Published in BMJ on June 12, 2006
Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS | NCT00461643
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med (2014) 3.57
Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2013) 2.43
Treatment options for polycystic ovary syndrome. Int J Womens Health (2011) 1.25
Unlicensed use of metformin in children and adolescents in the UK. Br J Clin Pharmacol (2012) 1.09
Fertility treatment in women with polycystic ovary syndrome: a decision analysis of different oral ovulation induction agents. Fertil Steril (2010) 0.95
Metformin in the treatment of infertility in polycystic ovarian syndrome: an alternative perspective. Fertil Steril (2008) 0.93
The management of patients with polycystic ovary syndrome. Nat Rev Endocrinol (2014) 0.88
Managing anovulatory infertility and polycystic ovary syndrome. BMJ (2007) 0.88
Inconsistent reporting of surrogate outcomes in randomised clinical trials: cohort study. BMJ (2010) 0.87
Metformin: direct inhibition of rat ovarian theca-interstitial cell proliferation. Fertil Steril (2012) 0.87
Comparison between Unilateral and Bilateral Ovarian Drilling in Clomiphene Citrate Resistance Polycystic Ovary Syndrome Patients: A Randomized Clinical Trial of Efficacy. Int J Fertil Steril (2015) 0.85
Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome? Hum Reprod (2008) 0.85
Impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women: do we need a new drug? J Clin Endocrinol Metab (2008) 0.83
Role of metformin in the management of polycystic ovary syndrome. Ther Adv Endocrinol Metab (2010) 0.82
Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective study. Reprod Biol Endocrinol (2010) 0.81
Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients. J Assist Reprod Genet (2009) 0.81
Metformin therapy in a hyperandrogenic anovulatory mutant murine model with polycystic ovarian syndrome characteristics improves oocyte maturity during superovulation. J Ovarian Res (2011) 0.80
Acupuncture and clomiphene citrate for live birth in polycystic ovary syndrome: study design of a randomized controlled trial. Evid Based Complement Alternat Med (2013) 0.80
Impaired oocyte quality induced by dehydroepiandrosterone is partially rescued by metformin treatment. PLoS One (2015) 0.80
Drugs for anovulatory infertility in polycystic ovary syndrome. BMJ (2006) 0.79
The M-OVIN study: does switching treatment to FSH and / or IUI lead to higher pregnancy rates in a subset of women with world health organization type II anovulation not conceiving after six ovulatory cycles with clomiphene citrate - a randomised controlled trial. BMC Womens Health (2013) 0.78
Enhanced ovarian folliclular development by metformin does not correlate with pregnancy rate: a randomized trial. Int J Fertil Steril (2012) 0.77
Reproductive endocrinology: live birth prediction in polycystic ovary syndrome. Nat Rev Endocrinol (2010) 0.76
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis. BMJ (2017) 0.76
A woman with polycystic ovary syndrome treated for infertility by in vitro fertilization. Nat Rev Endocrinol (2009) 0.75
Incorporating patient preference into the management of infertility in women with polycystic ovary syndrome. Patient Prefer Adherence (2012) 0.75
Altered Circulating Inflammatory Cytokines Are Associated with Anovulatory Polycystic Ovary Syndrome (PCOS) Women Resistant to Clomiphene Citrate Treatment. Med Sci Monit (2017) 0.75
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod (2004) 12.27
Incidence of early loss of pregnancy. N Engl J Med (1988) 9.21
Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev (1997) 5.83
Polycystic ovary syndrome. N Engl J Med (1995) 5.30
Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes (1989) 3.74
Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. N Engl J Med (1996) 2.77
Influence of past reproductive performance on risk of spontaneous abortion. BMJ (1989) 2.44
Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism (1994) 2.04
Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med (1998) 2.04
Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome. Cochrane Database Syst Rev (2003) 1.80
Efficacy of metformin in type II diabetes: results of a double-blind, placebo-controlled, dose-response trial. Am J Med (1997) 1.69
Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. Fertil Steril (2002) 1.57
Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab (2002) 1.53
Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril (2001) 1.43
Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab (1989) 1.16
Defects in beta-cell function in functional ovarian hyperandrogenism. J Clin Endocrinol Metab (1993) 1.16
A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. Fertil Steril (2002) 1.02
High singleton live birth rate following classical ovulation induction in normogonadotrophic anovulatory infertility (WHO 2). Hum Reprod (2003) 1.01
What is polycystic ovarian syndrome? A proposal for a consensus on the definition and diagnosis of polycystic ovarian syndrome. Hum Reprod (2002) 1.01
Insulin regulation of human ovarian androgens. Hum Reprod (1997) 0.98
Hyperandrogenism, insulin resistance and acanthosis nigricans. 10 years of progress. J Reprod Med (1994) 0.83
