol Chem (2007) 0.89
Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI. Mol Pharmacol (2006) 0.88
Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. Mol Pharmacol (2007) 0.88
Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors. Chembiochem (2014) 0.87
Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting. FEBS Lett (2004) 0.87
The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation. J Virol (2003) 0.87
Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer. Mol Pharmacol (2007) 0.87
MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes (2010) 0.86
PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation. J Biol Chem (2012) 0.85
Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor. Mol Pharmacol (2006) 0.84
The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins. J Biol Chem (2004) 0.84
β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia. Int J Endocrinol (2011) 0.84
A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39. Biochemistry (2008) 0.84
Virally encoded chemokines and chemokine receptors in the role of viral infections. Contrib Microbiol (2003) 0.84
Single-chain vascular endothelial growth factor variant with antagonist activity. J Biol Chem (2002) 0.83
Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist. J Virol (2004) 0.83
The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR. Biochemistry (2006) 0.83
Dissecting signaling and functions of adhesion G protein-coupled receptors. Ann N Y Acad Sci (2012) 0.83
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6. J Biol Chem (2003) 0.83
Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop. J Biol Chem (2012) 0.83
G protein-coupled receptor modulation with pepducins: moving closer to the clinic. Ann N Y Acad Sci (2011) 0.82
An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J Med Chem (2012) 0.81
Unique interaction pattern for a functionally biased ghrelin receptor agonist. J Biol Chem (2011) 0.81
The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor. J Biol Chem (2012) 0.81
PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions. PLoS One (2013) 0.80
Interaction of a non-peptide agonist with angiotensin II AT1 receptor mutants. Can J Physiol Pharmacol (2002) 0.79
Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism. FASEB J (2011) 0.79
Construction of covalently coupled, concatameric dimers of 7TM receptors. J Recept Signal Transduct Res (2009) 0.79
Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V. Mol Pharmacol (2006) 0.78
Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor. J Virol (2007) 0.77
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity. PLoS One (2010) 0.77
Viral leads for chemokine-modulatory drugs. Trends Pharmacol Sci (2003) 0.77
Model-based Discovery of Synthetic Agonists for the Zn<sup<2+</sup>-sensing G Protein Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions. J Med Chem (2017) 0.75