Obesity and asthma.

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Published in Am J Respir Crit Care Med on April 20, 2006

Authors

David A Beuther1, Scott T Weiss, E Rand Sutherland

Author Affiliations

1: National Jewish Medical and Research Center, 1400 Jackson Street, J220, Denver, CO 80206, USA.

Associated clinical trials:

Is Asthma in Subjects With Obstructive Sleep Apnoea (OSA) Due to Dysanapsis | NCT04142905

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On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. PLoS Genet (2009) 1.39

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Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol (2009) 1.38

Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. Am J Clin Nutr (2006) 1.38

The effects of airway microbiome on corticosteroid responsiveness in asthma. Am J Respir Crit Care Med (2013) 1.36