Use of clomiphene citrate in women. Fertil Steril (2003) 0.83
The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol (2003) 16.17
QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med (2011) 15.02
Preoperative biliary drainage for cancer of the head of the pancreas. N Engl J Med (2010) 10.21
Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet (2003) 7.91
The diagnostic odds ratio: a single indicator of test performance. J Clin Epidemiol (2003) 7.54
Sources of variation and bias in studies of diagnostic accuracy: a systematic review. Ann Intern Med (2004) 6.87
In vitro fertilization with preimplantation genetic screening. N Engl J Med (2007) 5.26
Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med (2010) 5.06
Systematic reviews of diagnostic test accuracy. Ann Intern Med (2008) 4.84
Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection. Nat Genet (2003) 3.97
Exploring sources of heterogeneity in systematic reviews of diagnostic tests. Stat Med (2002) 3.61
Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging--a meta-analysis. Radiology (2004) 3.55
High mutation rates have driven extensive structural polymorphism among human Y chromosomes. Nat Genet (2006) 3.46
Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report. Lancet Oncol (2011) 3.36
Evidence of bias and variation in diagnostic accuracy studies. CMAJ (2006) 3.34
Estimation of residual glomerular filtration rate in dialysis patients from the plasma cystatin C level. Nephrol Dial Transplant (2007) 2.53
Diagnostic test accuracy may vary with prevalence: implications for evidence-based diagnosis. J Clin Epidemiol (2008) 2.50
Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Crit Care (2010) 2.50
The effect of contraindications and patient preference on dialysis modality selection in ESRD patients in The Netherlands. Am J Kidney Dis (2004) 2.40
Imaging strategies for detection of urgent conditions in patients with acute abdominal pain: diagnostic accuracy study. BMJ (2009) 2.35
Predictors of the rate of decline of residual renal function in incident dialysis patients. Kidney Int (2002) 2.12
Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis. N Engl J Med (2003) 2.12
Serum and urine cystatin C are poor biomarkers for acute kidney injury and renal replacement therapy. Intensive Care Med (2010) 2.01
Case-control and two-gate designs in diagnostic accuracy studies. Clin Chem (2005) 1.98
Assessing the value of diagnostic tests: a framework for designing and evaluating trials. BMJ (2012) 1.93
Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients. Nephrol Dial Transplant (2010) 1.90
Effect of starting with hemodialysis compared with peritoneal dialysis in patients new on dialysis treatment: a randomized controlled trial. Kidney Int (2003) 1.87
A change in the Dutch Directive on Medical Research Involving Human Subjects strongly increases the number of eligible intensive care patients: an observational study. Intensive Care Med (2006) 1.85
Colorectal liver metastases: CT, MR imaging, and PET for diagnosis--meta-analysis. Radiology (2005) 1.84
Mineral metabolism and cardiovascular morbidity and mortality risk: peritoneal dialysis patients compared with haemodialysis patients. Nephrol Dial Transplant (2006) 1.76
Effectiveness of human menopausal gonadotropin versus recombinant follicle-stimulating hormone for controlled ovarian hyperstimulation in assisted reproductive cycles: a meta-analysis. Fertil Steril (2003) 1.71
Therapeutic delay and survival after surgery for cancer of the pancreatic head with or without preoperative biliary drainage. Ann Surg (2010) 1.70
Decreased androgen concentrations and diminished general and sexual well-being in women with premature ovarian failure. Menopause (2008) 1.68
The role of metformin in polycystic ovary syndrome: a systematic review. Hum Reprod Update (2007) 1.67
The relative importance of residual renal function compared with peritoneal clearance for patient survival and quality of life: an analysis of the Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD )-2. Am J Kidney Dis (2003) 1.66
Techniques and reasons to remain interested in the Y chromosome. Fertil Steril (2006) 1.66
Is there a place for corifollitropin alfa in IVF/ICSI cycles? A systematic review and meta-analysis. Fertil Steril (2012) 1.66
Propagation of human spermatogonial stem cells in vitro. JAMA (2009) 1.64
In vitro propagation of human prepubertal spermatogonial stem cells. JAMA (2011) 1.63
Relative contribution of residual renal function and different measures of adequacy to survival in hemodialysis patients: an analysis of the Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD)-2. J Am Soc Nephrol (2004) 1.62
The Kidney Disease Outcomes Quality Initiative (K/DOQI) Guideline for Bone Metabolism and Disease in CKD: association with mortality in dialysis patients. Am J Kidney Dis (2005) 1.60
Differences between univariate and bivariate models for summarizing diagnostic accuracy may not be large. J Clin Epidemiol (2009) 1.58
Healthy overweight male partners of subfertile couples should not worry about their semen quality. Fertil Steril (2009) 1.58
Ultrasonography, computed tomography and magnetic resonance imaging for diagnosis and determining resectability of pancreatic adenocarcinoma: a meta-analysis. J Comput Assist Tomogr (2005) 1.56
