Published in Diabetes on April 01, 2006
Whole genome expression profiling associates activation of unfolded protein response with impaired production and release of epinephrine after recurrent hypoglycemia. PLoS One (2017) 1.39
Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia. Diabetes (2008) 1.33
Bringing light to the dark side of insulin: a journey across the blood-brain barrier. Diabetes (2008) 1.30
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell Mol Life Sci (2010) 1.27
Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo. Diabetes (2010) 1.26
Sweet talk in the brain: glucosensing, neural networks, and hypoglycemic counterregulation. Front Neuroendocrinol (2009) 1.25
Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann N Y Acad Sci (2011) 1.11
Neuroendocrine responses to hypoglycemia. Ann N Y Acad Sci (2010) 1.10
Small decrements in systemic glucose provoke increases in hypothalamic blood flow prior to the release of counterregulatory hormones. Diabetes (2008) 1.08
Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia. Am J Physiol Endocrinol Metab (2010) 1.06
Increased GABAergic output in the ventromedial hypothalamus contributes to impaired hypoglycemic counterregulation in diabetic rats. Diabetes (2011) 1.00
Influence of VMH fuel sensing on hypoglycemic responses. Trends Endocrinol Metab (2013) 0.91
Modulation of β-adrenergic receptors in the ventromedial hypothalamus influences counterregulatory responses to hypoglycemia. Diabetes (2011) 0.90
Effects of antecedent GABAA activation with alprazolam on counterregulatory responses to hypoglycemia in healthy humans. Diabetes (2010) 0.86
Glucose sensing during hypoglycemia: lessons from the lab. Diabetes Care (2009) 0.84
Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats. Diabetes (2015) 0.83
Brain glucose sensing, glucokinase and neural control of metabolism and islet function. Diabetes Obes Metab (2014) 0.82
Lactate-induced release of GABA in the ventromedial hypothalamus contributes to counterregulatory failure in recurrent hypoglycemia and diabetes. Diabetes (2013) 0.82
Mechanisms of hypoglycemia and exercise-associated autonomic dysfunction. Trans Am Clin Climatol Assoc (2014) 0.80
Central but not systemic lipid infusion augments the counterregulatory response to hypoglycemia. Am J Physiol Endocrinol Metab (2009) 0.80
Partial blockade of nicotinic acetylcholine receptors improves the counterregulatory response to hypoglycemia in recurrently hypoglycemic rats. Am J Physiol Endocrinol Metab (2014) 0.80
Initial experience with seven tesla magnetic resonance spectroscopy of hypothalamic GABA during hyperinsulinemic euglycemia and hypoglycemia in healthy humans. Magn Reson Med (2013) 0.78
2. Hypoglycemia Detection. Transl Endocrinol Metab (2012) 0.78
Effects of Antecedent GABA A Receptor Activation on Counterregulatory Responses to Exercise in Healthy Man. Diabetes (2015) 0.78
Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia. Mol Metab (2015) 0.77
Posttranscriptional regulation of adrenal TH gene expression contributes to the maladaptive responses triggered by insulin-induced recurrent hypoglycemia. Physiol Rep (2015) 0.77
Inhibition of deprivation-induced food intake by GABA(A) antagonists: roles of the hypothalamic, endocrine and alimentary mechanisms. J Clin Biochem Nutr (2012) 0.75
Effects of γ-Aminobutyric Acid A Receptor Activation on Counterregulatory Responses to Subsequent Exercise in Individuals With Type 1 Diabetes. Diabetes (2016) 0.75
Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetes. Br J Pharmacol (2016) 0.75
Obesity and the metabolic syndrome in children and adolescents. N Engl J Med (2004) 13.99
Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med (2002) 11.32
Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. JAMA (2013) 4.30
Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25
Implementation of a safe and effective insulin infusion protocol in a medical intensive care unit. Diabetes Care (2004) 3.13
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab (2007) 3.02
Do sensor glucose levels accurately predict plasma glucose concentrations during hypoglycemia and hyperinsulinemia? Diabetes Care (2002) 2.15
Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia. Diabetes (2003) 1.97
Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits. Diabetes Care (2010) 1.91
Experience with the continuous glucose monitoring system in a medical intensive care unit. Diabetes Technol Ther (2004) 1.76
Prevention or delay of type 2 diabetes. Diabetes Care (2004) 1.73
Influence of an early-onset age of type 1 diabetes on cerebral structure and cognitive function. Diabetes Care (2005) 1.72
Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiol Learn Mem (2010) 1.70
Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways. Cell Metab (2007) 1.70
Extracellular metabolites in the cortex and hippocampus of epileptic patients. Ann Neurol (2005) 1.55
The influence of insulin on circulating ghrelin. Am J Physiol Endocrinol Metab (2003) 1.54
Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia. J Cereb Blood Flow Metab (2002) 1.48
Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses. Diabetes (2004) 1.43
Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia. Diabetes (2007) 1.42
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. J Clin Invest (2011) 1.42
The normal glucose tolerance continuum in obese youth: evidence for impairment in beta-cell function independent of insulin resistance. J Clin Endocrinol Metab (2004) 1.35
Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia. Diabetes (2008) 1.33
Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels. Diabetes Care (2012) 1.32
Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation. J Clin Invest (2006) 1.30
Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia. Diabetes (2006) 1.30
Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats. Diabetes (2005) 1.27
Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo. Diabetes (2010) 1.26
Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. Diabetes (2009) 1.21
Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus. Diabetes (2004) 1.21
Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. J Clin Invest (2013) 1.20
Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia. Diabetes (2003) 1.20
NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. Proc Natl Acad Sci U S A (2007) 1.19
Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration. Endocrinology (2008) 1.18
Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation. Diabetes (2003) 1.17
Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivo. Diabetes (2009) 1.16
Hypoglycemia in type 1 diabetes. Diabetes (2010) 1.13
Effect of recurrent hypoglycemia on spatial cognition and cognitive metabolism in normal and diabetic rats. Diabetes (2004) 1.12
Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation. Diabetes (2006) 1.11
A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice. Diabetes (2002) 1.10
ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia. Diabetes (2007) 1.09
From artificial cerebro-spinal fluid (aCSF) to artificial extracellular fluid (aECF): microdialysis perfusate composition effects on in vivo brain ECF glucose measurements. J Neurosci Methods (2004) 1.09
Small decrements in systemic glucose provoke increases in hypothalamic blood flow prior to the release of counterregulatory hormones. Diabetes (2008) 1.08
LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans. Cell Metab (2013) 1.08
Antecedent hypercortisolemia is not primarily responsible for generating hypoglycemia-associated autonomic failure. Diabetes (2006) 1.07
Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia. Am J Physiol Endocrinol Metab (2010) 1.06
The physiology and pathophysiology of the neural control of the counterregulatory response. Am J Physiol Regul Integr Comp Physiol (2011) 1.03
Identification of critical amino acid residues on human dihydrofolate reductase protein that mediate RNA recognition. Nucleic Acids Res (2002) 1.03
Increased GABAergic output in the ventromedial hypothalamus contributes to impaired hypoglycemic counterregulation in diabetic rats. Diabetes (2011) 1.00
Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation. Diabetes (2009) 1.00
Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation. Am J Physiol Endocrinol Metab (2007) 0.99
Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain. Am J Physiol Endocrinol Metab (2011) 0.97
The prevention or delay of type 2 diabetes. Diabetes Care (2003) 0.95
Insulin-induced hypoglycemia and its effect on the brain: unraveling metabolism by in vivo nuclear magnetic resonance. Diabetes (2011) 0.95
The prevention of type 2 diabetes mellitus. Endocrinol Metab Clin North Am (2005) 0.92
The medial amygdalar nucleus: a novel glucose-sensing region that modulates the counterregulatory response to hypoglycemia. Diabetes (2010) 0.92
Modulation of β-adrenergic receptors in the ventromedial hypothalamus influences counterregulatory responses to hypoglycemia. Diabetes (2011) 0.90
Modulation of memory with septal injections of morphine and glucose: effects on extracellular glucose levels in the hippocampus. Physiol Behav (2005) 0.89
Body mass index, metabolic factors, and striatal activation during stressful and neutral-relaxing states: an FMRI study. Neuropsychopharmacology (2010) 0.89
Radix astragali (huangqi) as a treatment for defective hypoglycemia counterregulation in diabetes. Am J Chin Med (2010) 0.88
5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells. J Cell Mol Med (2007) 0.87
Long-term, intermittent, insulin-induced hypoglycemia produces marked obesity without hyperphagia or insulin resistance: a model for weight gain with intensive insulin therapy. Am J Physiol Endocrinol Metab (2012) 0.87
Ex vivo and in vivo evaluation of the norepinephrine transporter ligand [11C]MRB for brown adipose tissue imaging. Nucl Med Biol (2012) 0.87
Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance. Obesity (Silver Spring) (2015) 0.87
Diabetes. Can tight glycemic control in diabetes benefit cognition? Nat Rev Neurol (2012) 0.87
The sharing partnership for innovative research in translation (SPIRiT) consortium: a model for collaboration across CTSA sites. Clin Transl Sci (2013) 0.86
In situ evidence that peripheral insulin resistance in adolescents with poorly controlled type 1 diabetes is associated with impaired suppression of lipolysis: a microdialysis study. Pediatr Res (2003) 0.86
Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart. Proc Natl Acad Sci U S A (2013) 0.85
Peripheral glucose homeostasis: does brain insulin matter? J Clin Invest (2011) 0.85
AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels. J Bioenerg Biomembr (2013) 0.84
Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia. J Clin Endocrinol Metab (2003) 0.84
EphA5-EphrinA5 interactions within the ventromedial hypothalamus influence counterregulatory hormone release and local glutamine/glutamate balance during hypoglycemia. Diabetes (2012) 0.84