Colorectal cancer: a model for epigenetic tumorigenesis.

PubWeight™: 1.62‹?› | Rank: Top 4%

🔗 View Article (PMC 1856668)

Published in Gut on July 13, 2006

Authors

J J L Wong1, N J Hawkins, R L Ward

Author Affiliations

1: School of Medical Sciences, University of NSW, Sydney, New South Wales, Australia.

Articles citing this

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut (2008) 6.26

Molecular classification and correlates in colorectal cancer. J Mol Diagn (2007) 3.25

Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull (2006) 2.46

Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. Gut (2007) 1.53

Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. Mol Cancer (2010) 1.50

Body size, physical activity and risk of colorectal cancer with or without the CpG island methylator phenotype (CIMP). PLoS One (2011) 1.32

Colorectal cancers with microsatellite instability display unique miRNA profiles. Clin Cancer Res (2011) 1.27

Early life exposure to famine and colorectal cancer risk: a role for epigenetic mechanisms. PLoS One (2009) 1.21

Heterocyclic aromatic amine pesticide use and human cancer risk: results from the U.S. Agricultural Health Study. Int J Cancer (2009) 1.10

Molecular events in primary and metastatic colorectal carcinoma: a review. Patholog Res Int (2012) 1.07

Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties. J Exp Clin Cancer Res (2011) 1.07

Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors. Genes Chromosomes Cancer (2009) 1.03

Why do results conflict regarding the prognostic value of the methylation status in colon cancers? The role of the preservation method. BMC Cancer (2012) 0.99

Tumor suppressor NDRG2 tips the balance of oncogenic TGF-β via EMT inhibition in colorectal cancer. Oncogenesis (2014) 0.96

Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo. Cancer Res (2008) 0.96

Curcumin modulates DNA methylation in colorectal cancer cells. PLoS One (2013) 0.96

Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells. Am J Pathol (2010) 0.96

Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. Exp Biol Med (Maywood) (2014) 0.95

Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer. BMC Cancer (2013) 0.95

Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. Gastroenterology (2014) 0.93

Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa. BMC Cancer (2011) 0.87

Diet and epigenetics in colon cancer. World J Gastroenterol (2009) 0.85

Chapter 5. Nuclear actin-related proteins in epigenetic control. Int Rev Cell Mol Biol (2009) 0.85

C/EBP-β-activated microRNA-223 promotes tumour growth through targeting RASA1 in human colorectal cancer. Br J Cancer (2015) 0.84

Combined detection of plasma GATA5 and SFRP2 methylation is a valid noninvasive biomarker for colorectal cancer and adenomas. World J Gastroenterol (2015) 0.83

MicroRNA-124a and microRNA-34b/c are frequently methylated in all histological types of colorectal cancer and polyps, and in the adjacent normal mucosa. Oncol Lett (2010) 0.82

DNA Methylation and Colorectal Cancer. Curr Colorectal Cancer Rep (2014) 0.82

Epigenetic biomarkers: potential applications in gastrointestinal cancers. ISRN Gastroenterol (2014) 0.81

Colorectal cancer screening in an equal access healthcare system. J Cancer (2013) 0.80

General aspects of colorectal cancer. ISRN Oncol (2012) 0.79

Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma. Mol Clin Oncol (2013) 0.78

Heredity and DNA methylation in colorectal cancer. Gut (2007) 0.78

Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma. Exp Ther Med (2012) 0.78

Leukocyte DNA methylation and colorectal cancer among male smokers. World J Gastrointest Oncol (2012) 0.78

Preoperative serum levels of mesothelin in patients with colon cancer. Dis Markers (2014) 0.77

Focus on 16p13.3 Locus in Colon Cancer. PLoS One (2015) 0.77

Colorectal cancer DNA methylation patterns from patients in Manaus, Brazil. Biol Res (2015) 0.76

Three Colon Adenocarcinomas Arising in a Patient with Serrated Polyposis Syndrome: Case Report and Review of the Literature. Viszeralmedizin (2014) 0.75

Abnormal DNA methylation as a cell-free circulating DNA biomarker for colorectal cancer detection: A review of literature. World J Gastrointest Oncol (2017) 0.75

Improved amplification efficiency on stool samples by addition of spermidine and its use for non-invasive detection of colorectal cancer. BMC Biotechnol (2015) 0.75