A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. Genomics (2004) 1.56
Publication and reporting of test accuracy studies registered in ClinicalTrials.gov. Clin Chem (2013) 1.55
Computed tomographic colonography compared with colonoscopy in patients at increased risk for colorectal cancer. Gastroenterology (2004) 1.55
Effects of antiretroviral therapy on semen quality. AIDS (2008) 1.54
Cardiovascular consequences of famine in the young. Eur Heart J (2011) 1.53
A systematic review finds that diagnostic reviews fail to incorporate quality despite available tools. J Clin Epidemiol (2005) 1.51
Prediction models in reproductive medicine: a critical appraisal. Hum Reprod Update (2009) 1.50
How to adjust for comorbidity in survival studies in ESRD patients: a comparison of different indices. Am J Kidney Dis (2002) 1.49
Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med (2005) 1.48
Hemodialysis and peritoneal dialysis: comparison of adjusted mortality rates according to the duration of dialysis: analysis of The Netherlands Cooperative Study on the Adequacy of Dialysis 2. J Am Soc Nephrol (2003) 1.48
The fetal origins of hypertension: a systematic review and meta-analysis of the evidence from animal experiments of maternal undernutrition. J Hypertens (2012) 1.46
Time-course of cytokines during delirium in elderly patients with hip fractures. J Am Geriatr Soc (2008) 1.45
Cytokines and acute phase response in delirium. J Psychosom Res (2007) 1.42
Semen analysis and prediction of natural conception. Hum Reprod (2014) 1.41
Using the principles of randomized controlled trial design to guide test evaluation. Med Decis Making (2009) 1.40
Immobilisation versus immediate mobilisation after intrauterine insemination: randomised controlled trial. BMJ (2009) 1.40
The clinical value of daily routine chest radiographs in a mixed medical-surgical intensive care unit is low. Crit Care (2006) 1.37
Impaired insulin secretion after prenatal exposure to the Dutch famine. Diabetes Care (2006) 1.32
Urinary hMG versus recombinant FSH for controlled ovarian hyperstimulation following an agonist long down-regulation protocol in IVF or ICSI treatment: a systematic review and meta-analysis. Hum Reprod (2007) 1.32
Reporting quality of diagnostic accuracy studies: a systematic review and meta-analysis of investigations on adherence to STARD. Evid Based Med (2013) 1.30
A systematic review and meta-analysis of diagnostic performance of imaging in acute cholecystitis. Radiology (2012) 1.29
Inappropriate use of the faecal occult blood test in a university hospital in the Netherlands. Eur J Gastroenterol Hepatol (2012) 1.28
Quantifying the added value of a diagnostic test or marker. Clin Chem (2012) 1.28
Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum Reprod (2007) 1.27
Variation of a test's sensitivity and specificity with disease prevalence. CMAJ (2013) 1.27
No beneficial effect of preimplantation genetic screening in women of advanced maternal age with a high risk for embryonic aneuploidy. Hum Reprod (2008) 1.26
Proposals for a phased evaluation of medical tests. Med Decis Making (2009) 1.25
A guide for diagnostic evaluations. Nat Rev Microbiol (2006) 1.25
Diagnosing vasovagal syncope based on quantitative history-taking: validation of the Calgary Syncope Symptom Score. Eur Heart J (2009) 1.24
Ovarian volume and antral follicle count for the prediction of low and hyper responders with in vitro fertilization. Reprod Biol Endocrinol (2007) 1.23
Full loss of residual renal function causes higher mortality in dialysis patients; findings from a marginal structural model. Nephrol Dial Transplant (2011) 1.22
Feedback and education improve physician compliance in use of lung-protective mechanical ventilation. Intensive Care Med (2005) 1.22
CT colonography at different radiation dose levels: feasibility of dose reduction. Radiology (2002) 1.21
Chromosomal mosaicism in human preimplantation embryos: a systematic review. Hum Reprod Update (2011) 1.21
Decision aids for patients facing a surgical treatment decision: a systematic review and meta-analysis. Ann Surg (2013) 1.20
Laparoscopic staging and subsequent palliation in patients with peripancreatic carcinoma. Ann Surg (2003) 1.20
Cognitive, functional, and quality-of-life outcomes of patients aged 80 and older who survived at least 1 year after planned or unplanned surgery or medical intensive care treatment. J Am Geriatr Soc (2008) 1.19
Graded compression ultrasonography and computed tomography in acute colonic diverticulitis: meta-analysis of test accuracy. Eur Radiol (2008) 1.17
Adjustment for comorbidity in studies on health status in ESRD patients: which comorbidity index to use? J Am Soc Nephrol (2003) 1.16
Elimination of daily routine chest radiographs in a mixed medical-surgical intensive care unit. Intensive Care Med (2007) 1.16
Performance of the postwash total motile sperm count as a predictor of pregnancy at the time of intrauterine insemination: a meta-analysis. Fertil Steril (2004) 1.16
Consequences of infertility in developing countries: results of a questionnaire and interview survey in the South of Vietnam. J Transl Med (2006) 1.15