Published in Cytokine Growth Factor Rev on June 30, 2006
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. JAMA (2009) 2.72
Structural biology of shared cytokine receptors. Annu Rev Immunol (2009) 2.27
Safety and immunologic effects of IL-15 administration in nonhuman primates. Blood (2009) 2.00
Interleukin-15 biology and its therapeutic implications in cancer. Trends Pharmacol Sci (2011) 1.64
Location and cellular stages of natural killer cell development. Trends Immunol (2013) 1.59
IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection. J Exp Med (2010) 1.52
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity. Am J Physiol Endocrinol Metab (2008) 1.38
Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol (2009) 1.36
Celiac disease: how complicated can it get? Immunogenetics (2010) 1.34
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human. J Clin Invest (2011) 1.30
IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest (2010) 1.28
Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis. J Neuroimmunol (2010) 1.20
Cerebral microvascular IL15 is a novel mediator of TNF action. J Neurochem (2009) 1.19
NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies. Oncoimmunology (2012) 1.15
IL-15: a central regulator of celiac disease immunopathology. Immunol Rev (2014) 1.14
Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction. Mech Ageing Dev (2009) 1.14
Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7. Eur J Immunol (2009) 1.12
How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha. Mol Cell Biol (2008) 1.11
The transcription factor c-Myc enhances KIR gene transcription through direct binding to an upstream distal promoter element. Blood (2008) 1.11
Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes. Proc Natl Acad Sci U S A (2010) 1.07
Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help. Cancer Res (2010) 1.07
Loss of IL-15 receptor α alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles. J Clin Invest (2011) 1.05
A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection. J Immunol (2010) 1.05
The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes. J Immunol (2012) 1.04
Sustained CD4(+) T cell-driven lymphopenia without a compensatory IL-7/IL-15 response among high-grade glioma patients treated with radiation and temozolomide. Oncoimmunology (2014) 1.03
The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use. Microbes Infect (2011) 1.01
Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease. PLoS Negl Trop Dis (2008) 1.01
Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway. J Virol (2010) 1.00
Cessation of blood-to-brain influx of interleukin-15 during development of EAE. J Cereb Blood Flow Metab (2009) 1.00
Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells. Mol Biol Cell (2011) 0.99
Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome. Cytokine (2008) 0.98
Higher constitutive IL15R alpha expression and lower IL-15 response threshold in coeliac disease patients. Clin Exp Immunol (2008) 0.96
Gliadin-mediated proliferation and innate immune activation in celiac disease are due to alterations in vesicular trafficking. PLoS One (2011) 0.96
Functions of IL-15 in anti-viral immunity: multiplicity and variety. Cytokine (2012) 0.94
B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. J Immunol (2011) 0.94
Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cis. Eur J Immunol (2009) 0.94
Cooperativity of adaptive and innate immunity: implications for cancer therapy. Cancer Immunol Immunother (2011) 0.93
IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function. Clin Cancer Res (2016) 0.93
Serum and muscle interleukin-15 levels decrease in aging mice: correlation with declines in soluble interleukin-15 receptor alpha expression. Exp Gerontol (2009) 0.92
Systemic elevation of interleukin-15 in vivo promotes apoptosis in skeletal muscles of young adult and aged rats. Biochem Biophys Res Commun (2008) 0.91
Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal-dependent memory. J Neurosci (2010) 0.91
Potential role of NK cells in the pathogenesis of inflammatory bowel disease. J Biomed Biotechnol (2011) 0.91
IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner. Proc Natl Acad Sci U S A (2013) 0.90
Serum IL-15 in patients with early systemic sclerosis: a potential novel marker of lung disease. Arthritis Res Ther (2007) 0.90
Pleiotropic effects of negative energy balance in the postpartum dairy cow on splenic gene expression: repercussions for innate and adaptive immunity. Physiol Genomics (2009) 0.89
