Published in Exp Cell Res on April 19, 2006
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
Gender specific differences in levels of DNA methylation at selected loci from human total blood: a tendency toward higher methylation levels in males. Hum Genet (2007) 2.36
Global methylation profiles in DNA from different blood cell types. Epigenetics (2011) 1.94
Tissue-specific dysregulation of DNA methylation in aging. Aging Cell (2010) 1.90
Global DNA demethylation during mouse erythropoiesis in vivo. Science (2011) 1.73
Epigenetic mechanisms and the development of asthma. J Allergy Clin Immunol (2012) 1.67
Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry (2013) 1.60
Cigarette smoking and DNA methylation. Front Genet (2013) 1.48
Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis. PLoS Genet (2011) 1.47
Sex- and diet-specific changes of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet. PLoS One (2010) 1.41
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Blood (2011) 1.40
Epigenetics of host-pathogen interactions: the road ahead and the road behind. PLoS Pathog (2012) 1.24
DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study. FASEB J (2012) 1.21
Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem (2009) 1.20
Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancer. Clin Cancer Res (2011) 1.15
Comparison of methods for quantification of global DNA methylation in human cells and tissues. PLoS One (2013) 1.14
Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases. Reprod Toxicol (2007) 1.13
Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes. Neuropsychopharmacology (2009) 1.12
Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. PLoS One (2012) 1.12
Global DNA methylation levels in white blood cell DNA from sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry. Epigenetics (2012) 1.11
SIGMA: a system for integrative genomic microarray analysis of cancer genomes. BMC Genomics (2006) 1.07
Epigenetic epidemiology: promises for public health research. Environ Mol Mutagen (2014) 1.06
Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines. Epigenetics (2011) 1.02
Adult global DNA methylation in relation to pre-natal nutrition. Int J Epidemiol (2011) 1.02
CpG island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancer. J Urol (2008) 1.00
miR-29 represses the activities of DNA methyltransferases and DNA demethylases. Int J Mol Sci (2013) 1.00
Aberrant DNA methylation and prostate cancer. Curr Genomics (2011) 0.98
Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers. Cancer Med (2012) 0.96
A high-throughput and sensitive method to measure global DNA methylation: application in lung cancer. BMC Cancer (2008) 0.95
DNA Methylation Analysis: Choosing the Right Method. Biology (Basel) (2016) 0.95
Prenatal synthetic glucocorticoid treatment changes DNA methylation states in male organ systems: multigenerational effects. Endocrinology (2012) 0.95
Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci. Hum Mol Genet (2011) 0.95
Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex. PLoS One (2013) 0.94
Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics. Mol Cell Biol (2011) 0.92
An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training. Epigenetics (2014) 0.91
Delivery type not associated with global methylation at birth. Clin Epigenetics (2012) 0.90
Genome-wide assays that identify and quantify modified cytosines in human disease studies. Epigenetics Chromatin (2015) 0.88
Global DNA methylation of ischemic stroke subtypes. PLoS One (2014) 0.87
Role of CpG context and content in evolutionary signatures of brain DNA methylation. Epigenetics (2011) 0.86
Epigenetic regulation of glucose transporter 4 by estrogen receptor β. Mol Endocrinol (2011) 0.86
Dietary alleviation of maternal obesity and diabetes: increased resistance to diet-induced obesity transcriptional and epigenetic signatures. PLoS One (2013) 0.85
In utero bisphenol A concentration, metabolism, and global DNA methylation across matched placenta, kidney, and liver in the human fetus. Chemosphere (2014) 0.85
Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth. Biol Reprod (2014) 0.85
Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism. PLoS One (2013) 0.84
Methylome analysis and epigenetic changes associated with menarcheal age. PLoS One (2013) 0.84
DNA methylation is developmentally regulated for genes essential for cardiogenesis. J Am Heart Assoc (2014) 0.83
DNA demethylation by 5-aza-2'-deoxycytidine is imprinted, targeted to euchromatin, and has limited transcriptional consequences. Epigenetics Chromatin (2015) 0.83
Global DNA methylation and risk of subclinical atherosclerosis in young adults: the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Atherosclerosis (2011) 0.83
Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP). PLoS One (2011) 0.81
Global methylation levels in peripheral blood leukocyte DNA by LUMA and breast cancer: a case-control study in Japanese women. Br J Cancer (2014) 0.81
Association of postmenopausal endogenous sex hormones with global methylation level of leukocyte DNA among Japanese women. BMC Cancer (2012) 0.81
Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies. Clin Epigenetics (2017) 0.81
Concordance in hippocampal and fecal Nr3c1 methylation is moderated by maternal behavior in the mouse. Ecol Evol (2012) 0.81
Methyl-Analyzer--whole genome DNA methylation profiling. Bioinformatics (2011) 0.80
DNA methylation, insulin resistance and second-generation antipsychotics in bipolar disorder. Epigenomics (2015) 0.80
