Published in Free Radic Biol Med on January 19, 2006
Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta (2012) 1.89
A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1 alpha. J Cell Sci (2006) 1.20
A simple and sensitive assay for ascorbate using a plate reader. Anal Biochem (2007) 1.06
An Assay for the Rate of Removal of Extracellular Hydrogen Peroxide by Cells. Redox Biol (2013) 1.01
Enhancing photodynamyc therapy efficacy by combination therapy: dated, current and oncoming strategies. Cancers (Basel) (2011) 0.90
Effect of ascorbic acid and hydrogen peroxide on mouse neuroblastoma cells. Mol Med Rep (2012) 0.79
Concentration dependence of vitamin C in combinations with vitamin E and zeaxanthin on light-induced toxicity to retinal pigment epithelial cells. Photochem Photobiol (2012) 0.78
Roles of hydrophilicities and hydrophobicities of dye and sacrificial electron donor on the photochemical pathway. J Photochem Photobiol A Chem (2012) 0.77
Catalase in vitro. Methods Enzymol (1984) 27.79
Photodynamic therapy. J Natl Cancer Inst (1998) 12.83
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med (2001) 11.92
How does photodynamic therapy work? Photochem Photobiol (1992) 4.49
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A (1996) 4.45
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A (2005) 3.30
Catalytic metals, ascorbate and free radicals: combinations to avoid. Radiat Res (1996) 2.68
Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem (1990) 2.33
In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals. J Biochem Biophys Methods (1988) 2.22
Photophysical and photosensitizing properties of benzoporphyrin derivative monoacid ring A (BPD-MA). Photochem Photobiol (1994) 1.42
Lifetime and diffusion of singlet oxygen in a cell. J Phys Chem B (2005) 1.39
The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide. Antioxid Redox Signal (2001) 1.39
Mechanisms of lipid peroxidation. J Free Radic Biol Med (1985) 1.36
Hyperoxia increases H2O2 production by brain in vivo. J Appl Physiol (1985) (1987) 1.20
Differential effects and transport kinetics of ascorbate derivatives in leukemic cell lines. Anticancer Res (1998) 1.20
Analysis of ascorbic acid and dehydroascorbic acid in biological samples. Methods Enzymol (1999) 1.19
Assay of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase. J Immunol Methods (1990) 1.18
Effect of freezing and thawing rates on denaturation of proteins in aqueous solutions. Biotechnol Bioeng (2003) 1.12
The effects of plasma lipoproteins on in vitro tumor cell killing and in vivo tumor photosensitization with benzoporphyrin derivative. Photochem Photobiol (1991) 1.10
Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms. J Biol Chem (1995) 1.08
Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid. Blood (1994) 1.08
Efficient transport and accumulation of vitamin C in HL-60 cells depleted of glutathione. J Biol Chem (1997) 1.07
BPD-MA-mediated photosensitization in vitro and in vivo: cellular adhesion and beta1 integrin expression in ovarian cancer cells. Br J Cancer (1999) 1.07
Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells. Cancer Res (1997) 1.04
Quantitative determination of water- and lipid-soluble antioxidants in neoplastic and non-neoplastic human breast tissue. Int J Cancer (1989) 1.04
Myeloperoxidase is involved in H2O2-induced apoptosis of HL-60 human leukemia cells. J Biol Chem (2000) 1.03
Benzophenothiazine and benzoporphyrin derivative combination phototherapy effectively eradicates large murine sarcomas. Photochem Photobiol (1996) 1.03
Photosensitising potency of structural analogues of benzoporphyrin derivative (BPD) in a mouse tumour model. Br J Cancer (1991) 1.02
Unequivocal evidence in support of the nonenzymatic redox coupling between glutathione/glutathione disulfide and ascorbic acid/dehydroascorbic acid. Biochim Biophys Acta (1992) 1.00
Intracellular accumulation of ascorbic acid is inhibited by flavonoids via blocking of dehydroascorbic acid and ascorbic acid uptakes in HL-60, U937 and Jurkat cells. J Nutr (2000) 1.00
Subcellular, time-resolved studies of singlet oxygen in single cells. J Am Chem Soc (2005) 1.00
Responses of vascular endothelial oxidant metabolism to lipopolysaccharide and tumor necrosis factor-alpha. Arch Biochem Biophys (1992) 0.98
Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells. Arch Biochem Biophys (2005) 0.95
Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy. Br J Cancer (1999) 0.95
Quenching of singlet oxygen by biomolecules from L1210 leukemia cells. Photochem Photobiol (1992) 0.93
Photodynamic treatment with benzoporphyrin derivative monoacid ring A produces protein tyrosine phosphorylation events and DNA fragmentation in murine P815 cells. Photochem Photobiol (1998) 0.91
Enhancement of etoposide (VP-16) cytotoxicity by enzymatic and photodynamically induced oxidative stress. Anticancer Drugs (1997) 0.89
Measurement of vitamin C in blood components by high-performance liquid chromatography. Implication in assessing vitamin C status. Ann N Y Acad Sci (1987) 0.88
Increased efficacy of in vitro Photofrin photosensitization of human oral squamous cell carcinoma by iron and ascorbate. J Photochem Photobiol B (1997) 0.88
