Published in J Clin Invest on July 01, 1948
THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES. J Clin Invest (1948) 22.17
THE BLOOD FLOW AND OXYGEN CONSUMPTION OF THE HUMAN BRAIN IN DIABETIC ACIDOSIS AND COMA. J Clin Invest (1948) 10.63
Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci U S A (1999) 3.44
The effects of an acute reduction in blood pressure by means of differential spinal sympathetic block on the cerebral circulation of hypertensive patients. J Clin Invest (1950) 2.77
Effects of hypoxia, hyperoxia, and hypercapnia on baseline and stimulus-evoked BOLD, CBF, and CMRO2 in spontaneously breathing animals. Neuroimage (2005) 2.59
Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI. Magn Reson Med (2008) 2.42
Regional brain blood flow in man during acute changes in arterial blood gases. J Physiol (2012) 2.34
Autoregulation of cerebral blood flow: influence of the arterial blood pressure on the blood flow through the cerebral cortex. J Neurol Neurosurg Psychiatry (1966) 2.15
Imaging oxygen consumption in forepaw somatosensory stimulation in rats under isoflurane anesthesia. Magn Reson Med (2004) 2.12
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury. J Cereb Blood Flow Metab (2005) 2.01
Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI. Magn Reson Med (2009) 1.97
Controlled trial of oxygen in uncomplicated myocardial infarction. Br Med J (1976) 1.95
Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes. Neuron (2015) 1.93
Threshold of response of the cerebral vessels of man to increase in blood carbon dioxide. J Clin Invest (1955) 1.90
The influence of carbon dioxide on brain activity and metabolism in conscious humans. J Cereb Blood Flow Metab (2010) 1.88
Integrative regulation of human brain blood flow. J Physiol (2014) 1.85
Regional cerebral blood flow during volitional breathing in man. J Physiol (1991) 1.84
MRI estimation of global brain oxygen consumption rate. J Cereb Blood Flow Metab (2010) 1.83
Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data. Proc Natl Acad Sci U S A (2001) 1.82
Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation. Hum Brain Mapp (2009) 1.82
The effects of carbon dioxide inhalation upon the cerebral blood flow and cerebral oxygen consumption in vascular disease. J Clin Invest (1953) 1.69
Effects of anesthesia on functional activation of cerebral blood flow and metabolism. Proc Natl Acad Sci U S A (2001) 1.67
Application of medical gases in the field of neurobiology. Med Gas Res (2011) 1.64
Alterations in cerebral metabolic rate and blood supply across the adult lifespan. Cereb Cortex (2010) 1.63
The effects on the respiration and performance during exercise of adding oxygen to the inspired air. J Physiol (1954) 1.61
Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI. J Cereb Blood Flow Metab (2010) 1.60
Raised intracranial pressure in emphysema. Br Med J (1954) 1.57
The influence of moderate hypercapnia on neural activity in the anesthetized nonhuman primate. Cereb Cortex (2008) 1.56
Cerebral circulation and metabolism in sickle cell and other chronic anemias, with observations on the effects of oxygen inhalation. J Clin Invest (1952) 1.56
THE EFFECT OF ANOXIC ANOXIA ON THE HUMAN KIDNEY. J Clin Invest (1949) 1.49
Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: implications for BOLD-fMRI. Neuroimage (2007) 1.45
Is it time to change the approach to oxygen therapy in the breathless patient? Thorax (2007) 1.45
Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans. J Physiol (2006) 1.44
The effects of intravenously administered aminophylline on cerebral circulation and metabolism in man. J Clin Invest (1950) 1.44
The changes in cerebral vascular resistance of man in experimental alkalosis and acidosis. J Clin Invest (1953) 1.44
Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex. Proc Natl Acad Sci U S A (2010) 1.44
