Published in Mol Cell Biol on August 01, 2006
Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer (2008) 4.34
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci U S A (2007) 3.20
The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol (2007) 3.14
Targeting Hedgehog--a cancer stem cell pathway. Clin Cancer Res (2010) 2.50
Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol (2010) 2.05
A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO J (2009) 1.95
Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. Cancer Res (2009) 1.78
Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res (2010) 1.50
Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res (2011) 1.35
Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Pharmacol Rev (2010) 1.33
Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Mol Med (2012) 1.27
Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal. J Biol Chem (2008) 1.23
Hedgehog signalling in breast cancer. Carcinogenesis (2009) 1.18
cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells. PLoS One (2010) 1.15
Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules. Mol Biol Cell (2007) 1.10
Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy. Semin Cell Dev Biol (2014) 1.08
Non-consensus GLI binding sites in Hedgehog target gene regulation. BMC Mol Biol (2010) 1.07
Basal cell carcinoma - molecular biology and potential new therapies. J Clin Invest (2012) 1.06
Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors. PLoS Comput Biol (2010) 1.06
Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer. Cancer Res (2013) 1.06
Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution. Philos Trans R Soc Lond B Biol Sci (2013) 1.06
Induction of specific microRNAs inhibits cutaneous wound healing. J Biol Chem (2012) 1.04
GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells. J Biol Chem (2008) 0.97
Sonic hedgehog-Gli1 signaling pathway regulates the epithelial mesenchymal transition (EMT) by mediating a new target gene, S100A4, in pancreatic cancer cells. PLoS One (2014) 0.96
Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis. Oncotarget (2014) 0.95
Cooperative Hedgehog-EGFR signaling. Front Biosci (Landmark Ed) (2012) 0.95
Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding. Oncotarget (2014) 0.94
Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling. Cancer Cell Int (2008) 0.93
Implications of hedgehog signaling antagonists for cancer therapy. Acta Biochim Biophys Sin (Shanghai) (2008) 0.92
Glioma-associated oncogene family zinc finger 1 expression and metastasis in patients with head and neck squamous cell carcinoma treated with radiation therapy (RTOG 9003). J Clin Oncol (2011) 0.92
Role of FGFR2-signaling in the pathogenesis of acne. Dermatoendocrinol (2009) 0.92
An old friend with new skills: Imiquimod as novel inhibitor of Hedgehog signaling in basal cell carcinoma. Oncoscience (2014) 0.91
Gli as a novel therapeutic target in malignant pleural mesothelioma. PLoS One (2013) 0.91
Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling. Dev Dyn (2008) 0.90
The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity. J Cell Sci (2015) 0.90
Robust shifts in S100a9 expression with aging: a novel mechanism for chronic inflammation. Sci Rep (2013) 0.89
A model of spatially restricted transcription in opposing gradients of activators and repressors. Mol Syst Biol (2012) 0.89
Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies. J Cell Mol Med (2009) 0.88
The sonic hedgehog signaling pathway maintains the cancer stem cell self-renewal of anaplastic thyroid cancer by inducing snail expression. J Clin Endocrinol Metab (2014) 0.88
Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines. PLoS One (2016) 0.87
Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy. Expert Rev Mol Med (2015) 0.87
Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity. J Biol Chem (2008) 0.87
Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome. Mol Cell Proteomics (2012) 0.86
Regulation of the spermatogonial stem cell niche. Reprod Domest Anim (2008) 0.85
Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis. J Biol Chem (2015) 0.84
Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia. Oncogene (2015) 0.83
Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration. Dev Dyn (2013) 0.83
SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties. J Cell Sci (2015) 0.83
Aberrantly activated Gli2-KIF20A axis is crucial for growth of hepatocellular carcinoma and predicts poor prognosis. Oncotarget (2016) 0.82
Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epithelium. IUBMB Life (2014) 0.79
Hedgehog/GLI signaling activates suppressor of cytokine signaling 1 (SOCS1) in epidermal and neural tumor cells. PLoS One (2013) 0.79
Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions. Cancers (Basel) (2015) 0.79
Akt1 interacts with epidermal growth factor receptors and hedgehog signaling to increase stem/transit amplifying cells in the embryonic mouse cortex. Dev Neurobiol (2011) 0.78
GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state. PLoS One (2011) 0.78
Olfactomedin 4 deficiency promotes prostate neoplastic progression and is associated with upregulation of the hedgehog-signaling pathway. Sci Rep (2015) 0.77
The Role of Hedgehog Signaling in Tumor Induced Bone Disease. Cancers (Basel) (2015) 0.77
Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. PLoS One (2013) 0.77
Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma. J Exp Pharmacol (2012) 0.75
Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling. Cell Commun Signal (2017) 0.75
Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation. Cancer Res (2016) 0.75
Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2. Oncotarget (2015) 0.75
Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing. Oncotarget (2016) 0.75
From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases. Cell Commun Signal (2017) 0.75
Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. PLoS One (2016) 0.75
GLI1 blockade potentiates the antitumor activity of PI3K antagonists in lung squamous cell carcinoma. Cancer Res (2017) 0.75
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
Untangling the ErbB signalling network. Nat Rev Mol Cell Biol (2001) 28.05
Cell signaling by receptor tyrosine kinases. Cell (2000) 18.16
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol (1988) 16.82
ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer (2005) 16.73
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75
Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation. Nat Biotechnol (1998) 13.99