Epigenetic silencing of protocadherin 10 in colorectal cancer. Oncol Lett (2017) 0.75

Targeting histone methylation for colorectal cancer. Therap Adv Gastroenterol (2016) 0.75

Epigenetics in diagnosis of colorectal cancer. Mol Biol Res Commun (2016) 0.75

Sessile Serrated Adenomas: How to Detect, Characterize and Resect. Gut Liver (2017) 0.75

Articles cited by this

(truncated to the top 100)

Translating the histone code. Science (2001) 56.77

Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82

Genetic instabilities in human cancers. Nature (1998) 22.76

Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med (2003) 18.04

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04

The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell (1996) 16.57

The history of cancer epigenetics. Nat Rev Cancer (2004) 14.38

Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci (2006) 13.32

CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A (1999) 13.02

Cancer epigenetics comes of age. Nat Genet (1999) 12.63

Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med (2003) 12.17

DNA methylation and human disease. Nat Rev Genet (2005) 12.00

Epigenetics in human disease and prospects for epigenetic therapy. Nature (2004) 11.46

Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer (2006) 11.22

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66

The epigenetic progenitor origin of human cancer. Nat Rev Genet (2006) 9.65

ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science (2003) 9.54

Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol (2003) 9.30

Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature (1983) 9.28

5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med (1995) 9.10

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45

Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol (2005) 8.15

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A (2000) 8.12

Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell (2005) 7.20

CpG island methylator phenotype in cancer. Nat Rev Cancer (2004) 7.13

Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science (2003) 6.85

Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci U S A (1993) 6.79

Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology (2005) 6.34

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet (2000) 5.72

DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet (2000) 5.29

Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med (2001) 5.22

MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst (2005) 5.22

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev (1994) 4.95

Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet (2006) 4.86

Germline epimutation of MLH1 in individuals with multiple cancers. Nat Genet (2004) 4.74

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol (2004) 4.72

Transcriptional activation of retrotransposons alters the expression of adjacent genes in wheat. Nat Genet (2002) 4.67

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res (1982) 4.61

Controlling elements in maize. Annu Rev Genet (1974) 4.44

Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res (1998) 4.39

BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut (2004) 4.06

Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer. Gastroenterology (2004) 4.03

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci U S A (1998) 3.90

Relaxation of imprinted genes in human cancer. Nature (1993) 3.86

Hypomethylation of DNA from benign and malignant human colon neoplasms. Science (1985) 3.72

CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology (2002) 3.70

Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59

The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res (1983) 3.51

Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet (2001) 3.46

BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair. Cancer Res (2003) 3.39

5-methylcytosine, gene regulation, and cancer. Adv Cancer Res (1983) 3.27

Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst (1993) 3.25

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour. Nature (1993) 3.24

The epigenetics of cancer etiology. Semin Cancer Biol (2004) 3.24

Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res (2002) 3.21

Retracted Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature (2004) 3.12

Morphology of sporadic colorectal cancer with DNA replication errors. Gut (1998) 3.11

Alcohol, low-methionine--low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst (1995) 3.10

Histone H3 variants specify modes of chromatin assembly. Proc Natl Acad Sci U S A (2002) 3.06

Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst (2001) 3.02

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol (2002) 3.00

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res (2000) 2.99

Microsatellite instability and colorectal cancer prognosis. Clin Cancer Res (2005) 2.92

Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability. Nat Med (1998) 2.91

Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res (2002) 2.84

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet (1989) 2.80

Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol (2003) 2.72

BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency. Oncogene (2003) 2.56

CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer. Clin Cancer Res (2003) 2.48

Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment. Nature (1977) 2.44

DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst (2005) 2.43

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell (2003) 2.38

BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin Cancer Res (2004) 2.37

Histone variant H2A.Z is required for early mammalian development. Curr Biol (2001) 2.36

Epigenetic changes in colorectal cancer. Cancer Metastasis Rev (2004) 2.35

Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut (2002) 2.31

Genetics supersedes epigenetics in colon cancer phenotype. Cancer Cell (2003) 2.24

Active repression of methylated genes by the chromosomal protein MBD1. Mol Cell Biol (2000) 2.12

Serrated adenoma of the colorectum and the DNA-methylator phenotype. Nat Clin Pract Oncol (2005) 2.08

