Published in Nat Med on July 23, 2006
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science (2011) 15.45
SPICE: exploration and analysis of post-cytometric complex multivariate datasets. Cytometry A (2011) 5.78
Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE. Nat Biotechnol (2011) 5.46
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J Exp Med (2007) 5.22
Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J Exp Med (2007) 3.66
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nat Biotechnol (2012) 3.65
Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. Eur J Immunol (2007) 3.18
A deep profiler's guide to cytometry. Trends Immunol (2012) 3.14
Paths to stemness: building the ultimate antitumour T cell. Nat Rev Cancer (2012) 2.79
Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur J Immunol (2008) 2.59
Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers. Nat Methods (2009) 2.57
The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays. Cancer Immunol Immunother (2007) 2.49
The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression. J Leukoc Biol (2008) 2.44
Data analysis in flow cytometry: the future just started. Cytometry A (2010) 2.18
A chromatic explosion: the development and future of multiparameter flow cytometry. Immunology (2008) 2.17
Optimizing a multicolor immunophenotyping assay. Clin Lab Med (2007) 2.12
CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia. J Allergy Clin Immunol (2011) 2.10
Designing multifunctional quantum dots for bioimaging, detection, and drug delivery. Chem Soc Rev (2010) 2.08
Single-cell RNA-seq: advances and future challenges. Nucleic Acids Res (2014) 2.06
Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology (2009) 1.78
Single-cell technologies for monitoring immune systems. Nat Immunol (2014) 1.78
Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. J Immunol Methods (2008) 1.62
Apoptosis and beyond: cytometry in studies of programmed cell death. Methods Cell Biol (2011) 1.61
Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. PLoS Pathog (2010) 1.59
Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy? J Immunother (2012) 1.47
Review Article: Recent advancements in optofluidic flow cytometer. Biomicrofluidics (2010) 1.45
Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo. J Virol (2007) 1.45
Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses. J Immunol (2007) 1.44
Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. J Immunol (2009) 1.42
Cytometry: today's technology and tomorrow's horizons. Methods (2012) 1.38
Single-cell mass cytometry for analysis of immune system functional states. Curr Opin Immunol (2013) 1.35
Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells. J Am Chem Soc (2009) 1.34
Nanoparticles for applications in cellular imaging. Nanoscale Res Lett (2007) 1.34
Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis. Nat Rev Immunol (2011) 1.32
Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure. J Virol (2009) 1.27
Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers. Cytometry A (2008) 1.26
A novel method for detection of phosphorylation in single cells by surface enhanced Raman scattering (SERS) using composite organic-inorganic nanoparticles (COINs). PLoS One (2009) 1.24
Multifunctional Quantum Dots for Personalized Medicine. Nano Today (2009) 1.19
Semiconductor quantum dots for bioimaging and biodiagnostic applications. Annu Rev Anal Chem (Palo Alto Calif) (2013) 1.18
Capsid-specific T-cell responses to natural infections with adeno-associated viruses in humans differ from those of nonhuman primates. Mol Ther (2011) 1.18
Integration of semiconductor quantum dots into nano-bio-chip systems for enumeration of CD4+ T cell counts at the point-of-need. Lab Chip (2008) 1.17
Publishing flow cytometry data. Am J Physiol Lung Cell Mol Physiol (2009) 1.14
Quality assurance for polychromatic flow cytometry using a suite of calibration beads. Nat Protoc (2012) 1.14
Metal-Containing Polystyrene Beads as Standards for Mass Cytometry. J Anal At Spectrom (2010) 1.11
Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets. J Immunol Methods (2007) 1.07
Inferring phenotypic properties from single-cell characteristics. PLoS One (2012) 1.06
Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening. Curr Opin Pharmacol (2007) 1.04
High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations. PLoS One (2011) 1.03
FlowFP: A Bioconductor Package for Fingerprinting Flow Cytometric Data. Adv Bioinformatics (2009) 1.03
T cell responses to whole SARS coronavirus in humans. J Immunol (2008) 1.03
Cytometry in cell necrobiology revisited. Recent advances and new vistas. Cytometry A (2010) 1.03
Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities. Cytometry A (2008) 0.99
MHC-based detection of antigen-specific CD8+ T cell responses. Cancer Immunol Immunother (2010) 0.98
Revealing the vectors of cellular identity with single-cell genomics. Nat Biotechnol (2016) 0.97