Differential blood flow responses to CO₂ in human internal and external carotid and vertebral arteries. J Physiol (2012) 1.43
General and regional circulatory responses to change in blood pH and carbon dioxide tension. J Clin Invest (1961) 1.42
Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat. J Physiol (1988) 1.38
The entry of radiosodium and of bromide into human cerebrospinal fluid. J Neurol Neurosurg Psychiatry (1957) 1.38
An adaptation of the nitrous oxide method to the study of the cerebral circulation in children; normal values for cerebral blood flow and cerebral metabolic rate in childhood. J Clin Invest (1957) 1.37
Studies on the interrelationship between the blood-brain barrier and entry of viruses into the central nervous system. I. The effect of carbon dioxide on type II poliovirus infection in mice. J Exp Med (1962) 1.37
Water content of the brain in anoxic-ischaemic encephalopathy in adult rats. Br J Exp Pathol (1961) 1.37
On the assessment of cerebrovascular reactivity using hypercapnia BOLD MRI. NMR Biomed (2009) 1.36
Effect of hypoxia and hyperoxia on cerebral blood flow, blood oxygenation, and oxidative metabolism. J Cereb Blood Flow Metab (2012) 1.35
Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. J Cereb Blood Flow Metab (2008) 1.35
Effect of acute carbon monoxide poisoning on work capacity; influence of 5% CO2 on rate of recovery. Br Med J (1958) 1.34
Correlative observations on cerebral metabolism and cardiac output in myxedema. J Clin Invest (1950) 1.34
Effects of acidosis on cardiovascular function in surgical patients. Ann Surg (1961) 1.33
Differential responses to CO2 and sympathetic stimulation in the cerebral and femoral circulations in humans. J Physiol (2005) 1.31
Blood-flow magnetic resonance imaging of the retina. Neuroimage (2007) 1.30
Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m. J Physiol (2010) 1.29
Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans. J Physiol (2010) 1.29
Baseline blood oxygenation modulates response amplitude: Physiologic basis for intersubject variations in functional MRI signals. Magn Reson Med (2008) 1.27
Enhanced cerebral CO2 reactivity during strenuous exercise in man. Eur J Appl Physiol (2005) 1.26
UNUSUAL NEUROLOGICAL AND CARDIOVASCULAR COMPLICATIONS OF RESPIRATORY FAILURE. Br Med J (1963) 1.23
Hemodynamic and metabolic changes induced by cocaine in anesthetized rat observed with multimodal functional MRI. Psychopharmacology (Berl) (2006) 1.21
HAEMODYNAMIC EFFECTS OF OXYGEN IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. Br Heart J (1965) 1.21
The ventilatory CO2 sensitivities from Read's rebreathing method and the steady-state method are not equal in man. J Physiol (1989) 1.19
Test-retest reproducibility of a rapid method to measure brain oxygen metabolism. Magn Reson Med (2012) 1.18
Blood flow magnetic resonance imaging of retinal degeneration. Invest Ophthalmol Vis Sci (2008) 1.18
The measure in vivo of regional cerebral oxygen utilization by means of oxyhemoglobin labeled with radioactive oxygen-15. J Clin Invest (1970) 1.17
Characterization of regional heterogeneity in cerebrovascular reactivity dynamics using novel hypocapnia task and BOLD fMRI. Neuroimage (2009) 1.16
The influence of oxygen on the ventilatory response to carbon dioxide in man. J Physiol (1990) 1.14
Evidence for a vascular contribution to diffusion FMRI at high b value. Proc Natl Acad Sci U S A (2007) 1.14
Measuring cerebrovascular reactivity: what stimulus to use? J Physiol (2013) 1.13
Layer-specific anatomical, physiological and functional MRI of the retina. NMR Biomed (2008) 1.13
Determination of whole-brain oxygen extraction fractions by fast measurement of blood T(2) in the jugular vein. Magn Reson Med (2010) 1.13
Cerebral hemodynamics during controlled hypotension induced by the continuous infusion of ganglionic blocking agents (hexamethonium, pendiomide and arfonad). J Clin Invest (1954) 1.13
