Published in J Cell Sci on July 01, 2006
RNA and disease. Cell (2009) 7.98
Alternative splicing: a pivotal step between eukaryotic transcription and translation. Nat Rev Mol Cell Biol (2013) 3.33
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet (2011) 2.99
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J Clin Invest (2011) 2.90
The pathobiology of splicing. J Pathol (2010) 2.52
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol (2012) 1.88
The emerging role of splicing factors in cancer. EMBO Rep (2008) 1.83
Antisense-mediated exon skipping: a versatile tool with therapeutic and research applications. RNA (2007) 1.78
A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell (2010) 1.72
Inference of isoforms from short sequence reads. J Comput Biol (2011) 1.72
Mechanisms of the androgen receptor splicing in prostate cancer cells. Oncogene (2013) 1.67
Alternative splicing and tumor progression. Curr Genomics (2008) 1.43
Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer. Proc Natl Acad Sci U S A (2008) 1.43
Analytical methods for inferring functional effects of single base pair substitutions in human cancers. Hum Genet (2009) 1.39
Key contribution of CPEB4-mediated translational control to cancer progression. Nat Med (2011) 1.37
Alternative splicing and biological heterogeneity in prostate cancer. Nat Rev Urol (2009) 1.33
MutPred Splice: machine learning-based prediction of exonic variants that disrupt splicing. Genome Biol (2014) 1.32
miRTar: an integrated system for identifying miRNA-target interactions in human. BMC Bioinformatics (2011) 1.30
Colorectal Neoplasia Differentially Expressed (CRNDE), a Novel Gene with Elevated Expression in Colorectal Adenomas and Adenocarcinomas. Genes Cancer (2011) 1.28
Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays. BMC Genomics (2008) 1.25
Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines. Brain (2009) 1.22
Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma. Gastroenterology (2008) 1.21
Entropy measures quantify global splicing disorders in cancer. PLoS Comput Biol (2008) 1.18
Aberrant RNA splicing and its functional consequences in cancer cells. Dis Model Mech (2008) 1.12
The emerging era of genomic data integration for analyzing splice isoform function. Trends Genet (2014) 1.11
Protein kinase C-dependent control of Bcl-x alternative splicing. Mol Cell Biol (2007) 1.10
Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma. PLoS One (2012) 1.09
In silico prediction of splice-altering single nucleotide variants in the human genome. Nucleic Acids Res (2014) 1.08
Splicing programs and cancer. J Nucleic Acids (2011) 1.06
Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75. Mol Cancer Res (2008) 1.04
Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities. Mol Cell Biol (2008) 1.04
The impact of alternative splicing in vivo: mouse models show the way. RNA (2007) 1.03
Tumor suppressor function of androgen receptor coactivator ARA70alpha in prostate cancer. Am J Pathol (2010) 1.02
Reduced expression and novel splice variants of ING4 in human gastric adenocarcinoma. J Pathol (2009) 1.01
The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. RNA (2008) 1.00
Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms. Hum Mol Genet (2008) 1.00
ASPicDB: a database of annotated transcript and protein variants generated by alternative splicing. Nucleic Acids Res (2010) 0.99
The exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript. Genes Dev (2014) 0.99
Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells. PLoS One (2011) 0.99
Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin. Nucleic Acids Res (2010) 0.98
Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas. Neuro Oncol (2008) 0.97
Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis. Cancer Res (2008) 0.96
Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts. Genome Biol (2010) 0.96
Alternative RNA splicing and cancer. Wiley Interdiscip Rev RNA (2013) 0.96
SON is a spliceosome-associated factor required for mitotic progression. Cell Cycle (2010) 0.95
Alternative splicing and the progesterone receptor in breast cancer. Breast Cancer Res (2008) 0.95
Splicing factor SRSF6 promotes hyperplasia of sensitized skin. Nat Struct Mol Biol (2014) 0.95
Unmasking alternative splicing inside protein-coding exons defines exitrons and their role in proteome plasticity. Genome Res (2015) 0.95
Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing. J Cell Biochem (2012) 0.94
Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development. RNA (2014) 0.92
PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis. Mol Carcinog (2011) 0.92
Re-splicing of mature mRNA in cancer cells promotes activation of distant weak alternative splice sites. Nucleic Acids Res (2012) 0.91
Progress toward therapy with antisense-mediated splicing modulation. Curr Opin Mol Ther (2009) 0.91
Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice. Mol Cancer (2008) 0.91
