Robustness trade-offs and host-microbial symbiosis in the immune system.

PubWeight™: 1.46‹?› | Rank: Top 5%

🔗 View Article (PMC 1681473)

Published in Mol Syst Biol on January 17, 2006

Authors

Hiroaki Kitano1, Kanae Oda

Author Affiliations

1: The Systems Biology Institute, Jingumae, Shibuya, Tokyo, Japan. kitano@symbio.jst.go.jp

Articles citing this

Towards a theory of biological robustness. Mol Syst Biol (2007) 3.82

Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-kappaB activation. PLoS Pathog (2008) 2.21

Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci U S A (2011) 2.00

Agent-based models in translational systems biology. Wiley Interdiscip Rev Syst Biol Med (2010) 1.70

A comprehensive map of the mTOR signaling network. Mol Syst Biol (2010) 1.59

Teleost microbiomes: the state of the art in their characterization, manipulation and importance in aquaculture and fisheries. Front Microbiol (2014) 1.39

Hierarchical modularity of nested bow-ties in metabolic networks. BMC Bioinformatics (2006) 1.33

R spider: a network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases. Nucleic Acids Res (2010) 1.26

Interference competition and high temperatures reduce the virulence of fig wasps and stabilize a fig-wasp mutualism. PLoS One (2009) 1.02

Biological robustness: paradigms, mechanisms, and systems principles. Front Genet (2012) 0.99

Detailed qualitative dynamic knowledge representation using a BioNetGen model of TLR-4 signaling and preconditioning. Math Biosci (2008) 0.99

Construction of a large scale integrated map of macrophage pathogen recognition and effector systems. BMC Syst Biol (2010) 0.98

Changes in coral microbial communities in response to a natural pH gradient. ISME J (2012) 0.97

A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans. PLoS Genet (2011) 0.97

Non-coding RNA transcripts: sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease. Neurosci Lett (2009) 0.96

Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system. Theor Biol Med Model (2010) 0.96

Comparing the yeast retrograde response and NF-κB stress responses: implications for aging. Aging Cell (2010) 0.96

A systems biology approach to construct the gene regulatory network of systemic inflammation via microarray and databases mining. BMC Med Genomics (2008) 0.94

Charting the NF-κB pathway interactome map. PLoS One (2012) 0.94

The dual role of dendritic cells in the immune response to human immunodeficiency virus type 1 infection. J Gen Virol (2008) 0.93

Changes in microbial communities associated with the sea anemone Anemonia viridis in a natural pH gradient. Microb Ecol (2012) 0.89

Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition. PLoS One (2013) 0.88

Evolution of bow-tie architectures in biology. PLoS Comput Biol (2015) 0.85

BowTieBuilder: modeling signal transduction pathways. BMC Syst Biol (2009) 0.84

A functional map of NFkappaB signaling identifies novel modulators and multiple system controls. Genome Biol (2007) 0.83

Inference of cancer-specific gene regulatory networks using soft computing rules. Gene Regul Syst Bio (2010) 0.82

A Hierarchical Mechanism of RIG-I Ubiquitination Provides Sensitivity, Robustness and Synergy in Antiviral Immune Responses. Sci Rep (2016) 0.77

Evolving robust gene regulatory networks. PLoS One (2015) 0.77

From mouse genetics to systems biology. Mamm Genome (2007) 0.77

Identification of Major Signaling Pathways in Prion Disease Progression Using Network Analysis. PLoS One (2015) 0.76

Topological properties of robust biological and computational networks. J R Soc Interface (2014) 0.75

The Unspecific Side of Acquired Immunity Against Infectious Disease: Causes and Consequences. Front Microbiol (2016) 0.75

Delineation of key regulatory elements identifies points of vulnerability in the mitogen-activated signaling network. Genome Res (2011) 0.75

Cross-hierarchy systems principles. Curr Opin Syst Biol (2016) 0.75

Articles cited by this

Environmental genome shotgun sequencing of the Sargasso Sea. Science (2004) 45.23

Network biology: understanding the cell's functional organization. Nat Rev Genet (2004) 36.62

Host-bacterial mutualism in the human intestine. Science (2005) 26.39

Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol (2001) 18.80

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12

Functional diversity of helper T lymphocytes. Nature (1996) 18.09

Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol (1977) 17.41

Toll-like receptors and innate immunity. Nat Rev Immunol (2001) 16.50

Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. Appl Environ Microbiol (1999) 16.09

NF-kappaB regulation in the immune system. Nat Rev Immunol (2002) 15.80

CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol (2002) 12.73

A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science (2003) 12.57

Molecular analysis of commensal host-microbial relationships in the intestine. Science (2001) 12.04

Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31

The lineage decisions of helper T cells. Nat Rev Immunol (2002) 10.61

Points of control in inflammation. Nature (2002) 10.61

Biological robustness. Nat Rev Genet (2004) 9.98

Biodiversity and ecosystem productivity in a fluctuating environment: the insurance hypothesis. Proc Natl Acad Sci U S A (1999) 9.93