Comparison of cerebral vascular reactivity measures obtained using breath-holding and CO2 inhalation. J Cereb Blood Flow Metab (2013) 1.12
Control of brain capillary blood flow. J Cereb Blood Flow Metab (2012) 1.12
Baroreflex-induced sympathetic activation does not alter cerebrovascular CO2 responsiveness in humans. J Physiol (2003) 1.12
Low oxygen tension in the management of newborn infants. Arch Dis Child (1957) 1.11
Circulatory effects of fast ventilator rates in preterm infants. Arch Dis Child (1990) 1.10
High temporal resolution MRI quantification of global cerebral metabolic rate of oxygen consumption in response to apneic challenge. J Cereb Blood Flow Metab (2013) 1.09
Notes on a case of congenital heart disease with cyanotic episodes. J Clin Invest (1950) 1.08
The mechanism of the changes in forearm vascular resistance during hypoxia. J Physiol (1958) 1.07
Cerebral hemodynamics in patients with heart failure associated and hypertension and the response to treatment. J Clin Invest (1955) 1.07
Quantitative basal CBF and CBF fMRI of rhesus monkeys using three-coil continuous arterial spin labeling. Neuroimage (2006) 1.07
Cardio- and cerebrovascular responses to the energy drink Red Bull in young adults: a randomized cross-over study. Eur J Nutr (2014) 1.06
Baseline CBF, and BOLD, CBF, and CMRO2 fMRI of visual and vibrotactile stimulations in baboons. J Cereb Blood Flow Metab (2010) 1.05
Dehydration affects cerebral blood flow but not its metabolic rate for oxygen during maximal exercise in trained humans. J Physiol (2014) 1.05
Cerebral blood flow and metabolism in children with severe head injuries. Part 2: Cerebrovascular resistance and its determinants. J Neurol Neurosurg Psychiatry (1995) 1.05
On improving the speed and reliability of T2-relaxation-under-spin-tagging (TRUST) MRI. Magn Reson Med (2011) 1.04
The cerebral vascular response to reduction in arterial carbon dioxide tension. J Clin Invest (1961) 1.04
Hyperoxia: good or bad for the injured brain? Curr Opin Crit Care (2008) 1.04
Magnetic resonance imaging of the retina. Jpn J Ophthalmol (2009) 1.03
Blood oxygenation level-dependent (BOLD)-based techniques for the quantification of brain hemodynamic and metabolic properties - theoretical models and experimental approaches. NMR Biomed (2012) 1.03
Probing ischemic tissue fate with BOLD fMRI of brief oxygen challenge. Brain Res (2011) 1.01
Magnetic resonance imaging of vascular oxygenation changes during hyperoxia and carbogen challenges in the human retina. Invest Ophthalmol Vis Sci (2011) 1.00
Test-retest stability of calibrated BOLD-fMRI in HIV- and HIV+ subjects. Neuroimage (2010) 1.00
Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment. Alzheimers Dement (2013) 0.99
Oxygen therapy in myocardial infarction: an historical perspective. J R Soc Med (2007) 0.99
Extracerebral absorption of near infrared light influences the detection of increased cerebral oxygenation monitored by near infrared spectroscopy. J Neurol Neurosurg Psychiatry (1995) 0.99
THE EFFECT OF BRIEF PROFOUND HYPOXIA UPON THE ARTERIAL AND VENOUS OXYGEN TENSIONS IN MAN. J Physiol (1963) 0.98
Dilated basilar arteries in patients with congenital central hypoventilation syndrome. Neurosci Lett (2009) 0.97
Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia. J Neurosci (2015) 0.97
The effect of basal vasodilation on hypercapnic and hypocapnic reactivity measured using magnetic resonance imaging. J Cereb Blood Flow Metab (2010) 0.95
A neuronal basis for task-negative responses in the human brain. Cereb Cortex (2010) 0.95
COMPARISON OF RESULTS OF THE NORMAL BALLISTOCARDIOGRAM AND A DIRECT FICK METHOD IN MEASURING THE CARDIAC OUTPUT IN MAN. J Clin Invest (1942) 23.16
THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES. J Clin Invest (1948) 22.17
THE EFFECTS OF ACTIVE AND PASSIVE HYPERVENTILATION ON CEREBRAL BLOOD FLOW, CEREBRAL OXYGEN CONSUMPTION, CARDIAC OUTPUT, AND BLOOD PRESSURE OF NORMAL YOUNG MEN. J Clin Invest (1946) 21.94