Inhibition of proteolysis in histiotrophic nutrition pathways alters DNA methylation and one-carbon metabolism in the organogenesis-stage rat conceptus. J Nutr Biochem (2013) 0.80
Subcutaneous 5-azacitidine treatment of naturally occurring canine urothelial carcinoma: a novel epigenetic approach to human urothelial carcinoma drug development. J Urol (2011) 0.80
Disagreement between two common biomarkers of global DNA methylation. Clin Epigenetics (2016) 0.80
Alterations in DNA methylation corresponding with lung inflammation and as a biomarker for disease development after MWCNT exposure. Nanotoxicology (2015) 0.80
Global DNA methylation changes and differential gene expression in Anaplasma phagocytophilum-infected human neutrophils. Clin Epigenetics (2015) 0.79
Effects of non-CpG site methylation on DNA thermal stability: a fluorescence study. Nucleic Acids Res (2015) 0.79
A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies. Haematologica (2012) 0.79
Mono-2-ethylhexyl phthalate (MEHP) alters histiotrophic nutrition pathways and epigenetic processes in the developing conceptus. J Nutr Biochem (2015) 0.78
Influence of DNMT genotype on global and site specific DNA methylation patterns in neonates and pregnant women. PLoS One (2013) 0.78
Evaluating the effect of ambient particulate pollution on DNA methylation in Alaskan sled dogs: potential applications for a sentinel model of human health. Sci Total Environ (2015) 0.78
Lipid metabolism is associated with developmental epigenetic programming. Sci Rep (2016) 0.77
Experimental approaches to the study of epigenomic dysregulation in ageing. Exp Gerontol (2010) 0.77
FASTmC: A Suite of Predictive Models for Nonreference-Based Estimations of DNA Methylation. G3 (Bethesda) (2015) 0.77
Epigenetic Biomarkers of Breast Cancer Risk: Across the Breast Cancer Prevention Continuum. Adv Exp Med Biol (2016) 0.77
DNA methylation screening and analysis. Methods Mol Biol (2012) 0.77
Clinical and public health research using methylated DNA immunoprecipitation (MeDIP): a comparison of commercially available kits to examine differential DNA methylation across the genome. Epigenetics (2012) 0.77
Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis. Oncotarget (2016) 0.76
Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring. Cell Death Dis (2014) 0.76
Alterations in DNA methylation and airway hyperreactivity in response to in utero exposure to environmental tobacco smoke. Inhal Toxicol (2015) 0.75
Embryonic environment and transgenerational effects in quail. Genet Sel Evol (2017) 0.75
High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion. PLoS One (2016) 0.75
Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth. Nat Genet (2016) 0.75
Role of epigenetic reprogramming of host genes in bacterial pathogenesis. Saudi J Biol Sci (2013) 0.75
DNA isolation method is a source of global DNA methylation variability measured with LUMA. Experimental analysis and a systematic review. PLoS One (2013) 0.75
Variation of global DNA methylation levels with age and in autistic children. Hum Genomics (2016) 0.75
The Role of Dietary Extra Virgin Olive Oil and Corn Oil on the Alteration of Epigenetic Patterns in the Rat DMBA-Induced Breast Cancer Model. PLoS One (2015) 0.75
Prenatal environmental tobacco smoke exposure increases allergic asthma risk with methylation changes in mice. Environ Mol Mutagen (2017) 0.75
Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med (2013) 9.65
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature (2007) 5.54
FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res (2007) 3.79
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
The Swedish Twin Registry in the third millennium: an update. Twin Res Hum Genet (2006) 3.58
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell (2013) 3.31
Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. N Engl J Med (2003) 3.07
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage. Genes Dev (2010) 2.90
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. Int J Cancer (2008) 2.84
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res (2005) 2.57
The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res (2007) 2.54
Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. Kidney Int (2005) 2.42
RNA cytosine methylation analysis by bisulfite sequencing. Nucleic Acids Res (2008) 2.42
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells. Nat Struct Mol Biol (2013) 2.33
An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform. Epigenetics (2013) 2.28
The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells. Blood (2008) 2.24
No evidence for heritability of Parkinson disease in Swedish twins. Neurology (2004) 2.10
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res (2006) 2.07
MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression. Cell Cycle (2011) 2.06
Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage. Mol Cell (2009) 2.05
Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet (2010) 2.03
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
MicroRNA expression profiles associated with mutational status and survival in malignant melanoma. J Invest Dermatol (2010) 1.93
Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. Blood (2011) 1.92
CCR5 deletion protects against inflammation-associated mortality in dialysis patients. J Am Soc Nephrol (2009) 1.88
5-methylcytosine in RNA: detection, enzymatic formation and biological functions. Nucleic Acids Res (2009) 1.85