Interleukin-15, IL-15 Receptor-Alpha, and Obesity: Concordance of Laboratory Animal and Human Genetic Studies. J Obes (2011) 0.89
Urea amidolyase (DUR1,2) contributes to virulence and kidney pathogenesis of Candida albicans. PLoS One (2012) 0.87
Interleukin-15 and soluble interleukin-15 receptor α in coronary artery disease patients: association with epicardial fat and indices of adipose tissue distribution. PLoS One (2014) 0.87
Cellular immunotherapy for carcinoma using genetically modified EGFR-specific T lymphocytes. Neoplasia (2013) 0.87
Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor. Psychoneuroendocrinology (2010) 0.86
Brain interleukin-15 in neuroinflammation and behavior. Neurosci Biobehav Rev (2012) 0.85
Interleukin-15 plays a central role in human kidney physiology and cancer through the γc signaling pathway. PLoS One (2012) 0.85
IL-15 participates in the respiratory innate immune response to influenza virus infection. PLoS One (2012) 0.84
Natural killer cells and their role in rheumatoid arthritis: friend or foe? ScientificWorldJournal (2012) 0.84
Rapid endocytosis of interleukin-15 by cerebral endothelia. J Neurochem (2011) 0.83
Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans. J Immunol (2008) 0.83
Delivery of interleukin-15 to B16 melanoma by electroporation leads to tumor regression and long-term survival. Technol Cancer Res Treat (2013) 0.82
Differential requirement for Hoxa9 in the development and differentiation of B, NK, and DC-lineage cells from Flt3+ multipotential progenitors. BMC Immunol (2013) 0.82
IL-15 is required for postexercise induction of the pro-oxidative mediators PPARδ and SIRT1 in male mice. Endocrinology (2013) 0.82
IL-4 receptor as a bridge between the immune system and muscle in experimental myasthenia gravis I: up-regulation of muscle IL-15 by IL-4. Clin Immunol (2009) 0.82
Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity. Proc Natl Acad Sci U S A (2016) 0.81
Immobilized MHC class I chain-related protein A synergizes with IL-15 and soluble 4-1BB ligand to expand NK cells with high cytotoxicity ex vivo. Cell Mol Immunol (2010) 0.81
Innate immunity modulation by the IL-33/ST2 system in intestinal mucosa. Biomed Res Int (2012) 0.81
Cytokines as Adjuvants for Vaccine and Cellular Therapies for Cancer. Am J Immunol (2009) 0.81
The use of an in vitro 3D melanoma model to predict in vivo plasmid transfection using electroporation. Biomaterials (2012) 0.81
Altered expression of cytokine signaling pathway genes in peripheral blood cells of alcohol dependent subjects: preliminary findings. Alcohol Clin Exp Res (2012) 0.81
Deficiency of interleukin-15 enhances susceptibility to acetaminophen-induced liver injury in mice. PLoS One (2012) 0.81
IL-15 augments TCR-induced CD4+ T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4+ T cells. PLoS One (2012) 0.81
Gene expression profiles are influenced by ISS, MOF, and clinical outcome in multiple injured patients: a genome-wide comparative analysis. Langenbecks Arch Surg (2007) 0.80
Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activation. Immunol Cell Biol (2009) 0.80
Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. PLoS One (2013) 0.80
Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system. Front Microbiol (2015) 0.80
Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression. Pharmacol Res (2016) 0.79
Subcellular expression pattern and role of IL-15 in pneumococci induced lung epithelial apoptosis. Histochem Cell Biol (2008) 0.79
Complement regulates conventional DC-mediated NK-cell activation by inducing TGF-β1 in Gr-1+ myeloid cells. Eur J Immunol (2012) 0.79
Rituximab-induced interleukin-15 reduction associated with clinical improvement in rheumatoid arthritis. Immunology (2014) 0.78
Overlapping, additive and counterregulatory effects of type II and I interferons on myeloid dendritic cell functions. ScientificWorldJournal (2011) 0.78
Transmembrane-Bound IL-15-Promoted Epithelial-Mesenchymal Transition in Renal Cancer Cells Requires the Src-Dependent Akt/GSK-3β/β-Catenin Pathway. Neoplasia (2015) 0.78
IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors. Cancer Res (2016) 0.78
IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease. Nat Commun (2016) 0.78
IL-15 Superagonist Expands mCD8+ T, NK and NKT Cells after Burn Injury but Fails to Improve Outcome during Burn Wound Infection. PLoS One (2016) 0.78
Effects of Eccentric and Concentric Emphasized Resistance Exercise on IL-15 Serum Levels and Its Relation to Inflammatory Markers in Athletes and Non-Athletes. Asian J Sports Med (2015) 0.78
STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells. Immunol Cell Biol (2015) 0.77
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes. Front Med (2014) 0.77
IL-15-deficient mice develop enhanced allergic responses to airway allergen exposure. Clin Exp Allergy (2017) 0.76
Skeletal muscle interleukin 15 promotes CD8(+) T-cell function and autoimmune myositis. Skelet Muscle (2015) 0.76
Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling. Clin Immunol (2014) 0.76
The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia. PLoS One (2010) 0.76
IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal Muscle Cells. Front Physiol (2016) 0.76
The NKG2D-IL-15 signaling pathway contributes to T-cell mediated pathology in inflammatory myopathies. Oncotarget (2015) 0.75
IL-15 temporally reorients IL-10 biased B-1a cells toward IL-12 expression. Cell Mol Immunol (2015) 0.75
The Effect of Cellular Stress on T and B Cell Memory Pathways in Immunized and Unimmunized BALB/c Mice. J Biol Chem (2016) 0.75
Splicing Regulation of Pro-Inflammatory Cytokines and Chemokines: At the Interface of the Neuroendocrine and Immune Systems. Biomolecules (2015) 0.75
IL-15/sIL-15Rα gene transfer induces weight loss and improves glucose homeostasis in obese mice. Gene Ther (2016) 0.75
Generation of CD2(+)CD8(+) NK Cells from c-kit(+) Bone Marrow Cells in Porcine. Korean J Physiol Pharmacol (2012) 0.75
IL-15, in synergy with RAE-1ɛ, stimulates TCR-independent proliferation and activation of CD8(+) T cells. Oncol Lett (2011) 0.75
IL-15: a novel prosurvival signaling pathway in cardiomyocytes. J Cardiovasc Pharmacol (2014) 0.75
Association of germline genetic variants in RFC, IL15 and VDR genes with minimal residual disease in pediatric B-cell precursor ALL. Sci Rep (2016) 0.75
Overexpression of interleukin-15 in mice promotes resistance to diet-induced obesity, increased insulin sensitivity, and markers of oxidative skeletal muscle metabolism. Int J Interferon Cytokine Mediat Res (2011) 0.75
Molecular principles of hair follicle induction and morphogenesis. Bioessays (2005) 3.08
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature (2010) 2.85
Alopecia areata. N Engl J Med (2012) 2.56
The hair follicle as a dynamic miniorgan. Curr Biol (2009) 2.52
Exploring the "hair growth-wound healing connection": anagen phase promotes wound re-epithelialization. J Invest Dermatol (2010) 2.48
IL-15 promotes the survival of naive and memory phenotype CD8+ T cells. J Immunol (2003) 2.28
Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J (2005) 2.23
Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming. J Immunol (2006) 2.20
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev (2006) 2.10
Interleukin-21 inhibits dendritic cell activation and maturation. Blood (2003) 2.00
IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. Nat Med (2007) 2.00
Hair follicle pigmentation. J Invest Dermatol (2005) 1.84
Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol (2006) 1.72
Retracted A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control. EMBO J (2005) 1.72
Neuroimmunology of stress: skin takes center stage. J Invest Dermatol (2006) 1.72
The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling. Bioessays (2006) 1.70
NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development (2006) 1.66
Neuronal plasticity of the "brain-skin connection": stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways. J Mol Med (Berl) (2007) 1.58
Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation. Eur J Immunol (2012) 1.57
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L. Proc Natl Acad Sci U S A (2005) 1.56
Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest (2007) 1.56
Cylindroma as tumor of hair follicle origin. J Invest Dermatol (2006) 1.56
Mast cells are required for normal healing of skin wounds in mice. FASEB J (2006) 1.50
Circadian clock genes contribute to the regulation of hair follicle cycling. PLoS Genet (2009) 1.49
Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol (2008) 1.47
Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche. Exp Dermatol (2008) 1.43
Thyrotropin-releasing hormone selectively stimulates human hair follicle pigmentation. J Invest Dermatol (2011) 1.43
Interleukin-21: a new modulator of immunity, infection, and cancer. Cytokine Growth Factor Rev (2007) 1.40
TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment. Blood (2005) 1.39
Ceramide mediates caspase-independent programmed cell death. FASEB J (2005) 1.36
Molecular biology of hair morphogenesis: development and cycling. J Exp Zool B Mol Dev Evol (2003) 1.36
IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells. Eur J Immunol (2008) 1.34
Neuropeptide control mechanisms in cutaneous biology: physiological and clinical significance. J Invest Dermatol (2006) 1.33
Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control. J Invest Dermatol (2003) 1.32
A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. Am J Pathol (2005) 1.27
Migration of melanoblasts into the developing murine hair follicle is accompanied by transient c-Kit expression. J Histochem Cytochem (2002) 1.26
Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia. J Invest Dermatol (2004) 1.24
Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin. Mol Cell Biol (2010) 1.23
Exploring the role of stem cells in cutaneous wound healing. Exp Dermatol (2009) 1.23
Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways. Am J Pathol (2003) 1.22
Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine. J Immunol (2009) 1.21
Developmental timing of hair follicle and dorsal skin innervation in mice. J Comp Neurol (2002) 1.20
The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization. Exp Dermatol (2009) 1.20
Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab (2007) 1.20
Skin as an endocrine organ: implications for its function. Drug Discov Today Dis Mech (2008) 1.19
Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. J Invest Dermatol (2007) 1.18
Retracted Reverse signaling through membrane-bound interleukin-15. J Biol Chem (2004) 1.17
Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. FASEB J (2003) 1.17
Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses. Eur J Immunol (2003) 1.16
p75 Neurotrophin receptor antagonist retards apoptosis-driven hair follicle involution (catagen). J Invest Dermatol (2003) 1.16
Retracted Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells. J Immunol (2005) 1.16
Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab (2008) 1.15
Retracted Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B. J Biol Chem (2002) 1.15
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development (2011) 1.15
Hair growth inhibition by psychoemotional stress: a mouse model for neural mechanisms in hair growth control. Exp Dermatol (2006) 1.13
Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit. Proc Natl Acad Sci U S A (2011) 1.13
Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo. J Immunol (2005) 1.13
Hair follicle stem cells: walking the maze. Eur J Cell Biol (2007) 1.12
TLR signaling in mast cells: common and unique features. Front Immunol (2012) 1.12
The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am J Pathol (2002) 1.11
How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha. Mol Cell Biol (2008) 1.11
Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control. Bioessays (2007) 1.11
FOXN1 is critical for onycholemmal terminal differentiation in nude (Foxn1) mice. J Invest Dermatol (2004) 1.10
Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo. J Invest Dermatol (2003) 1.10
Retracted Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15. J Biol Chem (2007) 1.10
Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions. Immunity (2009) 1.10
Retracted Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. Mol Cell Biol (2005) 1.10
The pathogenesis of primary cicatricial alopecias. Am J Pathol (2010) 1.09
Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b. J Exp Med (2011) 1.07
From the brain-skin connection: the neuroendocrine-immune misalliance of stress and itch. Neuroimmunomodulation (2007) 1.07
Activation of transient receptor potential vanilloid-3 inhibits human hair growth. J Invest Dermatol (2011) 1.05
A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors. FASEB J (2005) 1.03
The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells (2011) 1.03
A guide to assessing damage response pathways of the hair follicle: lessons from cyclophosphamide-induced alopecia in mice. J Invest Dermatol (2005) 1.03
Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. J Immunol (2009) 1.03
Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp Dermatol (2008) 1.03
Interleukin-15 mediates protection against experimental tuberculosis: a role for NKG2D-dependent effector mechanisms of CD8+ T cells. Eur J Immunol (2006) 1.02
TRP channels as novel players in the pathogenesis and therapy of itch. Biochim Biophys Acta (2007) 1.02
Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture. Exp Dermatol (2009) 1.02
Prolactin and the skin: a dermatological perspective on an ancient pleiotropic peptide hormone. J Invest Dermatol (2008) 1.01