A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor. Cancer Res (2002) 2.07

Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. Cancer Res (2003) 2.03

Epigenetics provides a new generation of oncogenes and tumour-suppressor genes. Br J Cancer (2006) 2.00

Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability. Gastroenterology (2001) 1.97

Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res (2001) 1.97

MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology (2005) 1.94

Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies. Environ Mol Mutagen (2004) 1.94

Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res (2001) 1.93

Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. J Clin Oncol (2003) 1.90

Genes, genetics, and epigenetics: a correspondence. Science (2001) 1.85

Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene (2000) 1.83

Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse. Cancer Res (2000) 1.81

Epigenetics as a mechanism driving polygenic clinical drug resistance. Br J Cancer (2006) 1.77

Control of transcription through intragenic patterns of nucleosome composition. Cell (2005) 1.77

Nonmethylated transposable elements and methylated genes in a chordate genome. Science (1999) 1.75

The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. J Biol Chem (2002) 1.74

Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int J Colorectal Dis (2003) 1.69

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation. Cancer Res (1999) 1.69

Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancers with microsatellite instability. Clin Gastroenterol Hepatol (2004) 1.64

The relationship between hypomethylation and CpG island methylation in colorectal neoplasia. Am J Pathol (2003) 1.60

Articles by these authors

Inactivation of poliovirus in digested sludge. Appl Environ Microbiol (1976) 6.23

Identification of the virucidal agent in wastewater sludge. Appl Environ Microbiol (1977) 3.42

Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst (2001) 3.02

Inactivation of enteric viruses in wastewater sludge through dewatering by evaporation. Appl Environ Microbiol (1977) 2.70

Heat inactivation of poliovirus in wastewater sludge. Appl Environ Microbiol (1976) 2.59

Effect of cytosine arabinoside on viral-specific protein synthesis in cells infected with herpes simplex virus. J Virol (1975) 2.40

Efficiency of human rotavirus propagation in cell culture. J Clin Microbiol (1984) 2.07

Positive spillover effects of prescribing requirements: increased cardiac testing in patients treated with trastuzumab for HER2+ metastatic breast cancer. Intern Med J (2012) 2.02

35Cl NMR studies of zinc adenosine diphosphate complexes. Biochem Biophys Res Commun (1967) 1.92

Human rotavirus studies in volunteers: determination of infectious dose and serological response to infection. J Infect Dis (1986) 1.68

K-ras codon 12 mutations in Barrett's oesophagus and adenocarcinomas of the oesophagus and oesophagogastric junction. J Gastroenterol Hepatol (2000) 1.64

Mechanism of poliovirus inactivation by ammonia. J Virol (1978) 1.64

Murine rotavirus genes encoding outer capsid proteins VP4 and VP7 are not major determinants of host range restriction and virulence. J Virol (1993) 1.64

Effector functions of antibody and CD8+ cells in resolution of rotavirus infection and protection against reinfection in mice. Virology (1995) 1.56

Nature of the scrapie agent: evidence against a viroid. J Virol (1974) 1.48

Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma. J Clin Pathol (2009) 1.47

Molecular characterization of serotype G9 rotavirus strains from a global collection. Virology (2000) 1.43

An upper limit on the stochastic gravitational-wave background of cosmological origin. Nature (2009) 1.42

Divergence of VP7 genes of G1 rotaviruses isolated from infants vaccinated with reassortant rhesus rotaviruses. Arch Virol (1996) 1.40

Concurrent administration of rhesus rotavirus tetravalent (RRV-TV) vaccine with pentavalent diphtheria-pertussis-tetanus-Haemophilus influenzae beta-inactivated polio and hepatitis B vaccines. Acta Paediatr (1999) 1.38

Serotypic and genotypic characterization of human serotype 10 rotaviruses from asymptomatic neonates. J Clin Microbiol (1993) 1.36

Development of an improved method for measuring neutralizing antibody to rotavirus. J Virol Methods (1991) 1.35

Acute intermittent porphyria: response of tachycardia and hypertension to propranolol. Br Med J (1973) 1.35

Effects of moisture content on long-term survival and regrowth of bacteria in wastewater sludge. Appl Environ Microbiol (1981) 1.35

Enteric virus and indicator bacteria levels in a water treatment system modified to reduce trihalomethane production. Appl Environ Microbiol (1984) 1.35