TGFbeta signaling in growth control, cancer, and heritable disorders. Cell (2000) 12.38
Capturing and profiling adult hair follicle stem cells. Nat Biotechnol (2004) 10.35
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 10.33
Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol (1995) 9.03
Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature (2003) 8.38
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science (1996) 8.06
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell (1996) 7.86
Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43
Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature (2004) 6.82
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science (1995) 6.58
Tissue repair and stem cell renewal in carcinogenesis. Nature (2004) 6.28
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell (2000) 6.08
Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectors. Protein Expr Purif (1999) 5.90
Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A (2005) 5.87
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Strain-dependent epithelial defects in mice lacking the EGF receptor. Science (1995) 5.22
The Hedgehog response network: sensors, switches, and routers. Science (2004) 5.20
A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development (1997) 5.09
Communicating with Hedgehogs. Nat Rev Mol Cell Biol (2005) 5.01
Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer (2003) 4.86
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development (2002) 4.80
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature (1995) 4.56
Getting under the skin of epidermal morphogenesis. Nat Rev Genet (2002) 4.54
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell (1997) 4.43
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nat Genet (1996) 4.36
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development (2005) 4.32
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development (1999) 4.06
Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol (2004) 4.00
Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer (2002) 3.91
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development (2000) 3.91
Basal cell carcinomas in mice overexpressing sonic hedgehog. Science (1997) 3.84
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc Natl Acad Sci U S A (2004) 3.68
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol Cell Biol (1990) 3.64
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature (1997) 3.64
Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science (1993) 3.62
Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol (1999) 3.62
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development (2004) 3.30
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol (2006) 3.29
Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J Biol Chem (1999) 3.25
ErbB receptors: directing key signaling networks throughout life. Annu Rev Pharmacol Toxicol (2004) 3.18
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development (2001) 3.14
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell (2004) 3.13
Enrichment for murine keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci U S A (2000) 3.12
Signaling networks: the origins of cellular multitasking. Cell (2000) 2.99
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci U S A (2006) 2.97
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia (2003) 2.89
The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature (1988) 2.87
Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet (2000) 2.82
Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development (1999) 2.77
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc Natl Acad Sci U S A (2000) 2.73
FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res (2002) 2.71
GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer (2006) 2.63
Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters. Curr Biol (2000) 2.58
Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem (2001) 2.56
Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex. Development (2003) 2.26
Hair cycle regulation of Hedgehog signal reception. Dev Biol (2003) 2.21
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev (2003) 2.12
MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev (2004) 2.07
The EGF receptor: a nexus for trafficking and signaling. Bioessays (2000) 2.02
Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma. Oncogene (2002) 1.99
Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res (2004) 1.98
Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype. J Investig Dermatol Symp Proc (1999) 1.96
Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat Med (1997) 1.93
A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet (2005) 1.89
Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev (2004) 1.84
Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene (2004) 1.82
High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Dev Cell (2004) 1.78
GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. J Invest Dermatol (2004) 1.76
Dual degradation signals control Gli protein stability and tumor formation. Genes Dev (2006) 1.75
Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development (2003) 1.68
Post-translational modifications influence transcription factor activity: a view from the ETS superfamily. Bioessays (2005) 1.67
Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem (2003) 1.65
GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. Proc Natl Acad Sci U S A (1999) 1.63
Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. Am J Pathol (1997) 1.62
The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A. Mol Cell Biol (1991) 1.62
Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem (2002) 1.60
Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase. J Biol Chem (2006) 1.51
A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene (1999) 1.49
Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling. Cancer Res (2006) 1.49
Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells. Curr Biol (2003) 1.46
Hedgehog signalling in cancer. Cell Mol Life Sci (2000) 1.44
The emergent design of the neural tube: prepattern, SHH morphogen and GLI code. Curr Opin Genet Dev (2003) 1.38
Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer. Cancer Res (2005) 1.38
FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma. J Invest Dermatol (2004) 1.34
A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr Biol (1995) 1.26
Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells. Int J Cancer (2006) 1.26
Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway. J Invest Dermatol (2005) 1.25
Cooperative requirement of the Gli proteins in neurogenesis. Development (2005) 1.25
Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development (2004) 1.24
Basal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient mice. Cancer Res (2004) 1.24
Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell (2010) 2.91
FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res (2002) 2.71
GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer (2006) 2.63
Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology (2011) 2.33
Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma. Oncogene (2002) 1.99
Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res (2004) 1.98
Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. Cancer Res (2009) 1.78
GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. J Invest Dermatol (2004) 1.76
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell (2012) 1.65
Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. Gastroenterology (2009) 1.64
Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event. Cancer Res (2005) 1.59
Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma. Carcinogenesis (2004) 1.50
Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology (2015) 1.49
The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners. Mutat Res (2008) 1.45
FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma. J Invest Dermatol (2004) 1.34
The mTOR pathway and its role in human genetic diseases. Mutat Res (2008) 1.33
Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Mol Med (2012) 1.27
Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes. Genomics (2006) 1.21
Cell-type and donor-specific transcriptional responses to interferon-alpha. Use of customized gene arrays. J Biol Chem (2002) 1.20
Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma. BMC Cancer (2010) 1.20
Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis. Gastroenterology (2010) 1.17
Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes. Mol Cancer (2010) 1.16
Chromogenic in situ hybridization: a novel approach to a practical and sensitive method for the detection of HER2 oncogene in archival human breast carcinoma. Lab Invest (2002) 1.15
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J (2011) 1.12
alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. Cancer Res (2008) 1.11
Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated. J Invest Dermatol (2010) 1.09
Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models. Scand J Gastroenterol (2007) 1.08
RNA expression profiling at the single molecule level. Genome Res (2006) 1.08
Non-consensus GLI binding sites in Hedgehog target gene regulation. BMC Mol Biol (2010) 1.07
JAK-STAT signaling in hepatic fibrosis. Front Biosci (Landmark Ed) (2011) 1.06
The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells. Oncogene (2004) 1.04
Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci (2007) 1.04
Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth. Mol Carcinog (2008) 1.04
Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebaceous glands and cultured sebocytes. J Invest Dermatol (2007) 1.04
Multi-modal treatment of calciphylaxis with sodium-thiosulfate, cinacalcet and sevelamer including long-term data. Kidney Blood Press Res (2013) 1.04
Comparison of real-time PCR signal-amplified in situ hybridization and conventional PCR for detection and quantification of human papillomavirus in archival cervical cancer tissue. J Clin Microbiol (2004) 1.03
p27Kip1 localization depends on the tumor suppressor protein tuberin. Hum Mol Genet (2007) 1.02
The functional and temporal characteristics of top-down modulation in visual selection. Cereb Cortex (2004) 1.01
Female gender may predict response to FOLFIRINOX in patients with unresectable pancreatic cancer: a single institution retrospective review. Int J Oncol (2013) 1.00
Predictive value of cumulus cell apoptosis with regard to blastocyst development of corresponding gametes. Fertil Steril (2005) 0.98
Expression profiling of aging in the human skin. Exp Gerontol (2006) 0.98
Steroid synthesis by primary human keratinocytes; implications for skin disease. Biochem Biophys Res Commun (2010) 0.98
Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene. J Mol Neurosci (2006) 0.98
GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells. J Biol Chem (2008) 0.97
HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study. Int J Cancer (2009) 0.97
Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation. Virchows Arch (2009) 0.97
Cooperative Hedgehog-EGFR signaling. Front Biosci (Landmark Ed) (2012) 0.95
Stem cells in amniotic fluid as new tools to study human genetic diseases. Stem Cell Rev (2007) 0.95
Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma. Cancer Res (2003) 0.93
The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer. Pancreatology (2008) 0.92
Animal and in vitro models for the study of hair follicles. J Investig Dermatol Symp Proc (2003) 0.92
Toll-like receptor 9 expression in breast and ovarian cancer is associated with poorly differentiated tumors. Cancer Sci (2010) 0.92
GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes. Carcinogenesis (2008) 0.92
Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII. Cancer Res (2010) 0.91
IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site. J Immunol (2003) 0.91
Efficient manipulation of Hedgehog/GLI signaling using retroviral expression systems. Methods Mol Biol (2007) 0.91
Generation of hypoallergenic DNA vaccines by forced ubiquitination: preventive and therapeutic effects in a mouse model of allergy. J Allergy Clin Immunol (2006) 0.89
Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit. Gastroenterology (2012) 0.89
Contrasting expression patterns of CCAAT/enhancer-binding protein transcription factors in the hair follicle and at different stages of the hair growth cycle. J Invest Dermatol (2002) 0.88
Methylated NEUROD1 promoter is a marker for chemosensitivity in breast cancer. Clin Cancer Res (2008) 0.87
Rapid and reliable detection of LINE-1 hypomethylation using high-resolution melting analysis. Clin Biochem (2010) 0.87
Immunization with a low-dose replicon DNA vaccine encoding Phl p 5 effectively prevents allergic sensitization. J Allergy Clin Immunol (2006) 0.87
Characterization of liver X receptor expression and function in human skin and the pilosebaceous unit. Exp Dermatol (2007) 0.87
CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility. Cancer Res (2012) 0.86