Alternative splicing regulation of telomerase: a new paradigm? Trends Genet (2014) 0.90
Post-transcriptional regulation in cancer progression : Microenvironmental control of alternative splicing and translation. J Cell Commun Signal (2012) 0.90
Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells. RNA (2014) 0.90
SRSF1-Regulated Alternative Splicing in Breast Cancer. Mol Cell (2015) 0.90
Poly (A)+ transcriptome assessment of ERBB2-induced alterations in breast cell lines. PLoS One (2011) 0.87
Impairment of pre-mRNA splicing in liver disease: mechanisms and consequences. World J Gastroenterol (2010) 0.86
CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells. Front Immunol (2015) 0.84
Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion. Cancer Inform (2015) 0.84
Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. PLoS One (2009) 0.83
A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1. Genome Res (2016) 0.82
Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome. Br J Cancer (2012) 0.82
Homologous SV40 RNA trans-splicing: a new mechanism for diversification of viral sequences and phenotypes. RNA Biol (2013) 0.82
Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators. Front Mol Biosci (2014) 0.82
Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation. EMBO J (2009) 0.81
Regulation of alternative splicing within the supraspliceosome. J Struct Biol (2011) 0.81
Genome-wide activation of latent donor splice sites in stress and disease. Nucleic Acids Res (2012) 0.81
A conserved tissue-specific homeodomain-less isoform of MEIS1 is downregulated in colorectal cancer. PLoS One (2011) 0.81
Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors. Cancer Res (2010) 0.81
Functional characterization and identification of mouse Rad51d splice variants. BMC Mol Biol (2009) 0.80
The Supraspliceosome - A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus. Comput Struct Biotechnol J (2014) 0.80
Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing. PLoS One (2015) 0.80
Metallation state of human manganese superoxide dismutase expressed in Saccharomyces cerevisiae. Arch Biochem Biophys (2012) 0.80
Analysis of protein isoforms: can we do it better? Proteomics (2012) 0.80
A genome-wide systematic analysis reveals different and predictive proliferation expression signatures of cancerous vs. non-cancerous cells. PLoS Genet (2013) 0.80
Full-length L1CAM and not its Δ2Δ27 splice variant promotes metastasis through induction of gelatinase expression. PLoS One (2011) 0.79
Extracting reaction networks from databases-opening Pandora's box. Brief Bioinform (2013) 0.79
Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibody. PLoS One (2012) 0.79
Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs. PLoS One (2011) 0.79
Role of pseudoexons and pseudointrons in human cancer. Int J Cell Biol (2013) 0.79
UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex. Acta Crystallogr D Struct Biol (2016) 0.78
Lentivirus mediated silencing of ubiquitin specific peptidase 39 inhibits cell proliferation of human hepatocellular carcinoma cells in vitro. Biol Res (2015) 0.78
Loss of exon 4 in a human T-cell factor-4 isoform promotes hepatic tumourigenicity. Liver Int (2013) 0.78
A comprehensive survey of human polymorphisms at conserved splice dinucleotides and its evolutionary relationship with alternative splicing. BMC Evol Biol (2010) 0.78
Co-transcriptional mRNP formation is coordinated within a molecular mRNP packaging station in S. cerevisiae. Bioessays (2015) 0.77
MET Exon 14 Alterations in Lung Cancer: Exon Skipping Extends Half-Life. Clin Cancer Res (2016) 0.76
Usage of cancer associated autoantibodies in the detection of disease. Cancer Biomark (2010) 0.76
Identification of a novel estrogen receptor-alpha variant and its upstream splicing regulator. Mol Endocrinol (2010) 0.76
Integrative genome-wide analysis of the determinants of RNA splicing in kidney renal clear cell carcinoma. Pac Symp Biocomput (2015) 0.75
Phenotypic reversion in analbuminemic rats due to an altered splicing mechanism. Proc Jpn Acad Ser B Phys Biol Sci (2007) 0.75
Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation. Cancer Res (2016) 0.75
Ultraconserved region-containing Transformer 2β4 controls senescence of colon cancer cells. Oncogenesis (2016) 0.75
Specific genomic cues regulate Cajal body assembly. RNA Biol (2016) 0.75
Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases. BMC Genomics (2016) 0.75
The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine. BMC Gastroenterol (2008) 0.75
Heat shock activates splicing at latent alternative 5' splice sites in nematodes. Nucleus (2015) 0.75
Multifunctional RNA processing protein SRm160 induces apoptosis and regulates eye and genital development in Drosophila. Genetics (2014) 0.75
A slow RNA polymerase II affects alternative splicing in vivo. Mol Cell (2003) 5.82