Active immunity against rotavirus infection in mice is correlated with viral replication and titers of serum rotavirus IgA following vaccination. Virology (1994) 1.33

Hydrogen production by Anabaena cylindrica: effects of varying ammonium and ferric ions, pH, and light. Appl Environ Microbiol (1978) 1.33

Identification of detergents as components of wastewater sludge that modify the thermal stability of reovirus and enteroviruses. Appl Environ Microbiol (1978) 1.33

Evaluation of WC3 rotavirus vaccine and correlates of protection in healthy infants. J Infect Dis (1990) 1.32

Detection of rare mutant alleles by restriction endonuclease-mediated selective-PCR: assay design and optimization. Clin Chem (2000) 1.32

Mechanism of inactivation of enteric viruses in fresh water. Appl Environ Microbiol (1986) 1.27

Measurement of human phospholipase A2 in arthritis plasma using a newly developed sandwich ELISA. Br J Rheumatol (1992) 1.25

Protection from rotavirus reinfection: 2-year prospective study. J Infect Dis (1991) 1.23

Antibody-dependent and -independent protection following intranasal immunization of mice with rotavirus particles. J Virol (1999) 1.22

Effects of topical betaxolol, timolol, and placebo on pulmonary function in asthmatic bronchitis. Am J Ophthalmol (1984) 1.21

Neutralization epitopes on rotavirus SA11 4fM outer capsid proteins. J Virol (1990) 1.20

pH modification of the effects of detergents on the stability of enteric viruses. Appl Environ Microbiol (1979) 1.19

Antibody-independent protection against rotavirus infection of mice stimulated by intranasal immunization with chimeric VP4 or VP6 protein. J Virol (1999) 1.18

Heat inactivation of enteric viruses in dewatered wastewater sludge. Appl Environ Microbiol (1978) 1.16

Comparison of VP4 and VP7 of five murine rotavirus strains. Virology (1994) 1.15

Evidence that resolution of rotavirus infection in mice is due to both CD4 and CD8 cell-dependent activities. J Virol (1997) 1.13

Discovery of an agent in wastewater sludge that reduces the heat required to inactivate reovirus. Appl Environ Microbiol (1977) 1.13

Comparison of methods for recovering indigenous viruses from raw wastewater sludge. Appl Environ Microbiol (1982) 1.13

Safety and immunogenicity of live, attenuated human rotavirus vaccine 89-12. Vaccine (1998) 1.12

Constitutional (germline) MLH1 epimutation as an aetiological mechanism for hereditary non-polyposis colorectal cancer. J Med Genet (2009) 1.11

Induction of cytopathogenicity in mammalian cell lines challenged with culturable enteric viruses and its enhancement by 5-iododeoxyuridine. Appl Environ Microbiol (1982) 1.10

Effect of mutation in immunodominant neutralization epitopes on the antigenicity of rotavirus SA-11. J Gen Virol (1985) 1.09

Developmentally-regulated expression of murine K-ras isoforms. Oncogene (1997) 1.09

Epidemiology of symptomatic human rotaviruses in Bangalore and Mysore, India, from 1988 to 1994 as determined by electropherotype, subgroup and serotype analysis. Arch Virol (1996) 1.09

Uptake of bacteriophage f2 through plant roots. Appl Environ Microbiol (1982) 1.07

Polyneuritis after Jungle Sores. Br Med J (1945) 1.07

Effects of wastewater sludge and its detergents on the stability of rotavirus. Appl Environ Microbiol (1980) 1.06

Comparison of seven kits for detection of rotavirus in fecal specimens with a sensitive, specific enzyme immunoassay. Diagn Microbiol Infect Dis (1987) 1.06

Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis. Cancer (1997) 1.06

Response of bacteria in wastewater sludge to moisture loss by evaporation and effect of moisture content on bacterial inactivation by ionizing radiation. Appl Environ Microbiol (1981) 1.06

The role of MYH and microsatellite instability in the development of sporadic colorectal cancer. Br J Cancer (2006) 1.06

Evidence that microorganisms cause inactivation of viruses in activated sludge. Appl Environ Microbiol (1982) 1.05

CpG island methylation is a common finding in colorectal cancer cell lines. Br J Cancer (2003) 1.04

Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer. Br J Cancer (2001) 1.04

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis. Oncogene (2012) 1.04

Identification of epitope regions recognized by tumor inhibitory and stimulatory anti-ErbB-2 monoclonal antibodies: implications for vaccine design. J Immunol (2001) 1.03

Inactivation of poliovirus in wastewater sludge with radiation and thermoradiation. Appl Environ Microbiol (1977) 1.03

Prevalence of Helicobacter pylori infection in 160 patients with Barrett's oesophagus or Barrett's adenocarcinoma. Aust N Z J Surg (2000) 1.03

Functional mapping of protective domains and epitopes in the rotavirus VP6 protein. J Virol (2000) 1.03

35C1 nuclear magnetic resonance studies of a zinc metalloenzyme carbonic anhydrase. Biochemistry (1969) 1.03

The protective effectiveness of natural rotavirus infection in an American Indian population. J Infect Dis (1998) 1.02

Local and systemic antibody response to rotavirus WC3 vaccine in adult volunteers. Antiviral Res (1989) 1.02

Inactivation of indigenous viruses in raw sludge by air drying. Appl Environ Microbiol (1983) 1.00

The efficacy of HER2-targeted agents in metastatic breast cancer: a meta-analysis. Ann Oncol (2010) 1.00

Defining T-cell-mediated immune responses in rotavirus-infected juvenile rhesus macaques. J Virol (2004) 1.00

Rising incidence of oesophageal adenocarcinoma in men in Australia. J Gastroenterol Hepatol (1998) 0.99

Long-term production of rotavirus antibody and protection against reinfection following a single infection of neonatal mice with murine rotavirus. Virology (1995) 0.98

Particle bombardment-mediated DNA vaccination with rotavirus VP6 induces high levels of serum rotavirus IgG but fails to protect mice against challenge. Virology (1997) 0.98

Active protection against rotavirus infection of mice following intraperitoneal immunization. Virology (1992) 0.98

Efficacy of live, attenuated, human rotavirus vaccine 89-12 in infants: a randomised placebo-controlled trial. Lancet (1999) 0.98

Osteomyelitis due to Mycobacterium haemophilum in a cardiac transplant patient: case report and analysis of interactions among clarithromycin, rifampin, and cyclosporine. Clin Infect Dis (1997) 0.97

Betaxolol vs timolol. A six-month double-blind comparison. Arch Ophthalmol (1986) 0.97

Seroepidemiologic evaluation of antibodies to rotavirus as correlates of the risk of clinically significant rotavirus diarrhea in rural Bangladesh. J Infect Dis (1992) 0.96

Inhibition of rotavirus in vitro transcription by optimal concentrations of monoclonal antibodies specific for rotavirus VP6. J Gen Virol (1992) 0.94

Stimulation of local immunity and protection in mice by intramuscular immunization with triple- or double-layered rotavirus particles and QS-21. Virology (1998) 0.94

Endocarditis complicating ulcerative colitis. Gastroenterology (1977) 0.94

Genomic segment reassortment in rotaviruses and other reoviridae. Adv Virus Res (1991) 0.94

Comparative study on the mechanisms of rotavirus inactivation by sodium dodecyl sulfate and ethylenediaminetetraacetate. Appl Environ Microbiol (1980) 0.94

Evidence for a coordination position available to solute molecules on one of the metals at the active center of reduced bovine superoxide di smutase. Biochem Biophys Res Commun (1976) 0.94

Directional limits on persistent gravitational waves using LIGO S5 science data. Phys Rev Lett (2011) 0.93

The T 4 -free thyroxine index as a test of thyroid function of first choice. J Clin Pathol (1972) 0.92

Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling. J Cancer Res Clin Oncol (2014) 0.90

A rotavirus vaccine for infants: the Asian experience. Ann Acad Med Singapore (2006) 0.90

Identification of a new neutralization epitope on VP7 of human serotype 2 rotavirus and evidence for electropherotype differences caused by single nucleotide substitutions. Virology (1993) 0.89

Possible role of neonatal infection with the asymptomatic reassortant rotavirus (RV) strain I321 in the decrease in hospital admissions for RV diarrhea, Bangalore, India, 1988-1999. J Infect Dis (2004) 0.89

Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice. Eur J Immunol (2001) 0.89

Clinicopathological significance of erbB-2 expression in colorectal carcinoma. Oncol Rep (1999) 0.89

The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer. Br J Cancer (2007) 0.88