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling. Cancer Res (2007) 1.85
Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells. Cancer Res (2010) 1.82
Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology (2002) 1.82
Pheochromocytoma and functional paraganglioma syndrome: no longer the 10% tumor. J Surg Oncol (2005) 1.78
Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. Ann Med (2007) 1.77
Genetic gating of human fear learning and extinction: possible implications for gene-environment interaction in anxiety disorder. Psychol Sci (2009) 1.76
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis. Nat Struct Mol Biol (2012) 1.75
Using LUMA: a Luminometric-based assay for global DNA-methylation. Epigenetics (2006) 1.74
Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs. Am J Hum Genet (2009) 1.73
Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle (2007) 1.71
A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients. Kidney Int Suppl (2003) 1.69
Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy. Int J Cancer (2008) 1.64
Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression. Blood (2011) 1.63
Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi. Nucleic Acids Res (2005) 1.63
A Dnmt2-like protein mediates DNA methylation in Drosophila. Development (2003) 1.61
Solving the Dnmt2 enigma. Chromosoma (2010) 1.59
Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines. Biochem Pharmacol (2007) 1.56
Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid carcinoma. Thyroid (2010) 1.51
Alterations of the SDHD gene locus in midgut carcinoids, Merkel cell carcinomas, pheochromocytomas, and abdominal paragangliomas. Genes Chromosomes Cancer (2002) 1.51
Mechanisms of Interferon-alpha induced apoptosis in malignant cells. Oncogene (2002) 1.50
Multigenic control of disease severity after virulent Mycobacterium tuberculosis infection in mice. Infect Immun (2003) 1.48
The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing. Hum Mutat (2015) 1.46
Genetic polymorphisms in monoamine systems and outcome of cognitive behavior therapy for social anxiety disorder. PLoS One (2013) 1.44
Dnmt2-dependent methylomes lack defined DNA methylation patterns. Proc Natl Acad Sci U S A (2013) 1.43
Azacytidine causes complex DNA methylation responses in myeloid leukemia. Mol Cancer Ther (2008) 1.43
Sex- and diet-specific changes of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet. PLoS One (2010) 1.41
MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion. J Biol Chem (2012) 1.39
Characterization of DNA demethylation effects induced by 5-Aza-2'-deoxycytidine in patients with myelodysplastic syndrome. Cancer Res (2005) 1.38
Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin. J Biol Chem (2002) 1.38
Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers. Proc Natl Acad Sci U S A (2006) 1.37
DNA methyltransferase inhibitors for cancer therapy. Cancer J (2007) 1.37
The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma. Endocr Relat Cancer (2011) 1.35
Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells. Exp Hematol (2008) 1.34
The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD. Mol Biol Cell (2007) 1.33
Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset. FASEB J (2012) 1.33
Validation of endogenous controls for quantitative gene expression analysis: application on brain cortices of human chronic alcoholics. Brain Res (2006) 1.29
Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas. Clin Cancer Res (2005) 1.29
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. Mol Biol Cell (2005) 1.29
Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics. Addict Biol (2011) 1.27
RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2. PLoS Genet (2013) 1.25
Two substrates are better than one: dual specificities for Dnmt2 methyltransferases. Trends Biochem Sci (2006) 1.24
Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines. Cancer Res (2009) 1.24
Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. J Biol Chem (2004) 1.24
Two Chinese families with pulverulent congenital cataracts and deltaG91 CRYBA1 mutations. Mol Vis (2007) 1.23
CRY2 is associated with depression. PLoS One (2010) 1.23
DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1. Exp Cell Res (2009) 1.22
A novel locus (RP33) for autosomal dominant retinitis pigmentosa mapping to chromosomal region 2cen-q12.1. Hum Genet (2006) 1.22
Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription. PLoS One (2008) 1.21
Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster. Nat Commun (2012) 1.21
Adenovirus-36 is associated with obesity in children and adults in Sweden as determined by rapid ELISA. PLoS One (2012) 1.20
Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach. Mol Divers (2010) 1.20
Capillary electrophoretic analysis of genomic DNA methylation levels. Nucleic Acids Res (2003) 1.19
Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system. PLoS One (2007) 1.19
Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines. PLoS One (2011) 1.19
The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Cancer Cell (2003) 1.18
Maturation of the hypothalamic arcuate agouti-related protein system during postnatal development in the mouse. Brain Res Dev Brain Res (2005) 1.18
DNA methylation with a sting: an active DNA methylation system in the honeybee. Bioessays (2007) 1.17
The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element. Proc Natl Acad Sci U S A (2009) 1.17
Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors. PLoS One (2010) 1.17