Published in Cancer Cell on June 01, 2006
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Metabolic genes in cancer: their roles in tumor progression and clinical implications. Biochim Biophys Acta (2010) 1.88
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A (2011) 1.87
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Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy. Proc Natl Acad Sci U S A (2007) 1.63
The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genet (2008) 1.60
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Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. Mol Cell Proteomics (2011) 1.59
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Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins. Blood (2009) 1.57
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Tumour-associated mutant p53 drives the Warburg effect. Nat Commun (2013) 1.52
Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol. Mol Cancer (2010) 1.50
Is cancer a disease of abnormal cellular metabolism? New angles on an old idea. Genet Med (2008) 1.50
Sugar and fat - that's where it's at: metabolic changes in tumors. Breast Cancer Res (2008) 1.49
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On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate. Neoplasia (2011) 1.45
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Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells. Mol Cell Biol (2011) 1.42
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The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. Proc Natl Acad Sci U S A (2009) 1.42
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PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev (2008) 1.38
Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation. J Mol Cell Cardiol (2010) 1.37
Hypoxia, glucose metabolism and the Warburg's effect. J Bioenerg Biomembr (2007) 1.37
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Metformin directly acts on mitochondria to alter cellular bioenergetics. Cancer Metab (2014) 1.34
The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am J Pathol (2008) 1.33
Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis. PLoS Genet (2012) 1.31
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The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R. J Biol Chem (2009) 1.30
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Stable isotope-resolved metabolomics and applications for drug development. Pharmacol Ther (2011) 1.29
Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell (2013) 1.29
AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway. Cancer Biol Ther (2013) 1.28
Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neuro Oncol (2008) 1.27
TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res (2010) 1.27
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer. Br J Cancer (2008) 1.27
STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect. BMC Med (2009) 1.26
TOR and ageing: a complex pathway for a complex process. Philos Trans R Soc Lond B Biol Sci (2011) 1.25
Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells. PLoS One (2012) 1.23
Mitochondrial respiration protects against oxygen-associated DNA damage. Nat Commun (2010) 1.23
The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies. Biochim Biophys Acta (2010) 1.22
Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment. Cell Death Dis (2014) 1.20
Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance. Cancer Res (2013) 1.19
Alterations of metabolic genes and metabolites in cancer. Semin Cell Dev Biol (2012) 1.18
Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3. Mitochondrion (2011) 1.17
Anticancer agents that counteract tumor glycolysis. ChemMedChem (2012) 1.17
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Superoxide activates mitochondrial uncoupling proteins. Nature (2002) 5.43
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab (2006) 5.01
A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell (2008) 4.80
Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat Cell Biol (2002) 3.34
Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity (2004) 3.09
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev (2004) 2.39
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest (2003) 2.35
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell (2002) 2.09
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab (2013) 1.91
miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway. Cell Metab (2010) 1.89
Superoxide and hydrogen peroxide production by Drosophila mitochondria. Free Radic Biol Med (2003) 1.87
Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev (2002) 1.80
A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci U S A (2007) 1.79
PGC1α and mitochondrial metabolism--emerging concepts and relevance in ageing and neurodegenerative disorders. J Cell Sci (2012) 1.73
Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy. Diabetes Care (2010) 1.55
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc Natl Acad Sci U S A (2007) 1.50
RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX. J Cell Sci (2003) 1.43
Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol (2002) 1.30
Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol (2003) 1.25
Placental adiponectin gene DNA methylation levels are associated with mothers' blood glucose concentration. Diabetes (2012) 1.24
Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Curr Biol (2002) 1.19
Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients. Pharmacogenetics (2002) 1.19
Chromosome instability and tumor predisposition inversely correlate with BLM protein levels. DNA Repair (Amst) (2003) 1.18
A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet (2009) 1.16
MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition. Cancer Res (2002) 1.15
Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases. Epigenetics (2013) 1.13
mTOR coordinates protein synthesis, mitochondrial activity and proliferation. Cell Cycle (2015) 1.11
A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene (2004) 1.11
Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint. Mol Cell Biol (2003) 1.09
Carbon source and myc expression influence the antiproliferative actions of metformin. Cancer Res (2012) 1.07
Going with the flow or life in the fast lane: contrasting mitochondrial responses to thermal change. J Exp Biol (2002) 1.03
PGC-1α promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply. Cancer Res (2012) 1.01
Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol Cell Biol (2006) 1.01
Bcl-2-mediated cell survival promotes metastasis of EpH4 betaMEKDD mammary epithelial cells. Mol Cancer Res (2004) 0.99
Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2. Exp Cell Res (2006) 0.99
Three-step model for condensin activation during mitotic chromosome condensation. Cell Cycle (2010) 0.96
Formin 1-isoform IV deficient cells exhibit defects in cell spreading and focal adhesion formation. PLoS One (2008) 0.95
A bifunctional targeted peptide that blocks HER-2 tyrosine kinase and disables mitochondrial function in HER-2-positive carcinoma cells. Cancer Res (2005) 0.94
Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population. Eur J Hum Genet (2007) 0.94
Formin1 disruption confers oligodactylism and alters Bmp signaling. Hum Mol Genet (2009) 0.93
Identifying genes preferentially expressed in undifferentiated embryonic stem cells. BMC Cell Biol (2007) 0.93
Impact of PGC-1α on the topology and rate of superoxide production by the mitochondrial electron transport chain. Free Radic Biol Med (2011) 0.90
Stomatin-like protein 2 deficiency in T cells is associated with altered mitochondrial respiration and defective CD4+ T cell responses. J Immunol (2012) 0.89
F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res (2004) 0.86
The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol (2007) 0.85
Adaptive plasticity of skeletal muscle energetics in hibernating frogs: mitochondrial proton leak during metabolic depression. J Exp Biol (2002) 0.84
Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. J Immunol (2009) 0.81
Primary causes of decreased mitochondrial oxygen consumption during metabolic depression in snail cells. Am J Physiol Regul Integr Comp Physiol (2002) 0.81
Epigenetic dysregulation of the IGF system in placenta of newborns exposed to maternal impaired glucose tolerance. Epigenomics (2014) 0.77
Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis. Oncogene (2002) 0.77
Low plasma adiponectin exacerbates the risk of premature coronary artery disease in familial hypercholesterolemia. Atherosclerosis (2006) 0.76
The RNA code: nature's Rosetta Stone. Proc Natl Acad Sci U S A (2014) 0.75
zeta-/- Thalassemic mice are affected by two modifying loci and display unanticipated somatic recombination leading to inherited variation. Hum Mol Genet (2005) 0.75
An interview with... Philip Leder. Interview by Errol C. Friedberg. Nat Rev Mol Cell Biol (2008) 0.75