Alternative splicing: multiple control mechanisms and involvement in human disease. Trends Genet (2002) 4.97
Epigenetics in alternative pre-mRNA splicing. Cell (2011) 4.74
DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation. Cell (2009) 3.66
Control of alternative splicing through siRNA-mediated transcriptional gene silencing. Nat Struct Mol Biol (2009) 3.47
Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing. Proc Natl Acad Sci U S A (2009) 2.94
RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20. Nat Struct Mol Biol (2006) 2.81
Transcriptional activators differ in their abilities to control alternative splicing. J Biol Chem (2002) 2.56
Chromatin, transcript elongation and alternative splicing. Nat Struct Mol Biol (2006) 2.35
Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT. Nat Struct Mol Biol (2005) 2.06
A methyl transferase links the circadian clock to the regulation of alternative splicing. Nature (2010) 1.88
The carboxy terminal domain of RNA polymerase II and alternative splicing. Trends Biochem Sci (2010) 1.67
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation. Proc Natl Acad Sci U S A (2002) 1.61
Promoter architecture modulates CFTR exon 9 skipping. J Biol Chem (2002) 1.41
A chloroplast retrograde signal regulates nuclear alternative splicing. Science (2014) 1.36
Regulation of alternative splicing through coupling with transcription and chromatin structure. Annu Rev Biochem (2015) 1.26
A polar mechanism coordinates different regions of alternative splicing within a single gene. Mol Cell (2005) 1.26
Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells. Mol Cell Biol (2005) 1.25
When chromatin meets splicing. Nat Struct Mol Biol (2009) 1.16
Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells. Mol Cell Biol (2003) 1.14
Influence of polymerase II processivity on alternative splicing depends on splice site strength. J Biol Chem (2003) 1.07
Transcriptional elongation and alternative splicing. Biochim Biophys Acta (2012) 1.04
Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via phosphatidylinositol 3-kinase. J Biol Chem (2004) 1.01
Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation. EMBO J (2013) 1.01
Cross-talk between signaling pathways regulates alternative splicing: a novel role for JNK. J Biol Chem (2005) 0.99
The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis. EMBO Rep (2014) 0.94
Connections between chromatin signatures and splicing. Wiley Interdiscip Rev RNA (2012) 0.94
Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. PLoS One (2012) 0.94
Identification of the cellular targets of the transcription factor TCERG1 reveals a prevalent role in mRNA processing. J Biol Chem (2008) 0.91
Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential. Oncol Rep (2006) 0.89
Control of alternative pre-mRNA splicing by RNA Pol II elongation: faster is not always better. IUBMB Life (2003) 0.88
RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing. Genet Res Int (2011) 0.84
Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases. Mol Biochem Parasitol (2003) 0.82
A splicing regulator promotes transcriptional elongation. Nat Struct Mol Biol (2008) 0.82
Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver. Proc Natl Acad Sci U S A (2004) 0.82
Coupling between transcription and alternative splicing. Cancer Treat Res (2013) 0.82
A yeast sterol carrier protein with fatty-acid and fatty-acyl-CoA binding activity. Arch Biochem Biophys (2006) 0.81
Regulation of fibronectin alternative splicing by a basement membrane-like extracellular matrix. FEBS Lett (2002) 0.81
An early ancestor in the evolution of splicing: a Trypanosoma cruzi serine-arginine-rich protein (TcSR) is functional in cis-splicing. Mol Biochem Parasitol (2003) 0.80
Alternative splicing at the right time. RNA Biol (2011) 0.80
Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation. Commun Integr Biol (2009) 0.80
Gene silencing: small RNAs control RNA polymerase II elongation. Curr Biol (2010) 0.79
Long range chromatin organization: a new layer in splicing regulation? Transcription (2014) 0.78
The pathology of pre-mRNA splicing: a meeting in the Italian Alps. Workshop on pre-mRNA processing and disease. EMBO Rep (2007) 0.78
Progesterone receptor induces bcl-x expression through intragenic binding sites favoring RNA polymerase II elongation. Nucleic Acids Res (2013) 0.78
Let there be light: regulation of gene expression in plants. RNA Biol (2014) 0.77
Fibronectin transcription in liver cells: promoter occupation and function in sinusoidal endothelial cells and hepatocytes. Biochem Biophys Res Commun (2002) 0.76
Shortcuts to the end. Nat Struct Mol Biol (2004) 0.76
Long range chromatin organization: a new layer in splicing regulation? Transcription (2014) 0.76
Shedding light on the chloroplast as a remote control of nuclear gene expression. Plant Signal Behav (2014) 0.75
Epigenetics at the base of alternative splicing changes that promote colorectal cancer. J Clin Invest (2017) 0.75