Hydrogen peroxide and hydroxyl free radical production by hematoporphyrin derivative, ascorbate and light. Cancer Lett (1985) 0.86
Singlet oxygen quenchers and the photodynamic inactivation of E. coli ribosomes by methylene blue. Biochem Biophys Res Commun (1976) 0.84
Production of lipid-derived free radicals in L1210 murine leukemia cells is an early oxidative event in the photodynamic action of Photofrin. Photochem Photobiol (1997) 0.83
Porphyrin-mediated photosensitization - taking the apoptosis fast lane. Curr Opin Drug Discov Devel (2000) 0.82
Photodynamic therapy with systemic administration of photosensitizers in dermatology. J Photochem Photobiol B (1996) 0.80
Ascorbate-assisted, phthalocyanine-sensitized photohaemolysis of human erythrocytes. Int J Radiat Biol (1992) 0.79
[Selective-occlusive method of drug administration in the treatment of experimental liver tumors]. Khirurgiia (Mosk) (2001) 0.78
Uptake and cytotoxicity of ascorbic acid and dehydroascorbic acid in neuroblastoma (SK-N-SH) and neuroectodermal (SK-N-LO) cells. Anticancer Res (1994) 0.78
Dye-mediated photolysis is capable of eliminating drug-resistant (MDR+) tumor cells. Blood (1993) 0.78
Hypericin and photodynamic treatment do not interfere with transport of vitamin C during respiratory burst. Free Radic Res (2004) 0.78
Time-resolved studies of singlet-oxygen emission from L1210 leukemia cells labeled with 5-(N-hexadecanoyl)amino eosin. A comparison with a one-dimensional model of singlet-oxygen diffusion and quenching. Photochem Photobiol (1993) 0.77
Simultaneous and ultrarapid determination of reactive oxygen species and reduced glutathione in apoptotic leukemia cells by microchip electrophoresis. Electrophoresis (2005) 0.77
Singlet oxygen chemiluminescence at gas-liquid interfaces: theoretical analysis with a one-dimensional model of singlet oxygen quenching and diffusion. Arch Biochem Biophys (1994) 0.76
[Effect of hematoporphyrin derivative (HPD) plus light on DNA repair synthesis and enhancement of HPD photosensitization by vitamin C in mouse hepatoma]. Zhonghua Zhong Liu Za Zhi (1992) 0.76
Quenching of singlet oxygen by human red cell ghosts. Photochem Photobiol (1991) 0.76
[Effect of ascorbate on the permeation and photosensitizing activity of hematoporphyrin derivative (HPD) in tumor]. Zhonghua Zhong Liu Za Zhi (1997) 0.76
Relative sensitivity of leukemic (CML) and normal progenitor cells to treatment with the photosensitizer benzoporphyrin derivative and light. J Hematother (1993) 0.76
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A (2005) 3.30
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A (2007) 2.71
Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem (2004) 1.94
Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta (2012) 1.89
Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT. Int J Radiat Oncol Biol Phys (2009) 1.83
Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide. Free Radic Biol Med (2010) 1.61
Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer. Clin Cancer Res (2010) 1.57
A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state. Free Radic Biol Med (2006) 1.50
Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species. J Biol Chem (2002) 1.47
Free radical and drug oxidation products in an intensive care unit sedative: propofol with sulfite. Crit Care Med (2003) 1.44
Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones. J Org Chem (2008) 1.38
The rate of oxygen utilization by cells. Free Radic Biol Med (2011) 1.36
Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells. Oncogene (2005) 1.30
Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Oncogene (2005) 1.26
Semiquinone radicals from oxygenated polychlorinated biphenyls: electron paramagnetic resonance studies. Chem Res Toxicol (2008) 1.25
Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone. J Biol Chem (2011) 1.19
Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones. Proc Natl Acad Sci U S A (2009) 1.19
Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha. Antioxid Redox Signal (2009) 1.13
Milk from mothers of both premature and full-term infants provides better antioxidant protection than does infant formula. Pediatr Res (2002) 1.08
A simple and sensitive assay for ascorbate using a plate reader. Anal Biochem (2007) 1.06
Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells. Free Radic Biol Med (2008) 1.03
The rate of cellular hydrogen peroxide removal shows dependency on GSH: mathematical insight into in vivo H2O2 and GPx concentrations. Free Radic Res (2007) 1.02
Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide. Cancer Res (2008) 1.02
Chronic ethanol consumption decreases murine Langerhans cell numbers and delays migration of Langerhans cells as well as dermal dendritic cells. Alcohol Clin Exp Res (2008) 1.01
An Assay for the Rate of Removal of Extracellular Hydrogen Peroxide by Cells. Redox Biol (2013) 1.01
Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation. Cancer Res (2013) 0.99
Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. Cancer Res (2011) 0.99
MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr) (2011) 0.99
The concentration of glutathione in human erythrocytes is a heritable trait. Free Radic Biol Med (2013) 0.97
