The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity.

PubWeight™: 1.25‹?› | Rank: Top 10%

🔗 View Article (PMID 16687395)

Published in J Biol Chem on May 10, 2006

Authors

Claudia Haller1, Susanne Rauch, Nico Michel, Sebastian Hannemann, Maik J Lehmann, Oliver T Keppler, Oliver T Fackler

Author Affiliations

1: Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany.

Articles citing this

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells. Nat Med (2012) 4.27

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells. PLoS One (2015) 1.38

HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein. J Biol Chem (2008) 1.38

HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes. J Virol (2009) 1.28

Dual role of Cdc42 in spindle orientation control of adherent cells. Mol Cell Biol (2009) 1.24

Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology (2007) 1.08

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation. Retrovirology (2012) 1.05

Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity. J Virol (2007) 1.04

HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling. PLoS One (2007) 1.02

HIV-1 Nef: a multifaceted modulator of T cell receptor signaling. Cell Commun Signal (2012) 0.99

HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins. J Virol (2014) 0.99

Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling. J Virol (2010) 0.98

How HIV takes advantage of the cytoskeleton in entry and replication. Viruses (2011) 0.96

The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling. Mol Biol Cell (2006) 0.96

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo. Proc Natl Acad Sci U S A (2012) 0.95

Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins. J Virol (2009) 0.94

Viral modulation of T-cell receptor signaling. J Virol (2008) 0.93

HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation. PLoS Pathog (2010) 0.92

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function. Retrovirology (2012) 0.87

Targeting Rho-GTPases in immune cell migration and inflammation. Br J Pharmacol (2014) 0.85

HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J Biol Chem (2014) 0.84

Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2. Retrovirology (2011) 0.84

Nef inhibits glucose uptake in adipocytes and contributes to insulin resistance in human immunodeficiency virus type I infection. J Infect Dis (2011) 0.83

High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain. PLoS One (2012) 0.82

The HIV-1 gp120/V3 modifies the response of uninfected CD4 T cells to antigen presentation: mapping of the specific transcriptional signature. J Transl Med (2011) 0.80

Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef. J Biol Chem (2014) 0.80

Dendritic Cells in HIV-1 and HCV Infection: Can They Help Win the Battle? Virology (Auckl) (2013) 0.79

HIV-1 Nef and T-cell activation: a history of contradictions. Future Virol (2013) 0.78

Rho'ing in and out of cells: viral interactions with Rho GTPase signaling. Small GTPases (2014) 0.78

Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef. Future Virol (2012) 0.78

HIV-1 Infection of T Lymphocytes and Macrophages Affects Their Migration via Nef. Front Immunol (2015) 0.77

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio (2015) 0.77

HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination. J Biol Chem (2012) 0.77

Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor. Viruses (2015) 0.76

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor. J Virol (2016) 0.76

PIP2: choreographer of actin-adaptor proteins in the HIV-1 dance. Trends Microbiol (2014) 0.76

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities. PLoS One (2015) 0.75

Articles by these authors

Semen-derived amyloid fibrils drastically enhance HIV infection. Cell (2007) 5.23

Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. Traffic (2003) 4.61

Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nat Cell Biol (2007) 4.37

HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor. Cell Host Microbe (2009) 4.36

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells. Nat Med (2012) 4.27

HIV-1 buds predominantly at the plasma membrane of primary human macrophages. PLoS Pathog (2007) 2.44

Construction and characterization of a fluorescently labeled infectious human immunodeficiency virus type 1 derivative. J Virol (2004) 2.24

Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry. J Virol (2005) 2.12

Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides. PLoS Biol (2012) 2.03

The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation. Structure (2008) 1.85

Efficient nonviral gene delivery into primary lymphocytes from rats and mice. FASEB J (2006) 1.78

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev (2007) 1.77

Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells. PLoS Pathog (2009) 1.73

Active sites of thioredoxin reductases: why selenoproteins? Proc Natl Acad Sci U S A (2003) 1.69

Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients. Hepatology (2013) 1.68

In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells. J Virol (2003) 1.63

HIV-1 Nef interferes with host cell motility by deregulation of Cofilin. Cell Host Microbe (2009) 1.50

Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency syndrome patients: protease inhibitor-mediated neurotoxicity. Ann Neurol (2006) 1.49

The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4. Curr Biol (2005) 1.48

HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity. J Biol Chem (2009) 1.47

Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu. J Virol (2010) 1.40

In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans. Proc Natl Acad Sci U S A (2011) 1.36

Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1. J Biol Chem (2005) 1.30

HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction. MBio (2011) 1.30

Activation of the Rac-binding partner FHOD1 induces actin stress fibers via a ROCK-dependent mechanism. J Biol Chem (2003) 1.29

Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery. J Biol Chem (2002) 1.24

Versatile biosynthetic engineering of sialic acid in living cells using synthetic sialic acid analogues. J Biol Chem (2001) 1.22

Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. Virology (2006) 1.21

Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts. J Virol (2004) 1.20

The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing. J Biol Chem (2008) 1.20

Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection. J Virol (2006) 1.17

Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses. J Virol (2010) 1.17

Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef. J Virol (2005) 1.13

CTL-mediated selective pressure influences dynamic evolution and pathogenic functions of HIV-1 Nef. J Immunol (2008) 1.13

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1. J Leukoc Biol (2005) 1.12

Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density. Retrovirology (2008) 1.11

HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcription. Proc Natl Acad Sci U S A (2007) 1.09

Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein. PLoS Pathog (2012) 1.08

Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology (2007) 1.08

SH4-domain-induced plasma membrane dynamization promotes bleb-associated cell motility. J Cell Sci (2007) 1.07

Peripheral nerve-derived HIV-1 is predominantly CCR5-dependent and causes neuronal degeneration and neuroinflammation. Virology (2005) 1.07

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release. Retrovirology (2011) 1.07

A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology (2012) 1.06

Conformation-specific display of 4E10 and 2F5 epitopes on self-assembling protein nanoparticles as a potential HIV vaccine. Chem Biol Drug Des (2012) 1.06

Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity. J Virol (2007) 1.04

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes. Cell Res (2013) 1.04

cAMP synthesis and degradation by phagosomes regulate actin assembly and fusion events: consequences for mycobacteria. J Cell Sci (2006) 1.04

Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins. Mol Biol Cell (2002) 1.03

HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling. PLoS One (2007) 1.02

HIV-1 at the immunological and T-lymphocytic virological synapse. Biol Chem (2008) 1.02

Architecture and regulation of the HIV-1 assembly and holding compartment in macrophages. J Virol (2011) 1.00

Tissue-resident macrophages are productively infected ex vivo by primary X4 isolates of human immunodeficiency virus type 1. J Virol (2005) 0.99

HIV-1 Nef: a multifaceted modulator of T cell receptor signaling. Cell Commun Signal (2012) 0.99

FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation. Exp Cell Res (2005) 0.99

Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling. J Virol (2010) 0.98

p21 regulates the HIV-1 restriction factor SAMHD1. Proc Natl Acad Sci U S A (2014) 0.97

Visualizing fusion of pseudotyped HIV-1 particles in real time by live cell microscopy. Retrovirology (2009) 0.97

How HIV takes advantage of the cytoskeleton in entry and replication. Viruses (2011) 0.96

The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling. Mol Biol Cell (2006) 0.96

From experimental setup to bioinformatics: an RNAi screening platform to identify host factors involved in HIV-1 replication. Biotechnol J (2010) 0.96

FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers. J Cell Sci (2013) 0.96

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo. Proc Natl Acad Sci U S A (2012) 0.95

Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration. Retrovirology (2008) 0.95

The exported Plasmodium berghei protein IBIS1 delineates membranous structures in infected red blood cells. Mol Microbiol (2012) 0.95

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling. Blood (2011) 0.95

Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody. Blood (2011) 0.95

Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1. J Virol (2004) 0.94

Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting. Virology (2007) 0.94

Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression. Retrovirology (2007) 0.94

A quantitative measure for alterations in the actin cytoskeleton investigated with automated high-throughput microscopy. Cytometry A (2010) 0.94

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS One (2011) 0.94

Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins. J Virol (2009) 0.94

Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec. Retrovirology (2009) 0.93

Nef does not inhibit F-actin remodelling and HIV-1 cell-cell transmission at the T lymphocyte virological synapse. Eur J Cell Biol (2010) 0.93

Construction and characterization of an HIV-1 group O infectious molecular clone and analysis of vpr- and nef-negative derivatives. Virology (2004) 0.93

Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host. Cell Host Microbe (2012) 0.92

Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo. Retrovirology (2009) 0.91

The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner. J Gen Virol (2006) 0.91

Role of macrophages in HIV infection and persistence. Expert Rev Clin Immunol (2006) 0.90

Glycoprotein H and α4β1 integrins determine the entry pathway of alphaherpesviruses. J Virol (2013) 0.90