THE BLOOD FLOW AND OXYGEN CONSUMPTION OF THE HUMAN BRAIN IN DIABETIC ACIDOSIS AND COMA. J Clin Invest (1948) 10.63
THE EFFECTS OF INCREASED INTRACRANIAL PRESSURE ON CEREBRAL CIRCULATORY FUNCTIONS IN MAN. J Clin Invest (1948) 7.15
THE BLOOD FLOW IN THE BRAIN AND THE LEG OF MAN, AND THE CHANGES INDUCED BY ALTERATION OF BLOOD GASES. J Clin Invest (1932) 6.26
THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES. J Clin Invest (1948) 22.17
THE EFFECTS OF ACTIVE AND PASSIVE HYPERVENTILATION ON CEREBRAL BLOOD FLOW, CEREBRAL OXYGEN CONSUMPTION, CARDIAC OUTPUT, AND BLOOD PRESSURE OF NORMAL YOUNG MEN. J Clin Invest (1946) 21.94
Direct observation of kinesin stepping by optical trapping interferometry. Nature (1993) 13.82
THE BLOOD FLOW AND OXYGEN CONSUMPTION OF THE HUMAN BRAIN IN DIABETIC ACIDOSIS AND COMA. J Clin Invest (1948) 10.63
THE EFFECTS OF INCREASED INTRACRANIAL PRESSURE ON CEREBRAL CIRCULATORY FUNCTIONS IN MAN. J Clin Invest (1948) 7.15
THE BLOOD FLOW, VASCULAR RESISTANCE, AND OXYGEN CONSUMPTION OF THE BRAIN IN ESSENTIAL HYPERTENSION. J Clin Invest (1948) 3.95
Nonequilibrium mechanics of active cytoskeletal networks. Science (2007) 3.94
Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. Science (2005) 3.41
Two-dimensional tracking of ncd motility by back focal plane interferometry. Biophys J (1998) 2.38
Enrichment, isolation, and cultural characteristics of marine strains of Clostridium botulinum type C. Appl Microbiol (1971) 2.34
Interference model for back-focal-plane displacement detection in optical tweezers. Opt Lett (1998) 2.34
Bacteriophage capsids: tough nanoshells with complex elastic properties. Proc Natl Acad Sci U S A (2004) 2.30
Conformation and elasticity of the isolated red blood cell membrane skeleton. Biophys J (1992) 2.13
Nanoindentation studies of full and empty viral capsids and the effects of capsid protein mutations on elasticity and strength. Proc Natl Acad Sci U S A (2006) 2.11
Studies of synthetic peptide analogs of the amphipathic helix. Structure of complexes with dimyristoyl phosphatidylcholine. J Biol Chem (1985) 1.89
Signals and noise in micromechanical measurements. Methods Cell Biol (1998) 1.81
Working strokes by single molecules of the kinesin-related microtubule motor ncd. Nat Cell Biol (2000) 1.71
Minimal growth temperature, sodium chloride tolerance, pH sensitivity, and toxin production of marine and terrestrial strains of Clostridium botulinum type C. Appl Microbiol (1971) 1.69
Deformation and collapse of microtubules on the nanometer scale. Phys Rev Lett (2003) 1.64
Effect of sodium chloride and pH on the outgrowth of spores of type E Clostridium botulinum at optimal and suboptimal temperatures. Appl Microbiol (1966) 1.61
Solid-state carbon-13 nuclear magnetic resonance of the lecithin gel to liquid-crystalline phase transition. Biochemistry (1981) 1.59
Solubilization of phosphatidylcholine bilayers by octyl glucoside. Biochemistry (1982) 1.34
Protein tracking and detection of protein motion using atomic force microscopy. Biophys J (1996) 1.28
Monolayer coupling in sphingomyelin bilayer systems. Nature (1978) 1.26
High-frequency stress relaxation in semiflexible polymer solutions and networks. Phys Rev Lett (2006) 1.07
A nuclear magnetic resonance study of sphingomyelin in bilayer systems. Biochemistry (1977) 1.06
Results of the American Association of Bioanalysts national proficiency testing programme in andrology. Hum Reprod (2000) 1.06
Structural and mechanical study of a self-assembling protein nanotube. Nano Lett (2006) 1.06
Correlated fluctuations of microparticles in viscoelastic solutions: quantitative measurement of material properties by microrheology in the presence of optical traps. Phys Rev E Stat Nonlin Soft Matter Phys (2006) 0.97
Fusion of dipalmitoylphosphatidylcholine vesicles. Biochemistry (1980) 0.95