Chitosan gallate as a novel potential polysaccharide antioxidant: an EPR study. Carbohydr Res (2009) 0.96
Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle. Cancer Res (2012) 0.96
Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells. Arch Biochem Biophys (2005) 0.95
Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products. Pediatr Res (2002) 0.95
Overexpression of manganese superoxide dismutase promotes the survival of prostate cancer cells exposed to hyperthermia. Free Radic Res (2004) 0.95
Regulation of pancreatic cancer growth by superoxide. Mol Carcinog (2012) 0.94
The heritability of metabolite concentrations in stored human red blood cells. Transfusion (2014) 0.94
Comparing beta-carotene, vitamin E and nitric oxide as membrane antioxidants. Biol Chem (2002) 0.94
CaMKII is essential for the proasthmatic effects of oxidation. Sci Transl Med (2013) 0.93
Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanism. Am J Physiol Cell Physiol (2002) 0.92
Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice. Free Radic Biol Med (2003) 0.91
v-Ha-ras mitogenic signaling through superoxide and derived reactive oxygen species. Mol Carcinog (2002) 0.91
Ascorbate reacts with singlet oxygen to produce hydrogen peroxide. Photochem Photobiol (2007) 0.90
High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages. Am J Respir Cell Mol Biol (2004) 0.89
Nitric oxide as a cellular antioxidant: a little goes a long way. Free Radic Biol Med (2005) 0.89
L-PhGPx expression can be suppressed by antisense oligodeoxynucleotides. Arch Biochem Biophys (2003) 0.88
Aging augments mitochondrial susceptibility to heat stress. Am J Physiol Regul Integr Comp Physiol (2009) 0.88
Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase. Biochem J (2012) 0.87
Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2. Free Radic Biol Med (2011) 0.86
Nitric oxide decreases the stability of DMPO spin adducts. Nitric Oxide (2006) 0.85
Free radicals produced by the oxidation of gallic acid: An electron paramagnetic resonance study. Chem Cent J (2010) 0.84
Inactivation of anthracyclines by serum heme proteins. Chem Res Toxicol (2007) 0.84
Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism. Free Radic Biol Med (2008) 0.84
Detection of lipid radicals using EPR. Antioxid Redox Signal (2004) 0.82
Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements. Nutr J (2010) 0.82
Observation of an unusual electronically distorted semiquinone radical of PCB metabolites in the active site of prostaglandin H synthase-2. Chemosphere (2010) 0.82
Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen. Antioxid Redox Signal (2006) 0.82
Dysregulation of hepatic iron with aging: implications for heat stress-induced oxidative liver injury. Am J Physiol Regul Integr Comp Physiol (2008) 0.82
The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. Resuscitation (2004) 0.82
Endogenous production and exogenous exposure to nitric oxide augment doxorubicin cytotoxicity for breast cancer cells but not cardiac myoblasts. Nitric Oxide (2004) 0.82
Signaling pathways in adenoid cystic cancers: implications for treatment. Cancer Biol Ther (2009) 0.81
UVA/B-induced formation of free radicals from decabromodiphenyl ether. Environ Sci Technol (2009) 0.81
Comment on "Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer," i.e., all we are saying is, give C a chance. Free Radic Biol Med (2011) 0.80
The nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP) increases free radical generation and degrades left ventricular function after myocardial ischemia-reperfusion. Resuscitation (2003) 0.79
Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers. J Pediatr Gastroenterol Nutr (2012) 0.79
Phospholipid hydroperoxide glutathione peroxidase induces a delay in G1 of the cell cycle. Free Radic Res (2003) 0.78
Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes. Am J Physiol Cell Physiol (2007) 0.77
Forkhead box M1 regulates quiescence-associated radioresistance of human head and neck squamous carcinoma cells. Radiat Res (2014) 0.76
Iron supplements and oxidative stress in very low birth weight infants. J Pediatr (2008) 0.75
Monohydroxylated Polybrominated Diphenyl Ethers (OH-PBDEs) and Dihydroxylated Polybrominated Biphenyls (Di-OH-PBBs): Novel Photoproducts of 2,6-Dibromophenol. Environ Sci Technol (2015) 0.75
Introduction to the symposium-in-print: photobiology of the skin and eye in memory of Colin F. Chignell. Photochem Photobiol (2010) 0.75
Electron paramagnetic resonance for quantitation of nitric oxide in aqueous solutions. Methods Enzymol (2002) 0.75
Magnesium reduces free radical concentration and preserves left ventricular function after direct current shocks. Resuscitation (2003) 0.75
The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. Resuscitation (2003) 0.75
Role of nitric oxide and membrane phospholipid polyunsaturation in oxidative cell death. Subcell Biochem (2002) 0.75
O2(⋅-) and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell (2017) 0.75
In vivo detection of transition metals and nitrosyl-heme complexes using ex vivo electron paramagnetic resonance spectroscopy. Methods Mol Biol (2002) 0.75