Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.

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Published in Protein Sci on April 01, 2006

Authors

Steven M Dunn1, Pierre J Rizkallah, Emma Baston, Tara Mahon, Brian Cameron, Ruth Moysey, Feng Gao, Malkit Sami, Jonathan Boulter, Yi Li, Bent K Jakobsen

Author Affiliations

1: Avidex Limited, Abingdon, Oxon, OX14 4RX, UK.

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