Utilization of an Escherichia coli mutant for carbon-13 enrichment of tRNA for NMR studies. Nucleic Acids Res (1975) 0.94
Vesicle- vesicle interactions in sonicated dispersions of dipalmitoylphosphatidylcholine. Biochemistry (1981) 0.94
Effect of surface curvature on stability, thermodynamic behavior, and osmotic activity of dipalmitoylphosphatidylcholine single lamellar vesicles. Biochemistry (1981) 0.94
Highly processive motility is not a general feature of the kinesins. Eur Biophys J (1998) 0.93
Phosphatidylcholine 13C-labeled carbonyls as a probe of bilayer structure. Biochemistry (1977) 0.92
Transbilayer distribution of phosphatidylethanolamine in large and small unilamellar vesicles. Biochemistry (1981) 0.88
Guanine-uracil base-pairing. Biochem Biophys Res Commun (1972) 0.85
High-frequency microrheology of wormlike micelles. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 0.84
Heat resistance of spores of marine and terrestrial strains of Clostridium botulinum type C. Appl Microbiol (1971) 0.84
Nonspecific toxicites in the mouse assay test for botulinum toxin. Appl Microbiol (1968) 0.83
Imaging microtubules and kinesin decorated microtubules using tapping mode atomic force microscopy in fluids. Eur Biophys J (2000) 0.83
Twin optical traps for two-particle cross-correlation measurements: eliminating cross-talk. Rev Sci Instrum (2008) 0.78
Analysis of cholesterol in all lipoprotein classes by single vertical ultracentrifugation of fingerstick blood and controlled-dispersion flow analysis. Clin Chem (1992) 0.77
Transbilayer distribution in small unilamellar phosphatidylglycerol-phosphatidylcholine vesicles. Biochemistry (1981) 0.77
Differential interference contrast microscopy using light-emitting diode illumination in conjunction with dual optical traps. Rev Sci Instrum (2013) 0.77
Short-time inertial response of viscoelastic fluids: observation of vortex propagation. Phys Rev Lett (2005) 0.77
Cerebral blood flow and metabolism in schizophrenia. The effects of barbiturate semi-narcosis, insulin coma and electroshock. 1948. Am J Psychiatry (1994) 0.76
Short-time inertial response of viscoelastic fluids measured with Brownian motion and with active probes. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 0.76
Pharmacological support for man on long space flights. Proc Natl Acad Sci U S A (1965) 0.75
Multidimensional scaling analysis of the printed media's explanations of the riots of the summer of 1967. J Pers Soc Psychol (1972) 0.75
The early days of the indifferent gas method for measuring cerebral blood flow. J Cereb Blood Flow Metab (1982) 0.75
Pharmacological Support for Men on Long Space Flights. Science (1965) 0.75
[Pulmonary leiomyomas and leiomyosarcomes (author's transl)]. Ann Chir Thorac Cardiovasc (1978) 0.75
Alfred Newton Richards, March 22, 1876-March 24, 1966. Biogr Mem Natl Acad Sci (1971) 0.75
[Pulmonary leiomyomas and leiomyosarcomas. (Presentation of three cases and a review of the literature) (author's transl)]. Schweiz Rundsch Med Prax (1978) 0.75
Instability of myelin tubes under dehydration: deswelling of layered cylindrical structures. Phys Rev E Stat Nonlin Soft Matter Phys (2001) 0.75
Pulmonary hypertension resulting from oxygen exposure. NADC-MR-6802. NADC-MR Rep (1968) 0.75
Alfred Newton Richards. Arch Int Pharmacodyn Ther (1966) 0.75
Personality impression formation as a function of relatedness of information and length of set. J Pers Soc Psychol (1969) 0.75
Effect of cytochrome b5 on the transbilayer distribution of phospholipids in model membranes. Biochemistry (1982) 0.75
New challenges for clinical pharmacology. J Clin Pharmacol J New Drugs (1969) 0.75
Sequential effects in impression formation with binary intermittent responding. J Exp Psychol (1969) 0.75
Alfred Newton Richards 1876-1966. Ann Intern Med (1969) 0.75
High-bandwidth viscoelastic properties of aging colloidal glasses and gels. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 0.75