Dynamic immune cell accumulation during flow-induced atherogenesis in mouse carotid artery: an expanded flow cytometry method. Arterioscler Thromb Vasc Biol (2012) 0.93
Isolation of viable antigen-specific CD8+ T cells based on membrane-bound tumor necrosis factor (TNF)-α expression. J Immunol Methods (2011) 0.93
Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection. J Virol (2007) 0.92
Lab-on-a-chip flow cytometer employing color-space-time coding. Appl Phys Lett (2010) 0.92
Flow cytometry-based apoptosis detection. Methods Mol Biol (2009) 0.92
Multicolor multicycle molecular profiling with quantum dots for single-cell analysis. Nat Protoc (2013) 0.91
Aromatic aldehyde and hydrazine activated peptide coated quantum dots for easy bioconjugation and live cell imaging. Bioconjug Chem (2011) 0.89
Biotin-4-fluorescein based fluorescence quenching assay for determination of biotin binding capacity of streptavidin conjugated quantum dots. Bioconjug Chem (2011) 0.88
Autoimmune diseases - connecting risk alleles with molecular traits of the immune system. Nat Rev Genet (2016) 0.88
Sensitive and rapid quantification of C-reactive protein using quantum dot-labeled microplate immunoassay. J Transl Med (2012) 0.87
High-throughput 13-parameter immunophenotyping identifies shifts in the circulating T-cell compartment following reperfusion in patients with acute myocardial infarction. PLoS One (2012) 0.87
QDs versus Alexa: reality of promising tools for immunocytochemistry. J Nanobiotechnology (2009) 0.85
Heavy metal contaminants can eliminate quantum dot fluorescence. Cytometry A (2011) 0.85
The dynamic lives of T cells: new approaches and themes. Trends Immunol (2012) 0.85
Detection, phenotyping, and quantification of antigen-specific T cells using a peptide-MHC dodecamer. Proc Natl Acad Sci U S A (2016) 0.84
β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure. Diabetes (2014) 0.84
Recent advances in diagnosis, prevention, and treatment of human respiratory syncytial virus. Adv Virol (2013) 0.84
Multiparameter analysis of stimulated human peripheral blood mononuclear cells: A comparison of mass and fluorescence cytometry. Cytometry A (2015) 0.84
WebFlow: a software package for high-throughput analysis of flow cytometry data. Assay Drug Dev Technol (2009) 0.82
Optical hyperspectral imaging in microscopy and spectroscopy - a review of data acquisition. J Biophotonics (2014) 0.82
Direct detection of FoxP3 expression in thymic double-negative CD4-CD8- cells by flow cytometry. Sci Rep (2014) 0.81
Immune cell profiling to guide therapeutic decisions in rheumatic diseases. Nat Rev Rheumatol (2015) 0.81
Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers. J Infect Dis (2015) 0.80
Toward the measurement of multiple fluorescence lifetimes in flow cytometry: maximizing multi-harmonic content from cells and microspheres. J Biophotonics (2015) 0.79
Emerging affinity-based techniques in proteomics. Expert Rev Proteomics (2009) 0.79
Potential use of quantum dots in flow cytometry. Int J Mol Sci (2008) 0.79
Sequential array cytometry: multi-parameter imaging with a single fluorescent channel. Ann Biomed Eng (2010) 0.78
Nanowire array chips for molecular typing of rare trafficking leukocytes with application to neurodegenerative pathology. Nanoscale (2014) 0.78
Quantitative differentiation of dyes with overlapping one-photon spectra by femtosecond pulse shaping. J Lumin (2010) 0.78
A fluorescence displacement assay for antidepressant drug discovery based on ligand-conjugated quantum dots. J Am Chem Soc (2011) 0.78
Magnetic-activated cell sorting of TCR-engineered T cells, using tCD34 as a gene marker, but not peptide-MHC multimers, results in significant numbers of functional CD4+ and CD8+ T cells. Hum Gene Ther Methods (2012) 0.78
Labeling of neuronal receptors and transporters with quantum dots. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2012) 0.78
Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations. J Immunol (2014) 0.78
Studying the human immunome: the complexity of comprehensive leukocyte immunophenotyping. Curr Top Microbiol Immunol (2014) 0.78
Design and synthesis of water-soluble bioconjugatable trans-AB-porphyrins. Tetrahedron (2008) 0.78
A high-sensitivity lanthanide nanoparticle reporter for mass cytometry: tests on microgels as a proxy for cells. Langmuir (2014) 0.78
Nanomedicine: tiny particles and machines give huge gains. Ann Biomed Eng (2013) 0.77
Addressing Key Technical Aspects of Quantum Dot Probe Preparation for Bioassays. Part Part Syst Charact (2014) 0.77
Finding multiple needles in one immune haystack. Nat Methods (2009) 0.77
Label-free single-cell protein quantification using a drop-based mix-and-read system. Sci Rep (2015) 0.76
From measuring noise toward integrated single-cell biology. Front Genet (2014) 0.75
Optical Properties of CdSe/ZnS Nanocrystals. J Res Natl Inst Stand Technol (2014) 0.75