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci U S A (2002) 9.78

The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med (2002) 9.26

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature (1993) 8.75

Mucosal flora in inflammatory bowel disease. Gastroenterology (2002) 8.42

How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr (2002) 8.31

Inferences, questions and possibilities in Toll-like receptor signalling. Nature (2004) 7.57

Food-web structure and network theory: The role of connectance and size. Proc Natl Acad Sci U S A (2002) 7.14

Robustness of cellular functions. Cell (2004) 6.65

Sequence analysis of peptides bound to MHC class II molecules. Nature (1991) 5.99

Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr (2000) 5.84

Honor thy symbionts. Proc Natl Acad Sci U S A (2003) 5.72

Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol (2003) 5.54

Mechanisms of suppression by suppressor T cells. Nat Immunol (2005) 5.52

Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol (2005) 5.35

Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology (2000) 5.34

Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut (2004) 5.32

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science (2005) 5.25

Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol (2004) 5.24

Dendritic cell regulation of TH1-TH2 development. Nat Immunol (2000) 5.13

Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov (2004) 5.08

Microbial community genomics in the ocean. Nat Rev Microbiol (2005) 4.71

Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov (2003) 4.46

Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology (2001) 4.44

Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology (2003) 4.40

The dynamics of CD4+ T-cell depletion in HIV disease. Nature (2001) 4.37

Complexity and robustness. Proc Natl Acad Sci U S A (2002) 3.88

Regulatory T cells: friend or foe in immunity to infection? Nat Rev Immunol (2004) 3.61

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat Immunol (2001) 3.59

Chemokines as regulators of T cell differentiation. Nat Immunol (2001) 3.37

Bow ties, metabolism and disease. Trends Biotechnol (2004) 3.28

Type 1 T regulatory cells. Immunol Rev (2001) 3.26

The connectivity structure, giant strong component and centrality of metabolic networks. Bioinformatics (2003) 2.73

Bacterial strategies for overcoming host innate and adaptive immune responses. Nat Immunol (2002) 2.33

Adaptors as central mediators of signal transduction in immune cells. Nat Immunol (2003) 2.13

Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med (2003) 2.04

Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol Cell Biol (2002) 1.87

Treatment and prevention of antibiotic associated diarrhea. Int J Antimicrob Agents (2000) 1.80

CD4(+) regulatory T cells. Curr Opin Immunol (2001) 1.78

Phylogenetic diversity, abundance, and axial distribution of bacteria in the intestinal tract of two soil-feeding termites (Cubitermes spp.). Appl Environ Microbiol (2003) 1.77

Microorganisms and autoimmunity: making the barren field fertile? Nat Rev Microbiol (2003) 1.76

Toll-like receptors as potential therapeutic targets for multiple diseases. Nat Rev Drug Discov (2002) 1.75

Highly optimized tolerance: robustness and design in complex systems Phys Rev Lett (2000) 1.73

Scale-rich metabolic networks. Phys Rev Lett (2005) 1.66

The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells. Nat Immunol (2001) 1.63

Molecular mimicry in the MHC: hidden clues to autoimmunity? Immunol Today (1996) 1.60

Colonic bacterial flora: changing understandings in the molecular age. J Nutr (2004) 1.58

Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance. Immunol Rev (1995) 1.58

Targeting enteric bacteria in treatment of inflammatory bowel diseases: why, how, and when. Curr Opin Gastroenterol (2003) 1.54

Probiotic therapy of intestinal inflammation and infections. Curr Opin Gastroenterol (2005) 1.52

Probiotics and gastrointestinal diseases. J Intern Med (2005) 1.47

T(H)1 and T(H)2 cells: a historical perspective. Nat Rev Immunol (2002) 1.40

IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms. Microbes Infect (2001) 1.37

Intestinal microbial flora of the of the American cockroach, Periplaneta americana L. Appl Environ Microbiol (1979) 1.37

Adverse reactions to TNF-alpha inhibitors in rheumatoid arthritis. Lancet (2002) 1.30

Cut and trim: generating MHC class I peptide ligands. Curr Opin Immunol (2001) 1.25

Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies. Joint Bone Spine (2002) 1.11

Presence of eubacteria in biopsies from Crohn's disease inflammatory lesions as determined by 16S rRNA gene-based PCR. J Med Microbiol (1999) 1.01

The functions of mucosal T cells in containing the indigenous commensal flora of the intestine. Cell Mol Life Sci (2002) 0.99

Bacterial flora from the gut of the wild and cultured banana prawn, Penaeus merguiensis. J Appl Microbiol (2002) 0.94

Potent antagonism of Escherichia coli, Bacteroides ovatus, Fusobacterium varium, and Enterococcus faecalis, alone or in combination, for enteropathogens in anaerobic continuous flow cultures. J Med Microbiol (1986) 0.80

Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease? Novartis Found Symp (2004) 0.79

The protective effect of infections on immune disorders. J Pediatr Gastroenterol Nutr (2005) 0.76

Factors influencing potent antagonistic effects of Escherichia coli and Bacteroides ovatus on Staphylococcus aureus in anaerobic continuous flow cultures. Can J Microbiol (1988) 0.76