Published in Genes Dev on April 17, 2006
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A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell (2010) 2.77
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The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
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CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol (2010) 2.36
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Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster. RNA (2006) 2.26
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Retracted The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin. Mol Cell (2011) 2.07
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Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98. Cell Death Dis (2010) 1.98
Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns. Breast Cancer Res (2010) 1.97
The quest for the 1p36 tumor suppressor. Cancer Res (2008) 1.95
The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia. Blood (2008) 1.95
Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog (2010) 1.94
Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J (2009) 1.94
miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis. Oncotarget (2010) 1.92
Cancer epigenetics: linking basic biology to clinical medicine. Cell Res (2011) 1.88
Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc Natl Acad Sci U S A (2010) 1.83
Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer. Cancer Res (2009) 1.80
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Brain function and chromatin plasticity. Nature (2010) 1.75
The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat Struct Mol Biol (2009) 1.75
Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells. PLoS One (2008) 1.72
Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit. J Cell Biol (2007) 1.72
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Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30
The Polycomb group protein EZH2 directly controls DNA methylation. Nature (2005) 13.67
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature (2003) 12.06
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The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood (2005) 2.99
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Polycomb group proteins in cell cycle progression and cancer. Cell Cycle (2004) 1.94
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Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J (2004) 1.88
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Identification of target genes of the p16INK4A-pRB-E2F pathway. J Biol Chem (2003) 1.83
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell (2013) 1.78
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Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol (2005) 1.61
ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res (2009) 1.60
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol (2009) 1.55
E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep (2005) 1.51
Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J (2011) 1.50
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J Biol Chem (2004) 1.46
Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells. Mol Cell (2012) 1.43
Epigenetic control of embryonic stem cell fate. J Exp Med (2010) 1.40
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Haematologica (2013) 1.40
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia. Cancer Cell (2013) 1.38
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J Cell Biol (2011) 1.34
The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors. Clin Cancer Res (2011) 1.26
A role for ADAM12 in breast tumor progression and stromal cell apoptosis. Cancer Res (2005) 1.24
Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36. Mol Cell Proteomics (2010) 1.23
ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. J Cell Sci (2003) 1.21
Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells. Nucleic Acids Res (2011) 1.16
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat Cell Biol (2013) 1.16
A role for the transcription factor HEY1 in glioblastoma. J Cell Mol Med (2008) 1.16
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation. Genome Biol (2013) 1.13
Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry. Nat Genet (2002) 1.13
Reduced hepatic tumor incidence in cyclin G1-deficient mice. Hepatology (2003) 1.12
NPAT expression is regulated by E2F and is essential for cell cycle progression. Mol Cell Biol (2003) 1.12
Middle-down hybrid chromatography/tandem mass spectrometry workflow for characterization of combinatorial post-translational modifications in histones. Proteomics (2014) 1.11
The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. PLoS Genet (2013) 1.09
The role of p53 and pRB in apoptosis and cancer. Curr Opin Genet Dev (2002) 1.09
The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development. Mol Cell Biol (2014) 1.07
Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells. PLoS One (2013) 1.07
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. Dev Cell (2013) 1.06
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