Unfold High-Dimensional Clouds for Exhaustive Gating of Flow Cytometry Data. IEEE/ACM Trans Comput Biol Bioinform (2015) 0.75
Facile and rapid detection of respiratory syncytial virus using metallic nanoparticles. J Nanobiotechnology (2016) 0.75
Toward deterministic and semiautomated SPADE analysis. Cytometry A (2017) 0.75
Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med (2006) 24.38
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood (2006) 17.38
Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies. J Virol (2005) 15.61
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science (2010) 14.91
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med (2004) 13.55
Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature (2005) 13.15
Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med (2012) 12.98
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods (2003) 11.81
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med (2007) 11.80
T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol (2008) 11.65
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol (2008) 10.26
Antiretroviral-drug resistance among patients recently infected with HIV. N Engl J Med (2002) 9.70
HIV preferentially infects HIV-specific CD4+ T cells. Nature (2002) 9.28
HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet (2008) 8.37
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med (2006) 8.18
Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol (2002) 7.92
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science (2011) 7.92
A human memory T cell subset with stem cell-like properties. Nat Med (2011) 7.47
Seventeen-colour flow cytometry: unravelling the immune system. Nat Rev Immunol (2004) 7.37
Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science (2003) 6.92
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood (2002) 6.73
Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates. Nature (2003) 6.35
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity (2003) 6.19
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J Exp Med (2007) 5.58
Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector. J Infect Dis (2006) 5.53
Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know. Nat Med (2004) 5.49
T cell dynamics in HIV-1 infection. Annu Rev Immunol (2001) 5.29
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J Exp Med (2007) 5.22
HIV disease: fallout from a mucosal catastrophe? Nat Immunol (2006) 5.08
Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A (2008) 4.71
Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination. J Immunol Methods (2007) 4.69
Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science (2013) 4.60
Noninvasive imaging of quantum dots in mice. Bioconjug Chem (2004) 4.59
Standardization of cytokine flow cytometry assays. BMC Immunol (2005) 4.55
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood (2008) 4.34
T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. J Virol (2004) 4.02
Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med (2009) 3.94
T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity (2004) 3.69
AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells. Blood (2009) 3.65
Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J Exp Med (2005) 3.63
Ex vivo identification, isolation and analysis of tumor-cytolytic T cells. Nat Med (2003) 3.60
Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proc Natl Acad Sci U S A (2009) 3.58
A new "Logicle" display method avoids deceptive effects of logarithmic scaling for low signals and compensated data. Cytometry A (2006) 3.49
Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine. J Infect Dis (2006) 3.40
Quality assurance for polychromatic flow cytometry. Nat Protoc (2006) 3.34
The molecular basis for public T-cell responses? Nat Rev Immunol (2008) 3.32
Amine reactive dyes: an effective tool to discriminate live and dead cells in polychromatic flow cytometry. J Immunol Methods (2006) 3.32
Vaccination in humans generates broad T cell cytokine responses. J Immunol (2004) 3.27
Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation. J Exp Med (2006) 3.26
Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine. N Engl J Med (2013) 3.24
CD8+ T cell efficacy in vaccination and disease. Nat Med (2008) 3.20
DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials. Lancet Infect Dis (2011) 3.19
Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. Eur J Immunol (2007) 3.18
A deep profiler's guide to cytometry. Trends Immunol (2012) 3.14
A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape. J Immunol (2002) 3.07
A West Nile virus DNA vaccine induces neutralizing antibody in healthy adults during a phase 1 clinical trial. J Infect Dis (2007) 3.02
Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control. PLoS Pathog (2010) 2.99
Sentinel lymph node imaging using quantum dots in mouse tumor models. Bioconjug Chem (2007) 2.98
Intracellular cytokine optimization and standard operating procedure. Nat Protoc (2006) 2.96