PubRank

Binghui Shen

Author PubWeight™ 65.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell 2004 3.33
2 Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat Med 2007 2.48
3 Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily. Cell 2011 2.44
4 Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. Mol Cell 2008 2.12
5 Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol 2008 1.95
6 Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression. Mol Cell 2012 1.76
7 Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Mol Cell 2012 1.63
8 Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. EMBO Rep 2005 1.56
9 CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J 2003 1.45
10 Okazaki fragment maturation: nucleases take centre stage. J Mol Cell Biol 2011 1.42
11 Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice. Mol Cell Biol 2007 1.37
12 Functional regulation of FEN1 nuclease and its link to cancer. Nucleic Acids Res 2010 1.35
13 PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans. Biochem Biophys Res Commun 2003 1.30
14 Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding. Nat Chem Biol 2010 1.29
15 Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1. J Biol Chem 2008 1.27
16 The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis. J Biol Chem 2009 1.27
17 Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J 2013 1.25
18 Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease. J Mol Biol 2005 1.19
19 Concerted action of exonuclease and Gap-dependent endonuclease activities of FEN-1 contributes to the resolution of triplet repeat sequences (CTG)n- and (GAA)n-derived secondary structures formed during maturation of Okazaki fragments. J Biol Chem 2006 1.17
20 Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers. Mol Cancer Res 2008 1.10
21 The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations. Nucleic Acids Res 2006 1.09
22 Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk. Hum Mutat 2009 1.08
23 Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes. Cancer Res 2002 1.08
24 Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability. Am J Hum Genet 2013 1.05
25 Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways. J Mol Biol 2007 1.05
26 Distinct roles of two Mg2+ binding sites in regulation of murine flap endonuclease-1 activities. Biochemistry 2002 1.03
27 Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair. Mol Cell Biol 2008 1.02
28 Three tandem HRDC domains have synergistic effect on the RecQ functions in Deinococcus radiodurans. DNA Repair (Amst) 2006 1.00
29 Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer. Cell Res 2011 0.98
30 Deinococcus radiodurans PprI switches on DNA damage response and cellular survival networks after radiation damage. Mol Cell Proteomics 2008 0.98
31 Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. Nucleic Acids Res 2009 0.98
32 Search for apoptotic nucleases in yeast: role of Tat-D nuclease in apoptotic DNA degradation. J Biol Chem 2005 0.97
33 Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues. Biochemistry 2005 0.96
34 Expression of Deinococcus radiodurans PprI enhances the radioresistance of Escherichia coli. DNA Repair (Amst) 2003 0.95
35 Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression. Nat Commun 2012 0.95
36 Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance. J Biol Chem 2008 0.93
37 Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome. Cancer Res 2002 0.92
38 Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2. DNA Repair (Amst) 2012 0.92
39 Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in alpha-segment processing during Okazaki fragment maturation. Biochemistry 2003 0.92
40 The wonders of flap endonucleases: structure, function, mechanism and regulation. Subcell Biochem 2012 0.90
41 A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians. Mech Ageing Dev 2009 0.90
42 Mutational spectra of p53 in geographically localized esophageal squamous cell carcinoma groups in China. Cancer 2004 0.89
43 High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice. Mutat Res 2011 0.88
44 Dual negative regulatory mechanisms of RecX on RecA functions in radiation resistance, DNA recombination and consequent genome instability in Deinococcus radiodurans. DNA Repair (Amst) 2005 0.87
45 The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage. Exp Cell Res 2006 0.86
46 Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination. J Biol Chem 2002 0.85
47 Interaction interface of human flap endonuclease-1 with its DNA substrates. J Biol Chem 2004 0.85
48 B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity. Mol Cancer Res 2013 0.85
49 LexA analog (dra0074) is a regulatory protein that is irrelevant to recA induction. J Biochem 2004 0.84
50 Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability. DNA Repair (Amst) 2003 0.84
51 Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma. Melanoma Res 2011 0.81
52 DNA2, a new player in telomere maintenance and tumor suppression. Cell Cycle 2013 0.79
53 Suppression of Saccharomyces cerevisiae rad27 null mutant phenotypes by the 5' nuclease domain of Escherichia coli DNA polymerase I. Curr Genet 2002 0.77
54 The DNase domain-containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development. Cell Cycle 2012 0.76
55 Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature 2016 0.75
56 FEN1-mediated α-segment error editing during Okazaki fragment maturation. Cell Cycle 2015 0.75
57 Examining the roles of DNA2 during mammalian end resection. Cell Cycle 2012 0.75