Published in Bioinformatics on July 15, 2006
The BioPAX community standard for pathway data sharing. Nat Biotechnol (2010) 9.19
The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia. Blood (2007) 1.99
Dynamic analysis of integrated signaling, metabolic, and regulatory networks. PLoS Comput Biol (2008) 1.81
Emergent decision-making in biological signal transduction networks. Proc Natl Acad Sci U S A (2008) 1.69
Integrated analysis of breast cancer cell lines reveals unique signaling pathways. Genome Biol (2009) 1.25
Parameter estimation in systems biology models using spline approximation. BMC Syst Biol (2011) 1.14
Bringing metabolic networks to life: integration of kinetic, metabolic, and proteomic data. Theor Biol Med Model (2006) 1.09
Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch. PLoS Comput Biol (2009) 0.90
Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling. PLoS One (2010) 0.89
Systematic parameter estimation in data-rich environments for cell signalling dynamics. Bioinformatics (2013) 0.85
Brief overview of bioinformatics activities in Singapore. PLoS Comput Biol (2009) 0.84
A quantitative model of thermal injury-induced acute inflammation. Math Biosci (2010) 0.82
A unique transformation from ordinary differential equations to reaction networks. PLoS One (2010) 0.82
Computational systems biology in cancer: modeling methods and applications. Gene Regul Syst Bio (2007) 0.81
In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology. Biophys J (2013) 0.79
Bayesian experts in exploring reaction kinetics of transcription circuits. Bioinformatics (2010) 0.78
Evolution of multiple phosphodiesterase isoforms in stickleback involved in cAMP signal transduction pathway. BMC Syst Biol (2009) 0.78
A framework for scalable parameter estimation of gene circuit models using structural information. Bioinformatics (2013) 0.78
Signaling networks in Leishmania macrophages deciphered through integrated systems biology: a mathematical modeling approach. Syst Synth Biol (2013) 0.76
A survey on evolutionary algorithm based hybrid intelligence in bioinformatics. Biomed Res Int (2014) 0.76
Parameter Estimation Using Divide-and-Conquer Methods for Differential Equation Models. J Biom Biostat (2016) 0.75
Automated parameter estimation for biological models using Bayesian statistical model checking. BMC Bioinformatics (2015) 0.75
Fuzzy Stochastic Petri Nets for Modeling Biological Systems with Uncertain Kinetic Parameters. PLoS One (2016) 0.75
Systems Biology of Immunomodulation for Post-Stroke Neuroplasticity: Multimodal Implications of Pharmacotherapy and Neurorehabilitation. Front Neurol (2016) 0.75
Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology (2007) 3.99
RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma. Sci Transl Med (2010) 3.53
Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet (2003) 2.31
The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J Immunol (2008) 1.75
Retracted A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities. Proc Natl Acad Sci U S A (2008) 1.69
A family of ductile intermetallic compounds. Nat Mater (2003) 1.66
Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. Cancer Res (2011) 1.58
Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. Inflamm Bowel Dis (2009) 1.53
A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.39
Stochastic roadmap simulation: an efficient representation and algorithm for analyzing molecular motion. J Comput Biol (2003) 1.15
Scalable GMP compliant suspension culture system for human ES cells. Stem Cell Res (2012) 1.14
Replication-competent lentivirus analysis of clinical grade vector products. Mol Ther (2010) 1.04
Phosphorylation of the survival kinase Akt by superoxide is dependent on an ascorbate-reversible oxidation of PTEN. Free Radic Biol Med (2007) 1.01
Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo. Cancer Res (2009) 1.00
Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis. Innate Immun (2009) 0.97
A permissive apoptotic environment: function of a decrease in intracellular superoxide anion and cytosolic acidification. Biochem Biophys Res Commun (2002) 0.94
The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia. BMC Gastroenterol (2010) 0.93
Approximate probabilistic analysis of biopathway dynamics. Bioinformatics (2012) 0.92
Improved statistical model checking methods for pathway analysis. BMC Bioinformatics (2012) 0.92
DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience. Cortex (2012) 0.92
Teaching NeuroImages: methotrexate leukoencephalopathy mimicking a transient ischemic attack. Neurology (2010) 0.90
Using robotics to fold proteins and dock ligands. Bioinformatics (2002) 0.89
Epigenetic stability, adaptability, and reversibility in human embryonic stem cells. Proc Natl Acad Sci U S A (2012) 0.89
Methane emissions from free-ranging cattle: comparison of tracer and integrated horizontal flux techniques. J Environ Qual (2008) 0.88
Hydrogen peroxide-induced apoptosis: oxidative or reductive stress? Methods Enzymol (2002) 0.88
A computational and experimental study of the regulatory mechanisms of the complement system. PLoS Comput Biol (2011) 0.85
Systematic parameter estimation in data-rich environments for cell signalling dynamics. Bioinformatics (2013) 0.85
Using stochastic roadmap simulation to predict experimental quantities in protein folding kinetics: folding rates and phi-values. J Comput Biol (2007) 0.85
Computational models of protein kinematics and dynamics: beyond simulation. Annu Rev Anal Chem (Palo Alto Calif) (2012) 0.84
Modest advances in survival for patients with colorectal-associated peritoneal carcinomatosis in the era of modern chemotherapy. J Surg Oncol (2012) 0.83
Protein conformational flexibility analysis with noisy data. J Comput Biol (2008) 0.82
A robust approach for the quantitation of viral concentration in an adenoviral vector-based human immunodeficiency virus vaccine by real-time quantitative polymerase chain reaction. Hum Gene Ther (2006) 0.81
Markov dynamic models for long-timescale protein motion. Bioinformatics (2010) 0.80
Redox control of cytosolic Akt phosphorylation in PTEN null cells. Free Radic Biol Med (2012) 0.80
Activation of a non-genomic Pim-1/Bad-Pser75 module is required for an efficient pro-survival effect of Bcl-xL induced by androgen in LNCaP cells. Int J Biochem Cell Biol (2010) 0.79
Production of CGMP-Grade Lentiviral Vectors. Bioprocess Int (2012) 0.79
Retraction for Garman et al: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities. Proc Natl Acad Sci U S A (2011) 0.78
Thermal inactivation of adenovirus type 5. J Virol Methods (2004) 0.78
Modeling and analysis of biopathways dynamics. J Bioinform Comput Biol (2012) 0.76
pFlexAna: detecting conformational changes in remotely related proteins. Nucleic Acids Res (2008) 0.75
Robust Timing Calibration for PET Using L1-Norm Minimization. IEEE Trans Med Imaging (2017) 0.75
Nonpharmacological treatment options for epilepsy. Semin Pediatr Neurol (2005) 0.75
A hybrid Factored Frontier algorithm for Dynamic Bayesian Networks with a biopathways application. IEEE/ACM Trans Comput Biol Bioinform (2012) 0.75
Inactivation of adenovirus type 5 by caustics. Biotechnol Prog (2005) 0.75
QT Corrections for Long QT Risk Assessment: Implications for the Preparticipation Examination. Clin J Sport Med (2017) 0.75
Optimizing QT Interval Measurement for the Preparticipation Screening of Young Athletes. Med Sci Sports Exerc (2016) 0.75